Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2

American Journal of Surgical Pathology

Volumn 25, Issue 10, 2001, Pages 1225-1230

  Castrillon, D H ^a   Sun, D ^a   Weremowicz, S ^a   Fisher, R A ^a   Crum, C P ^a   Genest, D R ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Genomic imprinting; Hydatidiform mole; Immunohistochemistry; P57KIP2

Indexed keywords

CHORIONIC GONADOTROPIN BETA SUBUNIT; GENE PRODUCT; MONOCLONAL ANTIBODY; PROTEIN P57;

ADULT; AGED; ARTICLE; DNA METHYLATION; FEMALE; FLOW CYTOMETRY; GENOME IMPRINTING; GESTATIONAL AGE; HISTOPATHOLOGY; HUMAN; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; MOLECULAR MIMICRY; OBSERVER VARIATION; PATERNITY; POLYMERASE CHAIN REACTION; PREGNANCY TERMINATION; SPONTANEOUS ABORTION; TUMOR SUPPRESSOR GENE;

ABORTION, SPONTANEOUS; ADULT; CYCLIN-DEPENDENT KINASE INHIBITOR P57; DIAGNOSIS, DIFFERENTIAL; DNA, NEOPLASM; ENZYME INHIBITORS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMIC IMPRINTING; GESTATIONAL AGE; HUMANS; HYDATIDIFORM MOLE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; NUCLEAR PROTEINS; PLACENTA; PREGNANCY; UTERINE NEOPLASMS;

EID: 0034816993     PISSN: 01475185     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000478-200110000-00001     Document Type: Article

References (27)

1. Relaxation of imprinting in trophoblastic disease
2. Molecular genetic testing from paraffin-embedded tissue distinguishes nonmolar hydropic abortion from hydatidiform mole
3. Human GRB10 is imprinted and expressed from the paternal and maternal allele in a highly tissue- and isoform-specific fashion
4. Differential expression of p57kip2, a maternally imprinted cdk inhibitor, in normal human placenta and gestational trophoblastic disease
5. Diagnostic considerations in molar gestations
6. Genomic imprinting: Implications for human disease
7. Repetitive complete hydatidiform mole can be biparental in origin and either male or female
8. Rapid diagnosis and classification of hydatidiform moles with polymerase chain reaction
9. Frequency of heterozygous complete hydatidiform moles, estimated by locus-specific minisatellite and Y chromosome-specific probes
10. Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry
11. Androgenetic origin of hydatidiform mole
12. Very early complete hydatidiform mole
13. Interphase cytogenetic analysis of single cell suspensions prepared from previously formalin-fixed and paraffin-embedded tissues
14. Placentomegaly with massive hydrops of placental stem villi, diploid DNA content, and fetal omphaloceles: Possible association with Beckwith-Wiedemann syndrome
15. The role of DNA flow cytometry in evaluation of partial and complete hydatidiform moles and hydropic abortions
16. Parental origin of triploidy in human fetuses: Evidence for genomic imprinting
17. Inter- and intrapathologist variability in the diagnosis of gestational trophoblastic neoplasia
18. Complete hydatidiform mole: Comparison of clinicopathologic features, current and past
19. A clinical, histopathological and flow cytometric study of 149 complete moles, 146 partial moles and 107 non-molar hydropic abortions
20. Determinants of villous trophoblastic hyperplasia in spontaneous abortions
21. Recent advances in gestational trophoblastic disease
22. Choriocarcinoma and partial hydatidiform moles
23. p57(Kip2) regulates the proper development of labyrinthine and spongiotrophoblasts
24. Human p57(KIP2) defines a new imprinted domain on chromosome 11p but is not a tumour suppressor gene in Wilms tumour
25. Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: Relation to expression and imprinting
26. Parental origin and phenotype of triploidy in spontaneous abortions: Predominance of diandry and association with the partial hydatidiform mole
27. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicate a role in Beck-with-Wiedemann syndrome