A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13

Human Molecular Genetics

Volumn 8, Issue 9, 1999, Pages 1799-1805

  Arngrímsson, Reynir ^a   Siguröardóttir, Sigrún ^b   Frigge, Michael L ^b   Bjarnadóttir, Ragnheiöur I ^c   Jónsson, Thorlákur ^b   Stefánsson, Hreinn ^b   Baldursdóttir, Ásdís ^a   Einarsdóttir, Anna S ^b   Palsson, Birgir ^b   Snorradóttir, Steinunn ^b   Lachmeijer, A M A ^a   Nicolae, Dan ^b,d   Kong, Augustine ^b,d   Bragason, Birkir Thor ^b   Gulcher, Jeffrey R ^b   Geirsson, Reynir Tómas ^c   Stefánsson, Kári ^b  

^a UNIVERSITY OF ICELAND   (Iceland)

^b DECODE GENETICS   (Iceland)

^c LANDSPITALI UNIVERSITY HOSPITAL   (Iceland)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 2P; DISEASE PREDISPOSITION; ECLAMPSIA; FAMILIAL DISEASE; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC SCREENING; GENOME; HUMAN; HUMAN TISSUE; HYPERTENSION; ICELAND; INFANT MORTALITY; MAJOR CLINICAL STUDY; MATERNAL DISEASE; MATERNAL HYPERTENSION; MATERNAL MORTALITY; PATHOPHYSIOLOGY; PREECLAMPSIA; PRENATAL CARE; PRIORITY JOURNAL; PROTEINURIA;

CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 2; FEMALE; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; GENOTYPE; HAPLOTYPES; HUMANS; ICELAND; LINKAGE (GENETICS); LOD SCORE; PEDIGREE; PRE-ECLAMPSIA; PREGNANCY;

EID: 0344132050     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/8.9.1799     Document Type: Article

References (30)

1. Roberts, J.M. and Redman, C.W.G. (1993) Preeclampsia: more than pregnancy-induced hypertension. Lancet, 341, 1447-1451.
2. Davey, D. and MacGillivray, I. (1988) Classification and definition of the hypertensive disorders of pregnancy. Am. J. Obstet. Gynecol., 158, 892-898.
3. Working Group on High Blood Pressure in Pregnancy (1990) National high blood pressure education program working group report on high blood pressure in pregnancy. Am. J. Obstet. Gynecol., 163, 1689-1712.
4. Witlin, A.G. and Sibai, B.M. (1997) Hypertension in pregnancy: current concepts of preeclampsia. Annu. Rev. Med., 48, 115-127.
5. Geirsson, R.T., Arngrimsson, R., Apalset, E., Einarsson, A. and Snaedal, G. (1994) Falling population incidence of eclampsia: a case control study of short term outcome. Acta Obstet. Gynecol. Scand., 73, 465-467.
6. Hogberg, U. and Joelsson, I. (1985) The decline in maternal mortality in Sweden, 1931-80. Acta Obstet. Gynecol. Scand., 64, 583-592.
7. Duley, L. (1992) Maternal mortality associated with hypertensive disorder of pregnancy in Africa, Asia, Latin America and the Caribbean. Br. J. Obstet. Gynaecol., 99, 547-553.
8. Eskenasi, B., Fenster, L., Sidney, S. and Elkin, E.P. (1993) Fetal growth retardation in infants of multiparous and nulliparous women with preeclampsia. Am. J. Obstet. Gynecol., 169, 1112-1118.
9. Khong, T.Y., deWolf, F., Robertsoon, W.B. and Brosens, I. (1986) Inadequate maternal vascular response to placentation in pregnancies complicated by preeclampsia and small-for-gestational age infants. Br. J. Obstet. Gynaecol., 93, 1049-1059.
10. Pijnenborg, R., Anthony, J., Davey, D.A., Rees, A., Tiltman, A., Vercruysse, L. and van Assche, A. (1991) Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br. J. Obstet. Gynaecol., 98, 648-655.
11. Dekker, G.A., de Vries, J.I., Doelitzsch, P.M., Huijgens, P.C., von Blomberg, B.M., Jakobs, C. and van Geijn, H.P. (1995) Underlying disorders associated with severe early-onset preeclampsia. Am. J. Obstet. Gynecol., 173, 1042-1048.
12. Jonsdottir, L.S., Amgrimsson, R., Geirsson, R.T., Sigvaldason, H. and Sigfusson, N. (1995) Death rates from ischemic heart disease among women with previous history of preeclampsia syndrome. Acta Obstet. Gynecol. Scand., 74, 772-776.
13. Chesley, L.C. and Cooper, D.W. (1986) Genetics of hypertension in pregnancy: possible single gene control of preeclampsia and eclampsia in the descendants of eclamptic women. Br. J. Obstet. Gynaecol., 93, 898-904.
14. Sutherland, A., Cooper, D.W., Howie, P.W., Liston, W.A. and MacGillivray, I. (1981) The incidence of severe preeclampsia amongst mothers and mothers-in-law of preeclamptics and controls. Br. J. Obstet. Gynaecol., 88, 785-793.
15. Arngrímsson, R., Bjornsson, S., Geirsson, R.T., Bjornsson, H., Walker, J.J. and Snaedal, G. (1990) Genetic and familial predisposition to eclampsia and preeclampsia in defined island population. Br. J. Obstet. Gynecol., 97, 762-770.
16. Amgrímsson, R., Bjornsson, H. and Geirsson, R.T. (1995) Analysis of different inheritance patterns in preeclampsia/eclampsia syndrome. Hypertens. Preg., 14, 27-38.
17. Gulcher, J.R. and Stefansson, K. (1998) Population genomics: laying the groundwork for genetic disease modeling and targeting. Clin. Chem. Lab. Med., 36, 523-527.
18. Kong, A. and Cox, N.J. (1997) Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet., 61, 1179-1188.
19. Kruglyak, L., Daly, M.J., Reeve-Daly, M.P. and Lander, E.S. (1996) Parametric and nonparametric analysis: a unified multipoint approach. Am. J. Hum. Genet., 58, 1347-1363.
20. Whittemore, A.S. and Halpern, J. (1994) A class of tests for linkage using affected pedigree members. Biometrics, 50, 118-127.
21. Lander, E. and Kruglyak, L. (1995) Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nature Genet., 11, 241-247.
22. Harrison, G.A., Humphrey, K.E., Jones, N., Badenhop, R., Guo, G., Elakis, G., Kaye, J.A., Turner, R.J., Grehan, M., Wilton, A.N., Brennecke, S.P. and Cooper, D.W. (1997) A genome-wide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. Am. J. Hum. Genet., 60, 1158-1167.
23. Ward, K., Hata, A., Jeunemaitre, X., Helin, C., Nelson, L., Namikawa, C., Farrington, P.F., Ogasawara, M., Suzumori, K., Tomoda, S. et al. (1993) A molecular variant of angiotensinogen associated with preeclampsia. Nature Genet., 4, 59-61.
24. Arngrimsson, R., Purandare, S., Connor, M., Walker, J.J., Bjornsson, S., Soubrier, F., Kotelevtsev, Y.V., Geirsson, R.T. and Bjornsson, H. (1993) Angiotensinogen: a candidate gene involved in preeclampsia? Nature Genet., 4, 114-115.
25. Arngrimsson, R., Hayward, C., Nadaud, S., Baldursdottir, A., Walker, J.J., Liston, W.A., Bjarnadottir, R.I., Brock, D.J., and Geirsson, R.T., Connor, J.M. and Soubrier, F. (1997) Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. Am. J. Hum. Genet., 61, 354-362.
26. Ott, J. (1991) Analysis of Human Genetic Linkage. The Johns Hopkins University Press, Baltimore, MD.
27. Broman, K.W., Murray, J.C., Sheffield, V.C., White, R.L. and Weber, J.L. (1998) Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am. J. Hum. Genet., 63, 861-869.
28. Dib, C., Faure, S., Fizames, C., Samson, D., Drouot, N., Vignal, A., Millasseau, P., Marc, S., Hazan, J., Seboun, E., Lathrop, M., Gyapay, G., Morissette, J. and Weissenbach, J. (1996) A comprehensive map of the human genome based on 5264 microsatellites. Nature, 380, 152-154.
29. O'Connell, J.R. and Weeks, D.E. (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am. J. Hum. Genet., 63, 259-266.
30. Badner, J.A., Gershon, E.S. and Goldin, L.R. (1998) Optimal ascertainment strategies to detect linkage to common disease alleles. Am. J. Hum. Genet., 63, 880-888.