Delivery of quantum dot-siRNA nanoplexes in SK-N-SH cells for BACE1 gene silencing and intracellular imaging

Molecular Therapy Nucleic Acids

Volumn 1, Issue 4, 2012, Pages e20-

  Li, Shengliang ^a   Liu, Zhonghua ^a   Ji, Fengtao ^a,b   Xiao, Zijian ^a   Wang, Minjuan ^a   Peng, Yingji ^a   Zhang, Yulin ^a   Liu, Ling ^b   Liang, Zibing ^a   Li, Feng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

Author keywords

Alzheimer's disease; BACE1; Quantum dot; siRNA; SK N SH cells

Indexed keywords

EID: 84868354242     PISSN: None     EISSN: 21622531     Source Type: Journal    
DOI: 10.1038/mtna.2012.11     Document Type: Article

References (37)

1. Hardy, J and Selkoe, DJ (2002). The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356. (Pubitemid 34790756)
2. Selkoe, DJ (2001). Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81: 741-766. (Pubitemid 32267077)
3. Gonzalez-Alegre, P (2007). Therapeutic RNA interference for neurodegenerative diseases: From promise to progress. Pharmacol Ther 114: 34-55. (Pubitemid 46509658)
4. Singer, O, Marr, RA, Rockenstein, E, Crews, L, Coufal, NG, Gage, FH et al. (2005). Targeting BACE1 with siRNAs ameliorates Alzheimer disease neuropathology in a transgenic model. Nat Neurosci 8: 1343-1349. (Pubitemid 41630422)
5. Laird, FM, Cai, H, Savonenko, AV, Farah, MH, He, K, Melnikova, T et al. (2005). BACE1, a major determinant of selective vulnerability of the brain to amyloid-?amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. J Neurosci 25: 11693-11709. (Pubitemid 43098462)
6. Bumcrot, D, Manoharan, M, Koteliansky, V and Sah, DW (2006). RNAi therapeutics: a potential new class of pharmaceutical drugs. Nat Chem Biol 2: 711-719. (Pubitemid 44764213)
7. Reynolds, A, Leake, D, Boese, Q, Scaringe, S, Marshall, WS and Khvorova, A (2004). Rational siRNA design for RNA interference. Nat Biotechnol 22: 326-330. (Pubitemid 38295766)
8. Wullner, U, Neef, I, Tur, MK and Barth, S (2009). Targeted delivery of short interfering RNAs-strategies for in vivo delivery. Recent Pat Anticancer Drug Discov 4: 1-8.
9. Xu, G, Yong, KT, Roy, I, Mahajan, SD, Ding, H, Schwartz, SA et al. (2008). Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier. Bioconjug Chem 19: 1179-1185. (Pubitemid 351877059)
10. Liu, L, Guo, K, Lu, J, Venkatraman, SS, Luo, D, Ng, KC et al. (2008). Biologically active core/shell nanoparticles self-assembled from cholesterol-terminated PEG-TAT for drug delivery across the blood-brain barrier. Biomaterials 29: 1509-1517.
11. Michalet, X, Pinaud, FF, Bentolila, LA, Tsay, JM, Doose, S, Li, JJ et al. (2005). Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307: 538-544. (Pubitemid 40165671)
12. Alivisatos, P (2004). The use of nanocrystals in biological detection. Nat Biotechnol 22: 47-52. (Pubitemid 38057955)
13. Chan, WC, Maxwell, DJ, Gao, X, Bailey, RE, Han, M and Nie, S (2002). Luminescent quantum dots for multiplexed biological detection and imaging. Curr Opin Biotechnol 13: 40-46. (Pubitemid 34146546)
14. Gao, X, Cui, Y, Levenson, RM, Chung, LW and Nie, S (2004). In vivo cancer targeting and imaging with semiconductor quantum dots. Nat Biotechnol 22: 969-976. (Pubitemid 39014473)
15. Zrazhevskiy, P and Gao, X (2009). Multifunctional Quantum Dots for Personalized Medicine. Nano Today 4: 414-428.
16. van der voort, HTM and Strasters, KC (1995). Restoration of confocal images for quantitative image analysis. J Microsc 178: 165-181.
17. Zhang, LW and Monteiro-Riviere, NA (2009). Mechanisms of quantum dot nanoparticle cellular uptake. Toxicol Sci 110: 138-155.
18. Buono, C, Anzinger, JJ, Amar, M and Kruth, HS (2009). Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions. J Clin Invest 119: 1373-1381.
19. Nabiev, I, Mitchell, S, Davies, A, Williams, Y, Kelleher, D, Moore, R et al. (2007). Nonfunctionalized nanocrystals can exploit a cell's active transport machinery delivering them to specific nuclear and cytoplasmic compartments. Nano Lett 7: 3452-3461. (Pubitemid 350216045)
20. Brandenberger, C, Clift, MJ, Vanhecke, D, Mühlfeld, C, Stone, V, Gehr, P et al. (2010). Intracellular imaging of nanoparticles: is it an elemental mistake to believe what you see? Part Fibre Toxicol 7: 15.
21. Derfus, AM, Chen, AA, Min, DH, Ruoslahti, E and Bhatia, SN (2007). Targeted quantum dot conjugates for siRNA delivery. Bioconjug Chem 18: 1391-1396. (Pubitemid 47464045)
22. Lee, JS, Green, JJ, Love, KT, Sunshine, J, Langer, R and Anderson, DG (2009). Gold, poly(betaamino ester) nanoparticles for small interfering RNA delivery. Nano Lett 9: 2402-2406.
23. Wu, X, Liu, H, Liu, J, Haley, KN, Treadway, JA, Larson, JP et al. (2003). Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots. Nat Biotechnol 21: 41-46. (Pubitemid 36055825)
24. Smith, AM, Dave, S, Nie, S, True, L and Gao, X (2006). Multicolor quantum dots for molecular diagnostics of cancer. Expert Rev Mol Diagn 6: 231-244. (Pubitemid 44167151)
25. Mayhew, TM, Mühlfeld, C, Vanhecke, D and Ochs, M (2009). A review of recent methods for efficiently quantifying immunogold and other nanoparticles using TEM sections through cells, tissues and organs. Ann Anat 191: 153-170.
26. Dang, TN, Arseneault, M, Zarkovic, N, Waeg, G and Ramassamy, C (2010). Molecular regulations induced by acrolein in neuroblastoma SK-N-SH cells: relevance to Alzheimer's disease. J Alzheimers Dis 21: 1197-1216.
27. Peng, Y, Lee, DY, Jiang, L, Ma, Z, Schachter, SC and Lemere, CA (2007). Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. Neuroscience 150: 386-395. (Pubitemid 350199698)
28. Li, JM, Zhao, MX, Su, H, Wang, YY, Tan, CP, Ji, LN et al. (2011). Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 32: 7978-7987.
29. Dukes, MJ, Peckys, DB and de Jonge, N (2010). Correlative fluorescence microscopy and scanning transmission electron microscopy of quantum-dot-labeled proteins in whole cells in liquid. ACS Nano 4: 4110-4116.
30. Johnson, LN, Cashman, SM and Kumar-Singh, R (2008). Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea. Mol Ther 16: 107-114.
31. Ruan, G, Agrawal, A, Marcus, AI and Nie, S (2007). Imaging and tracking of tat peptideconjugated quantum dots in living cells: new insights into nanoparticle uptake, intracellular transport, and vesicle shedding. J Am Chem Soc 129: 14759-14766. (Pubitemid 350207890)
32. Mei, BC, Susumu, K, Medintz, IL, Delehanty, JB, Mountziaris, TJ and Mattoussi, H (2008). Modular poly(ethylene glycol) ligands for biocompatible semiconductor and gold nanocrystals with extended pH and ionic stability. J Mater Chem 18: 4949-4958.
33. Lovric, J, Bazzi, HS, Cuie, Y, Fortin, GR, Winnik, FM and Maysinger, D (2005). Differences in subcellular distribution and toxicity of green and red emitting CdTe quantum dots. J Mol Med 83: 377-385. (Pubitemid 41201802)
34. Shiohara, A, Hoshino, A, Hanaki, K, Suzuki, K and Yamamoto, K (2004). On the cytotoxicity caused by quantum dots. Microbiol Immunol 48: 669-675.
35. Qu, L and Peng, X (2002). Control of photoluminescence properties of CdSe nanocrystals in growth. J Am Chem Soc 124: 2049-2055. (Pubitemid 34215323)
36. Peng, ZA and Peng, X (2001). Formation of high-quality CdTe, CdSe, and CdS nanocrystals using CdO as precursor. J Am Chem Soc 123: 183-184. (Pubitemid 32052980)
37. Nitin, N, LaConte, LE, Zurkiya, O, Hu, X and Bao, G (2004). Functionalization and peptidebased delivery of magnetic nanoparticles as an intracellular MRI contrast agent. J Biol Inorg Chem 9: 706-712. (Pubitemid 39279249)