Bioconjugated quantum rods as targeted probes for efficient transmigration across an in vitro blood-brain barrier

Bioconjugate Chemistry

Volumn 19, Issue 6, 2008, Pages 1179-1185

  Xu, Gaixia ^a,c   Yong, Ken Tye ^a   Roy, Indrajit ^a   Mahajan, Supriya D ^b   Ding, Hong ^a   Schwartz, Stanley A ^b   Prasad, Paras N ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b BUFFALO GENERAL HOSPITAL   (United States)

^c SHENZHEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD; DIAGNOSIS; QUANTUM CHEMISTRY;

BIO-CONJUGATED; BLOOD-BRAIN BARRIER; BLOOD-BRAIN BARRIER MODELS; CONCENTRATION-DEPENDENT; IN-VITRO; MIGRATION RATES; MULTIPLEXING TECHNIQUES; QUANTUM RODS; RECEPTOR-MEDIATED TRANSPORTS; TIME DEPENDENT;

BIOMOLECULES;

CLAUDIN 4; NANOPARTICLE; QUANTUM ROD; TRANSFERRIN RECEPTOR;

ABSORPTION SPECTROSCOPY; ARTICLE; BLOOD BRAIN BARRIER; CANCER CELL; CONCENTRATION (PARAMETERS); CONJUGATION; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG TARGETING; FLUORESCENCE MICROSCOPY; MIGRATION; NANOPROBE; NANOTECHNOLOGY; NONHUMAN; PHOTOLUMINESCENCE; PROTEIN TRANSPORT; REACTION TIME; TRANSPORT AND BINDING PHENOMENA;

EID: 45849130218     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc700477u     Document Type: Article

References (39)

1. Dallasta, L. M. (1999) Blood-brain barrier tight junction disruption in human immunodeficiency virus-1 encephalitis. Am. J. Pathol. 155, 1915-1927.
2. Ge, S., Song, L., and Pachter, J. S. (2005) Where is the blood-brain barrier. . .really? J. Neurosci. Res. 79, 421-427.
3. Wolburg, H., and Lippoldt, A. (2002) Tight junctions of the blood-brain barrier: development, composition and regulation. Vasc. Pharmacol. 38, 323-337.
4. Abbott, N. J. (2004) Prediction of blood-brain barrier permeation in drug discovery from in vivo, in vitro and in silico models. Drug Discovery Today: Technol. 1, 407-416.
5. Abbott, N. J. (2005) Dynamics of CNS barriers: evolution, differentiation and modulation. Cell. Mol. Neurobiol. 25, 5-23.
6. Abbott, N. J., Lars, R., and Elisabeth, H. (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat. Rev. Neurosci. 7, 41-53.
7. Begley, D. J., and Brightman, M. W. (2003) Structural and functional aspects of the blood-brain barrier. Prog. Drug Res. 61, 40-78.
8. Cornell-Bell, A. H., Finkbeiner, S. M., Cooper, M. S., and Smith, S. J. (1990) Glutamate induces calcium waves in cultured astrocytes: long-range glial signalling. Science 247, 470-473.
9. Schroeter, M. L. (1999) Astrocytes enhance radical defence in capillary endothelial cells constituting the blood-brain barrier. FEBS Lett. 449, 241-244.
10. Gloor, S. M., Wachtel, M., Bolliger, M. F., Ishihara, H., Landmann, R., and Frei, K. (2001) Molecular and cellular permeability control at the blood-brain barrier. Brain Res. Rev. 36, 258-264.
11. Huber, J. D., Egleton, R. D., and Davis, T. P. (2001) Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci. 24, 719-725.
12. Teichberg, V. I. (2007) From the liver to the brain across the blood-brain barrier. Proc. Natl. Acad. Sci. U.S.A. 104, 7315-7316.
13. Pardridge, W. M. (2002) Drug and gene targeting to the brain with molecular trojan horses. Nat. Rev. Drug Discovery 1, 131-139.
14. Pardridge, W. M. (2003) Blood-brain barrier drug targeting: the future of brain drug development. Mol. Interv. 3, 90-105.
15. Abbott, N. J. (2002) Astrocyte-endothelial interactions and blood-brain barrier permeability. J. Anat. 200, 629-638.
16. Emerich, D. F., and Thanos, C. G. (2007) Targeted nanoparticle-based drug delivery and diagnosis. J. Drug Targeting 15, 163-183.
17. Tiwari, S. B., and Amiji, M. M. (2006) A review of nanocarrier-based CNS delivery systems. Curr. Drug Delivery 3, 219-232.
18. Verma, B.J. S. a. I. M. (2007) Targeted delivery of proteins across the blood brain barrier. Proc. Natl Acad. Sci. U.S.A. 104, 7594-7599.
19. Yang, C. S., Chang, C. H., Tsai, P. J., Chen, W. Y., Tseng, F. G., and Lo, L. W. (2004) Nanoparticle-based in vivo investigation on blood-brain barrier permeability following ischemia and reperfusion. Anal. Chem. 76, 4465-4471.
20. Yesim, A., Yemisci, M., Andrieux, K., Gursoy, R. N., Alonso, M. J., Fernandez-Megia, E., Novoa-Carballal, R., Quinoa, E., Riguera, R., Sargon, M. F., Celik, H. H., Demir, A. S., Hincal, A. A., Dalkara, T., Capan, Y., and Couvreur, P. (2005) Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26. Bioconjugate Chem. 16, 1503-1511.
21. Costantino, L., Gandolfi, F., Bossy-Nobs, L., Tosi, G., Gurny, R., Rivasi, F., Angela Vandelli, M., and Forni, F. (2006) Nanoparticulate drug carriers based on hybrid poly(D,L-lactide-co-glycolide)-dendron structures. Biomaterials 27, 4635-4645.
22. Vinogradov, S. V., Batrakova, E. V., and Kabanov, A. V. (2004) Nanogels for oligonucleotide delivery to the brain. Bioconjugate Chem. 15, 50-60.
23. Zhu, J., Tang, A., Law, L. P., Feng, M., Ho, K. M., Lee, D. K. L., Harris, F. W., and Li, P. (2005) Amphiphilic coreshell nanoparticles with poly(ethylenimine) shells as potential gene delivery carriers. Bioconjugate Chem. 16, 139-146.
24. Pardridge, W. M. (2007) Drug targeting to the Brain. Pharm. Res. 24, 1733-1744.
25. Bruchez, M., Jr., Moronne, M., Gin, P., Weiss, S., and Alivisatos, A. P. (1998) Semiconductor nanocrystals as fluorescent biological labels. Science 281, 2013-2016.
26. Chan, W. C., and nbsp, W, and Nie, S. (1998) Quantum dot bioconjugates for ultrasensitive nonisotopic detection. Science 281, 2016-2018.
27. Peng, X., Manna, L., Yang, W., Wickham, J., Scher, E., Kadavanich, A., and Alivisatos, A. P. (2000) Shape control of CdSe nanocrystals. Nature 404, 59-61.
28. Peng, Z. A., and Peng, X. (2002) Nearly monodisperse and shape-controlled CdSe nanocrystals via alternative routes: nucleation and growth. J. Am. Chem. Soc. 124, 3343-3353.
29. Fu, A., Gu, W., Boussert, B., Koski, K., Gerion, D., Manna, L., LeGros, M., Larabell, C. A., and Alivisatos, A. P. (2007) Semiconductor quantum rods as single molecule fluorescent biological labels. Nano Lett. 7, 179-182.
30. Medintz, I. L., Uyeda, H. T., Goldman, E. R., and Mattoussi, H. (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat. Mater. 4, 435-446.
31. Michalet, X., Pinaud, F. F., Bentolila, L. A., Tsay, J. M., Doose, S., Li, J. J., Sundaresan, G., Wu, A. M., Gambhir, S. S., and Weiss, S. (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307, 538-544.
32. Bagalkot, V., Zhang, L., Levy-Nissenbaum, E., Jon, S., Kantoff, P. W., Langer, R., and Farokhzad, O. C. (2007) Quantum dot-aptamer conjugates for synchronous cancer imaging, therapy, and sensing of drug delivery based on bifluorescence resonance energy transfer. Nano Lett. 7, 3065-3070.
33. Derfus, A. M., Chen, A. A., Min, D. H., Ruoslahti, E., and Bhatia, S. N. (2007) Targeted quantum dot conjugates for siRNA delivery. Bioconjugate Chem. 18, 1391-1396.
34. Qian, J., Yong, K. T., Roy, I., Ohulchanskyy, T. Y., Bergey, E. J., Lee, H. H., Tramposch, K. M., He, S., Maitra, A., and Prasad, P. N. (2007) Imaging pancreatic cancer using surface-functionalized quantum dots. J. Phys. Chem. B 111, 6969-6972.
35. Yong, K. T., Qian, J., Roy, I., Lee, H. H., Bergey, E. J., Tramposch, K. M., He, S., Swihart, M. T., Maitra, A., and Prasad, P. N. (2007) Quantum rod bioconjugates as targeted probes for confocal and two-photon fluorescence imaging of cancer cells. Nano Lett. 7, 761-765.
36. Duport, S. (1998) An in vitro blood-brain barrier model: cocultures between endothelial cells and organotypic brain slice cultures. Proc. Natl Acad. Sci. U.S.A. 95, 1840-1845.
37. Mahajan, S., Schwartz, S. A., Sykes, D., Chawda, R., Aalinkeel, R., and Nair, M. P. N. (2004) Effect of HIV peptides on trans-endothelial migration of dendritic cells across the blood brain barrier. 12th International Congress of Immunology and 4th Annual Conference of FOCIS 153-159.
38. Persidsky, Y., and Gendelman, H. E. (1997) Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia. J. Leukocyte Biol. 62, 100-106.
39. Sun, H., Li, H., and Sadler, P. J. (1999) Transferrin as a metal ion mediator. Chem. Rev. 99, 2817-2842.