Ezh1 is required for hematopoietic stem cell maintenance and prevents senescence-like cell cycle arrest

Cell Stem Cell

Volumn 11, Issue 5, 2012, Pages 649-662

  Hidalgo, Isabel ^a   Herrera Merchan, Antonio ^a   Ligos, Jose Manuel ^a   Carramolino, Laura ^a   Nuñez, Javier ^a   Martinez, Fernando ^a   Dominguez, Orlando ^b   Torres, Miguel ^a   Gonzalez, Susana ^a  

^a CENTRO NACIONAL DE INVESTIGACIONES CARDIOVASCULARES CNIC   (Spain)

^b Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HISTONE METHYLTRANSFERASE; POLYCOMB GROUP PROTEIN; PROTEIN EZH1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; CHIMERA; CONTROLLED STUDY; DNA DAMAGE; EMBRYONIC STEM CELL; ENZYME ACTIVE SITE; EPIGENETICS; GENE DELETION; GENE EXPRESSION; GENOTYPE; GERMINAL CENTER; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; IN VITRO STUDY; LOXP SITE; MICROENVIRONMENT; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SENESCENCE; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL AGING; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL PROLIFERATION; GENES, P16; HEMATOPOIETIC STEM CELLS; METHYLATION; MICE; MICE, TRANSGENIC; POLYCOMB REPRESSIVE COMPLEX 2;

EID: 84868340057     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2012.08.001     Document Type: Article

References (44)

1. B.E. Bernstein, T.S. Mikkelsen, X. Xie, M. Kamal, D.J. Huebert, J. Cuff, B. Fry, A. Meissner, M. Wernig, and K. Plath A bivalent chromatin structure marks key developmental genes in embryonic stem cells Cell 125 2006 315 326
2. L.A. Boyer, K. Plath, J. Zeitlinger, T. Brambrink, L.A. Medeiros, T.I. Lee, S.S. Levine, M. Wernig, A. Tajonar, and M.K. Ray Polycomb complexes repress developmental regulators in murine embryonic stem cells Nature 441 2006 349 353
3. A.P. Bracken, N. Dietrich, D. Pasini, K.H. Hansen, and K. Helin Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions Genes Dev. 20 2006 1123 1136
4. A.P. Bracken, D. Kleine-Kohlbrecher, N. Dietrich, D. Pasini, G. Gargiulo, C. Beekman, K. Theilgaard-Mönch, S. Minucci, B.T. Porse, and J.C. Marine The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells Genes Dev. 21 2007 525 530
5. R. Cao, H. Wang, J. He, H. Erdjument-Bromage, P. Tempst, and Y. Zhang Role of hPHF1 in H3K27 methylation and Hox gene silencing Mol. Cell. Biol. 28 2008 1862 1872
6. S.M. Chambers, N.C. Boles, K.Y. Lin, M.P. Tierney, T.V. Bowman, S.B. Bradfute, A.J. Chen, A.A. Merchant, O. Sirin, and D.C. Weksberg Hematopoietic fingerprints: an expression database of stem cells and their progeny Cell Stem Cell 1 2007 578 591
7. S.M. Chambers, C.A. Shaw, C. Gatza, C.J. Fisk, L.A. Donehower, and M.A. Goodell Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation PLoS Biol. 5 2007 e201
8. H. Chen, X. Gu, I.H. Su, R. Bottino, J.L. Contreras, A. Tarakhovsky, and S.K. Kim Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus Genes Dev. 23 2009 975 985
9. M. Collado, and M. Serrano The power and the promise of oncogene-induced senescence markers Nat. Rev. Cancer 6 2006 472 476
10. M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233
11. J.P. Coppé, P.Y. Desprez, A. Krtolica, and J. Campisi The senescence-associated secretory phenotype: the dark side of tumor suppression Annu. Rev. Pathol. 5 2010 99 118
12. F. Debacq-Chainiaux, J.D. Erusalimsky, J. Campisi, and O. Toussaint Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo Nat. Protoc. 4 2009 1798 1806
13. R. Di Micco, G. Sulli, M. Dobreva, M. Liontos, O.A. Botrugno, G. Gargiulo, R. dal Zuffo, V. Matti, G. d'Ario, and E. Montani Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer Nat. Cell Biol. 13 2011 292 302
14. E. Ezhkova, H.A. Pasolli, J.S. Parker, N. Stokes, I.H. Su, G. Hannon, A. Tarakhovsky, and E. Fuchs Ezh2 orchestrates gene expression for the stepwise differentiation of tissue-specific stem cells Cell 136 2009 1122 1135
15. E. Ezhkova, W.H. Lien, N. Stokes, H.A. Pasolli, J.M. Silva, and E. Fuchs EZH1 and EZH2 cogovern histone H3K27 trimethylation and are essential for hair follicle homeostasis and wound repair Genes Dev. 25 2011 485 498
16. E.C. Forsberg, E. Passegué, S.S. Prohaska, A.J. Wagers, M. Koeva, J.M. Stuart, and I.L. Weissman Molecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells PLoS ONE 5 2010 e8785
17. A. Freund, A.V. Orjalo, P.Y. Desprez, and J. Campisi Inflammatory networks during cellular senescence: causes and consequences Trends Mol. Med. 16 2010 238 246
18. A.D. Goldberg, C.D. Allis, and E. Bernstein Epigenetics: a landscape takes shape Cell 128 2007 635 638
19. S. Gonzalez, P. Klatt, S. Delgado, E. Conde, F. Lopez-Rios, M. Sanchez-Cespedes, J. Mendez, F. Antequera, and M. Serrano Oncogenic activity of Cdc6 through repression of the INK4/ARF locus Nature 440 2006 702 706
20. J. He, E.M. Kallin, Y. Tsukada, and Y. Zhang The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b) Nat. Struct. Mol. Biol. 15 2008 1169 1175
21. Y. Jacob, H. Stroud, C. Leblanc, S. Feng, L. Zhuo, E. Caro, C. Hassel, C. Gutierrez, S.D. Michaels, and S.E. Jacobsen Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases Nature 466 2010 987 991
22. J.J. Jacobs, K. Kieboom, S. Marino, R.A. DePinho, and M. van Lohuizen The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus Nature 397 1999 164 168
23. A. Kaneda, T. Fujita, M. Anai, S. Yamamoto, G. Nagae, M. Morikawa, S. Tsuji, M. Oshima, K. Miyazono, and H. Aburatani Activation of Bmp2-Smad1 signal and its regulation by coordinated alteration of H3K27 trimethylation in Ras-induced senescence PLoS Genet. 7 2011 e1002359
24. T.W. Kang, T. Yevsa, N. Woller, L. Hoenicke, T. Wuestefeld, D. Dauch, A. Hohmeyer, M. Gereke, R. Rudalska, and A. Potapova Senescence surveillance of pre-malignant hepatocytes limits liver cancer development Nature 479 2011 547 551
25. T. Kuilman, C. Michaloglou, W.J. Mooi, and D.S. Peeper The essence of senescence Genes Dev. 24 2010 2463 2479
26. G. Laible, A. Wolf, R. Dorn, G. Reuter, C. Nislow, A. Lebersorger, D. Popkin, L. Pillus, and T. Jenuwein Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres EMBO J. 16 1997 3219 3232
27. S.W. Lowe, E. Cepero, and G. Evan Intrinsic tumour suppression Nature 432 2004 307 315
28. I.J. Majewski, M.E. Blewitt, C.A. de Graaf, E.J. McManus, M. Bahlo, A.A. Hilton, C.D. Hyland, G.K. Smyth, J.E. Corbin, and D. Metcalf Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity PLoS Biol. 6 2008 e93
29. R. Margueron, and D. Reinberg The Polycomb complex PRC2 and its mark in life Nature 469 2011 343 349
30. R. Margueron, G. Li, K. Sarma, A. Blais, J. Zavadil, C.L. Woodcock, B.D. Dynlacht, and D. Reinberg Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms Mol. Cell 32 2008 503 518
31. M. Mochizuki-Kashio, Y. Mishima, S. Miyagi, M. Negishi, A. Saraya, T. Konuma, J. Shinga, H. Koseki, and A. Iwama Dependency on the polycomb gene Ezh2 distinguishes fetal from adult hematopoietic stem cells Blood 118 2011 6553 6561
32. C. Nardella, J.G. Clohessy, A. Alimonti, and P.P. Pandolfi Pro-senescence therapy for cancer treatment Nat. Rev. Cancer 11 2011 503 511
33. M. Narita, S. Nũnez, E. Heard, M. Narita, A.W. Lin, S.A. Hearn, D.L. Spector, G.J. Hannon, and S.W. Lowe Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Cell 113 2003 703 716
34. S.Y. Ng, T. Yoshida, J. Zhang, and K. Georgopoulos Genome-wide lineage-specific transcriptional networks underscore Ikaros-dependent lymphoid priming in hematopoietic stem cells Immunity 30 2009 493 507
35. H. Oguro, J. Yuan, H. Ichikawa, T. Ikawa, S. Yamazaki, H. Kawamoto, H. Nakauchi, and A. Iwama Poised lineage specification in multipotential hematopoietic stem and progenitor cells by the polycomb protein Bmi1 Cell Stem Cell 6 2010 279 286
36. D. Pasini, A.P. Bracken, M.R. Jensen, E. Lazzerini Denchi, and K. Helin Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity EMBO J. 23 2004 4061 4071
37. J.D. Pereira, S.N. Sansom, J. Smith, M.W. Dobenecker, A. Tarakhovsky, and F.J. Livesey Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex Proc. Natl. Acad. Sci. USA 107 2010 15957 15962
38. A. Prieur, and D.S. Peeper Cellular senescence in vivo: a barrier to tumorigenesis Curr. Opin. Cell Biol. 20 2008 150 155
39. M. Sauvageau, and G. Sauvageau Polycomb group proteins: multi-faceted regulators of somatic stem cells and cancer Cell Stem Cell 7 2010 299 313
40. X. Shen, Y. Liu, Y.J. Hsu, Y. Fujiwara, J. Kim, X. Mao, G.C. Yuan, and S.H. Orkin EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency Mol. Cell 32 2008 491 502
41. M. Stadtfeld, and T. Graf Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing Development 132 2005 203 213
42. I.H. Su, A. Basavaraj, A.N. Krutchinsky, O. Hobert, A. Ullrich, B.T. Chait, and A. Tarakhovsky Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement Nat. Immunol. 4 2003 124 131
43. G. Swiers, M. de Bruijn, and N.A. Speck Hematopoietic stem cell emergence in the conceptus and the role of Runx1 Int. J. Dev. Biol. 54 2010 1151 1163
44. W. Wagner, S. Bork, P. Horn, D. Krunic, T. Walenda, A. Diehlmann, V. Benes, J. Blake, F.X. Huber, and V. Eckstein Aging and replicative senescence have related effects on human stem and progenitor cells PLoS ONE 4 2009 e5846