Vascular bioactivation of nitroglycerin by aldehyde dehydrogenase-2: Reaction intermediates revealed by crystallography and mass spectrometry

Journal of Biological Chemistry

Volumn 287, Issue 45, 2012, Pages 38124-38134

  Lang, Barbara S ^a   Gorren, Antonius C F ^a   Oberdorfer, Gustav ^a   Wenzl, M Verena ^a   Furdui, Cristina M ^b   Poole, Leslie B ^b   Mayer, Bernd ^a   Gruber, Karl ^a  

^a UNIVERSITY OF GRAZ   (Austria)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVATION; REACTION STEPS;

CRYSTALLOGRAPHY; MASS SPECTROMETRY; NITRATES; ORGANIC COMPOUNDS;

ALDEHYDES;

ALDEHYDE DEHYDROGENASE ISOENZYME 2; GLYCERYL TRINITRATE; SULFINIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME MECHANISM; MASS SPECTROMETRY; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ANALYSIS; VASODILATATION; WILD TYPE;

ALDEHYDE DEHYDROGENASE; AMINO ACID SUBSTITUTION; BIOCATALYSIS; BLOOD VESSELS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; ISOFLAVONES; MASS SPECTROMETRY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTANT PROTEINS; MUTATION; NITRATES; NITROGLYCERIN; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SULFUR COMPOUNDS;

EID: 84868322214     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.371716     Document Type: Article

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