Human aldehyde dehydrogenase gene family

European Journal of Biochemistry

Volumn 251, Issue 3, 1998, Pages 549-557

  Yoshida, Akira ^a   Rzhetsky, Andrey ^b   Hsu, Lily C ^a   Chang, Cheng ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b New York Presbyterian Columbia University Medical Center   (United States)

Author keywords

Detoxification; Evolution; Gene family; Genetic disease; Genetic variant; Genomic organization; Phylogenetic tree

Indexed keywords

ALDEHYDE DEHYDROGENASE;

EVOLUTION; GENE DUPLICATION; GENETIC ORGANIZATION; GENETIC VARIABILITY; MULTIGENE FAMILY; PHYLOGENY; PRIORITY JOURNAL; REVIEW;

EID: 0032006030     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2510549.x     Document Type: Review

References (77)

1. Racker, E. (1949) Bovine liver aldehyde dehydrogenase, J. Biol. Chem. 177, 883-892.
2. Deitrich, R. A. (1966) Tissue and subcellular distribution of mammalian aldehyde-oxidizing capacity, Biochem. Pharmacol. 15, 1911-1922.
3. Harada, S., Agarwal, S. & Goedde, H. W. (1980) Electrophoretic and biochemical studies of human aldehyde dehydrogenase isozymes in various tissues, Life Sci. 26, 1771-1780.
4. Pietruszko, R. (1983) Aldehyde dehydrogenase isozymes, in Isozymes: Current topics in biological and medical research, vol. 8 (Rattazzi, M. C., Scandalios, J. G. & Whitt, A. S., eds) pp. 195-217, Alan R. Liss, New York.
5. Hsu, L. C., Tani, K., Fujiyoshi, T., Kurachi, K. & Yoshida, A. (1985) Cloning of cDNAs for human aldehyde dehydrogenases 1 and 2, Proc. Natl Acad. Sci. USA 92, 2703-2707.
6. Chambliss, K. L., Caudle, D. L., Hinson, D. D., Moomaw, C. R., Slaughter, C. A., Jakobs, C. & Gibson, K. M. (1995) Molecular cloning of mature NAD-dependent succinic semialdehyde dehydrogenase from rat and human, J. Biol. Chem. 70, 461-467.
7. Kedishvili, N. Y., Popov, K. M., Rougraff, P. M., Zhao, Y., Crabb, D. W. & Harris, R. A. (1992) CoA-dependent methylmalonate semi-aldehyde dehydrogenase, a unique member of the aldehyde dehydrogenase superfamily, J. Biol. Chem. 267, 19724-19729.
8. Hsu, L. C., Chang, W.-C. & Yoshida, A. (1989) Genomic structure of the human cytosolic aldehyde dehydrogenase gene, Genomics 5, 857-865.
9. Hsu, L. C., Bendel, R. E. & Yoshida, A. (1988) Genomic structure of the human mitochondrial aldehyde dehydrogenase gene, Genomics 2, 57-65.
10. Hsu, L. C., Chang, W.-C., Shibuya, A. & Yoshida, A. (1992) Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure and expression in E. coli, J. Biol. Chem. 267, 3030-3037.
11. Hsu, L. C., Chang, W.-C., Chang, C., Tsukamoto, N. & Yoshida, A. (1996) The human aldehyde dehydrogenase 3 gene (ALDH3): Identification of a new exon and diverse mRNA isoforms, and functional analysis of the promoter, Gene Expr. 6, 87-99.
12. 1-pyrroline-5-carboxylate dehydrogenase, J. Biol. Chem. 271, 9795-9800.
13. Hsu, L. C. & Chang, W.-C. (1991) Cloning and characterization of a new functional human aldehyde dehydrogenase gene, J. Biol. Chem. 266, 12257-12265.
14. Hsu, L. C., Chang, W.-C., Hiraoka, L. & Hsieh, C. L. (1994) Molecular cloning, genomic organization and chromosomal localization of an additional human aldehyde dehydrogenase gene, ALDH6, Genomics 24, 333-341.
15. Hsu, L. C., Chang, W.-C. & Yoshida, A. (1994) Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family, Gene 151, 285-289.
16. Hsu, L. C., Chang, W.-C. & Yoshida, A. (1997) Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: Genomic organization and genomic gene structure comparison, Gene 189, 89-94.
17. Lin, S. W., Chen, J., Hsu, L. C., Hsieh, C. L. & Yoshida, A. (1996) Human γ-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression, Genomics 34, 376-380.
18. Chang, C. & Yoshida, A. (1997) Human fatty aldehyde dehydrogenase gene (ALDH10): Organization and tissue-dependent expression, Genomics 39, 80-85.
19. Rogers, G. R., Markova, N. G., deLaurenzi, V., Rizzo, W. B. & Compton, J. G. (1997) Genomic organization and expression of human fatty aldehyde dehydrogenase (FALDH), Genomics 39, 127-135.
20. Trettel, F., Malaspina, P., Judice, C., Novelleto, A., Slaughter, C. A., Candle, D. L., Hinson, D. D., Chambliss, K. L. & Gibson, K. M. (1997) Human succinic semialdehyde dehydrogenase, Adv. Exp. Med. Biol. 424, 253-260.
21. Lee, P., Kuhl, K., Gelbart, T., Kamimura, T., West, C. & Beutler, E. (1994) Homology between a human protein and a protein of green pea, Genomics 21, 371-378.
22. Harrington, M. G., Henehan, G. T. M. & Tipton, K. F. (1987) The rat and human aldehyde dehydrogenase isozymes in ethanol metabolism, Prog. Clin. Biol. Res. 232, 111-125.
23. Mitchell, D. Y. & Petersen, D. R. (1987) The oxidation of α, β-unsaturated aldehyde products of lipid peroxidation by rat liver aldehyde dehydrogenases, Toxicol. Appl. Pharmacol. 87, 403-410.
24. Jakoby, W. B. & Ziegler, D. M. (1990) The enzymes of detoxification, J. Biol. Chem. 265, 20715-20718.
25. Yoshida, A., Hsu, L. C. & Davé, V. (1992) Retinal oxidation activity and biological role of human cytosolic aldehyde dehydrogenase, Enzyme 46, 239-244.
26. Pereira, F., Roseman, E., Nylen, E., Kaufman, M., Ansky, L. & Wrongemann, K. (1991) The 56 kDa androgen binding protein is an aldehyde dehydrogenase, Biochem. Biophys. Res. Commun. 175, 831-838.
27. Yoshida, A., Hsu, L. C. & Yanagawa, Y. (1993) Biological role of human cytosolic aldehyde dehydrogenase-1: Hormonal response, retinal oxidation and implication in testicular feminization, Adv. Exp. Med. Biol. 328, 37-44.
28. Zhao, D., McCaffery, P., Ivins, K. J., Neve, R. L., Hogan, P., Chin, W. W. & Drager, U. C. (1996) Molecular identification of a major retinoic-acid-synthesizing enzyme, a retinaldehyde-specific dehydrogenase, Eur. J. Biochem. 240, 15-22.
29. Wang, X., Penzes, P. & Napoli, J. L. (1996) Cloning of cDNA encoding an aldehyde dehydrogenase and its expression in Escherichia coli, J. Biol. Chem. 271, 16288-16293.
30. Yoshida, A. (1983) A possible structural variant of human cytosolic aldehyde dehydrogenase with diminished enzyme activity, Am. J. Hum. Genet. 35, 1115-1116.
31. Eckey, R., Agarwal, D. P., Saha, N. & Goedde, H. W. (1986) Detection and partial characterization of a variant cytosolic aldehyde dehydrogenase isozyme, Hum. Genet. 72, 95-97.
32. Yoshida, A., Ward, R. J. & Peters, T. J. (1989) Cytosolic aldehyde dehydrogenase (ALDH1) variants found in alcohol flushers, Ann. Hum. Genet. 53, 1-7.
33. Hilton, J. (1984) Role of aldehyde dehydrogenase in cyclophosphamide-resistant L1210 leukemia, Cancer Res. 44, 5156-5160.
34. Sladek, N. E. & Landkamer, G. L. (1985) Restoration of sensitivity to oxazaphosphorines by inhibitors of aldehyde dehydrogenase activity in cultured oxazaphosphorine-resistant 1,1210 and cross-linking agent-resistant P388 cell lines, Cancer Res. 45, 1549-1555.
35. Yoshida, A., Davé, V., Han, H. & Scanlon, K. J. (1993) Enhanced transcription of the cytosolic ALDH gene in cyclophosphamide resistant human carcinoma cells, Adv. Exp. Med. Biol. 328, 63-72.
36. 2 dehydrogenase is identical to cytosolic aldehyde dehydrogenase, FEBS Lett. 345, 99-103.
37. King, C. T. & Holmes, R. S. (1997) Human corneal and lens aldehyde dehydrogenases: Purification and properties of human lens ALDH1 and differential expression as major soluable proteins in human lens (ALDH1) and cornea (ALDH3), Adv. Exp. Med. Biol. 414, 19-27.
38. Yoshida, A. (1991) Genetic polymorphisms of alcohol metabolizing enzymes related to alcohol sensitivity and alcoholic diseases, Alcohol Alcohol. 29, 693-696.
39. Novorudovsky, A. & Goldman, D. (1995) Population genetics of mitochondrial aldehyde dehydrogenase (ALDH2) in American Indian and Asian populations, Am. J. Hum. Genet. 55, A966.
40. Shibuya, A., Takeuchi, H., Shibata, K. & Yoshida, A. (1994) Immunohistochemical study of hepatocellular carcinoma-specific aldehyde dehydrogenase, Alcohol Alcohol. 29, 119-123.
41. Lindahl, R. (1992) Aldehyde dehydrogenases and their role in carcinogenesis, Crit. Rev. Biochem. Mol. Biol. 27, 283-335.
42. Bunting, K. D. & Townsend, A. J. (1996) Protection by transfected rat or human class 3 aldehyde dehydrogenase against the cytotoxic effect of oxazaphosphorine alkylating agents in hamster V79 cell lines, J. Biol. Chem. 271, 11891-11896.
43. Sreerama, L. & Sladek, N. E. (1993) Identification and characterization of a novel class 3 aldehyde dehydrogenase overexpressed in a human breast adenocarcinoma cell line exhibiting oxazaphosphorine-specific acquired resistance, Biochem. Pharmacol. 45, 2487-2505.
44. Sreerama, L., Rekha, G. K. & Sladek, N. E. (1995) Pheolic antioxidant-induced overexpression of clan-3 aldehyde dehydrogenase and oxazaphosphorine-specific resistance, Biochem. Pharmacol. 49, 669-675.
45. Sreerama, L. & Sladek, N. E. (1996) Overexpression of glutathione-S transferases, dt-diaphorase and an apparently tumour-specific cytosolic class-3 aldehyde dehydrogenase by Warthin tumours and mucoepidermoid carcinomas of human parotid gland, Arch. Oral Biol. 41, 597-605.
46. Yin, S.-J., Cheng, T.-C. Chang, C.-P., Chen, Y.-J., Tang, H. S., Chang, T.-M. & Wu, C. W. (1988) Human stomach aldehyde dehydrogenase (ALDH): A genetic model proposed tor ALDH III isozymes, Biochem. Genet. 26, 343-360.
47. Tsukamoto, N., Chang, C. & Yoshida, A. (1997) Mutations associated with Sjöeren-Larsson syndrome, Ann. Hum. Genet. 6, 235-242.
48. Liu, Z.-J., Sun Y.-J., Rose, J., Chung, Y.-J., Hsiao, C.-D., Chang, W.-R., Kuo, I., Perozich, J., Lindahl, R., Hempel, J. & Wang, B.-C. (1997) The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold, Nat. Struct. Biol. 4, 317-326.
49. Santisteban, I., Povey, S., West, L. F., Parrington, J. M. & Hopkinson, D. A. (1985) Chromosomal assignment, biochemical and immunological studies on human aldehyde dehydrogenase, ALDH3, Ann. Hum. Genet. 49, 87-100.
50. Algar, E. M., Cheung, B., Hayes, J., Holmes, R. S. & Beacham, I. R. (1993) Bovine corneal aldehyde dehydrogenases: Evidence for multiple gene product, Adv. Exp. Med. Biol. 328, 153-157.
51. Forte-McRobbie, C. M. & Pietruszko, R. (1986) Purification and characterization of human liver high Km aldehyde dehydrogenase and its identification as glutamic γ-semialdehyde dehydrogenase, J. Biol. Chem. 261, 2154-2163.
52. Efron, M. L. (1965) Familial hyperprolinemia: Report of a second case associated with congenital renal malformations, hereditary and mild mental retardation, with demonstration of an enzyme defect, New Engl. J. Med. 272, 1243-1254.
53. Valle, D., Goodman, G. I., Harris, S. C. & Phang, J. M. (1979) Genetic evidence for a common enzyme catalyzing the second step in the degradation of proline and hydroxyproline, J. Clin. Invest. 64, 1365-1370.
54. Ambroziak, W. & Pietruszko, R. (1993) Metabolic role of aldehyde dehydrogenase, Adv. Exp. Med. Biol. 328, 5-15.
55. Sobue, K. & Nakajima, T. (1978) Changes in concentrations of polyamines and γ-aminobutyric acid and their formation in chick embryo brain during development, J. Neurochem. 30, 277-279.
56. Kikonyogo, A. & Pietruszko, R. (1996) Aldehyde dehydrogenase from adult brain that dehydrogenates γ-aminobutyraldehyde: Purification, characterization, cloning and distribution, Biochem. J. 316, 317-324.
57. DeLaurenzi, V., Rogers, G. R., Hamrock, J. D., Marekov, L. N., Dompton, J. G., Markova, N. & Rizzo, W. B. (1996) Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene, Nat. Genet. 12, 52-57.
58. Jakobs, C., Jaeken, J. & Gibson, K. M. (1993) Inherited disorders of GABA metabolism, J. Inher. Metab. Dis. 16, 704-715.
59. Yoshida, A. (1992) Molecular genetics of human aldehyde dehydrogenase, Pharmacogenetics 2, 139-147.
60. Stewart, M. J., Malek, K., Xiao, Q., Dipple, K. M. & Crabb, D. W. (1995) The novel aldehyde dehydrogenase gene, ALDH5, encodes an active aldehyde dehydrogenase enzyme, Biochem. Biophys. Res. Commun. 211, 144-151.
61. Goodwin, G. W., Rougraff, P. M., Davis, E. J. & Harris, R. A. (1989) Purification and characterization of methylmalonate-semialdehyde dehydrogenase from rat liver, J. Biol. Chem. 264, 14965-14971.
62. Wang, X. & Weiner, H. (1995) Involvement of glutamate 268 in the active site of human liver mitochondrial (class 2) aldehyde dehydrogenase as probed by site-directed mutagenesis, Biochemistry 34, 237-243.
63. Steinmetz, C. G., Xie, P., Weiner, H. & Hurley, T. D. (1997) Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion, Structure 5, 701-711.
64. Farrés, J., Wang, T. Y., Cunningham, S. J. & Weiner, H. (1995) Investigation of active site cysteine residue of rat mitochondrial aldehyde dehydrogenase by site-directed mutagenesis, Biochemistry, 34, 2592-2598.
65. Liu Z.-J., San Y.-J., Rose J., Chung Y.-J., Hsiao C.-D., Chang W.-R., Kuo I., Perozich J., Lindahl R., Hempel J. & Wang B.-C. (1997) The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold, Nat. Struct. Biol. 4, 317-326.
66. Sheikh, S., Ni, L., Hurley, T. D. & Weiner, H. (1997) The potential roles of the conserved amino acids in human liver mitochondrial aldehyde dehydrogenase, J. Biol. Chem. 272, 18817-18822.
67. Ni, L., Sheikh, S. & Weiner, H. (1997) Involvement of glutamate 399 and lysine 192 in the mechanism of human liver mitochondrial aldehyde dehydrogenase, J. Biol. Chem. 272, 18823-18826.
68. Knoll, A. H. (1991) End of the Proterozoic, Eur. Sci. Am. 265, 64-73.
69. Knoll, A. H. (1992) The early evolution of eukaryotes: a geological perspective, Science 256, 622-627.
70. Han, T.-M. & Runnegar, B. (1992) Megascopic eukaryotic algae form the 2.1-billion-year-old negaunee ion-formation, Michigan, Science 257, 232-235.
71. Schope, J. W. (1993) Microfossils of the early Archean apex chart: new evidence of the antiquity of life, Science 260, 640-646.
72. Rzhestsky, A., Ayala, F. J., Hsu, L. C., Chang, C. & Yoshida, A. (1997) Exon/intron structure of aldehyde dehydrogenase genes supports the "introns-late" theory, Proc. Natl Acad. Sci. USA 94, 6820-6825.
73. Saitou, N. & Nei, M. (1987) The neighbor-joining method: a new method for reconstructing phylogenetic trees, Mol. Biol. Evol. 4, 406-425.
74. Zuckerkandle, E. & Pauling, L. (1965) Evolutionary divergence and convergence in proteins, in Evolving genes and proteins (Bryson, V. & Vogel, H. J., eds) pp. 97-166, Plenum Press, New York.
75. Felsenstein, J. (1985) Confidence limits on phylogenies: an approach using the bootstrap, Evolution 39, 783-791.
76. Takezaki, N., Rzhetsky, A. & Nei, M. (1995) Phylogenetic test of molecular clock and linearized trees, Mol. Biol. Evol. 12, 823-833.
77. Hedges, S. B., Parker, P. H., Sibley, C. G. & Kumar, S. (1996) Continental breakup and ordinal diversification of birds and animals, Nature 381, 226-229.