Mammalian sleep genetics

Neurogenetics

Volumn 13, Issue 4, 2012, Pages 287-326

  Kelly, Jessica M ^a   Bianchi, Matt T ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Architecture; Circadian; Electroencephalogram; Phenotype; Transgenic

Indexed keywords

BINDING PROTEIN; CARNITINE; CORTICOTROPIN RELEASING FACTOR; CRYPTOCHROME 1; CRYPTOCHROME 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOCHROME P450; EPIDERMAL GROWTH FACTOR RECEPTOR; FATTY ACID AMIDASE; GHRELIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; HALORHODOPSIN; LEPTIN; MELANIN CONCENTRATING HORMONE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITRIC OXIDE SYNTHASE; NORADRENALIN; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B; PHOSPHOLIPASE C; PROLACTIN; PROSTAGLANDIN D; PROSTAGLANDIN E RECEPTOR 3; RAS PROTEIN; RETINOIC ACID RECEPTOR BETA; TRANSCRIPTION FACTOR CLOCK; UNINDEXED DRUG;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL GENETICS; BRAIN DEPTH STIMULATION; BREATHING; CELL ACTIVATION; CELL MEMBRANE DEPOLARIZATION; CIRCADIAN RHYTHM; CYCLIC AMP RESPONSIVE ELEMENT; DARKNESS; DIET RESTRICTION; DOWN SYNDROME; ELECTRIC POTENTIAL; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; GENE; GENE MUTATION; GENETIC MANIPULATION; GENETIC POLYMORPHISM; GROWTH HORMONE BLOOD LEVEL; HOMOZYGOSITY; HUMAN; HUNTINGTON CHOREA; HYPERPOLARIZATION; IMMUNE FUNCTION TEST; IMMUNE SYSTEM; INFECTION; INOCULATION; INTRACELLULAR SIGNALING; LATERAL HYPOTHALAMUS; LIGHT; LOCUS CERULEUS; MOTOR ACTIVITY; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NEUROTRANSMISSION; NONHUMAN; NONREM SLEEP; PHENOTYPE; PHOTOSTIMULATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REM SLEEP; REST; REVIEW; SLEEP; SLEEP DEPRIVATION; SLEEP STAGE; SLEEP WAKING CYCLE; SOMNOLENCE; STEATOSIS; TEMPERATURE; TRANSGENIC ANIMAL; TRANSGENICS;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CIRCADIAN RHYTHM; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; MALE; MICE; OPTOGENETICS; POLYMORPHISM, GENETIC; RATS; SIGNAL TRANSDUCTION; SLEEP; SLEEP DEPRIVATION; WAKEFULNESS;

ANIMALIA; MAMMALIA;

EID: 84868303972     PISSN: 13646745     EISSN: 13646753     Source Type: Journal    
DOI: 10.1007/s10048-012-0341-x     Document Type: Review

References (174)

1. Lonart G, Tang X, Simsek-Duran F, Machida M, Sanford LD (2008) The role of active zone protein Rab3 interacting molecule 1 alpha in the regulation of norepinephrine release, response to novelty, and sleep. Neuroscience 154(2):821-831
2. Ambree O, Touma C, Gortz N, Keyvani K, Paulus W, Palme R, Sachser N (2006) Activity changes and marked stereotypic behavior precede Abeta pathology in TgCRND8 Alzheimer mice. Neurobiol Aging 27(7):955-964
3. Willie JT, Chemelli RM, Sinton CM, Tokita S, Williams SC, Kisanuki YY, Marcus JN, Lee C, Elmquist JK, Kohlmeier KA et al (2003) Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of non-REM and REM sleep regulatory processes. Neuron 38(5):715-730 (Pubitemid 36694779)
4. Daan S, Spoelstra K, Albrecht U, Schmutz I, Daan M, Daan B, Rienks F, Poletaeva I, Dell'Omo G, Vyssotski A et al (2011) Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele. J Biol Rhythms 26(2):118-129
5. Kawada N, Solis G, Ivey N, Connors S, Dennehy K, Modlinger P, Hamel R, Kawada JT, Imai E, Langenbach R et al (2005) Cyclooxygenase-1-deficient mice have high sleep-to-wake blood pressure ratios and renal vasoconstriction. Hypertension 45 (6):1131-1138 (Pubitemid 40770317)
6. Anaclet C, Parmentier R, Ouk K, Guidon G, Buda C, Sastre JP, Akaoka H, Sergeeva OA, Yanagisawa M, Ohtsu H et al (2009) Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models. J Neurosci 29(46):14423-14438
7. Swihart BJ, Caffo B, Bandeen-Roche K, Punjabi NM (2008) Characterizing sleep structure using the hypnogram. J Clin Sleep Med 4(4):349-355
8. Bianchi MT, Cash SS, Mietus J, Peng CK, Thomas R (2010) Obstructive sleep apnea alters sleep stage transition dynamics. PLoS One 5(6):e11356
9. Blumberg MS, Seelke AM, Lowen SB, Karlsson KA (2005) Dynamics of sleep-wake cyclicity in developing rats. Proc Natl Acad Sci U S A 102(41):14860-14864 (Pubitemid 41457146)
10. Lo CC, Chou T, Penzel T, Scammell TE, Strecker RE, Stanley HE, Ivanov P (2004) Common scale-invariant patterns of sleep- wake transitions across mammalian species. Proc Natl Acad Sci U S A 101(50):17545-17548 (Pubitemid 39657440)
11. Chu-Shore J, Westover MB, Bianchi MT (2010) Power law versus exponential state transition dynamics: application to sleep-wake architecture. PLoS One 5(12):e14204
12. Norman RG, Scott MA, Ayappa I, Walsleben JA, Rapoport DM (2006) Sleep continuity measured by survival curve analysis. Sleep 29(12):1625-1631 (Pubitemid 44936472)
13. Bianchi MT, Botzolakis EJ (2010) Targeting ligand-gated ion channels in neurology and psychiatry: is pharmacological promiscuity an obstacle or an opportunity? BMC Pharmacol 10:3
14. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K (2005) Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci 8(9):1263-1268 (Pubitemid 43348147)
15. Carter ME, Yizhar O, Chikahisa S, Nguyen H, Adamantidis A, Nishino S, Deisseroth K, de Lecea L (2010) Tuning arousal with optogenetic modulation of locus coeruleus neurons. Nat Neurosci 13(12):1526-1533
16. Franken P, Thomason R, Heller HC, O'Hara BF (2007) A noncircadian role for clock-genes in sleep homeostasis: a strain comparison. BMC Neurosci 8:87
17. Franken P, Malafosse A, Tafti M (1998) Genetic variation in EEG activity during sleep in inbred mice. Am J Physiol 275(4 Pt 2): R1127-R1137
18. Franken P, Chollet D, Tafti M (2001) The homeostatic regulation of sleep need is under genetic control. J Neurosci 21(8):2610-2621 (Pubitemid 32298203)
19. Toh KL, Jones CR, He Y, Eide EJ, HinzWA, Virshup DM, Ptacek LJ, Fu YH (2001) An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 291 (5506):1040-1043 (Pubitemid 32157412)
20. Xu Y, Padiath QS, Shapiro RE, Jones CR, Wu SC, Saigoh N, Saigoh K, Ptacek LJ, Fu YH (2005) Functional consequences of a CKIdelta mutation causing familial advanced sleep phase syndrome. Nature 434(7033):640-644 (Pubitemid 40488555)
21. Shiromani PJ, Xu M, Winston EM, Shiromani SN, Gerashchenko D, Weaver DR (2004) Sleep rhythmicity and homeostasis in mice with targeted disruption of mPeriod genes. Am J Physiol Regul Integr Comp Physiol 287(1):R47-R57 (Pubitemid 38856310)
22. Kopp C, Albrecht U, Zheng B, Tobler I (2002) Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice. Eur J Neurosci 16(6):1099-1106 (Pubitemid 35463559)
23. Viola AU, Archer SN, James LM, Groeger JA, Lo JC, Skene DJ, von Schantz M, Dijk DJ (2007) PER3 polymorphism predicts sleep structure and waking performance. Curr Biol 17(7):613-618 (Pubitemid 46497792)
24. Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M (2003) A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 26(4):413-415 (Pubitemid 39610658)
25. He Y, Jones CR, Fujiki N, Xu Y, Guo B, Holder JL Jr, Rossner MJ, Nishino S, Fu YH (2009) The transcriptional repressor DEC2 regulates sleep length in mammals. Science 325(5942):866-870
26. Rossner MJ, Oster H, Wichert SP, Reinecke L, Wehr MC, Reinecke J, Eichele G, Taneja R, Nave KA (2008) Disturbed clockwork resetting in Sharp-1 and Sharp-2 single and double mutant mice. PLoS One 3(7):e2762
27. Prosser HM, Bradley A, Chesham JE, Ebling FJ, Hastings MH, Maywood ES (2007) Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei. Proc Natl Acad Sci U S A 104(2):648-653 (Pubitemid 46123079)
28. Li JD, Hu WP, Boehmer L, Cheng MY, Lee AG, Jilek A, Siegel JM, Zhou QY (2006) Attenuated circadian rhythms in mice lacking the prokineticin 2 gene. J Neurosci 26(45):11615-11623 (Pubitemid 44772133)
29. Hu WP, Li JD, Zhang C, Boehmer L, Siegel JM, Zhou QY (2007) Altered circadian and homeostatic sleep regulation in prokineticin 2-deficient mice. Sleep 30(3):247-256 (Pubitemid 46494399)
30. Naylor E, Bergmann BM, Krauski K, Zee PC, Takahashi JS, Vitaterna MH, Turek FW (2000) The circadian clock mutation alters sleep homeostasis in the mouse. J Neurosci 20(21):8138- 8143
31. Wisor JP, O'Hara BF, Terao A, Selby CP, Kilduff TS, Sancar A, Edgar DM, Franken P (2002) A role for cryptochromes in sleep regulation. BMC Neurosci 3:20
32. Laposky A, Easton A, Dugovic C, Walisser J, Bradfield C, Turek F (2005) Deletion of the mammalian circadian clock gene BMAL1/Mop3 alters baseline sleep architecture and the response to sleep deprivation. Sleep 28(4):395-409 (Pubitemid 40489834)
33. Wisor JP, Jiang P, Striz M, O'Hara BF (2009) Effects of ramelteon and triazolam in a mouse genetic model of early morning awakenings. Brain Res 1296:46-55
34. Zhang J, Obal F Jr, Fang J, Collins BJ, Krueger JM (1996) Nonrapid eye movement sleep is suppressed in transgenic mice with a deficiency in the somatotropic system. Neurosci Lett 220(2):97-100 (Pubitemid 26426593)
35. Obal F Jr, Alt J, Taishi P, Gardi J, Krueger JM (2003) Sleep in mice with nonfunctional growth hormone-releasing hormone receptors. Am J Physiol Regul Integr Comp Physiol 284(1): R131-R139 (Pubitemid 36008664)
36. Peterfi Z, Obal F Jr, Taishi P, Gardi J, Kacsoh B, Unterman T, Krueger JM (2006) Sleep in spontaneous dwarf rats. Brain Res 1108(1):133-146 (Pubitemid 44294683)
37. Hajdu I, Obal F Jr, Fang J, Krueger JM, Rollo CD (2002) Sleep of transgenic mice producing excess rat growth hormone. Am J Physiol Regul Integr Comp Physiol 282(1):R70-R76 (Pubitemid 34663913)
38. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ (2001) Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294 (5551):2511-2515 (Pubitemid 34027284)
39. Romanowski CP, Fenzl T, Flachskamm C, Wurst W, Holsboer F, Deussing JM, Kimura M (2010) Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep 33(4):427-436
40. Willie JT, Sinton CM, Maratos-Flier E, Yanagisawa M (2008) Abnormal response of melanin-concentrating hormone deficient mice to fasting: hyperactivity and rapid eye movement sleep suppression. Neuroscience 156(4):819-829
41. Ahnaou A, Dautzenberg FM, Huysmans H, Steckler T, Drinkenburg WH(2011) Contribution ofmelanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: evidence from MCH1 (/) mice. Behav Brain Res 218(1):42-50
42. Obal F Jr, Garcia-Garcia F,Kacsoh B, Taishi P, Bohnet S,Horseman ND, Krueger JM (2005) Rapid eye movement sleep is reduced in prolactin-deficient mice. J Neurosci 25(44):10282-10289 (Pubitemid 41636225)
43. Vyazovskiy VV, Kopp C, Wigger E, Jones ME, Simpson ER, Tobler I (2006) Sleep and rest regulation in young and old oestrogen-deficient female mice. J Neuroendocrinol 18(8):567-576
44. Franken P, Tafti M (2003) Genetics of sleep and sleep disorders. Front Biosci 8:e381-e397
45. Hara J, Beuckmann CT, Nambu T, Willie JT, Chemelli RM, Sinton CM, Sugiyama F, Yagami K, Goto K, Yanagisawa M et al (2001) Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30(2):345-354 (Pubitemid 32530580)
46. Blumberg MS, Coleman CM, Johnson ED, Shaw C (2007) Developmental divergence of sleep-wake patterns in orexin knockout and wild-type mice. Eur J Neurosci 25(2):512-518
47. Bruni O, Ferri R, Miano S, Verrillo E, Vittori E, Della Marca G, Farina B, Mennuni G (2002) Sleep cyclic alternating pattern in normal school-age children. Clin Neurophysiol 113(11):1806-1814 (Pubitemid 35335471)
48. Hunsley MS, Curtis WR, Palmiter RD (2006) Behavioral and sleep/wake characteristics of mice lacking norepinephrine and hypocretin. Genes Brain Behav 5(6):451-457 (Pubitemid 44199565)
49. De la Herran-Arita AK, Guerra-Crespo M, Drucker-Colin R (2011) Narcolepsy and orexins: an example of progress in sleep research. Front Neurol 2:26
50. Mochizuki T, Crocker A, McCormack S, Yanagisawa M, Sakurai T, Scammell TE (2004) Behavioral state instability in orexin knock-out mice. J Neurosci 24(28):6291-6300 (Pubitemid 38944219)
51. Mieda M, Hasegawa E, Kisanuki YY, Sinton CM, Yanagisawa M, Sakurai T (2011) Differential roles of orexin receptor-1 and -2 in the regulation of non-REM and REM sleep. J Neurosci 31 (17):6518-6526
52. Willie JT, Renthal W, Chemelli RM, Miller MS, Scammell TE, Yanagisawa M, Sinton CM (2005) Modafinil more effectively induces wakefulness in orexin-null mice than in wild-type littermates. Neuroscience 130(4):983-995 (Pubitemid 40094630)
53. Wisor JP, Edgar DM, Yesavage J, Ryan HS, McCormick CM, Lapustea N, Murphy GM Jr (2005) Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: a role for cholinergic transmission. Neuroscience 131 (2):375-385 (Pubitemid 40222446)
54. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L (2007) Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature 450(7168):420-424 (Pubitemid 350126754)
55. Laposky AD, Shelton J, Bass J, Dugovic C, Perrino N, Turek FW (2006) Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol 290(4):R894-R903
56. Douglas CL, Bowman GN, Baghdoyan HA, Lydic R (2005) C57BL/6J and B6.V-LEPOB mice differ in the cholinergic modulation of sleep and breathing. J Appl Physiol 98(3):918-929 (Pubitemid 40283673)
57. Szentirmai E, Kapas L, Sun Y, Smith RG, Krueger JM (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc Natl Acad Sci U S A 106(33):14069-14074
58. Szentirmai E, Kapas L, Sun Y, Smith RG, Krueger JM (2010) Restricted feeding-induced sleep, activity, and body temperature changes in normal and preproghrelin-deficient mice. Am J Physiol Regul Integr Comp Physiol 298(2):R467-R477
59. Szentirmai E, Kapas L, Sun Y, Smith RG, Krueger JM (2007) Spontaneous sleep and homeostatic sleep regulation in ghrelin knockout mice. Am J Physiol Regul Integr Comp Physiol 293(1): R510-R517 (Pubitemid 47092210)
60. Pellinen J, Szentirmai E (2012) The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice. PLoS One 7 (2):e30651
61. Yoshida G, Li MX, Horiuchi M, Nakagawa S, Sakata M, Kuchiiwa S, Kuchiiwa T, Jalil MA, Begum L, Lu YB et al (2006) Fasting-induced reduction in locomotor activity and reduced response of orexin neurons in carnitine-deficient mice. Neurosci Res 55(1):78-86
62. Shin J, Kim D, Bianchi R, Wong RK, Shin HS (2005) Genetic dissection of theta rhythm heterogeneity in mice. Proc Natl Acad Sci U S A 102(50):18165-18170 (Pubitemid 41798519)
63. Graves LA, Hellman K, Veasey S, Blendy JA, Pack AI, Abel T (2003) Genetic evidence for a role of CREB in sustained cortical arousal. J Neurophysiol 90(2):1152-1159 (Pubitemid 37092594)
64. Ferland RJ, Li X, Buhlmann JE, Bu X, Walsh CA, Lim B (2005) Characterization of Rho-GDIgamma and Rho-GDIalpha mRNA in the developing and mature brain with an analysis of mice with targeted deletions of Rho-GDIgamma. Brain Res 1054(1):9-21 (Pubitemid 41188124)
65. Maret S, Franken P, Dauvilliers Y, Ghyselinck NB, Chambon P, Tafti M (2005) Retinoic acid signaling affects cortical synchrony during sleep. Science 310(5745):111-113 (Pubitemid 41434547)
66. Kapfhamer D, Valladares O, Sun Y, Nolan PM, Rux JJ, Arnold SE, Veasey SC, Bucan M (2002) Mutations in Rab3a alter circadian period and homeostatic response to sleep loss in the mouse. Nat Genet 32(2):290-295
67. Feil R, Hofmann F, Kleppisch T (2005) Function of cGMPdependent protein kinases in the nervous system. Rev Neurosci 16(1):23-41 (Pubitemid 40444828)
68. Langmesser S, Franken P, Feil S, Emmenegger Y, Albrecht U, Feil R (2009) cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness. PLoS One 4(1):e4238
69. Kalinchuk AV, McCarley RW, Porkka-Heiskanen T, Basheer R (2010) Sleep deprivation triggers inducible nitric oxidedependent nitric oxide production in wake-active basal forebrain neurons. J Neurosci 30(40):13254-13264
70. Chen L, Majde JA, Krueger JM (2003) Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes. Brain Res 973(2):214-222 (Pubitemid 36549159)
71. Huitron-Resendiz S, Sanchez-Alavez M, Wills DN, Cravatt BF, Henriksen SJ (2004) Characterization of the sleep-wake patterns in mice lacking fatty acid amide hydrolase. Sleep 27(5):857-865 (Pubitemid 39095717)
72. Tafti M, Petit B, Chollet D, Neidhart E, de Bilbao F, Kiss JZ, Wood PA, Franken P (2003) Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Nat Genet 34(3):320-325 (Pubitemid 36792866)
73. Mizoguchi A, Eguchi N, Kimura K, Kiyohara Y, Qu WM, Huang ZL, Mochizuki T, Lazarus M, Kobayashi T, Kaneko T et al (2001) Dominant localization of prostaglandin D receptors on arachnoid trabecular cells in mouse basal forebrain and their involvement in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A 98(20):11674-11679 (Pubitemid 32928787)
74. Qu WM, Huang ZL, Xu XH, Aritake K, Eguchi N, Nambu F, Narumiya S, Urade Y, Hayaishi O (2006) Lipocalin-type prostaglandin D synthase produces prostaglandin D2 involved in regulation of physiological sleep. Proc Natl Acad Sci U S A 103 (47):17949-17954 (Pubitemid 44852266)
75. Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O (2000) Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A 97(9):4903-4907 (Pubitemid 30238655)
76. Sanchez-Alavez M, Klein I, Brownell SE, Tabarean IV, Davis CN, Conti B, Bartfai T (2007) Night eating and obesity in the EP3Rdeficient mouse. Proc Natl Acad Sci U S A 104(8):3009-3014 (Pubitemid 46327994)
77. Durand E, Dauger S, Pattyn A, Gaultier C, Goridis C, Gallego J (2005) Sleep-disordered breathing in newborn mice heterozygous for the transcription factor Phox2b. Am J Respir Crit Care Med 172(2):238-243 (Pubitemid 40981200)
78. Franken P, Dudley CA, Estill SJ, Barakat M, Thomason R, O'Hara BF, McKnight SL (2006) NPAS2 as a transcriptional regulator of non-rapid eye movement sleep: genotype and sex interactions. Proc Natl Acad Sci U S A 103(18):7118-7123
79. Dudley CA, Erbel-Sieler C, Estill SJ, Reick M, Franken P, Pitts S, McKnight SL (2003) Altered patterns of sleep and behavioral adaptability in NPAS2-deficient mice. Science 301(5631):379-383 (Pubitemid 36877075)
80. Zhan G, Serrano F, Fenik P, Hsu R, Kong L, Pratico D, Klann E, Veasey SC (2005) NADPH oxidase mediates hypersomnolence and brain oxidative injury in a murine model of sleep apnea. Am J Respir Crit Care Med 172(7):921-929 (Pubitemid 41369078)
81. Deboer T, Fontana A, Tobler I (2002) Tumor necrosis factor (TNF) ligand and TNF receptor deficiency affects sleep and the sleep EEG. J Neurophysiol 88(2):839-846 (Pubitemid 34874416)
82. Kapas L, Bohnet SG, Traynor TR, Majde JA, Szentirmai E, Magrath P, Taishi P, Krueger JM (2008) Spontaneous and influenza virus-induced sleep are altered in TNF-alpha doublereceptor deficient mice. J Appl Physiol 105(4):1187-1198
83. Fang J, Wang Y, Krueger JM (1997) Mice lacking the TNF 55 kDa receptor fail to sleep more after TNFalpha treatment. J Neurosci 17(15):5949-5955 (Pubitemid 27310508)
84. Jhaveri KA, Ramkumar V, Trammell RA, Toth LA (2006) Spontaneous, homeostatic, and inflammation-induced sleep in NF-kappaB p50 knockout mice. Am J Physiol Regul Integr Comp Physiol 291(5):R1516-R1526
85. Toth LA, Opp MR (2001) Cytokine- and microbially induced sleep responses of interleukin-10 deficient mice. Am J Physiol Regul Integr Comp Physiol 280(6):R1806-R1814
86. Fang J, Wang Y, Krueger JM (1998) Effects of interleukin-1 beta on sleep are mediated by the type I receptor. Am J Physiol 274(3 Pt 2):R655-R660
87. Morrow JD, Opp MR (2005) Sleep-wake behavior and responses of interleukin-6-deficient mice to sleep deprivation. Brain Behav Immun 19(1):28-39 (Pubitemid 39592807)
88. Bohnet SG, Traynor TR, Majde JA, Kacsoh B, Krueger JM (2004) Mice deficient in the interferon type I receptor have reduced REM sleep and altered hypothalamic hypocretin, prolactin and 2′,5′-oligoadenylate synthetase expression. Brain Res 1027(1-2):117-125 (Pubitemid 39371001)
89. Wisor JP, Clegern WC, Schmidt MA (2011) Toll-like receptor 4 is a regulator of monocyte and electroencephalographic responses to sleep loss. Sleep 34(10):1335-1345
90. Bianchi MT (2008) Non-serotonin anti-depressant actions: direct ion channel modulation by SSRIs and the concept of single agent poly-pharmacy. Med Hypotheses 70(5):951-956 (Pubitemid 351400707)
91. Rammes G, Rupprecht R (2007) Modulation of ligand-gated ion channels by antidepressants and antipsychotics. Mol Neurobiol 35(2):160-174 (Pubitemid 350131693)
92. Shelton J, Bonaventure P, Li X, Yun S, Lovenberg T, Dugovic C (2009) 5-HT7 receptor deletion enhances REM sleep suppression induced by selective serotonin reuptake inhibitors, but not by direct stimulation of 5-HT1A receptor. Neuropharmacology 56 (2):448-454
93. Boutrel B, Monaca C, Hen R, Hamon M, Adrien J (2002) Involvement of 5-HT1A receptors in homeostatic and stressinduced adaptive regulations of paradoxical sleep: studies in 5- HT1A knock-out mice. J Neurosci 22(11):4686-4692 (Pubitemid 37465683)
94. Boutrel B, Franc B, Hen R, Hamon M, Adrien J (1999) Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-outmice. J Neurosci 19(8):3204-3212 (Pubitemid 29174012)
95. Popa D, Lena C, Fabre V, Prenat C, Gingrich J, Escourrou P, Hamon M, Adrien J (2005) Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J Neurosci 25(49):11231-11238 (Pubitemid 43083697)
96. Frank MG, Stryker MP, Tecott LH (2002) Sleep and sleep homeostasis in mice lacking the 5-HT2c receptor. Neuropsychopharmacology 27(5):869-873 (Pubitemid 35335903)
97. Hedlund PB, Huitron-Resendiz S, Henriksen SJ, Sutcliffe JG (2005) 5-HT7 receptor inhibition and inactivation induce antidepressantlike behavior and sleep pattern. Biol Psychiatry 58 (10):831-837 (Pubitemid 41677422)
98. Monaca C, Boutrel B, Hen R, HamonM, Adrien J (2003) 5-HT 1A/ 1B receptor-mediated effects of the selective serotonin reuptake inhibitor, citalopram, on sleep: studies in 5-HT 1A and 5-HT 1B knockout mice. Neuropsychopharmacology 28(5):850-856
99. Real C, Seif I, Adrien J, Escourrou P (2009) Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. Respir Physiol Neurobiol 168(3):230-238
100. Smith I, Lasserson TJ, Wright J (2006) Drug therapy for obstructive sleep apnoea in adults. Cochrane Database Syst Rev (2): CD003002
101. Alexandre C, Popa D, Fabre V, Bouali S, Venault P, Lesch KP, Hamon M, Adrien J (2006) Early life blockade of 5- hydroxytryptamine 1A receptors normalizes sleep and depression-like behavior in adult knock-out mice lacking the serotonin transporter. J Neurosci 26(20):5554-5564 (Pubitemid 44318406)
102. Wisor JP, Wurts SW, Hall FS, Lesch KP, Murphy DL, Uhl GR, Edgar DM (2003) Altered rapid eye movement sleep timing in serotonin transporter knockout mice. Neuroreport 14(2):233-238 (Pubitemid 36308417)
103. Alenina N, Kikic D, Todiras M, Mosienko V, Qadri F, Plehm R, Boye P, Vilianovitch L, Sohr R, Tenner K et al (2009) Growth retardation and altered autonomic control in mice lacking brain serotonin. Proc Natl Acad Sci U S A 106(25):10332-10337
104. Parmentier R, Ohtsu H, Djebbara-Hannas Z, Valatx JL, Watanabe T, Lin JS (2002) Anatomical, physiological, and pharmacological characteristics of histidine decarboxylase knock-out mice: evidence for the role of brain histamine in behavioral and sleep- wake control. J Neurosci 22(17):7695-7711 (Pubitemid 35386369)
105. Inoue I, Yanai K, Kitamura D, Taniuchi I, Kobayashi T, Niimura K, Watanabe T (1996) Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors. Proc Natl Acad Sci U S A 93(23):13316-13320 (Pubitemid 26382813)
106. Toyota H, Dugovic C, Koehl M, Laposky AD, Weber C, Ngo K, Wu Y, Lee DH, Yanai K, Sakurai E et al (2002) Behavioral characterization of mice lacking histamine H(3) receptors. Mol Pharmacol 62(2):389-397 (Pubitemid 34804119)
107. Huang ZL, Mochizuki T, QuWM, Hong ZY,Watanabe T, Urade Y, Hayaishi O (2006) Altered sleep-wake characteristics and lack of arousal response to H3 receptor antagonist in histamine H1 receptor knockout mice. Proc Natl Acad Sci U S A 103(12):4687-4692
108. Parmentier R, Anaclet C, Guhennec C, Brousseau E, Bricout D, Giboulot T, Bozyczko-Coyne D, Spiegel K, Ohtsu H,Williams M et al (2007) The brain H3-receptor as a novel therapeutic target for vigilance and sleep-wake disorders. Biochem Pharmacol 73 (8):1157-1171 (Pubitemid 46413178)
109. Huang ZL, Qu WM, Li WD, Mochizuki T, Eguchi N, Watanabe T, Urade Y, Hayaishi O (2001) Arousal effect of orexin A depends on activation of the histaminergic system. Proc Natl Acad Sci U S A 98(17):9965-9970 (Pubitemid 32769411)
110. Carter ME, Adamantidis A, Ohtsu H, Deisseroth K, de Lecea L (2009) Sleep homeostasis modulates hypocretin-mediated sleepto- wake transitions. J Neurosci 29(35):10939-10949
111. Bianchi MT (2010) Context dependent benzodiazepine modulation of GABA(A) receptor opening frequency. Curr Neuropharmacol 8 (1):10-17
112. Laposky AD, Homanics GE, Basile A, Mendelson WB (2001) Deletion of the GABA(A) receptor beta 3 subunit eliminates the hypnotic actions of oleamide in mice. Neuroreport 12(18):4143-4147 (Pubitemid 33152468)
113. Wisor JP, DeLorey TM, Homanics GE, Edgar DM (2002) Sleep states and sleep electroencephalographic spectral power in mice lacking the beta 3 subunit of the GABA(A) receptor. Brain Res 955(1-2):221-228 (Pubitemid 35284853)
114. Matsuki T, Nomiyama M, Takahira H, Hirashima N, Kunita S, Takahashi S, Yagami K, Kilduff TS, Bettler B, Yanagisawa M et al (2009) Selective loss of GABA(B) receptors in orexinproducing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A 106(11):4459-4464
115. Winsky-Sommerer R, Knapman A, Fedele DE, Schofield CM, Vyazovskiy VV, Rudolph U, Huguenard JR, Fritschy JM, Tobler I (2008) Normal sleep homeostasis and lack of epilepsy phenotype in GABA A receptor alpha3 subunit-knockout mice. Neuroscience 154(2):595-605
116. Tobler I, Kopp C, Deboer T, Rudolph U (2001) Diazepaminduced changes in sleep: role of the alpha 1 GABA(A) receptor subtype. Proc Natl Acad Sci U S A 98(11):6464-6469 (Pubitemid 32488260)
117. Tobler I, Kopp C, Deboer T, Rudolph U, Low K, Tobler I (2001) Diazepam-induced changes in sleep: role of the alpha 1 GABAA receptor subtype. Proc Natl Acad Sci U S A 98(11):6464-6469 (Pubitemid 32488260)
118. Kopp C, Rudolph U, Low K, Tobler I (2004) Modulation of rhythmic brain activity by diazepam: GABA(A) receptor subtype and state specificity. Proc Natl Acad Sci U S A 101(10):3674-3679 (Pubitemid 38338253)
119. Quinlan JJ, Firestone LL, Homanics GE (2000) Mice lacking the long splice variant of the gamma 2 subunit of the GABA(A) receptor are more sensitive to benzodiazepines. Pharmacol Biochem Behav 66(2):371-374 (Pubitemid 30394625)
120. Coyne L, Lees G, Nicholson RA, Zheng J, Neufield KD (2002) The sleep hormone oleamide modulates inhibitory ionotropic receptors in mammalian CNS in vitro. Br J Pharmacol 135(8):1977-1987 (Pubitemid 34478310)
121. Winsky-Sommerer R, Vyazovskiy VV, Homanics GE, Tobler I (2007) The EEG effects of THIP (Gaboxadol) on sleep and waking are mediated by the GABA(A)delta-subunit-containing receptors. Eur J Neurosci 25(6):1893-1899 (Pubitemid 46550020)
122. Brown N, Kerby J, Bonnert TP, Whiting PJ, Wafford KA (2002) Pharmacological characterization of a novel cell line expressing human alpha(4)beta(3)delta GABA(A) receptors. Br J Pharmacol 136(7):965-974
123. Mortensen M, Ebert B, Wafford K, Smart TG (2010) Distinct activities of GABA agonists at synaptic- and extrasynaptic-type GABAA receptors. J Physiol 588(Pt 8):1251-1268
124. Meera P, Wallner M, Otis TS (2011) Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors. J Neurophysiol 106(4):2057-2064
125. Boehm SL 2nd, Homanics GE, Blednov YA, Harris RA (2006) Delta-subunit containing GABAA receptor knockout mice are less sensitive to the actions of 4,5,6,7-tetrahydroisoxazolo-[5,4-c]pyridin-3-ol. Eur J Pharmacol 541(3):158-162 (Pubitemid 44192371)
126. Jones BE, Bobillier P, Pin C, Jouvet M (1973) The effect of lesions of catecholamine-containing neurons upon monoamine content of the brain and EEG and behavioral waking in the cat. Brain Res 58(1):157-177
127. Trulson ME (1985) Simultaneous recording of substantia nigra neurons and voltammetric release of dopamine in the caudate of behaving cats. Brain Res Bull 15(2):221-223 (Pubitemid 15017264)
128. Nishino S, Mao J, Sampathkumaran R, Shelton J (1998) Increased dopaminergic transmission mediates the wakepromoting effects of CNS stimulants. Sleep Res Online 1(1):49-61
129. Wisor JP, Nishino S, Sora I, Uhl GH, Mignot E, Edgar DM (2001) Dopaminergic role in stimulant-induced wakefulness. J Neurosci 21(5):1787-1794 (Pubitemid 32184295)
130. Steenland HW, Kim SS, Zhuo M (2008) GluR3 subunit regulates sleep, breathing and seizure generation. Eur J Neurosci 27 (5):1166-1173 (Pubitemid 351432330)
131. Hunsley MS, Palmiter RD (2004) Altered sleep latency and arousal regulation in mice lacking norepinephrine. Pharmacol Biochem Behav 78(4):765-773 (Pubitemid 39037737)
132. Stenberg D, Litonius E, Halldner L, Johansson B, Fredholm BB, Porkka-Heiskanen T (2003) Sleep and its homeostatic regulation in mice lacking the adenosine A1 receptor. J Sleep Res 12(4):283-290 (Pubitemid 38010434)
133. Bjorness TE, Kelly CL, Gao T, Poffenberger V, Greene RW (2009) Control and function of the homeostatic sleep response by adenosine A1 receptors. J Neurosci 29(5):1267-1276
134. Retey JV, Adam M, Honegger E, Khatami R, Luhmann UF, Jung HH, Berger W, Landolt HP (2005) A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A 102(43):15676-15681 (Pubitemid 41528115)
135. Bachmann V, Klaus F, Bodenmann S, Schafer N, Brugger P, Huber S, Berger W, Landolt HP (2012) Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex 22(4):962-970
136. Childs E, Hohoff C, Deckert J, Xu K, Badner J, de Wit H (2008) Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. Neuropsychopharmacology 33 (12):2791-2800
137. Retey JV, Adam M, Khatami R, Luhmann UF, Jung HH, Berger W, Landolt HP (2007) A genetic variation in the adenosine A2A receptor gene (ADORA2A) contributes to individual sensitivity to caffeine effects on sleep. Clin Pharmacol Ther 81(5):692-698 (Pubitemid 46625104)
138. Goutagny R, Comte JC, Salvert D, Gomeza J, Yamada M, Wess J, Luppi PH, Fort P (2005) Paradoxical sleep in mice lacking M3 and M2/M4 muscarinic receptors. Neuropsychobiology 52(3):140-146
139. Fonck C, Cohen BN, Nashmi R, Whiteaker P, Wagenaar DA, Rodrigues-Pinguet N, Deshpande P, McKinney S, Kwoh S, Munoz J et al (2005) Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha 4*nicotinic receptors. J Neurosci 25(49):11396-11411 (Pubitemid 43083712)
140. Lena C, Popa D, Grailhe R, Escourrou P, Changeux JP, Adrien J (2004) Beta2-containing nicotinic receptors contribute to the organization of sleep and regulate putative micro-arousals in mice. J Neurosci 24(25):5711-5718 (Pubitemid 38857225)
141. Crunelli V, Cope DW, Hughes SW (2006) Thalamic T-type Ca2+ channels and NREM sleep. Cell Calcium 40(2):175-190 (Pubitemid 43942299)
142. Lee J, Kim D, Shin HS (2004) Lack of delta waves and sleep disturbances during non-rapid eye movement sleep in mice lacking alpha1G-subunit of T-type calcium channels. Proc Natl Acad Sci U S A 101(52):18195-18199 (Pubitemid 40054096)
143. Anderson MP, Mochizuki T, Xie J, Fischler W, Manger JP, Talley EM, Scammell TE, Tonegawa S (2005) Thalamic Cav3.1T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A 102(5):1743-1748 (Pubitemid 40209238)
144. Beuckmann CT, Sinton CM, Miyamoto N, Ino M, Yanagisawa M (2003) N-type calcium channel alpha1B subunit (Cav2.2) knockout mice display hyperactivity and vigilance state differences. J Neurosci 23(17):6793-6797 (Pubitemid 36951207)
145. Cueni L, Canepari M, Lujan R, Emmenegger Y, Watanabe M, Bond CT, Franken P, Adelman JP, Luthi A (2008) T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nat Neurosci 11(6):683-692 (Pubitemid 351748121)
146. Joho RH, Ho CS, Marks GA (1999) Increased gamma- and decreased delta-oscillations in a mouse deficient for a potassium channel expressed in fast-spiking interneurons. J Neurophysiol 82(4):1855-1864 (Pubitemid 29471273)
147. Joho RH, Marks GA, Espinosa F (2006) Kv3 potassium channels control the duration of different arousal states by distinct stochastic and clock-like mechanisms. Eur J Neurosci 23(6):1567-1574
148. Vyazovskiy VV, Deboer T, Rudy B, Lau D, Borbely AA, Tobler I (2002) Sleep EEG in mice that are deficient in the potassium channel subunit K.v.3.2. Brain Res 947(2):204-211
149. Douglas CL, Vyazovskiy V, Southard T, Chiu SY, Messing A, Tononi G, Cirelli C (2007) Sleep in Kcna2 knockout mice. BMC Biol 5:42
150. Pang DS, Robledo CJ, Carr DR, Gent TC, Vyssotski AL, Caley A, Zecharia AY, Wisden W, Brickley SG, Franks NP (2009) An unexpected role for TASK-3 potassium channels in network oscillations with implications for sleep mechanisms and anesthetic action. Proc Natl Acad Sci U S A 106(41):17546-17551
151. Gotter AL, Santarelli VP, Doran SM, Tannenbaum PL, Kraus RL, Rosahl TW, Meziane H, Montial M, Reiss DR, Wessner K et al (2011) TASK-3 as a potential antidepressant target. Brain Res 1416:69-79
152. Papale LA, Paul KN, Sawyer NT, Manns JR, Tufik S, Escayg A (2010) Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory. J Biol Chem 285(22):16553-16561
153. Franken P, Lopez-Molina L, Marcacci L, Schibler U, Tafti M (2000) The transcription factor DBP affects circadian sleep consolidation and rhythmic EEG activity. J Neurosci 20(2):617-625 (Pubitemid 30225564)
154. Ryu KY, Fujiki N, Kazantzis M, Garza JC, Bouley DM, Stahl A, Lu XY, Nishino S, Kopito RR (2010) Loss of polyubiquitin gene Ubb leads to metabolic and sleep abnormalities in mice. Neuropathol Appl Neurobiol 36(4):285-299
155. Colas D, Wagstaff J, Fort P, Salvert D, Sarda N (2005) Sleep disturbances in Ube3a maternal-deficient mice modeling Angelman syndrome. Neurobiol Dis 20(2):471-478 (Pubitemid 41476273)
156. Shiromani PJ, Basheer R, Thakkar J, Wagner D, Greco MA, Charness ME (2000) Sleep and wakefulness in c-fos and fos B gene knockout mice. Brain Res Mol Brain Res 80(1):75-87 (Pubitemid 30612439)
157. Maret S, Dorsaz S, Gurcel L, Pradervand S, Petit B, Pfister C, Hagenbuchle O, O'Hara BF, Franken P, Tafti M (2007) Homer1a is a core brain molecular correlate of sleep loss. Proc Natl Acad Sci U S A 104(50):20090-20095
158. Brown K, Mastrianni JA (2010) The prion diseases. J Geriatr Psychiatry Neurol 23(4):277-298
159. Tobler I, Deboer T, Fischer M (1997) Sleep and sleep regulation in normal and prion protein-deficientmice. JNeurosci 17(5):1869-1879 (Pubitemid 27089831)
160. Tobler I, Gaus SE, Deboer T, Achermann P, Fischer M, Rulicke T, Moser M, Oesch B, McBride PA, Manson JC (1996) Altered circadian activity rhythms and sleep in mice devoid of prion protein. Nature 380(6575):639-642 (Pubitemid 26119019)
161. Huber R, Deboer T, Tobler I (2002) Sleep deprivation in prion protein deficient mice sleep deprivation in prion protein deficient mice and control mice: genotype dependent regional rebound. Neuroreport 13(1):1-4 (Pubitemid 34102016)
162. Sanchez-Alavez M, Conti B, Moroncini G, Criado JR (2007) Contributions of neuronal prion protein on sleep recovery and stress response following sleep deprivation. Brain Res 1158:71-80 (Pubitemid 47068416)
163. Dossena S, Imeri L, Mangieri M, Garofoli A, Ferrari L, Senatore A, Restelli E, Balducci C, Fiordaliso F, Salio M et al (2008) Mutant prion protein expression causes motor and memory deficits and abnormal sleep patterns in a transgenic mouse model. Neuron 60(4):598-609
164. Deschenes CL, McCurry SM (2009) Current treatments for sleep disturbances in individuals with dementia. Curr Psychiatry Rep 11(1):20-26
165. Dauvilliers Y (2007) Insomnia in patients with neurodegenerative conditions. Sleep Med 8(Suppl 4):S27-S34 (Pubitemid 351391691)
166. Colas D, London J, Gharib A, Cespuglio R, Sarda N (2004) Sleep-wake architecture in mouse models for Down syndrome. Neurobiol Dis 16(2):291-299 (Pubitemid 38757311)
167. Hu K, Van Someren EJ, Shea SA, Scheer FA (2009) Reduction of scale invariance of activity fluctuations with aging and Alzheimer's disease: involvement of the circadian pacemaker. Proc Natl Acad Sci U S A 106(8):2490-2494
168. Zhang B, Veasey SC, Wood MA, Leng LZ, Kaminski C, Leight S, Abel T, Lee VM, Trojanowski JQ (2005) Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. Am J Pathol 167(5):1361-1369 (Pubitemid 41541422)
169. Huitron-Resendiz S, Sanchez-Alavez M, Gallegos R, Berg G, Crawford E, Giacchino JL, Games D, Henriksen SJ, Criado JR (2002) Age-independent and age-related deficits in visuospatial learning, sleep-wake states, thermoregulation and motor activity in PDAPP mice. Brain Res 928(1-2):126-137 (Pubitemid 34159059)
170. Robertson J, Curley J, Kaye J, Quinn J, Pfankuch T, Raber J (2005) apoE isoforms and measures of anxiety in probable AD patients and Apoe/ mice. Neurobiol Aging 26(5):637-643 (Pubitemid 40228755)
171. Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES (2005) Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease. J Neurosci 25(1):157-163 (Pubitemid 40110776)
172. Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ (2007) Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J Neurosci 27(29):7869-7878 (Pubitemid 47093825)
173. Colas D, London J, Cespuglio R, Sarda N (2003) Polysomnography in transgenic hSOD1 mice as Down syndrome model. J Neural Transm Suppl 67:165-171 (Pubitemid 38339932)
174. Rial RV, Nicolau MC, Gamundi A, Akaarir M, Aparicio S, Garau C, Tejada S, Roca C, Gene L, Moranta D et al (2007) The trivial function of sleep. Sleep Med Rev 11(4):311-325 (Pubitemid 47031018)