The effects of C75, an inhibitor of fatty acid synthase, on sleep and metabolism in mice

PLoS ONE

Volumn 7, Issue 2, 2012, Pages

  Pellinen, Jacob ^a   Szentirmai, Éva ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C 75; CARBON DIOXIDE; FATTY ACID SYNTHASE INHIBITOR; GHRELIN; GHRELIN RECEPTOR; OXYGEN; UNCLASSIFIED DRUG; 4 METHYLENE 2 OCTYL 5 OXOFURAN 3 CARBOXYLIC ACID; 4-METHYLENE-2-OCTYL-5-OXOFURAN-3-CARBOXYLIC ACID; DRUG DERIVATIVE; ENZYME INHIBITOR; FATTY ACID SYNTHASE; GAMMA BUTYROLACTONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANOREXIA; ARTICLE; BODY TEMPERATURE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MECHANISM; ELECTROENCEPHALOGRAM; ENERGY EXPENDITURE; FEEDING BEHAVIOR; FOOD INTAKE; HORMONE ACTION; KNOCKOUT MOUSE; LOCOMOTION; LUNG GAS EXCHANGE; MALE; METABOLIC INHIBITION; METABOLIC PARAMETERS; METABOLISM; MOTOR ACTIVITY; MOUSE; NONHUMAN; OXYGEN CONSUMPTION; PROTEIN DEFICIENCY; PROTEIN SYNTHESIS INHIBITION; REM SLEEP; SIGNAL TRANSDUCTION; SLEEP; SLEEP WAKING CYCLE; SLOW BRAIN WAVE; STRAIN DIFFERENCE; WAKEFULNESS; WILD TYPE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; LIPID METABOLISM;

MUS;

4-BUTYROLACTONE; ANIMALS; ENZYME INHIBITORS; FATTY ACID SYNTHETASE COMPLEX; LIPID METABOLISM; MICE; SLEEP;

EID: 84856820276     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030651     Document Type: Article

References (59)

1. Danguir J, Nicolaidis S, Gerard H, (1979) Relations between feeding and sleep patterns in the rat. J Comp Physiol Psychol 93: 820-830.
2. Borbély AA, (1977) Sleep in the rat during food deprivation and subsequent restitution of food. Brain Res 124: 457-471.
3. Shemyakin A, Kapás L, (2001) L-364,718, a cholecystokinin-A receptor antagonist, suppresses feeding-induced sleep in rats. Am J Physiol Regul Integr Comp Physiol 280: R1420-R1426.
4. Danguir J, Nicolaidis S, (1979) Dependence of sleep on nutrients' availability. Physiol Behav 22: 735-740.
5. Danguir J, Nicolaidis S, (1978) Sleep and feeding patterns in the ventromedial hypothalamic lesioned rat. Physiol Behav 21: 769-777.
6. Danguir J, (1987) Cafeteria diet promotes sleep in rats. Appetite 8: 49-53.
7. Jenkins JB, Omori T, Guan Z, Vgontzas AN, Bixler EO, et al. (2006) Sleep is increased in mice with obesity induced by high-fat food. Physiol Behav 87: 255-262.
8. Laposky AD, Shelton J, Bass J, Dugovic C, Perrino N, et al. (2006) Altered sleep regulation in leptin-deficient mice. Am J Physiol Regul Integr Comp Physiol 290: R894-R903.
9. Danguir J, (1989) Sleep patterns in the genetically obese Zucker rat: effect of acarbose treatment. Am J Physiol 256: R281-R283.
10. Mansbach RS, Lorenz DN, (1983) Cholecystokinin (CCK-8) elicits prandial sleep in rats. Physiol Behav 30: 179-183.
11. Kapás L, Obál F Jr, Alföldi P, Rubicsek G, Penke B, et al. (1988) Effects of nocturnal intraperitoneal administration of cholecystokinin in rats: simultaneous increase in sleep, increase in EEG slow-wave activity, reduction of motor activity, suppression of eating, and decrease in brain temperature. Brain Res 438: 155-164.
12. Kapás L, Obál F Jr, Opp MR, Johannsen L, Krueger JM, (1991) Intraperitoneal injection of cholecystokinin elicits sleep in rabbits. Physiol Behav 50: 1241-1244.
13. Sangiah S, Caldwell DF, Villeneuve MJ, Clancy JJ, (1982) Sleep: sequential reduction of paradoxical (REM) and elevation of slow-wave (NREM) sleep by a non-convulsive dose of insulin in rats. Life Sci 31: 763-769.
14. Danguir J, Nicolaidis S, (1984) Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats. Brain Res 306: 97-103.
15. Sinton CM, Fitch TE, Gershenfeld HK, (1999) The effects of leptin on REM sleep and slow wave delta in rats are reversed by food deprivation. J Sleep Res 8: 197-203.
16. Shoham S, Davenne D, Cady AB, Dinarello CA, Krueger JM, (1987) Recombinant tumor necrosis factor and interleukin 1 enhance slow-wave sleep. Am J Physiol 253: R142-R149.
17. Kapás L, Krueger JM, (1992) Tumor necrosis factor-beta induces sleep, fever, and anorexia. Am J Physiol 263: R703-R707.
18. Ronnett GV, Kim EK, Landree LE, Tu Y, (2005) Fatty acid metabolism as a target for obesity treatment. Physiol Behav 85: 25-35.
19. Kuhajda FP, Pizer ES, Li JN, Mani NS, Frehywot GL, et al. (2000) Synthesis and antitumor activity of an inhibitor of fatty acid synthase. Proc Natl Acad Sci USA 97: 3450-3454.
20. Rohrbach KW, Han S, Gan J, O'Tanyi EJ, Zhang H, et al. (2005) Disconnection between the early onset anorectic effects by C75 and hypothalamic fatty acid synthase inhibition in rodents. Eur J Pharmacol 511: 31-41.
21. Rendina AR, Cheng D, (2005) Characterization of the inactivation of rat fatty acid synthase by C75: inhibition of partial reactions and protection by substrates. Biochem J 388: 895-903.
22. Esposito M, Pellinen J, Kapás L, Szentirmai É, (2011) Impaired wake-promoting mechanisms in ghrelin receptor deficient mice. Eur J Neurosci doi:10.1111/j.1460-9568.2011.07946.x.
23. Kageyama H, Takenoya F, Shiba K, Shioda S, (2010) Neuronal circuits involving ghrelin in the hypothalamus-mediated regulation of feeding. Neuropeptides 44: 133-138.
24. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660.
25. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, et al. (1997) Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 48: 23-29.
26. Zigman JM, Jones JE, Lee CE, Saper CB, Elmquist JK, (2006) Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 494: 528-548.
27. Mitchell V, Bouret S, Beauvillain JC, Schilling A, Perret M, et al. (2001) Comparative distribution of mRNA encoding the growth hormone secretagogue-receptor (GHS-R) in Microcebus murinus (Primate, lemurian) and rat forebrain and pituitary. J Comp Neurol 429: 469-489.
28. Tschöp M, Smiley DL, Heiman ML, (2000) Ghrelin induces adiposity in rodents. Nature 407: 908-913.
29. Wren AM, Small CJ, Ward HL, Murphy KG, Dakin CL, et al. (2000) The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141: 4325-4328.
30. Tolle V, Bassant MH, Zizzari P, Poindessous-Jazat F, Tomasetto C, et al. (2002) Ultradian rhythmicity of ghrelin secretion in relation with GH, feeding behavior, and sleep-wake patterns in rats. Endocrinology 143: 1353-1361.
31. Szentirmai E, Hajdu I, Obal F Jr, Krueger JM, (2006) Ghrelin-induced sleep responses in ad libitum fed and food-restricted rats. Brain Res 1088: 131-140.
32. Szentirmai É, Kapás L, Krueger JM, (2007) Ghrelin microinjection into forebrain sites induces wakefulness and feeding in rats. Am J Physiol Regul Integr Comp Physiol 292: R575-R585.
33. Yasuda T, Masaki T, Kakuma T, Yoshimatsu H., Centrally administered ghrelin suppresses sympathetic nerve activity in brown adipose tissue of rats. Neurosci Lett 2003;349: 75-78.
34. Mano-Otagiri A, Ohata H, Iwasaki-Sekino A, Nemoto T, Shibasaki T., Ghrelin suppresses noradrenaline release in the brown adipose tissue of rats. J Endocrinol 2009;201: 341-349.
35. Szentirmai É, Kapás L, Sun Y, Smith RG, Krueger JM, (2009) The preproghrelin gene is required for the normal integration of thermoregulation and sleep in mice. Proc Natl Acad Sci USA 106: 14069-14074.
36. Hu Z, Cha SH, van Haasteren G, Wang J, Lane MD, (2005) Effect of centrally administered C75, a fatty acid synthase inhibitor, on ghrelin secretion and its downstream effects. Proc Natl Acad Sci USA 102: 3972-3977.
37. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, et al. (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288: 2379-2381.
38. Thupari JN, Landree LE, Ronnett GV, Kuhajda FP, (2002) C75 increases peripheral energy utilization and fatty acid oxidation in diet-induced obesity. Proc Natl Acad Sci USA 99: 9498-9502.
39. Clegg DJ, Wortman MD, Benoit SC, McOsker CC, Seeley RJ, (2002) Comparison of central and peripheral administration of C75 on food intake, body weight, and conditioned taste aversion. Diabetes 51: 3196-3201.
40. Bewick GA, Kent A, Campbell D, Patterson M, Ghatei MA, et al. (2009) Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity. Diabetes 58: 840-846.
41. Sun Y, Wang P, Zheng H, Smith RG, (2004) Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 101: 4679-4684.
42. Lin L, Saha PK, Ma X, Henshaw IO, Shao L, et al. (2011) Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell doi:10.1111/j.1474-9726.2011.00740.x.
43. Ma X, Lin L, Qin G, Lu X, Fiorotto M, et al. (2011) Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PLoS One 6: e16391 10.1371/journal.pone.0016391.
44. Sun Y, Butte NF, Garcia JM, Smith RG, (2007) Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology 149: 843-850.
45. Jerlhag E, (2008) Systemic administration of ghrelin induces conditioned place preference and stimulates accumbal dopamine. Addict Biol 13: 358-363.
46. Gao S, Lane MD, (2003) Effect of the anorectic fatty acid synthase inhibitor C75 on neuronal activity in the hypothalamus and brainstem. Proc Natl Acad Sci USA 100: 5628-5633.
47. Danguir J, Nicolaidis S, Perino-Martel MC, (1976) Effects of lithium chloride on sleep patterns in the rat. Pharmacol Biochem Behav 5: 547-550.
48. Venkatakrishna-Bhatt H, Bures J, (1978) Electrophysiological changes induced by paradoxical sleep deprivation and lithium chloride poisoning in rats. Brain Res 152: 97-103.
49. Jones CA, Perez E, Amici R, Luppi M, Baracchi F, et al. (2008) Lithium affects REM sleep occurrence, autonomic activity and brain second messengers in the rat. Behav Brain Res 187: 254-261.
50. Nachman M, Ashe JH, (1973) Learned taste aversions in rats as a function of dosage, concentration, and route of administration of LiCl. Physiol Behav 10: 73-78.
51. Takahashi KA, Smart JL, Liu H, Cone RD, (2004) The anorexigenic fatty acid synthase inhibitor, C75, is a nonspecific neuronal activator. Endocrinology 145: 184-193.
52. Gu Y, Gonzalez MF, Chin DY, Deutsch JA, (1993) Expression of c-fos in brain subcortical structures in response to nauseant lithium chloride and osmotic pressure in rats. Neurosci Lett 157: 49-52.
53. Lamprecht R, Dudai Y, (1995) Differential modulation of brain immediate early genes by intraperitoneal LiCl. Neuroreport 7: 289-293.
54. Rinaman L, Dzmura V, (2007) Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride. Am J Physiol Regul Integr Comp Physiol 293: R1495-R1503.
55. Mansouri A, Aja S, Moran TH, Ronnett G, Kuhajda FP, et al. (2008) Intraperitoneal injections of low doses of C75 elicit a behaviorally specific and vagal afferent-independent inhibition of eating in rats. Am J Physiol Regul Integr Comp Physiol 295: R799-R805.
56. Pfluger PT, Kirchner H, Günnel S, Schrott B, Perez-Tilve D, et al. (2008) Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure. Am J Physiol Gastrointest Liver Physiol 294: G610-G618.
57. Longo KA, Charoenthongtrakul S, Giuliana DJ, Govek EK, McDonagh T, et al. (2008) Improved insulin sensitivity and metabolic flexibility in ghrelin receptor knockout mice. Regul Pept 150: 55-61.
58. Shimokawa T, Kumar MV, Lane MD, (2002) Effect of a fatty acid synthase inhibitor on food intake and expression of hypothalamic neuropeptides. Proc Natl Acad Sci USA 99: 66-71.
59. Kim EK, Miller I, Landree LE, Borisy-Rudin FF, Brown P, et al. (2002) Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment. Am J Physiol Endocrinol Metab 283: E867-E879.