메뉴 건너뛰기




Volumn 131, Issue 2, 2005, Pages 375-385

Sleep and circadian abnormalities in a transgenic mouse model of Alzheimer's disease: A role for cholinergic transmission

Author keywords

Amyloid precursor protein; Donepezil; Electroencephalogram; Sleep deprivation; Tg2576; amyloid immunization

Indexed keywords

AMYLOID BETA PROTEIN; CHOLINESTERASE INHIBITOR; DONEPEZIL; MONOCLONAL ANTIBODY;

EID: 13544275103     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2004.11.018     Document Type: Article
Times cited : (144)

References (75)
  • 1
    • 0037145719 scopus 로고    scopus 로고
    • Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein
    • J. Apelt, A. Kumar, R. Schliebs Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein Brain Res 953 2002 17
    • (2002) Brain Res , vol.953 , pp. 17
    • Apelt, J.1    Kumar, A.2    Schliebs, R.3
  • 2
    • 0037088959 scopus 로고    scopus 로고
    • Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls
    • G.W. Arendash, D.L. King Intra- and intertask relationships in a behavioral test battery given to Tg2576 transgenic mice and controls Physiol Behav 75 2002 643 652
    • (2002) Physiol Behav , vol.75 , pp. 643-652
    • Arendash, G.W.1    King, D.L.2
  • 3
  • 5
    • 12244312497 scopus 로고    scopus 로고
    • Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology
    • M. Bigl, J. Apelt, K. Eschrich, R. Schliebs Cortical glucose metabolism is altered in aged transgenic Tg2576 mice that demonstrate Alzheimer plaque pathology J Neural Transm 110 2003 77 94
    • (2003) J Neural Transm , vol.110 , pp. 77-94
    • Bigl, M.1    Apelt, J.2    Eschrich, K.3    Schliebs, R.4
  • 6
    • 0030463936 scopus 로고    scopus 로고
    • Muscarinic receptors mediate carbachol-induced phase shifts of circadian activity rhythms in Syrian hamsters
    • K.G. Bina, B. Rusak Muscarinic receptors mediate carbachol-induced phase shifts of circadian activity rhythms in Syrian hamsters Brain Res 743 1996 202 211
    • (1996) Brain Res , vol.743 , pp. 202-211
    • Bina, K.G.1    Rusak, B.2
  • 7
    • 0027217021 scopus 로고
    • Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat
    • K.G. Bina, B. Rusak, K. Semba Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rat J Comp Neurol 335 1993 295 307
    • (1993) J Comp Neurol , vol.335 , pp. 295-307
    • Bina, K.G.1    Rusak, B.2    Semba, K.3
  • 9
    • 0035102386 scopus 로고    scopus 로고
    • Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice
    • M.J. Callahan, W.J. Lipinski, F. Bian, R.A. Durham, A. Pack, L.C. Walker Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice Am J Pathol 158 2001 1173 1177
    • (2001) Am J Pathol , vol.158 , pp. 1173-1177
    • Callahan, M.J.1    Lipinski, W.J.2    Bian, F.3    Durham, R.A.4    Pack, A.5    Walker, L.C.6
  • 10
    • 0034668837 scopus 로고    scopus 로고
    • Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep
    • E.G. Cape, I.D. Manns, A. Alonso, A. Beaudet, B.E. Jones Neurotensin-induced bursting of cholinergic basal forebrain neurons promotes gamma and theta cortical activity together with waking and paradoxical sleep J Neurosci 20 2000 8452 8461
    • (2000) J Neurosci , vol.20 , pp. 8452-8461
    • Cape, E.G.1    Manns, I.D.2    Alonso, A.3    Beaudet, A.4    Jones, B.E.5
  • 11
    • 0344011437 scopus 로고    scopus 로고
    • Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms
    • T.C. Chou, T.E. Scammell, J.J. Gooley, S.E. Gaus, C.B. Saper, J. Lu Critical role of dorsomedial hypothalamic nucleus in a wide range of behavioral circadian rhythms J Neurosci 23 2003 10691 10702
    • (2003) J Neurosci , vol.23 , pp. 10691-10702
    • Chou, T.C.1    Scammell, T.E.2    Gooley, J.J.3    Gaus, S.E.4    Saper, C.B.5    Lu, J.6
  • 12
    • 0030464914 scopus 로고    scopus 로고
    • Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease
    • B.J. Cummings, C.J. Pike, R. Shankle, C.W. Cotman Beta-amyloid deposition and other measures of neuropathology predict cognitive status in Alzheimer's disease Neurobiol Aging 17 1996 921 933
    • (1996) Neurobiol Aging , vol.17 , pp. 921-933
    • Cummings, B.J.1    Pike, C.J.2    Shankle, R.3    Cotman, C.W.4
  • 13
    • 0036240395 scopus 로고    scopus 로고
    • Immunization reverses memory deficits without reducing Abeta burden in Alzheimer's disease model
    • Dodart Immunization reverses memory deficits without reducing Abeta burden in Alzheimer's disease model Nat Neurosci 5 2002 452 457
    • (2002) Nat Neurosci , vol.5 , pp. 452-457
    • Dodart1
  • 14
    • 0025740262 scopus 로고
    • Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice
    • D.M. Edgar, T.S. Kilduff, C.E. Martin, W.C. Dement Influence of running wheel activity on free-running sleep/wake and drinking circadian rhythms in mice Physiol Behav 50 1991 373 378
    • (1991) Physiol Behav , vol.50 , pp. 373-378
    • Edgar, D.M.1    Kilduff, T.S.2    Martin, C.E.3    Dement, W.C.4
  • 15
    • 0035654686 scopus 로고    scopus 로고
    • Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats
    • Y. Endo, K. Shinohara, Y. Fueta, M. Irie Influences of cholinergic neurotoxin ethylcholine aziridinium ion on circadian rhythms in rats Neurosci Res 41 2001 385 390
    • (2001) Neurosci Res , vol.41 , pp. 385-390
    • Endo, Y.1    Shinohara, K.2    Fueta, Y.3    Irie, M.4
  • 16
    • 0023009645 scopus 로고
    • Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease
    • P. Etienne, Y. Robitaille, P. Wood, S. Gauthier, N.P. Nair, R. Quirion Nucleus basalis neuronal loss, neuritic plaques and choline acetyltransferase activity in advanced Alzheimer's disease Neuroscience 19 1986 1279 1291
    • (1986) Neuroscience , vol.19 , pp. 1279-1291
    • Etienne, P.1    Robitaille, Y.2    Wood, P.3    Gauthier, S.4    Nair, N.P.5    Quirion, R.6
  • 18
    • 0031738539 scopus 로고    scopus 로고
    • Genetic variation in EEG activity during sleep in inbred mice
    • P. Franken, A. Malafosse, M. Tafti Genetic variation in EEG activity during sleep in inbred mice Am J Physiol 44 1998 R1127 R1137
    • (1998) Am J Physiol , vol.44
    • Franken, P.1    Malafosse, A.2    Tafti, M.3
  • 20
    • 0141818332 scopus 로고    scopus 로고
    • Cholinergic function and Alzheimer's disease
    • E. Giacobini Cholinergic function and Alzheimer's disease Int J Geriatr Psychiatry 18 2003 S1 S5
    • (2003) Int J Geriatr Psychiatry , vol.18
    • Giacobini, E.1
  • 21
    • 0025041389 scopus 로고
    • The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease
    • E. Goudsmit, M.A. Hofman, E. Fliers, D.F. Swaab The supraoptic and paraventricular nuclei of the human hypothalamus in relation to sex, age and Alzheimer's disease Neurobiol Aging 11 1990 529 536
    • (1990) Neurobiol Aging , vol.11 , pp. 529-536
    • Goudsmit, E.1    Hofman, M.A.2    Fliers, E.3    Swaab, D.F.4
  • 22
    • 0035313943 scopus 로고    scopus 로고
    • Sleep and memory: A molecular perspective
    • L. Graves, A. Pack, T. Abel Sleep and memory a molecular perspective Trends Neurosci 24 2001 237 243
    • (2001) Trends Neurosci , vol.24 , pp. 237-243
    • Graves, L.1    Pack, A.2    Abel, T.3
  • 24
    • 0034117262 scopus 로고    scopus 로고
    • Beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis: Effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease
    • T. Harkany, B. Penke, P.G. Luiten beta-Amyloid excitotoxicity in rat magnocellular nucleus basalis effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease Ann NY Acad Sci 903 2000 374 386
    • (2000) Ann NY Acad Sci , vol.903 , pp. 374-386
    • Harkany, T.1    Penke, B.2    Luiten, P.G.3
  • 25
    • 0032417251 scopus 로고    scopus 로고
    • Transgenic mice expressing Alzheimer amyloid precursor proteins
    • K. Hsiao Transgenic mice expressing Alzheimer amyloid precursor proteins Exp Gerontol 33 1998 883 889
    • (1998) Exp Gerontol , vol.33 , pp. 883-889
    • Hsiao, K.1
  • 29
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related a beta deposits and neuropil abnormalities, but no neuronal loss in CA1
    • M.C. Irizarry, M. McNamara, K. Fedorchak, K. Hsiao, B.T. Hyman APPSw transgenic mice develop age-related A beta deposits and neuropil abnormalities, but no neuronal loss in CA1 J Neuropathol Exp Neurol 56 1997 965 973
    • (1997) J Neuropathol Exp Neurol , vol.56 , pp. 965-973
    • Irizarry, M.C.1    McNamara, M.2    Fedorchak, K.3    Hsiao, K.4    Hyman, B.T.5
  • 30
    • 0344873128 scopus 로고    scopus 로고
    • Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex
    • B.E. Jones Activity, modulation and role of basal forebrain cholinergic neurons innervating the cerebral cortex Prog Brain Res 145 2004 157 169
    • (2004) Prog Brain Res , vol.145 , pp. 157-169
    • Jones, B.E.1
  • 31
    • 11144356498 scopus 로고    scopus 로고
    • Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by Apolipoprotein e and phosphorylated tau accumulation in the Tg2576 model of Alzheimer's disease
    • T. Kawarabayashi, M. Shoji, L.H. Younkin, L. Wen-Lang, D.W. Dickson, T. Murakami, E. Matsubara, K. Abe, K.H. Ashe, S.G. Younkin Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by Apolipoprotein E and phosphorylated tau accumulation in the Tg2576 model of Alzheimer's disease J Neurosci 24 2004 3801 3809
    • (2004) J Neurosci , vol.24 , pp. 3801-3809
    • Kawarabayashi, T.1    Shoji, M.2    Younkin, L.H.3    Wen-Lang, L.4    Dickson, D.W.5    Murakami, T.6    Matsubara, E.7    Abe, K.8    Ashe, K.H.9    Younkin, S.G.10
  • 32
    • 0033199822 scopus 로고    scopus 로고
    • Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease
    • D.L. King, G.W. Arendash, F. Crawford, T. Sterk, J. Menendez, M.J. Mullan Progressive and gender-dependent cognitive impairment in the APP(SW) transgenic mouse model for Alzheimer's disease Behav Brain Res 103 1999 145 162
    • (1999) Behav Brain Res , vol.103 , pp. 145-162
    • King, D.L.1    Arendash, G.W.2    Crawford, F.3    Sterk, T.4    Menendez, J.5    Mullan, M.J.6
  • 33
    • 0242383891 scopus 로고    scopus 로고
    • Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology
    • M. Klingner, J. Apelt, A. Kumar, D. Sorger, O. Sabri, J. Steinbach, M. Scheunemann, R. Schliebs Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology Int J Dev Neurosci 21 2003 357 369
    • (2003) Int J Dev Neurosci , vol.21 , pp. 357-369
    • Klingner, M.1    Apelt, J.2    Kumar, A.3    Sorger, D.4    Sabri, O.5    Steinbach, J.6    Scheunemann, M.7    Schliebs, R.8
  • 35
    • 0035503597 scopus 로고    scopus 로고
    • The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse
    • G.P. Lim, T. Chu, F. Yang, W. Beech, S.A. Frautschy, G.M. Cole The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse J Neurosci 21 2001 8370 8377
    • (2001) J Neurosci , vol.21 , pp. 8370-8377
    • Lim, G.P.1    Chu, T.2    Yang, F.3    Beech, W.4    Frautschy, S.A.5    Cole, G.M.6
  • 36
    • 0030030035 scopus 로고    scopus 로고
    • Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night
    • C. Liu, M.U. Gillette Cholinergic regulation of the suprachiasmatic nucleus circadian rhythm via a muscarinic mechanism at night J Neurosci 16 1996 744 751
    • (1996) J Neurosci , vol.16 , pp. 744-751
    • Liu, C.1    Gillette, M.U.2
  • 37
    • 3943092621 scopus 로고    scopus 로고
    • Pathways towards and away from Alzheimer's disease
    • M.P. Mattson Pathways towards and away from Alzheimer's disease Nature 430 2004 631 639
    • (2004) Nature , vol.430 , pp. 631-639
    • Mattson, M.P.1
  • 39
    • 0031054008 scopus 로고    scopus 로고
    • Different manifestations of circadian rhythms in senile dementia of Alzheimer's type and multi- infarct dementia
    • K. Mishima, M. Okawa, K. Satoh, T. Shimizu, S. Hozumi, Y. Hishikawa Different manifestations of circadian rhythms in senile dementia of Alzheimer's type and multi- infarct dementia Neurobiol Aging 18 1997 105 109
    • (1997) Neurobiol Aging , vol.18 , pp. 105-109
    • Mishima, K.1    Okawa, M.2    Satoh, K.3    Shimizu, T.4    Hozumi, S.5    Hishikawa, Y.6
  • 40
    • 0142012147 scopus 로고    scopus 로고
    • Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta
    • O.M. Mitrasinovic, G.M. Murphy Jr Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Abeta Neurobiol Aging 24 2003 807 815
    • (2003) Neurobiol Aging , vol.24 , pp. 807-815
    • Mitrasinovic, O.M.1    Murphy Jr., G.M.2
  • 41
    • 0028303123 scopus 로고
    • Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders
    • G.M. Murphy Jr, L.S. Forno, L. Higgins, J.M. Scardina, L.F. Eng, B. Cordell Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders Am J Pathol 144 1994 1082 1088
    • (1994) Am J Pathol , vol.144 , pp. 1082-1088
    • Murphy Jr., G.M.1    Forno, L.S.2    Higgins, L.3    Scardina, J.M.4    Eng, L.F.5    Cordell, B.6
  • 42
    • 7744243271 scopus 로고    scopus 로고
    • Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease
    • K. Noda-Saita, K. Terai, A. Iwai, M. Tsukamoto, Y. Shitaka, S. Kawabata, M. Okada, T. Yamaguchi Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease Acta Neuropathol (Berl) 108 2004 435 442
    • (2004) Acta Neuropathol (Berl) , vol.108 , pp. 435-442
    • Noda-Saita, K.1    Terai, K.2    Iwai, A.3    Tsukamoto, M.4    Shitaka, Y.5    Kawabata, S.6    Okada, M.7    Yamaguchi, T.8
  • 43
    • 0035896244 scopus 로고    scopus 로고
    • Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats
    • H. Ogura, T. Kosasa, Y. Kuriya, Y. Yamanishi Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats Eur J Pharmacol 415 2001 157 164
    • (2001) Eur J Pharmacol , vol.415 , pp. 157-164
    • Ogura, H.1    Kosasa, T.2    Kuriya, Y.3    Yamanishi, Y.4
  • 45
    • 0141867633 scopus 로고    scopus 로고
    • The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition: A part 3 study of the main mechanism of cholinesterase inhibitors in dementia
    • M. Onofrj, A. Thomas, D. Iacono, A.L. Luciano, A. Di Iorio The effects of a cholinesterase inhibitor are prominent in patients with fluctuating cognition a part 3 study of the main mechanism of cholinesterase inhibitors in dementia Clin Neuropharmacol 26 2003 239 251
    • (2003) Clin Neuropharmacol , vol.26 , pp. 239-251
    • Onofrj, M.1    Thomas, A.2    Iacono, D.3    Luciano, A.L.4    Di Iorio, A.5
  • 46
  • 47
    • 0024999542 scopus 로고
    • Sleep problems in the community elderly as predictors of death and nursing home placement
    • C.P. Pollak, D. Perlick, J.P. Linsner, J. Wenston, F. Hsieh Sleep problems in the community elderly as predictors of death and nursing home placement J Community Health 15 1990 123 135
    • (1990) J Community Health , vol.15 , pp. 123-135
    • Pollak, C.P.1    Perlick, D.2    Linsner, J.P.3    Wenston, J.4    Hsieh, F.5
  • 48
    • 0032925164 scopus 로고    scopus 로고
    • Adenosine in sleep and wakefulness
    • T. Porkka-Heiskanen Adenosine in sleep and wakefulness Ann Med 31 1999 125 129
    • (1999) Ann Med , vol.31 , pp. 125-129
    • Porkka-Heiskanen, T.1
  • 51
    • 0029788661 scopus 로고    scopus 로고
    • Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence
    • A.G. Reaume, D.S. Howland, S.P. Trusko, M.J. Savage, D.M. Lang, B.D. Greenberg, R. Siman, R.W. Scott Enhanced amyloidogenic processing of the beta-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Abeta sequence J Biol Chem 271 1996 23380 23388
    • (1996) J Biol Chem , vol.271 , pp. 23380-23388
    • Reaume, A.G.1    Howland, D.S.2    Trusko, S.P.3    Savage, M.J.4    Lang, D.M.5    Greenberg, B.D.6    Siman, R.7    Scott, R.W.8
  • 52
    • 0023876672 scopus 로고
    • The nature and management of sleep/wake disturbance in Alzheimer's dementia
    • C.F. Reynolds 3rd, C.C. Hoch, J. Stack, D. Campbell The nature and management of sleep/wake disturbance in Alzheimer's dementia Psychopharmacol Bull 24 1988 43 48
    • (1988) Psychopharmacol Bull , vol.24 , pp. 43-48
    • Reynolds III, C.F.1    Hoch, C.C.2    Stack, J.3    Campbell, D.4
  • 53
    • 0028882055 scopus 로고
    • Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease
    • A. Satlin, L. Volicer, E.G. Stopa, D. Harper Circadian locomotor activity and core-body temperature rhythms in Alzheimer's disease Neurobiol Aging 16 1995 765 771
    • (1995) Neurobiol Aging , vol.16 , pp. 765-771
    • Satlin, A.1    Volicer, L.2    Stopa, E.G.3    Harper, D.4
  • 54
    • 0036580703 scopus 로고    scopus 로고
    • Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition
    • M.J. Savage, Y.G. Lin, J.R. Ciallella, D.G. Flood, R.W. Scott Activation of c-Jun N-terminal kinase and p38 in an Alzheimer's disease model is associated with amyloid deposition J Neurosci 22 2002 3376 3385
    • (2002) J Neurosci , vol.22 , pp. 3376-3385
    • Savage, M.J.1    Lin, Y.G.2    Ciallella, J.R.3    Flood, D.G.4    Scott, R.W.5
  • 55
    • 0025514411 scopus 로고
    • Circadian timekeeping in BALB/C and C57BL/6 inbred mouse strains
    • W.J. Schwartz, P. Zimmerman Circadian timekeeping in BALB/C and C57BL/6 inbred mouse strains J Neurosci 10 1990 3686 3694
    • (1990) J Neurosci , vol.10 , pp. 3686-3694
    • Schwartz, W.J.1    Zimmerman, P.2
  • 56
    • 0024787327 scopus 로고
    • Organization of central cholinergic systems
    • K. Semba, H.C. Fibiger Organization of central cholinergic systems Prog Brain Res 79 1989 37 63
    • (1989) Prog Brain Res , vol.79 , pp. 37-63
    • Semba, K.1    Fibiger, H.C.2
  • 57
    • 0028149042 scopus 로고
    • Free-running period of circadian rhythms is shorter in rats with a genetically upregulated central cholinergic system
    • P.J. Shiromani, D. Overstreet Free-running period of circadian rhythms is shorter in rats with a genetically upregulated central cholinergic system Biol Psychiatry 36 1994 622 626
    • (1994) Biol Psychiatry , vol.36 , pp. 622-626
    • Shiromani, P.J.1    Overstreet, D.2
  • 59
    • 0344873126 scopus 로고    scopus 로고
    • Acetylcholine in the cerebral cortex
    • M. Steriade Acetylcholine in the cerebral cortex Prog Brain Res 145 2004 179 196
    • (2004) Prog Brain Res , vol.145 , pp. 179-196
    • Steriade, M.1
  • 61
    • 0023930647 scopus 로고
    • The human suprachiasmatic nucleus; Neuropeptide changes in senium and Alzheimer's disease
    • D.F. Swaab, B. Fisser, W. Kamphorst, D. Troost The human suprachiasmatic nucleus; neuropeptide changes in senium and Alzheimer's disease Basic Appl Histochem 32 1988 43 54
    • (1988) Basic Appl Histochem , vol.32 , pp. 43-54
    • Swaab, D.F.1    Fisser, B.2    Kamphorst, W.3    Troost, D.4
  • 63
    • 0035805091 scopus 로고    scopus 로고
    • Apolipoprotein e deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse: Implications for the pathogenesis of Alzheimer's disease
    • K. Terai, A. Iwai, S. Kawabata, M. Sasamata, K. Miyata, T. Yamaguchi Apolipoprotein E deposition and astrogliosis are associated with maturation of beta-amyloid plaques in betaAPPswe transgenic mouse implications for the pathogenesis of Alzheimer's disease Brain Res 900 2001 48 56
    • (2001) Brain Res , vol.900 , pp. 48-56
    • Terai, K.1    Iwai, A.2    Kawabata, S.3    Sasamata, M.4    Miyata, K.5    Yamaguchi, T.6
  • 64
    • 0036011309 scopus 로고    scopus 로고
    • EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos
    • O.A. Timofeeva, C.J. Gordon EEG spectra, behavioral states and motor activity in rats exposed to acetylcholinesterase inhibitor chlorpyrifos Pharmacol Biochem Behav 72 2002 669 679
    • (2002) Pharmacol Biochem Behav , vol.72 , pp. 669-679
    • Timofeeva, O.A.1    Gordon, C.J.2
  • 65
    • 0030461882 scopus 로고    scopus 로고
    • The cellular and molecular correlates of cognitive impairments in the Alzheimer's disease brain
    • J.Q. Trojanowski The cellular and molecular correlates of cognitive impairments in the Alzheimer's disease brain Neurobiol Aging 17 1996 941 943
    • (1996) Neurobiol Aging , vol.17 , pp. 941-943
    • Trojanowski, J.Q.1
  • 66
    • 0022417046 scopus 로고
    • Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens
    • A.N. van den Pol, K.L. Tsujimoto Neurotransmitters of the hypothalamic suprachiasmatic nucleus immunocytochemical analysis of 25 neuronal antigens Neuroscience 15 1985 1049 1086
    • (1985) Neuroscience , vol.15 , pp. 1049-1086
    • Van Den Pol, A.N.1    Tsujimoto, K.L.2
  • 67
    • 0025917257 scopus 로고
    • Real-time automated sleep scoring: Validation of a microcomputer-based system for mice
    • R.N. Van Gelder, D.M. Edgar, W.C. Dement Real-time automated sleep scoring validation of a microcomputer-based system for mice Sleep 14 1991 48 55
    • (1991) Sleep , vol.14 , pp. 48-55
    • Van Gelder, R.N.1    Edgar, D.M.2    Dement, W.C.3
  • 68
    • 0026181266 scopus 로고
    • Sleep in Alzheimer's disease and other dementing disorders
    • M.V. Vitiello, J.S. Poceta, P.N. Prinz Sleep in Alzheimer's disease and other dementing disorders Can J Psychol 45 1991 221 239
    • (1991) Can J Psychol , vol.45 , pp. 221-239
    • Vitiello, M.V.1    Poceta, J.S.2    Prinz, P.N.3
  • 70
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • G.L. Wenk Neuropathologic changes in Alzheimer's disease J Clin Psychiatry 64 Suppl 9 2003 7 10
    • (2003) J Clin Psychiatry , vol.64 , Issue.SUPPL. 9 , pp. 7-10
    • Wenk, G.L.1
  • 73
    • 0038808966 scopus 로고    scopus 로고
    • Disorders of the circadian clock: Etiology and possible therapeutic targets
    • J.P. Wisor Disorders of the circadian clock etiology and possible therapeutic targets Curr Drug Targets CNS Neurolog Disord 1 2002 555 566
    • (2002) Curr Drug Targets CNS Neurolog Disord , vol.1 , pp. 555-566
    • Wisor, J.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.