Design, synthesis and biological evaluation of new peptide-based ureas and thioureas as potential antagonists of the thrombin receptor PAR1

European Journal of Medicinal Chemistry

Volumn 58, Issue , 2012, Pages 98-111

  Ventosa Andrés, Pilar ^a   Valdivielso, Ángel M ^a   Pappos, Ioannis ^b   Teresa Garcia Lopez M ^a   Tsopanoglou, Nikos E ^b   Herranz, Rosario ^a  

^a INSTITUTO DE QUÍMICA MÉDICA   (Spain)

^b UNIVERSITY OF PATRAS   (Greece)

Author keywords

Amino nitriles; PAR1 antagonists; Peptide derived thioureas; Peptide derived ureas; Platelet antiaggregant activity

Indexed keywords

AMINO ACID; HYDRAZINE DERIVATIVE; ISOCYANIC ACID DERIVATIVE; N A [1 [3 (2,4 DICHLOROPHENYL)UREIDO]3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [1 (3 BENZYLUREIDO) 3 PHENYLPROPAN 2 YL]ORNITHINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [1 [3 (2,4 DICHLOROPHENYL)UREIDO] 3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [1 [3 (4 METHOXYPHENETHYL)UREIDO] 3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [1 [[3 (4 FLUOROPHENETHYL)UREIDO] 3 PHENYL] PROPAN 2 YL]LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [1 [[3 (4 FLUOROPHENETHYL)UREIDO] 3 PHENYL]PROPAN 2 YL] LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [3 PHENYL 1 (3 PHENYLUREIDO)PROPAN 2 YL]LYSINE; N ALPHA [3 PHENYL 1 (3 PHENYLUREIDO)PROPAN 2 YL]LYSINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [3 PHENYL 1 (3 PHENYLUREIDO)PROPAN 2 YL]ORNITHINE BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [4 PHENYL 1 (3 PHENYLUREIDO)BUTAN 2 YL]BENZYL AMIDE DIHYDROCHLORIDE; N ALPHA [4 PHENYL 1 (3 PHENYLUREIDO)BUTAN 2 YL]ORNITHINE BENZYL AMIDE DIHYDROCHLORIDE; N DELTA BOC N ALPHA [1 (3 BENZYLUREIDO) 3 PHENYLPROPAN 2 YL]ORNITHINE BENZYL AMIDE; N DELTA BOC N ALPHA [3 PHENYL 1 (3 PHENYLTHIOUREIDO)PROPAN 2 YL]ORNITHINE BENZYL AMIDE; N DELTA BOC N ALPHA [3 PHENYL 1 (3 PHENYLUREIDO)PROPAN 2 YL]ORNITHINE BENZYL AMIDE; N DELTA BOC N ALPHA [3 PHENYL 1 (FMOC)AMINOPROPAN 2 YL]ORNITHINE BENZYL AMIDE; N EPSILON BOC N ALPHA [1 [3 (2,4 DICHLOROPHENYL)UREIDO] 3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE; N EPSILON BOC N ALPHA [1 [3 (4 METHOXYPHENETHYL)UREIDO] 3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE; N EPSILON BOC N ALPHA [1 [3 [1 (2,6 DICHLOROBENZYL) 3 (PYRROLIDIN 1 YLMETHYL) 1H INDAZOL 6 YL]UREIDO] 3 PHENYLPROPAN 2 YL]LYSINE BENZYL AMIDE; N EPSILON BOC N ALPHA [3 PHENYL 1 (FMOC)AMINOPROPAN 2 YL]LYSINE BENZYL AMIDE; NITRILE; RWJ 58259; THIOUREA DERIVATIVE; THROMBIN RECEPTOR; UNCLASSIFIED DRUG; UREA; VORAPAXAR;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; PROTON TRANSPORT; THROMBOCYTE AGGREGATION;

DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MOLECULAR STRUCTURE; PEPTIDES; PLATELET AGGREGATION; RECEPTOR, PAR-1; REFERENCE VALUES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 84868244622     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.10.015     Document Type: Article

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