Correlation of protease-activated receptor-1 with differentiation markers in squamous cell carcinoma of the head and neck and its implication in lymph node metastasis

Clinical Cancer Research

Volumn 10, Issue 24, 2004, Pages 8451-8459

  Zhang, Xin ^a   Hunt, Jennifer L ^c   Landsittel, Doug P ^b   Muller, Susan ^a   Adler Storthz, Karen ^d   Ferris, Robert L ^c   Shin, Dong M ^a   Chen, Zhuo ^a  

^a EMORY UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS DENTAL BRANCH AT HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKERATIN 1; CYTOKERATIN 10; CYTOKERATIN 11; G PROTEIN COUPLED RECEPTOR; INVOLUCRIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEINASE ACTIVATED RECEPTOR 1; TUMOR MARKER; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; ASTROCYTE; CANCER CELL CULTURE; CANCER GROWTH; CERVICAL LYMPH NODE; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; LYMPH NODE METASTASIS; MALE; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SQUAMOUS CELL CARCINOMA; THROMBOCYTE; TUMOR DIFFERENTIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CELL DIFFERENTIATION; DISEASE PROGRESSION; DNA, COMPLEMENTARY; ENZYME INHIBITORS; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; KERATINOCYTES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN PRECURSORS; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; TRANSFECTION; TUMOR MARKERS, BIOLOGICAL;

EID: 11144243984     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-0546     Document Type: Article

References (45)

1. American Cancer Society. Cancer facts and figures 2003. American Cancer Society, 2003.
2. Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nature Rev Cancer 2002;2:563-72.
3. Fidler IJ, The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited. Nature Rev Cancer 2003;3:1-6.
4. Fidler IJ, Radinsky R. Genetic control of cancer metastasis. J Natl Cancer Inst 1990;82:166-8.
5. Ponta H, Hofmann M, Herrlich P. Recent advances in the genetics of metastasis. Eur J Biochem 1994;232:48-9.
6. Nierodzik ML, Kajumo F, Karpatkin S. Effect of thrombin treatment of tumor cells on adhesion of tumor cells to platelets in vitro and metastasis in vivo. Cancer Res 1992;52:3267-72.
7. Grand RJA, Turnel AS, Grabham PW. Cellular consequence of thrombin-receptor activation. Biochem J 1996;313:353-68.
8. Walz DA, Fenton JW. The role of thrombin in tumor cell metastasis. Invasion and Metastasis 1995;14:303-8.
9. Wojtukiewicz MZ, Tang DG, Nelson KK, Walz DA, Diglio CA, Honn KV. Thrombin enhances tumor cell adhesive and metastatic properties via increased a11bβ3 expression on the cell surface. Thrombin Res 1992;68:233-45.
10. Wojtukiewicz MZ, Tang DG, Ciarelli JJ, et al. Thrombin increases the metastatic potential of tumor cells. Int J Cancer 1993;54:793-800.
11. Vu TK, Hung DT, Wheaton VI, Cough SR. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991;64:1057-68.
12. Tellez C, Bar-Eli M. Role and regulation of the thrombin receptor (PAR-1) in human melanoma. Oncogene 2003;22:3130-7.
13. Wojtukiewicz MZ, Tang DG, Ben-Josef E, Renaud C, Walz DA, Honn KV. Solid tumor cells express functional "tethered ligand" thrombin receptor. Cancer Res 1995;55:698-704.
14. Rudroff C, Schafberg H, Nowak G, Weinel R, Scheel J, Kaufmann R. Characterization of functional thrombin receptors in human pancreatic tumor cells (MIA PACA-2). Pancreas 1998;16:189-94.
15. Kaufmann R, Schafberg H, Rudroff C, Nowak G. Thrombin receptor activation results in calcium signaling and protein kinase C-dependent stimulation of DNA synthesis in Hep-2g laryngeal carcinoma cells. Cancer 1997;80:2068-74.
16. Liu Y, Gilcrease MZ, Henderson Y, Yuan XH, Clayman GL, Chen Z. Expression of protease-activator receptor 1 in oral squamous cell carcinoma. Cancer Lett 2001;169:173-80.
17. Even-Ram S, Uziely B, Cohen P, et al. Thrombin receptor overexpression in malignant and physiological invasion processes. Nat Med 1998;4:909-14.
18. Henrikson KP, Salazar SL, Fenton JW, Pentecost BT. Role of thrombin receptor in breast cancer invasiveness. Br J Cancer 1999;79:401-6.
19. Darmoul D, Gratio V, Devaud H, Lehy T, Laburthe M. Aberrant expression and activation of the thrombin receptor protease-activated receptor-1 induces cell proliferation and motility in human colon cancer cells. Am J Pathol 2003;162:1503-13.
20. Nierodzik ML, Chen K, Takeshita K, et al. Protease-activated receptor 1 (PAR-1) is required and rate-limiting for thrombin-enhanced experimental pulmonary metastasis. Blood 1998;92:3694-700.
21. Zain J, Huang Y, Feng X, Nierodzik ML, Li J, Karpatkin S. Concentration-dependent dual effect of thrombin on impaired growth/apoptosis or mitogenesis in tumor cells. Blood 2000;95:3133-8.
22. Huang Y, Li J, Karpatkin S. Thrombin inhibits tumor cell growth in association with up-regulation of p21 waf/cip1 and caspases via a p53-independent, STAT-1-dependent pathway. J Biol Chem 2000;275:6462-8.
23. Kamath L, Meydani A. Foss F, Kuliopulos A. Signaling from protease-activated receptor-1 inhibits migration and invasion of breast cancer cells. Cancer Res 2001;61:5933-40.
24. Zhang X. Liu Y, Gilcrease MZ, et al. A lymph node metastatic mouse model reveals alterations of metastasis-related gene expression in metastatic human oral carcinoma sublines selected from a poorly metastatic parental cell line. Cancer 2002;95:1663-72.
25. Chen Z, Zhang K, Zhang X, et al. Comparison of gene expression between metastatic derivation and their poorly metastatic parental cells implicates tumor-environment interaction in metastasis of head and neck squamous cell carcinoma. Clin Exp Metastasis 2003;20:335-42.
26. Sack PG. Cell, tissue and organ culture as in vitro models to study the biology of squamous cell carcinomas of the head and neck. Cancer Metastasis Rev 1996;15:27-51.
27. Wang H, Reiser G. The role of the Ca2+-sensitive tyrosine kinase PyK2 and Src in thrombin signaling in rat astrocytes. J Neurochem 2003;84:1349-57.
28. Trejo J, Connolly AJ, Coughlin SR. The cloned thrombin receptor is necessary and sufficient for activation of mitogen-activated protein kinase and mitogenesis in mouse lung fibroblasts. Loss of responses in fibroblasts from receptor knockout mice. J Biol Chem 1996;271:21536-41.
29. Rao GN, Runge MS. Cyclic AMP inhibition of thrombin-induced growth in vascular smooth muscle cells correlated with decreased JNK1 activity and c-Jun expression. J Biol Chem 1996;271:20805-10.
30. Daub H, Wallasch C, Lankenau A, Herrlich A, Ullrich A. Signal characteristics of G protein -transactivated EGF receptor. EMBO J 1997;16:7032-44.
31. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C, Ullrich A. EGF-receptor transactivation by G-protein -coupled receptors requires metalloproteinase cleavage of proHB-EGF. Natur (Lond) 1999;402:884-8.
32. Gutkind JS. The pathways connecting G protein-coupled receptors to the nucleus through divergent mitogen-activated protein kinase cascades. J Biol Chem 1998;273:1839-42.
33. Luttrell LM, Daaka Y, Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-pritein-coupled receptors. Curr Opin Cell Biol 1999;11:177-83.
34. Coughlin SR. Thrombin signaling and protease-activated receptors. Nature (Lond) 2000;407:258-64.
35. Wang H, Ubl JJ, Stricker R, Reiser G. Thrombin (PAR-1)-induced proliferation in astrocytes via MAPK involves multiple signaling pathways. Am J Physiol Cell Physiol 2002;283:C1351-64.
36. Ellis CA, Malik AB, Gilchrist A, et al. Thrombin induces proteinase-activated receptor-1 gene expression in endothelial cells via activation of Gi-linked Ras/mitogen-activated protein kinase pathway. J Biol Chem 1999;274:13718-27.
37. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z. Calcium- and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 2001;177:161-71.
38. Tibudan SS, Wang Y, Denning MF. Activation of protein kinase C trigger irreversible cell cycle withdrawal in human keratinocytes. J Investig Dermatol 2002;119:1282-9.
39. Rice RH, Green H. Presence in human epidermal cells of a soluble protein precursor of the cross-linked envelope: activation of the cross-linking by calcium ions. Cell 1979;18:681-94.
40. Hohl D, Lichti U, Breitkreutz D, Steinert PM, Roop DR. Transcription of the human loricrin gene in vitro is induced by calcium and cell density and suppressed by retinoic acid. J Invest Dermatol 1991;96:414-8.
41. Thacher SM, Rice RH. Keratinocyte-specific transglutaminase of cultured human epidermal cells: relation to cross-linked envelope formation and terminal differentiation. Cell 1985;40:685-95.
42. Hohl D. Cornified cell envelope. Dermatologica 1990;180:201-11.
43. Schmidt M, Frings M, Mono ML, et al. G protein-coupled receptor-induced sensitization of phospholipase C stimulationby receptor tyrosine kinases. J Biol Chem 2000;175:32603-10.
44. Remmert S, Rottmann M, Reichenbach M, Sommer K, Fr. Edrich HJ. Lymph node metastasis in head-neck tumors. Laryngorhinootologie 2001;80:27-35.
45. Schantz, SP, Biologic markers, cellular differentiation, and metastatic head and neck cancer. Eur Arch Otorhinolaryngol 1993;250:424-8.