Evidence for the preservation of native interand intra-molecular hydrogen bonds in the desolvated FK-binding protein·FK506 complex produced by electrospray ionization

Journal of the American Society for Mass Spectrometry

Volumn 23, Issue 10, 2012, Pages 1757-1767

  Hopper, Jonathan T S ^a,b   Rawlings, Andrew ^a   Afonso, José P ^a   Channing, Deborah ^a   Layfield, Robert ^a   Oldham, Neil J ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Gas phase protein structure; Hydrogen bonding; Noncovalent interactions; Protein ligand complex

Indexed keywords

AFFINITY MEASUREMENT; COLLISIONAL ACTIVATION; FK506-BINDING PROTEINS; GASPHASE; H-BONDS; INTERMOLECULAR INTERACTIONS; ION MOBILITY SPECTROMETRY; LOWER ENERGIES; NON-COVALENT INTERACTION; NONCOVALENT PROTEINS; ORDERED WATER; PROTEIN STRUCTURES; PROTEIN-LIGAND COMPLEXES; PROTEIN-LIGAND INTERACTIONS; SITE DIRECTED MUTAGENESIS; SOLUTION PHASE; STRUCTURAL INFORMATION; STRUCTURAL WEAKENING; WILD TYPES;

BINDING ENERGY; COMPLEXATION; DISSOCIATION; ELECTROSPRAY IONIZATION; LIGANDS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; PROTEINS;

HYDROGEN BONDS;

FK 506 BINDING PROTEIN; TACROLIMUS; WATER;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION; ELECTROSPRAY; ELECTROSPRAY MASS SPECTROMETRY; GAS; HYDROGEN BOND; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR STABILITY; PROTEIN CONFORMATION; PROTEIN TARGETING; PROTEIN UNFOLDING; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; WILD TYPE;

BINDING SITES; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MUTATION; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TACROLIMUS; TACROLIMUS BINDING PROTEINS;

EID: 84868237181     PISSN: 10440305     EISSN: 18791123     Source Type: Journal    
DOI: 10.1007/s13361-012-0430-y     Document Type: Article

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