-
1
-
-
0036729484
-
Seven-transmembrane receptors
-
Pierce, K. L.; Premont, R. T.; Lefkowitz, R. J. Seven-transmembrane receptors Nat. Rev. Mol. Cell Biol. 2002, 3, 639-650
-
(2002)
Nat. Rev. Mol. Cell Biol.
, vol.3
, pp. 639-650
-
-
Pierce, K.L.1
Premont, R.T.2
Lefkowitz, R.J.3
-
2
-
-
66249144426
-
The structure and function of G- protein-coupled receptors
-
Rosenbaum, D. M.; Rasmussen, S. G. F.; Kobilka, B. K. The structure and function of G- protein-coupled receptors Nature 2009, 459, 356-363
-
(2009)
Nature
, vol.459
, pp. 356-363
-
-
Rosenbaum, D.M.1
Rasmussen, S.G.F.2
Kobilka, B.K.3
-
3
-
-
33646526072
-
I want a new drug: G-protein-coupled receptors in drug development
-
Schlyer, S.; Horuk, R. I want a new drug: G-protein-coupled receptors in drug development Drug Discovery Today 2006, 11, 481-493
-
(2006)
Drug Discovery Today
, vol.11
, pp. 481-493
-
-
Schlyer, S.1
Horuk, R.2
-
4
-
-
0034529050
-
How cells handle cholesterol
-
Simons, K.; Ikonen, E. How cells handle cholesterol Science 2000, 290, 1721-1726
-
(2000)
Science
, vol.290
, pp. 1721-1726
-
-
Simons, K.1
Ikonen, E.2
-
5
-
-
0033793871
-
Regulation of receptor function by cholesterol
-
Burger, K.; Gimpl, G.; Fahrenholz, F. Regulation of receptor function by cholesterol Cell. Mol. Life Sci. 2000, 57, 1577-1592
-
(2000)
Cell. Mol. Life Sci.
, vol.57
, pp. 1577-1592
-
-
Burger, K.1
Gimpl, G.2
Fahrenholz, F.3
-
6
-
-
33744543610
-
Role of cholesterol in the function and organization of G-protein coupled receptors
-
Pucadyil, T. J.; Chattopadhyay, A. Role of cholesterol in the function and organization of G-protein coupled receptors Prog. Lipid Res. 2006, 45, 295-333
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 295-333
-
-
Pucadyil, T.J.1
Chattopadhyay, A.2
-
7
-
-
77952306521
-
Membrane cholesterol in the function and organization of G-protein coupled receptors
-
Paila, Y. D.; Chattopadhyay, A. Membrane cholesterol in the function and organization of G-protein coupled receptors Subcell. Biochem. 2010, 51, 439-466
-
(2010)
Subcell. Biochem.
, vol.51
, pp. 439-466
-
-
Paila, Y.D.1
Chattopadhyay, A.2
-
8
-
-
82955248059
-
Uncovering the intimate relationship between lipids, cholesterol and GPCR activation
-
Oates, J.; Watts, A. Uncovering the intimate relationship between lipids, cholesterol and GPCR activation Curr. Opin. Struct. Biol. 2011, 21, 802-807
-
(2011)
Curr. Opin. Struct. Biol.
, vol.21
, pp. 802-807
-
-
Oates, J.1
Watts, A.2
-
9
-
-
67651174545
-
The function of G-protein coupled receptors and membrane cholesterol: Specific or general interaction?
-
Paila, Y. D.; Chattopadhyay, A. The function of G-protein coupled receptors and membrane cholesterol: specific or general interaction? Glycoconjugate J. 2009, 26, 711-720
-
(2009)
Glycoconjugate J.
, vol.26
, pp. 711-720
-
-
Paila, Y.D.1
Chattopadhyay, A.2
-
10
-
-
78651405537
-
1-adrenergic receptor
-
1-adrenergic receptor Nature 2011, 469, 241-244
-
(2011)
Nature
, vol.469
, pp. 241-244
-
-
Warne, T.1
Moukhametzianov, R.2
Baker, J.G.3
Nehmé, R.4
Edwards, P.C.5
Leslie, A.G.6
Schertler, G.F.7
Tate, C.G.8
-
11
-
-
36448995359
-
2-adrenergic G protein-coupled receptor
-
2-adrenergic G protein-coupled receptor Science 2007, 318, 1258-1265
-
(2007)
Science
, vol.318
, pp. 1258-1265
-
-
Cherezov, V.1
Rosenbaum, D.M.2
Hanson, M.A.3
Rasmussen, S.G.F.4
Thian, F.S.5
Kobilka, T.S.6
Choi, H.-J.7
Kuhn, P.8
Weis, W.I.9
Kobilka, B.K.10
Stevens, R.C.11
-
12
-
-
44649172481
-
2-adrenergic receptor
-
2-adrenergic receptor Structure 2008, 16, 897-905
-
(2008)
Structure
, vol.16
, pp. 897-905
-
-
Hanson, M.A.1
Cherezov, V.2
Griffith, M.T.3
Roth, C.B.4
Jaakola, V.-P.5
Chien, E.Y.T.6
Velasquez, J.7
Kuhn, P.8
Stevens, R.C.9
-
13
-
-
84861961427
-
Structural basis for allosteric regulation of GPCRs by sodium ions
-
Liu, W.; Chun, E.; Thompson, A. A.; Chubukov, P.; Xu, F.; Katritch, V.; Han, G. W.; Roth, C. B.; Heitman, L. H.; IJzerman, A. P.; Cherezov, V.; Stevens, R. C. Structural basis for allosteric regulation of GPCRs by sodium ions Science 2012, 337, 232-236
-
(2012)
Science
, vol.337
, pp. 232-236
-
-
Liu, W.1
Chun, E.2
Thompson, A.A.3
Chubukov, P.4
Xu, F.5
Katritch, V.6
Han, G.W.7
Roth, C.B.8
Heitman, L.H.9
Ijzerman, A.P.10
Cherezov, V.11
Stevens, R.C.12
-
14
-
-
78650919372
-
Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors
-
Jafurulla, M.; Tiwari, S.; Chattopadhyay, A. Identification of cholesterol recognition amino acid consensus (CRAC) motif in G-protein coupled receptors Biochem. Biophys. Res. Commun. 2011, 404, 569-573
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.404
, pp. 569-573
-
-
Jafurulla, M.1
Tiwari, S.2
Chattopadhyay, A.3
-
15
-
-
33744512299
-
Cholesterol and the interaction of proteins with membrane domains
-
Epand, R. M. Cholesterol and the interaction of proteins with membrane domains Prog. Lipid Res. 2006, 45, 279-294
-
(2006)
Prog. Lipid Res.
, vol.45
, pp. 279-294
-
-
Epand, R.M.1
-
19
-
-
0037304917
-
1A agonists in the treatment of depression?
-
1A agonists in the treatment of depression? Biol. Psychiatry 2003, 53, 193-203
-
(2003)
Biol. Psychiatry
, vol.53
, pp. 193-203
-
-
Blier, P.1
Ward, N.M.2
-
20
-
-
0032692279
-
1A receptor blockers as potential drug candidates for the treatment of anxiety disorders
-
1A receptor blockers as potential drug candidates for the treatment of anxiety disorders Drug News Perspect. 1999, 12, 484-490
-
(1999)
Drug News Perspect.
, vol.12
, pp. 484-490
-
-
Griebel, G.1
-
25
-
-
34547474332
-
The MARTINI force field: Coarse grained model for biomolecular simulations
-
Marrink, S. J.; Risselada, H. J.; Yefimov, S.; Tieleman, D. P.; de Vries, A. H. The MARTINI force field: coarse grained model for biomolecular simulations J. Phys. Chem. B 2007, 111, 7812-7824
-
(2007)
J. Phys. Chem. B
, vol.111
, pp. 7812-7824
-
-
Marrink, S.J.1
Risselada, H.J.2
Yefimov, S.3
Tieleman, D.P.4
De Vries, A.H.5
-
26
-
-
49449113010
-
The MARTINI coarse-grained force field: Extension to proteins
-
Monticelli, L.; Kandasamy, S. K.; Periole, X.; Larson, R. G.; Tieleman, D. P.; Marrink, S. J. The MARTINI coarse-grained force field: Extension to proteins J. Chem. Theory Comput. 2008, 4, 819-834
-
(2008)
J. Chem. Theory Comput.
, vol.4
, pp. 819-834
-
-
Monticelli, L.1
Kandasamy, S.K.2
Periole, X.3
Larson, R.G.4
Tieleman, D.P.5
Marrink, S.J.6
-
28
-
-
46249092554
-
GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation
-
Hess, B.; Kutzner, C.; van der Spoel, D.; Lindahl, E. GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation J. Chem. Theory Comput. 2008, 4, 435-447
-
(2008)
J. Chem. Theory Comput.
, vol.4
, pp. 435-447
-
-
Hess, B.1
Kutzner, C.2
Van Der Spoel, D.3
Lindahl, E.4
-
29
-
-
33750587438
-
Molecular dynamics with coupling to an external bath
-
Berendsen, H. J. C.; Postma, J. P. M.; van gunsteren, W. F.; Dinola, A.; Haak, J. R. Molecular dynamics with coupling to an external bath J. Chem. Phys. 1984, 81, 3684-3690
-
(1984)
J. Chem. Phys.
, vol.81
, pp. 3684-3690
-
-
Berendsen, H.J.C.1
Postma, J.P.M.2
Van Gunsteren, W.F.3
Dinola, A.4
Haak, J.R.5
-
30
-
-
84858300656
-
Dimerization of amino acid side chains: Lessons from the comparison of different force fields
-
de Jong, D. H.; Periole, X.; Marrink, S. J. Dimerization of amino acid side chains: lessons from the comparison of different force fields J. Chem. Theory Comput. 2012, 8, 1003-1014
-
(2012)
J. Chem. Theory Comput.
, vol.8
, pp. 1003-1014
-
-
De Jong, D.H.1
Periole, X.2
Marrink, S.J.3
-
31
-
-
77958039571
-
Energy landscapes as a tool to integrate GPCR structure, dynamics, and function
-
Deupi, X.; Kobilka, B. K. Energy landscapes as a tool to integrate GPCR structure, dynamics, and function Physiology 2010, 25, 293-303
-
(2010)
Physiology
, vol.25
, pp. 293-303
-
-
Deupi, X.1
Kobilka, B.K.2
-
32
-
-
84856511452
-
Domain coupling in GPCRs: The engine for induced conformational changes
-
Unal, H.; Karnik, S. S. Domain coupling in GPCRs: the engine for induced conformational changes Trends Pharmacol. Sci. 2012, 33, 79-88
-
(2012)
Trends Pharmacol. Sci.
, vol.33
, pp. 79-88
-
-
Unal, H.1
Karnik, S.S.2
-
33
-
-
84863416846
-
Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid
-
Inagaki, S.; Ghirlando, R.; White, J. F.; Gvozdenovic-Jeremic, J.; Northup, J. K.; Grisshammer, R. Modulation of the interaction between neurotensin receptor NTS1 and Gq protein by lipid J. Mol. Biol. 2012, 417, 95-111
-
(2012)
J. Mol. Biol.
, vol.417
, pp. 95-111
-
-
Inagaki, S.1
Ghirlando, R.2
White, J.F.3
Gvozdenovic-Jeremic, J.4
Northup, J.K.5
Grisshammer, R.6
-
34
-
-
33947424778
-
G protein-coupled receptor systems and their lipid environment in health disorders during aging
-
Alemany, R.; Perona, J. S.; Sánchez-Dominguez, J. M.; Montero, E.; Canizares, J.; Bressani, R.; Escribá, P. V.; Ruiz-Guitierrez, V. G protein-coupled receptor systems and their lipid environment in health disorders during aging Biochim. Biophys. Acta 2007, 1768, 964-975
-
(2007)
Biochim. Biophys. Acta
, vol.1768
, pp. 964-975
-
-
Alemany, R.1
Perona, J.S.2
Sánchez-Dominguez, J.M.3
Montero, E.4
Canizares, J.5
Bressani, R.6
Escribá, P.V.7
Ruiz-Guitierrez, V.8
-
35
-
-
77953269718
-
Brain Cholesterol in normal and pathological aging
-
Martin, M.; Dotti, C. G.; Ledesma, M. D. Brain Cholesterol in normal and pathological aging Biochim. Biophys. Acta 2010, 1801, 934-944
-
(2010)
Biochim. Biophys. Acta
, vol.1801
, pp. 934-944
-
-
Martin, M.1
Dotti, C.G.2
Ledesma, M.D.3
-
36
-
-
79955811328
-
Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations
-
Grossfield, A. Recent progress in the study of G protein-coupled receptors with molecular dynamics computer simulations Biochim. Biophys. Acta 2011, 1808, 1868-1878
-
(2011)
Biochim. Biophys. Acta
, vol.1808
, pp. 1868-1878
-
-
Grossfield, A.1
-
37
-
-
67650266997
-
Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations
-
Khelashvili, G.; Grossfield, A.; Feller, S. E.; Pitman, M. C.; Weinstein, H. Structural and dynamic effects of cholesterol at preferred sites of interaction with rhodopsin identified from microsecond length molecular dynamics simulations Proteins 2009, 76, 403-417
-
(2009)
Proteins
, vol.76
, pp. 403-417
-
-
Khelashvili, G.1
Grossfield, A.2
Feller, S.E.3
Pitman, M.C.4
Weinstein, H.5
-
38
-
-
71049163000
-
2A adenosine receptor
-
2A adenosine receptor Structure 2009, 17, 1660-1668
-
(2009)
Structure
, vol.17
, pp. 1660-1668
-
-
Lyman, E.1
Higgs, C.2
Kim, B.3
Lupyan, D.4
Shelley, J.C.5
Farid, R.6
Voth, G.A.7
-
39
-
-
80052345585
-
Biological membranes: The importance of molecular detail
-
Lee, A. G. Biological membranes: the importance of molecular detail Trends Biochem. Sci. 2011, 36, 493-500
-
(2011)
Trends Biochem. Sci.
, vol.36
, pp. 493-500
-
-
Lee, A.G.1
-
40
-
-
34548146523
-
G protein-coupled receptors self assemble in dynamics simulations of model bilayers
-
Periole, X.; Huber, T.; Marrink, S.-J.; Sakmar, T. P. G protein-coupled receptors self assemble in dynamics simulations of model bilayers J. Am. Chem. Soc. 2007, 129, 10126-10132
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 10126-10132
-
-
Periole, X.1
Huber, T.2
Marrink, S.-J.3
Sakmar, T.P.4
-
41
-
-
77957901688
-
Lipid-mediated interactions tune the association of glycophorin A helix and its disruptive mutants in membranes
-
Sengupta, D.; Marrink, S. J. Lipid-mediated interactions tune the association of glycophorin A helix and its disruptive mutants in membranes Phys. Chem. Chem. Phys. 2010, 12, 12987-12996
-
(2010)
Phys. Chem. Chem. Phys.
, vol.12
, pp. 12987-12996
-
-
Sengupta, D.1
Marrink, S.J.2
-
42
-
-
79952153989
-
Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes
-
Schäfer, L. V.; de Jong, D. H.; Holt, A.; Rzepiela, A. J.; de Vries, A. H.; Poolman, B.; Killian, J. A.; Marrink, S. J. Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 1343-1348
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 1343-1348
-
-
Schäfer, L.V.1
De Jong, D.H.2
Holt, A.3
Rzepiela, A.J.4
De Vries, A.H.5
Poolman, B.6
Killian, J.A.7
Marrink, S.J.8
-
43
-
-
10844293498
-
1A receptor tagged to yellow fluorescent protein
-
1A receptor tagged to yellow fluorescent protein Biochemistry 2004, 43, 15852-15862
-
(2004)
Biochemistry
, vol.43
, pp. 15852-15862
-
-
Pucadyil, T.J.1
Kalipatnapu, S.2
Harikumar, K.G.3
Rangaraj, N.4
Karnik, S.S.5
Chattopadhyay, A.6
-
45
-
-
59249094898
-
Are specific nonannular cholesterol binding sites present in G-protein coupled receptors?
-
Paila, Y. D.; Tiwari, S.; Chattopadhyay, A. Are specific nonannular cholesterol binding sites present in G-protein coupled receptors? Biochim. Biophys. Acta 2009, 1788, 295-302
-
(2009)
Biochim. Biophys. Acta
, vol.1788
, pp. 295-302
-
-
Paila, Y.D.1
Tiwari, S.2
Chattopadhyay, A.3
-
46
-
-
0038364008
-
Lipid-protein interactions in biological membranes: A structural perspective
-
Lee, A. G. Lipid-protein interactions in biological membranes: a structural perspective Biochim. Biophys. Acta 2003, 1612, 1-40
-
(2003)
Biochim. Biophys. Acta
, vol.1612
, pp. 1-40
-
-
Lee, A.G.1
-
47
-
-
84863535732
-
-
Periole, X.; Knepp, A.; Sakmar, T. P.; Marrink, S. J.; Huber, T. J. Am. Chem. Soc. 2012, 134, 10959-10965
-
(2012)
J. Am. Chem. Soc.
, vol.134
, pp. 10959-10965
-
-
Periole, X.1
Knepp, A.2
Sakmar, T.P.3
Marrink, S.J.4
Huber, T.5
|