-
1
-
-
51949085076
-
Hedgehog: Functions and mechanisms
-
10.1101/gad.1693608 18794343
-
Hedgehog: functions and mechanisms. Varjosalo M, Taipale J, Genes Dev 2008 22 18 2454 2472 10.1101/gad.1693608 18794343
-
(2008)
Genes Dev
, vol.22
, Issue.18
, pp. 2454-2472
-
-
Varjosalo, M.1
Taipale, J.2
-
2
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
10.1101/gad.938601 11731473
-
Hedgehog signaling in animal development: paradigms and principles. Ingham PW, McMahon AP, Genes Dev 2001 15 23 3059 10.1101/gad.938601 11731473
-
(2001)
Genes Dev
, vol.15
, Issue.23
, pp. 3059
-
-
Ingham, P.W.1
McMahon, A.P.2
-
3
-
-
0035257660
-
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation
-
10.1038/84282 11175816
-
Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Bhardwaj G, Murdoch B, Wu D, Baker D, Williams K, Chadwick K, Ling L, Karanu F, Bhatia M, Nat Immunol 2001 2 2 172 180 10.1038/84282 11175816
-
(2001)
Nat Immunol
, vol.2
, Issue.2
, pp. 172-180
-
-
Bhardwaj, G.1
Murdoch, B.2
Wu, D.3
Baker, D.4
Williams, K.5
Chadwick, K.6
Ling, L.7
Karanu, F.8
Bhatia, M.9
-
4
-
-
13644261744
-
Activation of the hedgehog pathway in advanced prostate cancer
-
10.1186/1476-4598-3-29 15482598
-
Activation of the hedgehog pathway in advanced prostate cancer. Sheng T, Li C, Zhang X, Chi S, He N, Chen K, McCormick F, Gatalica Z, Xie J, Mol Cancer 2004 3 1 29 10.1186/1476-4598-3-29 15482598
-
(2004)
Mol Cancer
, vol.3
, Issue.1
, pp. 29
-
-
Sheng, T.1
Li, C.2
Zhang, X.3
Chi, S.4
He, N.5
Chen, K.6
McCormick, F.7
Gatalica, Z.8
Xie, J.9
-
5
-
-
0242669237
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer
-
10.1038/nature01493 12629553
-
Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Watkins DN, Berman DM, Burkholder SG, Wang B, Beachy PA, Baylin SB, Nature 2003 422 6929 313 317 10.1038/nature01493 12629553
-
(2003)
Nature
, vol.422
, Issue.6929
, pp. 313-317
-
-
Watkins, D.N.1
Berman, D.M.2
Burkholder, S.G.3
Wang, B.4
Beachy, P.A.5
Baylin, S.B.6
-
6
-
-
0242270878
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis
-
10.1038/nature02009 14520413
-
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Thayer SP, Di Magliano MP, Heiser PW, Nielsen CM, Roberts DJ, Lauwers GY, Qi YP, Gysin S, Fernández-del Castillo C, Yajnik V, Nature 2003 425 6960 851 856 10.1038/nature02009 14520413
-
(2003)
Nature
, vol.425
, Issue.6960
, pp. 851-856
-
-
Thayer, S.P.1
Di Magliano, M.P.2
Heiser, P.W.3
Nielsen, C.M.4
Roberts, D.J.5
Lauwers, G.Y.6
Qi, Y.P.7
Gysin, S.8
Fernández-Del Castillo, C.9
Yajnik, V.10
-
7
-
-
33745728170
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells
-
10.1158/0008-5472.CAN-06-0054 16778178
-
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cells. Liu S, Dontu G, Mantle ID, Patel S, Ahn N, Jackson KW, Suri P, Wicha MS, Cancer Res 2006 66 12 6063 10.1158/0008-5472.CAN- 06-0054 16778178
-
(2006)
Cancer Res
, vol.66
, Issue.12
, pp. 6063
-
-
Liu, S.1
Dontu, G.2
Mantle, I.D.3
Patel, S.4
Ahn, N.5
Jackson, K.W.6
Suri, P.7
Wicha, M.S.8
-
8
-
-
33748342931
-
The hedgehog pathway and neurological disorders
-
10.1146/annurev.neuro.29.051605.112858 16776596
-
The hedgehog pathway and neurological disorders. Dellovade T, Romer JT, Curran T, Rubin LL, Annu Rev Neurosci 2006 29 539 563 10.1146/annurev.neuro.29. 051605.112858 16776596
-
(2006)
Annu Rev Neurosci
, vol.29
, pp. 539-563
-
-
Dellovade, T.1
Romer, J.T.2
Curran, T.3
Rubin, L.L.4
-
9
-
-
0035054358
-
The hedgehog pathway and basal cell carcinomas
-
10.1093/hmg/10.7.757 11257109
-
The hedgehog pathway and basal cell carcinomas. Bale AE, Yu K, Hum Mol Genet 2001 10 7 757 762 10.1093/hmg/10.7.757 11257109
-
(2001)
Hum Mol Genet
, vol.10
, Issue.7
, pp. 757-762
-
-
Bale, A.E.1
Yu, K.2
-
10
-
-
33746171099
-
The primary cilium in cell signaling and cancer
-
10.1158/0008-5472.CAN-06-0462 16818613
-
The primary cilium in cell signaling and cancer. Michaud EJ, Yoder BK, Cancer Res 2006 66 13 6463 10.1158/0008-5472.CAN-06-0462 16818613
-
(2006)
Cancer Res
, vol.66
, Issue.13
, pp. 6463
-
-
Michaud, E.J.1
Yoder, B.K.2
-
11
-
-
0030955557
-
Basal cell carcinomas in mice overexpressing sonic hedgehog
-
10.1126/science.276.5313.817 9115210
-
Basal cell carcinomas in mice overexpressing sonic hedgehog. Oro AE, Higgins KM, Hu Z, Bonifas JM, Epstein EH Jr, Scott MP, Science 1997 276 5313 817 821 10.1126/science.276.5313.817 9115210
-
(1997)
Science
, vol.276
, Issue.5313
, pp. 817-821
-
-
Oro, A.E.1
Higgins, K.M.2
Hu, Z.3
Bonifas, J.M.4
Epstein Jr., E.H.5
Scott, M.P.6
-
12
-
-
0031913524
-
Activating Smoothened mutations in sporadic basal-cell carcinoma
-
10.1038/34201 9422511
-
Activating Smoothened mutations in sporadic basal-cell carcinoma. Xie J, Murone M, Luoh S-M, Ryan A, Gu Q, Zhang C, Bonifas JM, Lam C-W, Hynes M, Goddard A, et al. Nature 1998 391 6662 90 92 10.1038/34201 9422511
-
(1998)
Nature
, vol.391
, Issue.6662
, pp. 90-92
-
-
Xie, J.1
Murone, M.2
Luoh, S.-M.3
Ryan, A.4
Gu, Q.5
Zhang, C.6
Bonifas, J.M.7
Lam, C.-W.8
Hynes, M.9
Goddard, A.10
-
13
-
-
0034724219
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
-
10.1073/pnas.97.7.3438 10725363
-
Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Nilsson M, Undèn AB, Krause D, Malmqwist U, Raza K, Zaphiropoulos PG, Toftgård R, Proc Natl Acad Sci 2000 97 7 3438 3443 10.1073/pnas.97.7.3438 10725363
-
(2000)
Proc Natl Acad Sci
, vol.97
, Issue.7
, pp. 3438-3443
-
-
Nilsson, M.1
Undèn, A.B.2
Krause, D.3
Malmqwist, U.4
Raza, K.5
Zaphiropoulos, P.G.6
Toftgård, R.7
-
14
-
-
0034091805
-
Basal cell carcinomas in mice overexpressing Gli2 in skin
-
10.1038/73417 10700170
-
Basal cell carcinomas in mice overexpressing Gli2 in skin. Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui C, Dlugosz AA, Nat Genet 2000 24 3 216 217 10.1038/73417 10700170
-
(2000)
Nat Genet
, vol.24
, Issue.3
, pp. 216-217
-
-
Grachtchouk, M.1
Mo, R.2
Yu, S.3
Zhang, X.4
Sasaki, H.5
Hui, C.6
Dlugosz, A.A.7
-
15
-
-
33947517650
-
Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts
-
17273793
-
Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Lee SW, Moskowitz MA, Sims JR, Int J Mol Med 2007 19 3 445 17273793
-
(2007)
Int J Mol Med
, vol.19
, Issue.3
, pp. 445
-
-
Lee, S.W.1
Moskowitz, M.A.2
Sims, J.R.3
-
16
-
-
31544480393
-
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation
-
Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation. Li X, Deng W, Nail CD, Bailey SK, Kraus MH, Ruppert JM, Lobo-Ruppert SM, Oncogene 2005 25 4 609 621
-
(2005)
Oncogene
, vol.25
, Issue.4
, pp. 609-621
-
-
Li, X.1
Deng, W.2
Nail, C.D.3
Bailey, S.K.4
Kraus, M.H.5
Ruppert, J.M.6
Lobo-Ruppert, S.M.7
-
17
-
-
33644509505
-
Patched1 functions as a gatekeeper by promoting cell cycle progression
-
10.1158/0008-5472.CAN-05-2146 16489008
-
Patched1 functions as a gatekeeper by promoting cell cycle progression. Adolphe C, Hetherington R, Ellis T, Wainwright B, Cancer Res 2006 66 4 2081 2088 10.1158/0008-5472.CAN-05-2146 16489008
-
(2006)
Cancer Res
, vol.66
, Issue.4
, pp. 2081-2088
-
-
Adolphe, C.1
Hetherington, R.2
Ellis, T.3
Wainwright, B.4
-
18
-
-
5644264887
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of fas expression and apoptosis
-
10.1158/0008-5472.CAN-04-1393 15492281
-
Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of fas expression and apoptosis. Athar M, Li C, Tang X, Chi S, Zhang X, Kim AL, Tyring SK, Kopelovich L, Hebert J, Epstein EH, et al. Cancer Res 2004 64 20 7545 7552 10.1158/0008-5472.CAN-04-1393 15492281
-
(2004)
Cancer Res
, vol.64
, Issue.20
, pp. 7545-7552
-
-
Athar, M.1
Li, C.2
Tang, X.3
Chi, S.4
Zhang, X.5
Kim, A.L.6
Tyring, S.K.7
Kopelovich, L.8
Hebert, J.9
Epstein, E.H.10
-
19
-
-
0036829397
-
Inhibition of hedgehog signaling by direct binding of cyclopamine to Smoothened
-
10.1101/gad.1025302 12414725
-
Inhibition of hedgehog signaling by direct binding of cyclopamine to Smoothened. Chen JK, Taipale J, Cooper MK, Beachy PA, Genes Dev 2002 16 21 2743 2748 10.1101/gad.1025302 12414725
-
(2002)
Genes Dev
, vol.16
, Issue.21
, pp. 2743-2748
-
-
Chen, J.K.1
Taipale, J.2
Cooper, M.K.3
Beachy, P.A.4
-
20
-
-
46749103655
-
Strategies for Hedgehog inhibition and its potential role in cancer treatment
-
10.1016/j.ddstr.2008.03.002
-
Strategies for Hedgehog inhibition and its potential role in cancer treatment. Kolterud Å Toftgård R, Drug Discovery Today: Therapeutic Strategies 2007 4 4 229 235 10.1016/j.ddstr.2008.03.002
-
(2007)
Drug Discovery Today: Therapeutic Strategies
, vol.4
, Issue.4
, pp. 229-235
-
-
Kolterud, Å.1
Toftgård, R.2
-
21
-
-
0034738979
-
Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine
-
10.1038/35023008 10984056
-
Effects of oncogenic mutations in smoothened and patched can be reversed by cyclopamine. Taipale J, Chen JK, Cooper MK, Wang B, Mann RK, Milenkovic L, Scott MP, Beachy PA, Nature 2000 406 6799 1005 1009 10.1038/35023008 10984056
-
(2000)
Nature
, vol.406
, Issue.6799
, pp. 1005-1009
-
-
Taipale, J.1
Chen, J.K.2
Cooper, M.K.3
Wang, B.4
Mann, R.K.5
Milenkovic, L.6
Scott, M.P.7
Beachy, P.A.8
-
22
-
-
84871237644
-
A phase 1 study of IPI-926, a novel hedgehog pathway inhibitor, in patients with advanced or metastatic solid tumors
-
A phase 1 study of IPI-926, a novel hedgehog pathway inhibitor, in patients with advanced or metastatic solid tumors. Rudin C, Jimeno A, Miller W Jr, Eigl B, Gettinger S, Chang A, Faia K, Sweeney J, Loewen G, Ross R, Surgery 2011 32 94
-
(2011)
Surgery
, vol.32
, pp. 94
-
-
Rudin, C.1
Jimeno, A.2
Miller Jr., W.3
Eigl, B.4
Gettinger, S.5
Chang, A.6
Faia, K.7
Sweeney, J.8
Loewen, G.9
Ross, R.10
-
23
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits hedgehog pathway activity and cancer growth
-
10.1016/j.ccr.2010.02.027 20385363
-
Itraconazole, a commonly used antifungal that inhibits hedgehog pathway activity and cancer growth. Kim J, Tang JY, Gong R, Kim J, Lee JJ, Clemons KV, Chong CR, Chang KS, Fereshteh M, Gardner D, et al. Cancer Cell 2010 17 4 388 399 10.1016/j.ccr.2010.02.027 20385363
-
(2010)
Cancer Cell
, vol.17
, Issue.4
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
Kim, J.4
Lee, J.J.5
Clemons, K.V.6
Chong, C.R.7
Chang, K.S.8
Fereshteh, M.9
Gardner, D.10
-
24
-
-
77952541851
-
New developments in the discovery of small molecule Hedgehog pathway antagonists
-
10.1016/j.cbpa.2010.03.016 20399136
-
New developments in the discovery of small molecule Hedgehog pathway antagonists. Tremblay MR, McGovern K, Read MA, Castro AC, Curr Opin Chem Biol 2010 14 3 428 435 10.1016/j.cbpa.2010.03.016 20399136
-
(2010)
Curr Opin Chem Biol
, vol.14
, Issue.3
, pp. 428-435
-
-
Tremblay, M.R.1
McGovern, K.2
Read, M.A.3
Castro, A.C.4
-
25
-
-
84866365997
-
Molecular Pathways: The Hedgehog Signaling Pathway in Cancer
-
10.1158/1078-0432.CCR-11-2509 22718857
-
Molecular Pathways: The Hedgehog Signaling Pathway in Cancer. McMillan R, Matsui W, Clinical Cancer Research 2012 18 18 4883 4888 10.1158/1078-0432.CCR- 11-2509 22718857
-
(2012)
Clinical Cancer Research
, vol.18
, Issue.18
, pp. 4883-4888
-
-
McMillan, R.1
Matsui, W.2
-
27
-
-
84871211938
-
-
Genentech Genentech, Inc, South San Francisco, CA 23036338
-
Genentech, Erivedge [vismodegib; prescribing information] Genentech, Inc, South San Francisco, CA 2012 23036338
-
(2012)
Erivedge [Vismodegib; Prescribing Information]
-
-
|