Zerumbone causes Bax- and Bak-mediated apoptosis in human breast cancer cells and inhibits orthotopic xenograft growth in vivo

Breast Cancer Research and Treatment

Volumn 136, Issue 2, 2012, Pages 429-441

  Sehrawat, Anuradha ^a   Arlotti, Julie A ^b   Murakami, Akira ^c   Singh, Shivendra V ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^c KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bak; Bax; Bcl 2; Breast cancer; P53; PUMA; Zerumbone

Indexed keywords

CYCLIN B1; CYCLIN DEPENDENT KINASE 1; PROTEIN BAK; PROTEIN BAX; PROTEIN P53; PROTEIN TYROSINE PHOSPHATASE; ZERUMBONE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE S PHASE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG SAFETY; FEMALE; FIBROBLAST; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; FEMALE; HUMANS; MCF-7 CELLS; MICE; PROTO-ONCOGENE PROTEINS; SESQUITERPENES; TRANSCRIPTIONAL ACTIVATION; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEIN P53; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84868204647     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2280-5     Document Type: Article

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