Silica nanogelling of environment-responsive PEGylated polyplexes for enhanced stability and intracellular delivery of siRNA

Biomaterials

Volumn 34, Issue 2, 2013, Pages 562-570

  Gouda, Noha ^a,b   Miyata, Kanjiro ^c   Christie, R James ^c   Suma, Tomoya ^a   Kishimura, Akihiro ^a   Fukushima, Shigeto ^a   Nomoto, Takahiro ^a   Liu, Xueying ^c   Nishiyama, Nobuhiro ^c   Kataoka, Kazunori ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b Alexandria University Faculty of Pharmacy   (Egypt)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Disulfide cross link; PEG; Polyplex; Silica; SiRNA delivery

Indexed keywords

CELLULAR UPTAKE; CHARGE REDUCTION; DISULFIDE CROSS-LINK; ENHANCED STABILITY; GENE SILENCING; HELA CELL; HYDRATED SILICA; INHIBITION ASSAYS; INTRACELLULAR DELIVERY; INTRACELLULAR TRAFFICKING; LYSOSOMAL DEGRADATION; NANOGELS; POLYPLEX STABILITY; POLYPLEXES; PROTON SPONGE; SILANOL GROUPS; SIRNA DELIVERY; TRANSMISSION ELECTRON MICROGRAPH;

GENETIC ENGINEERING; NANOSTRUCTURED MATERIALS; POLYCONDENSATION; POLYETHYLENE GLYCOLS; RNA; SILICATES; SULFUR COMPOUNDS;

SILICA;

DISULFIDE; MACROGOL; POLYCATION; SILICON DIOXIDE; SMALL INTERFERING RNA;

ARTICLE; CONTROLLED STUDY; CROSS LINKING; CYTOTOXICITY; GENE SILENCING; HUMAN; HUMAN CELL; PARTICLE SIZE; PRIORITY JOURNAL; SURFACE CHARGE;

CROSS-LINKING REAGENTS; DISULFIDES; HELA CELLS; HUMANS; POLYAMINES; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; RNA INTERFERENCE; RNA, SMALL INTERFERING; SILICON DIOXIDE;

EID: 84868203868     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.09.077     Document Type: Article

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