Enhanced stability and gene silencing ability of siRNA-loaded polyion complexes formulated from polyaspartamide derivatives with a repetitive array of amino groups in the side chain

Biomaterials

Volumn 33, Issue 9, 2012, Pages 2770-2779

  Suma, Tomoya ^a   Miyata, Kanjiro ^b   Ishii, Takehiko ^a   Uchida, Satoshi ^b   Uchida, Hirokuni ^a   Itaka, Keiji ^b   Nishiyama, Nobuhiro ^b   Kataoka, Kazunori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Charge density; Endosomal escape; Poly(amino acid); Polyion complex; SiRNA

Indexed keywords

1 ,2-DIAMINOETHANE; 1 ,3-DIAMINOPROPANE; ACIDIC PH; AMINO GROUP; CARRIER SYSTEMS; CULTURED CELL; CYTOPLASMIC MEMBRANE; ENDOSOMAL COMPARTMENTS; ENDOSOMAL ESCAPE; ENDOSOMAL MEMBRANE; ENDOSOMAL PH; ENHANCED STABILITY; ENHANCED UPTAKE; FLUORESCENT DYES; GENE SILENCING; HIGH EFFICACY; MEMBRANE DAMAGE; MULTIVALENT INTERACTIONS; PH SENSITIVE; PHYSIOLOGICAL CONDITION; POLY(AMINO ACID)S; POLYASPARTAMIDES; POLYION COMPLEX; POSITIVE CHARGES; POSITIVELY CHARGED; SHARP CONTRAST; SIDE-CHAINS; SINGLE PLATFORM; SIRNA; TARGET GENE EXPRESSION;

AMINO ACIDS; BODY FLUIDS; CELL MEMBRANES; CHARGE DENSITY; CYTOLOGY; GENE EXPRESSION; GENETIC ENGINEERING; MOLECULAR BIOLOGY; POLYMERS; TITRATION; TOXICITY;

THERMOELECTRIC POWER;

1 METHYL 2 PYRROLIDINONE; 1,3 PROPANEDIAMINE; AMINO ACID; DIETHYLENETRIAMINE; ETHYLENEDIAMINE; FLUORESCENT DYE; POLYASPARTIC ACID; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; CELL ASSAY; CELL COMPARTMENTALIZATION; CELL CULTURE; CELL MEMBRANE; CHEMICAL INTERACTION; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; ENDOCYTOSIS; ENDOSOME; GENE DELIVERY SYSTEM; GENE EXPRESSION; GENE SILENCING; GENE TARGETING; GENETIC STABILITY; MEMBRANE DAMAGE; MEMBRANE STABILIZATION; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PH; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN MICROARRAY; PROTON TRANSPORT; RNA TRANSPORT;

AMINES; ANIMALS; CATIONS; CELL DEATH; CELL LINE; GENE SILENCING; INTRACELLULAR SPACE; MICE; PARTICLE SIZE; PEPTIDES; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 84855951314     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.12.022     Document Type: Article

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