Fingolimod inhibits PDGF-B-induced migration of vascular smooth muscle cell by down-regulating the S1PR1/S1PR3 pathway

Biochimie

Volumn 94, Issue 12, 2012, Pages 2523-2531

  Mousseau, Yoanne ^a   Mollard, Séverine ^a   Richard, Laurence ^a   Nizou, Angélique ^a   Faucher Durand, Karine ^a   Cook Moreau, Jeanne ^a   Qiu, Hao ^a   Baaj, Yasser ^a   Funalot, Benoit ^a   Fourcade, Laurent ^a   Sturtz, Franck G ^a  

^a DUPUYTREN UNIVERSITY HOSPITAL   (France)

Author keywords

Angiogenesis; Fingolimod; PDGF B; S1P; VSMC

Indexed keywords

FINGOLIMOD; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; SMALL INTERFERING RNA; SPHINGOLIPID; SPHINGOSINE 1 PHOSPHATE RECEPTOR; SPHINGOSINE 1 PHOSPHATE RECEPTOR 1; SPHINGOSINE 1 PHOSPHATE RECEPTOR 2; SPHINGOSINE 1 PHOSPHATE RECEPTOR 3; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL FUNCTION; CELL GROWTH; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; GENE EXPRESSION; GENE TARGETING; GROWTH INHIBITION; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASCULAR SMOOTH MUSCLE CELL;

ANIMALS; CELL MOVEMENT; CELL PROLIFERATION; CELLS, CULTURED; DOWN-REGULATION; IMMUNOHISTOCHEMISTRY; MALE; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PROPYLENE GLYCOLS; PROTO-ONCOGENE PROTEINS C-SIS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; RECEPTORS, LYSOSPHINGOLIPID; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SPHINGOSINE;

RATTUS;

EID: 84868201032     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2012.07.002     Document Type: Article

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