Regulation of Hepatitis C virus replication and gene expression by the MAPK-ERK pathway

Virologica Sinica

Volumn 27, Issue 5, 2012, Pages 278-285

  Pei, Rongjuan ^a,c   Zhang, Xiaoyong ^b   Xu, Song ^a,c   Meng, Zhongji ^b   Roggendorf, Michael ^b   Lu, Mengji ^b   Chen, Xinwen ^a  

^a WUHAN INSTITUTE OF VIROLOGY   (China)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Cell cycle progression; Hepatitis C Virus (HCV); Mitogen activated protein kinases extracellular signal regulated kinase (MAPK ERK)

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ALPHA INTERFERON; CYCLIN DEPENDENT KINASE; EPIDERMAL GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; ROSCOVITINE; VIRUS RNA;

ARTICLE; CELL CYCLE REGULATION; CELL LINE; CELL STRAIN CON1; ENZYME ACTIVATION; GENE EXPRESSION; HEPATITIS C VIRUS; NONHUMAN; PROTEIN EXPRESSION; REPLICON; REPORTER GENE; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSIENT TRANSFECTION; VIRUS LOAD; VIRUS REPLICATION;

CELL LINE; GENE EXPRESSION REGULATION, VIRAL; HEPACIVIRUS; HEPATOCYTES; HUMANS; INTERFERON-ALPHA; MAP KINASE SIGNALING SYSTEM; VIRAL PROTEINS; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 84868152278     PISSN: 16740769     EISSN: 1995820X     Source Type: Journal    
DOI: 10.1007/s12250-012-3257-6     Document Type: Article

References (41)

1. Aktas H, Cai H, Cooper G M. 1997. Ras links growth factor signaling to the cell cycle machinery via regulation of cyclin d1 and the cdk inhibitor p27kip1. Mol Cell Biol, 17(7): 3850-3857.
2. Alter M J. 1997. Epidemiology of hepatitis c. Hepatology, 26(S3): 62S-65S.
3. Bartenschlager R. 2006. Hepatitis c virus molecular clones: From cdna to infectious virus particles in cell culture. Current Opinion in Microbiology, 9(4): 416-422.
4. Binder M, Kochs G, Bartenschlager R, et al. 2007. Hepatitis c virus escape from the interferon regulatory factor 3 pathway by a passive and active evasion strategy. Hepatology, 46(5): 1365-1374.
5. Broering R, Wu J, Meng Z, et al. 2008. Toll-like receptorstimulated non-parenchymal liver cells can regulate hepatitis c virus replication. J Hepatol, 48(6): 914-922.
6. Brunet A, Danie' Le Roux, Lenorm P, et al. 1999. Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. The EMBO Journal, 18(3): 664-674.
7. Chang Y, Lei Y, Wu W, et al. 2007. Effect of hepatitis c virus core protein on interferon-induced antiviral genes expression and its mechanisms. Virologica Sinica, 22(5): 274-379.
8. Choo Q L, Kuo G, Weinera J, et al. 1989. Isolation of a cdna clone derived from a blood-borne non-a, non-b viral hepatitis genome. Science, 244(4902): 359-362.
9. Cyert M S. 2001. Regulation of nuclear localization during signaling. J Biol Chem, 276(24): 20805-20808.
10. Fimia G M, Evangelisti C, Alonzi T, et al. 2004. Conventional protein kinase c inhibition prevents alpha interferon-mediated hepatitis c virus replicon clearance by impairing stat activation. J Virol, 78(23): 12809-12816.
11. Foy E, Li K, Wang C, et al. 2003. Regulation of interferon regulatory factor-3 by the hepatitis c virus serine protease. Science, 300(5622): 1145-1148.
12. Foy E, Li K, Sumpter R, Jr, et al. 2005. Control of antiviral defenses through hepatitis c virus disruption of retinoic acid-inducible gene-i signaling. Proc Natl Acad Sci U S A, 102(8): 2986-2991.
13. Frese M, Schwarzle V, Barth K, et al. 2002. Interferon-gamma inhibits replication of subgenomic and genomic hepatitis c virus rnas. Hepatology, 35(3): 694-703.
14. Gretton S, Hughes M, Harris M. 2010. Hepatitis c virus rna replication is regulated by ras-erk signalling. J Gen Virol, 91(Pt 3): 671-680.
15. Guo J-T, Zhu Q, Seeger C. 2003. Cytopathic and noncytopathic interferon responses in cells expressing hepatitis c virus subgenomic replicons. J Virol, 77(20): 10769-10779.
16. Huang Y, Chen X C, Konduri M, et al. 2006. Mechanistic link between the anti-hcv effect of interferon gamma and control of viral replication by a ras-mapk signaling cascade. Hepatology, 43(1): 81-90.
17. Kawada M, Yamagoe S, Murakami Y, et al. 1997. Induction of p27kip1 degradation and anchorage independence by ras through the map kinase signaling pathway. Oncogene, 15(6): 629-637.
18. Krieger N, Lohmann V, Bartenschlager R. 2001. Enhancement of hepatitis c virus rna replication by cell culture-adaptive mutations. J Virol, 75(10): 4614-4624.
19. Li K, Foy E, Ferreon J C, et al. 2005. Immune evasion by hepatitis c virus ns3/4a protease-mediated cleavage of the toll-like receptor 3 adaptor protein trif. Proc Natl Acad Sci U S A, 102(8): 2992-2997.
20. Lindenbach B D, Evans M J, Syder a J, et al. 2005. Complete replication of hepatitis c virus in cell culture. Science, 309(5734): 623-626.
21. Lohmann V, Ouml, Rner F, et al. 1999. Replication of subgenomic hepatitis c virus rnas in a hepatoma cell line. Science, 285(5424): 110-113.
22. Maccorkle R, Tan T-H. 2005. Mitogen-activated protein kinases in cell-cycle control. Cell Biochemistry and Biophysics, 43(3): 451-461.
23. Macdonald A, Chan J K Y, Harris M. 2005. Perturbation of epidermal growth factor receptor complex formation and ras signalling in cells harbouring the hepatitis c virus subgenomic replicon. J Gen Virol, 86(4): 1027-1033.
24. Macdonald A, Crowder K, Street A, et al. 2003. The hepatitis c virus non-structural ns5a protein inhibits activating protein-1 function by perturbing ras-erk pathway signaling. J Biol Chem, 278(20): 17775-17784.
25. Mankouri J, Griffin S, Harris M. 2008. The hepatitis c virus non-structural protein ns5a alters the trafficking profile of the epidermal growth factor receptor. Traffic, 9(9): 1497-1509.
26. Mannova P, Beretta L. 2005. Activation of the n-ras-pi3k-aktmtor pathway by hepatitis c virus: Control of cell survival and viral replication. J Virol, 79(14): 8742-8749.
27. Meloche S, Pouyssegur J. 2007. The erk1//2 mitogen-activated protein kinase pathway as a master regulator of the g1-to s-phase transition. Oncogene, 26(22): 3227-3239.
28. Meylan E, Curran J, Hofmann K, et al. 2005. Cardif is an adaptor protein in the rig-i antiviral pathway and is targeted by hepatitis c virus. Nature, 437(7062): 1167-1172.
29. Murata T, Hijikata M, Shimotohno K. 2005. Enhancement of internal ribosome entry site-mediated translation and replication of hepatitis c virus by pd98059. Virology, 340(1): 105-115.
30. Ndjomou J, Park I W, Liu Y, et al. 2009. Up-regulation of hepatitis c virus replication and production by inhibition of mek/erk signaling. PLoS One, 4(10): e7498.
31. Nelson H B, Tang H. 2006. Effect of cell growth on hepatitis c virus (hcv) replication and a mechanism of cell confluence-based inhibition of hcv rna and protein expression. J Virol, 80(3): 1181-1190.
32. Schaeffer H J, Weber M J. 1999. Mitogen-activated protein kinases: Specific messages from ubiquitous messengers. Mol Cell Biol, 19(4): 2435-2444.
33. Seeff L B. 1997. Natural history of hepatitis c. Hepatology, 26(S3): 21S-28S.
34. Street A, Macdonald A, Crowder K, et al. 2004. The hepatitis c virus ns5a protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J Biol Chem, 279(13): 12232-12241.
35. Sumpter R, Jr, Loo Y M, Foy E, et al. 2005. Regulating intracellular antiviral defense and permissiveness to hepatitis c virus rna replication through a cellular rna helicase, rig-i. J Virol, 79(5): 2689-2699.
36. Takuwa N, Takuwa Y. 1997. Ras activity late in g1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into s phase in growth factor-stimulated nih 3t3 fibroblasts. Mol Cell Biol, 17(9): 5348-5358.
37. Tong M J, El-Farra N S, Reikes a R, et al. 1995. Clinical outcomes after transfusion-associated hepatitis c. N Engl J Med, 332(22): 1463-1466.
38. Trujillo-Murillo K, Rincon-Sancheza R, Martinez-Rodriguez H, et al. 2008. Acetylsalicylic acid inhibits hepatitis c virus rna and protein expression through cyclooxygenase 2 signaling pathways. Hepatology, 47(5): 1462-1472.
39. Wakita T, Pietschmann T, Kato T, et al. 2005. Production of infectious hepatitis c virus in tissue culture from a cloned viral genome. Nat Med, 11(7): 791-796.
40. Yokota T, Sakamoto N, Enomoto N, et al. 2003. Inhibition of intracellular hepatitis c virus replication by synthetic and vector-derived small interfering rnas. EMBO Rep, 4(6): 602-608.
41. Zhong J, Gastaminza P, Cheng G, et al. 2005. Robust hepatitis c virus infection in vitro. Proc Natl Acad Sci USA, 102(26): 9294-9299.