State-related alterations of gene expression in bipolar disorder: A systematic review

Bipolar Disorders

Volumn 14, Issue 7, 2012, Pages 684-696

  Munkholm, Klaus ^a   Vinberg, Maj ^a   Berk, Michael ^b,c,d   Kessing, Lars Vedel ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b DEAKIN UNIVERSITY   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

BDNF; Biomarker; Bipolar disorder; Depression; Etiology; Gene expression; Genetics; Mania; Systematic review

Indexed keywords

3',5' CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ADENYLATE CYCLASE; BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE KINASE; CHEMOKINE RECEPTOR CCR2; CYTOCHROME C OXIDASE; DUAL SPECIFICITY PHOSPHATASE 2; EPIREGULIN; ERYTHROPOIETIN RECEPTOR; FATTY ACID BINDING PROTEIN; G PROTEIN COUPLED RECEPTOR KINASE 3; GLUCOCORTICOID RECEPTOR ALPHA; HEAT SHOCK PROTEIN 70; HEMOGLOBIN A; HEMOGLOBIN BETA CHAIN; HISTONE DEACETYLASE 1; INTERLEUKIN 1BETA; MESSENGER RNA; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY D; NERVE CELL ADHESION MOLECULE; NERVE GROWTH FACTOR; NEURTURIN; PENTRAXIN 3; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; SEROTONIN 1A RECEPTOR; SYNTAXIN 1A; THROMBOPLASTIN; THROMBOSPONDIN; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

BIPOLAR DISORDER; BODY MASS; COCHRANE LIBRARY; CROSS-SECTIONAL STUDY; DEMOGRAPHY; DEPRESSION; EMBASE; GENE EXPRESSION; GENETIC DIFFERENCE; GENETIC TRAIT; HAMILTON SCALE; HUMAN; HYPOMANIA; MANIA; MEDLINE; MENTAL PATIENT; META ANALYSIS (TOPIC); MOOD DISORDER; PRACTICE GUIDELINE; PRIORITY JOURNAL; PSYCINFO; PUBLICATION; RAPID CYCLING BIPOLAR DISORDER; REAL TIME POLYMERASE CHAIN REACTION; REVIEW; SMOKING; SYSTEMATIC REVIEW;

ADOLESCENT; ADULT; BIPOLAR DISORDER; BRAIN-DERIVED NEUROTROPHIC FACTOR; CHILD; CHILD, PRESCHOOL; DATABASES, FACTUAL; FEMALE; GENE EXPRESSION; HISTORY, MEDIEVAL; HUMANS; INFANT; MALE; META-ANALYSIS AS TOPIC; MIDDLE AGED; YOUNG ADULT;

EID: 84868151102     PISSN: 13985647     EISSN: 13995618     Source Type: Journal    
DOI: 10.1111/bdi.12005     Document Type: Review

References (77)

1. Alizadeh AA, Eisen MB, Davis RE et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature 2000; 403: 503-511.
2. Khan J, Wei JS, Ringner M et al. Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks. Nat Med 2001; 7: 673-679.
3. Patino WD, Mian OY, Kang JG et al. Circulating transcriptome reveals markers of atherosclerosis. Proc Natl Acad Sci U S A 2005; 102: 3423-3428.
4. van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002; 347: 1999-2009.
5. Wang Y, Klijn JG, Zhang Y et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 2005; 365: 671-679.
6. McCullumsmith RE, Meador-Woodruff JH. Novel approaches to the study of postmortem brain in psychiatric illness: old limitations and new challenges. Biol Psychiatry 2011; 69: 127-133.
7. Pidsley R, Mill J. Epigenetic studies of psychosis: current findings, methodological approaches, and implications for postmortem research. Biol Psychiatry 2011; 69: 146-156.
8. Le-Niculescu H, Kurian SM, Yehyawi N et al. Identifying blood biomarkers for mood disorders using convergent functional genomics. Mol Psychiatry 2009; 14: 156-174.
9. Liew CC, Ma J, Tang HC, Zheng R, Dempsey AA. The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool. J Lab Clin Med 2006; 147: 126-132.
10. Gladkevich A, Kauffman HF, Korf J. Lymphocytes as a neural probe: potential for studying psychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28: 559-576.
11. Pasco JA, Nicholson GC, Williams LJ et al. Association of high-sensitivity C-reactive protein with de novo major depression. Br J Psychiatry 2010; 197: 372-377.
12. Berk M, Kapczinski F, Andreazza AC et al. Pathways underlying neuroprogression in bipolar disorder: focus on inflammation; oxidative stress and neurotrophic factors. Neurosci Biobehav Rev 2011; 35: 804-817.
13. Iwamoto K, Kato T. Gene expression profiling in schizophrenia and related mental disorders. Neuroscientist 2006; 12: 349-361.
14. Kato T, Kakiuchi C, Iwamoto K. Comprehensive gene expression analysis in bipolar disorder. Can J Psychiatry 2007; 52: 763-771.
15. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ 2009; 339: b2535.
16. Andreopoulos S, Wasserman M, Woo K, Li PP, Warsh JJ. Chronic lithium treatment of B lymphoblasts from bipolar disorder patients reduces transient receptor potential channel 3 levels. Pharmacogenomics J 2004; 4: 365-373.
17. Anitha A, Nakamura K, Yamada K et al. Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. Biol Psychiatry 2008; 63: 678-685.
18. Naydenov AV, MacDonald ML, Ongur D, Konradi C. Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress. Arch Gen Psychiatry 2007; 64: 555-564.
19. Padmos RC, Van Baal GC, Vonk R et al. Genetic and environmental influences on pro-inflammatory monocytes in bipolar disorder: a twin study. Arch Gen Psychiatry 2009; 66: 957-965.
20. Spleiss O, van CD, Scharer L, Adamovic K, Berger M, Gebicke-Haerter PJ. Abnormal G protein alpha(s) - and alpha(i2)-subunit mRNA expression in bipolar affective disorder. Mol Psychiatry 1998; 3: 512-520.
21. Vogel M, Pfeifer S, Schaub RT et al. Decreased levels of dopamine D3 receptor mRNA in schizophrenic and bipolar patients. Neuropsychobiology 2004; 50: 305-310.
22. Willmroth F, Drieling T, Lamla U, Marcushen M, Wark HJ, van Calker D. Sodium-myo-inositol co-transporter (SMIT-1) mRNA is increased in neutrophils of patients with bipolar 1 disorder and down-regulated under treatment with mood stabilizers. Int J Neuropsychopharmacol 2007; 10: 63-71.
23. Yoon IS, Li PP, Siu KP et al. Altered IMPA2 gene expression and calcium homeostasis in bipolar disorder. Mol Psychiatry 2001; 6: 678-683.
24. Begemann M, Sargin D, Rossner MJ et al. Episode-specific differential gene expression of peripheral blood mononuclear cells in rapid cycling supports novel treatment approaches. Mol Med 2008; 14: 546-552.
25. Beech RD, Lowthert L, Leffert JJ et al. Increased peripheral blood expression of electron transport chain genes in bipolar depression. Bipolar Disord 2010; 12: 813-824.
26. Drexhage RC, van der Heul-Nieuwenhuijsen L, Padmos RC et al. Inflammatory gene expression in monocytes of patients with schizophrenia: overlap and difference with bipolar disorder. A study in naturalistically treated patients. Int J Neuropsychopharmacol 2010; 13: 1369-1381.
27. Fujimoto M, Uchida S, Watanuki T et al. Reduced expression of glyoxalase-1 mRNA in mood disorder patients. Neurosci Lett 2008; 438: 196-199.
28. Iwamoto K, Bundo M, Washizuka S, Kakiuchi C, Kato T. Expression of HSPF1 and LIM in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. J Hum Genet 2004; 49: 227-231.
29. Karege F, Schwald M, El Kouaissi R. Drug-induced decrease of protein kinase a activity reveals alteration in BDNF expression of bipolar affective disorder. Neuropsychopharmacology 2004; 29: 805-812.
30. Karege F, Schwald M, Papadimitriou P, Lachausse C, Cisse M. The cAMP-dependent protein kinase A and brain-derived neurotrophic factor expression in lymphoblast cells of bipolar affective disorder. J Affect Disord 2004; 79: 187-192.
31. Lavebratt C, Sjoholm LK, Soronen P et al. CRY2 is associated with depression. PLoS ONE 2010; 5: e9407.
32. Nemanov L, Ebstein RP, Belmaker RH, Osher Y, Agam G. Effect of bipolar disorder on lymphocyte inositol monophosphatase mRNA levels. Int J Neuropsychopharmacol 1999; 2: 25-29.
33. Shaltiel G, Shamir A, Levi I, Bersudsky Y, Agam G. Lymphocyte G-protein receptor kinase (GRK)3 mRNA levels in bipolar disorder. Int J Neuropsychopharmacol 2006; 9: 761-766.
34. Washizuka S, Iwamoto K, Kakiuchi C, Bundo M, Kato T. Expression of mitochondrial complex I subunit gene NDUFV2 in the lymphoblastoid cells derived from patients with bipolar disorder and schizophrenia. Neurosci Res 2009; 63: 199-204.
35. Shamir A, Shaltiel G, Mark S, Bersudsky Y, Belmaker RH, Agam G. Human MIP synthase splice variants in bipolar disorder. Bipolar Disord 2007; 9: 766-771.
36. Hobara T, Uchida S, Otsuki K et al. Altered gene expression of histone deacetylases in mood disorder patients. J Psychiatr Res 2010; 44: 263-270.
37. Matsubara T, Funato H, Kobayashi A, Nobumoto M, Watanabe Y. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol Psychiatry 2006; 59: 689-695.
38. Otsuki K, Uchida S, Wakabayashi Y et al. Aberrant REST-mediated transcriptional regulation in major depressive disorder. J Psychiatr Res 2010; 44: 378-384.
39. Otsuki K, Uchida S, Watanuki T et al. Altered expression of neurotrophic factors in patients with major depression. J Psychiatr Res 2008; 42: 1145-1153.
40. Wakabayashi Y, Uchida S, Funato H et al. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. Prog Neuropsychopharmacol Biol Psychiatry 2008; 32: 1199-1205.
41. Whitney AR, Diehn M, Popper SJ et al. Individuality and variation in gene expression patterns in human blood. Proc Natl Acad Sci U S A 2003; 100: 1896-1901.
42. Eady JJ, Wortley GM, Wormstone YM et al. Variation in gene expression profiles of peripheral blood mononuclear cells from healthy volunteers. Physiol Genomics 2005; 22: 402-411.
43. Kim SJ, Dix DJ, Thompson KE et al. Effects of storage, RNA extraction, genechip type, and donor sex on gene expression profiling of human whole blood. Clin Chem 2007; 53: 1038-1045.
44. Min JL, Barrett A, Watts T et al. Variability of gene expression profiles in human blood and lymphoblastoid cell lines. BMC Genomics 2010; 11: 96.
45. Radich JP, Mao M, Stepaniants S et al. Individual-specific variation of gene expression in peripheral blood leukocytes. Genomics 2004; 83: 980-988.
46. Cheung VG, Conlin LK, Weber TM et al. Natural variation in human gene expression assessed in lymphoblastoid cells. Nat Genet 2003; 33: 422-425.
47. Hashimoto K. Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 2010; 64: 341-357.
48. Ng F, Berk M, Dean O, Bush AI. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int J Neuropsychopharmacol 2008; 11: 851-876.
49. Goldstein BI, Kemp DE, Soczynska JK, McIntyre RS. Inflammation and the phenomenology, pathophysiology, comorbidity, and treatment of bipolar disorder: a systematic review of the literature. J Clin Psychiatry 2009; 70: 1078-1090.
50. Maes M, Leonard B, Fernandez A et al. (Neuro)inflammation and neuroprogression as new pathways and drug targets in depression: From antioxidants to kinase inhibitors. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 659-663.
51. Wood SJ, Yucel M, Pantelis C, Berk M. Neurobiology of schizophrenia spectrum disorders: the role of oxidative stress. Ann Acad Med Singapore 2009; 38: 396-401.
52. Kapczinski F, Dal-Pizzol F, Teixeira AL et al. Peripheral biomarkers and illness activity in bipolar disorder. J Psychiatr Res 2011; 45: 156-161.
53. Kapczinski F, Dal-Pizzol F, Teixeira AL et al. A systemic toxicity index developed to assess peripheral changes in mood episodes. Mol Psychiatry 2010; 15: 784-786.
54. Fernandes BS, Gama CS, Cereser KM et al. Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: a systematic review and meta-regression analysis. J Psychiatr Res 2011; 45: 995-1004.
55. Gardner A, Boles RG. Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders. Prog Neuropsychopharmacol Biol Psychiatry 2011; 35: 730-743.
56. Ryan MM, Lockstone HE, Huffaker SJ, Wayland MT, Webster MJ, Bahn S. Gene expression analysis of bipolar disorder reveals downregulation of the ubiquitin cycle and alterations in synaptic genes. Mol Psychiatry 2006; 11: 965-978.
57. Padmos RC, Hillegers MH, Knijff EM et al. A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes. Arch Gen Psychiatry 2008; 65: 395-407.
58. Konradi C, Sillivan SE, Clay HB. Mitochondria, oligodendrocytes and inflammation in bipolar disorder: evidence from transcriptome studies points to intriguing parallels with multiple sclerosis. Neurobiol Dis 2012; 45: 37-47.
59. Iwamoto K, Bundo M, Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum Mol Genet 2005; 14: 241-253.
60. Sun X, Wang JF, Tseng M, Young LT. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J Psychiatry Neurosci 2006; 31: 189-196.
61. Konradi C, Eaton M, MacDonald ML, Walsh J, Benes FM, Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch Gen Psychiatry 2004; 61: 300-308.
62. MacDonald ML, Naydenov A, Chu M, Matzilevich D, Konradi C. Decrease in creatine kinase messenger RNA expression in the hippocampus and dorsolateral prefrontal cortex in bipolar disorder. Bipolar Disord 2006; 8: 255-264.
63. Kim HW, Rapoport SI, Rao JS. Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients. Neurobiol Dis 2010; 37: 596-603.
64. Pandey GN, Dwivedi Y, Rizavi HS, Ren X, Zhang H, Pavuluri MN. Brain-derived neurotrophic factor gene and protein expression in pediatric and adult depressed subjects. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 645-651.
65. Tsankova N, Renthal W, Kumar A, Nestler EJ. Epigenetic regulation in psychiatric disorders. Nature Reviews Neurosci 2007; 8: 355-367.
66. Petronis A. Epigenetics and bipolar disorder: new opportunities and challenges. Am J Med Genet C Semin Med Genet 2003; 123C: 65-75.
67. Hsieh J, Gage FH. Chromatin remodeling in neural development and plasticity. Curr Opin Cell Biol 2005; 17: 664-671.
68. Reik W, Walter J. Genomic imprinting: parental influence on the genome. Nat Rev Genet 2001; 2: 21-32.
69. Pinto C, Souza RP, Lioult D et al. Parent of origin effect and allelic expression imbalance of the serotonin transporter in bipolar disorder and suicidal behaviour. Eur Arch Psychiatry Clin Neurosci 2011; 261: 533-538.
70. McCarthy MJ, Barrett TB, Nissen S, Kelsoe JR, Turner EE. Allele specific analysis of the ADRBK2 gene in lymphoblastoid cells from bipolar disorder patients. J Psychiatr Res 2010; 44: 201-208.
71. De Luca V, Strauss J, Semeralul M et al. Analysis of BDNF Val66Met allele-specific mRNA levels in bipolar disorder. Neurosci Lett 2008; 441: 229-232.
72. Berk M, Copolov DL, Dean O et al. N-acetyl cysteine for depressive symptoms in bipolar disorder - a double-blind randomized placebo-controlled trial. Biol Psychiatry 2008; 64: 468-475.
73. Miskowiak KW, Vinberg M, Harmer CJ et al. Effects of erythropoietin on depressive symptoms and neurocognitive deficits in depression and bipolar disorder. Trials 2010; 11: 97.
74. Karen J, Rodriguez A, Friman T, Dencker L, Sundberg C, Scholz B. Effects of the histone deacetylase inhibitor valproic acid on human pericytes in vitro. PLoS ONE 2011; 6: e24954.
75. Jornada LK, Valvassori SS, Steckert AV et al. Lithium and valproate modulate antioxidant enzymes and prevent ouabain-induced oxidative damage in an animal model of mania. J Psychiatr Res 2011; 45: 162-168.
76. McEachin RC, Chen H, Sartor MA et al. A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. BMC Syst Biol 2010; 4: 158.
77. Gormanns P, Mueller NS, Ditzen C, Wolf S, Holsboer F, Turck CW. Phenome-transcriptome correlation unravels anxiety and depression related pathways. J Psychiatr Res 2011; 45: 973-979.