Aberrant REST-mediated transcriptional regulation in major depressive disorder

Journal of Psychiatric Research

Volumn 44, Issue 6, 2010, Pages 378-384

  Otsuki, Koji ^a   Uchida, Shusaku ^a   Wakabayashi, Yusuke ^a   Matsubara, Toshio ^a   Hobara, Teruyuki ^a   Funato, Hiromasa ^a   Watanabe, Yoshifumi ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bipolar disorder; Gene expression; Major depression; REST NRSF

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 5; APRIL PROTEIN; CORTICOTROPIN RELEASING FACTOR; MESSENGER RNA; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR SUPERFAMILY MEMBER 12; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIPOLAR DISORDER; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REMISSION; TRANSCRIPTION REGULATION;

EID: 77950949525     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.09.009     Document Type: Article

References (68)

1. Alesci S., Martinez P.E., Kelkar S., Ilias I., Ronsaville D.S., Listwak S.J., et al. Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. The Journal of Clinical Endocrinology and Metabolism 2005, 90:2522-2530.
2. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed. Washington, DC: American Psychiatric Press; 1994.
3. Anitha A., Nakamura K., Yamada K., Iwayama Y., Toyota T., Takei N., et al. Gene and expression analyses reveal enhanced expression of pericentrin 2 (PCNT2) in bipolar disorder. Biological Psychiatry 2008, 63:678-685.
4. Bahn S., Mimmack M., Ryan M., Caldwell M.A., Jauniaux E., Starkey M., et al. Neuronal target genes of the neuron-restrictive silencer factor in neurospheres derived from fetuses with Down's syndrome: a gene expression study. Lancet 2002, 359:310-315.
5. Ballas N., Grunseich C., Lu D.D., Speh J.C., Mandel G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 2005, 121:645-657.
6. Bessis A., Champtiaux N., Chatelin L., Changeux J.P. The neuron-restrictive silencer element: a dual enhancer/silencer crucial for patterned expression of a nicotinic receptor gene in the brain. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:5906-5911.
7. Brady L.S., Whitfield H.J., Fox R.J., Gold P.W., Herkenham M. Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications. The Journal of Clinical Investigation 1991, 87:831-837.
8. Britton D.R., Varela M., Garcia A., Rosenthal M. Dexamethasone suppresses pituitary-adrenal but not behavioral effects of centrally administered CRF. Life Sciences 1986, 38:211-216.
9. Bruce A.W., Donaldson I.J., Wood I.C., Yerbury S.A., Sadowski M.I., Chapman M., et al. Genome-wide analysis of repressor element 1 silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) target genes. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:10458-10463.
10. Calderone A., Jover T., Noh K.M., Tanaka H., Yokota H., Lin Y., et al. Ischemic insults derepress the gene silencer REST in neurons destined to die. Journal of Neuroscience 2003, 23:2112-2121.
11. Carlezon W.A., Duman R.S., Nestler E.J. The many faces of CREB. Trends in Neurosciences 2005, 28:436-445.
12. Chen Z.F., Paquette A.J., Anderson D.J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nature Genetics 1998, 20:136-142.
13. Chong J.A., Tapia-Ramirez J., Kim S., Toledo-Aral J.J., Zheng Y., Boutros M.C., et al. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995, 80:949-957.
14. Coyle J.T., Duman R.S. Finding the intracellular signaling pathways affected by mood disorder treatments. Neuron 2003, 38:157-160.
15. de Kloet E.R., Joels M., Holsboer F. Stress and the brain: from adaptation to disease. Nature Reviews Neuroscience 2005, 6:463-475.
16. Duman R.S., Monteggia L.M. A neurotrophic model for stress-related mood disorders. Biological Psychiatry 2006, 59:1116-1127.
17. Ekman R., Servenius B., Castro M.G., Lowry P.J., Cederlund A.S., Bergman O., et al. Biosynthesis of corticotropin-releasing hormone in human T-lymphocytes. Journal of Neuroimmunology 1993, 44:7-13.
18. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 2000, 23:477-501.
19. Iga J., Ueno S., Ohmori T. Molecular assessment of depression from mRNAs in the peripheral leukocytes. Annals of Medicine 2008, 40:336-342.
20. Iga J., Ueno S., Yamauchi K., Numata S., Kinouchi S., Tayoshi-Shibuya S., et al. Altered HDAC5 and CREB mRNA expressions in the peripheral leukocytes of major depression. Progress in Neuro-psychopharmacology and Biological Psychiatry 2007, 31:628-632.
21. Iwamoto K., Kakiuchi C., Bundo M., Ikeda K., Kato T. Molecular characterization of bipolar disorder by comparing gene expression profiles of postmortem brains of major mental disorders. Molecular Psychiatry 2004, 9:406-416.
22. Johnson R., Gamblin R.J., Ooi L., Bruce A.W., Donaldson I.J., Westhead D.R., et al. Identification of the REST regulon reveals extensive transposable element-mediated binding site duplication. Nucleic Acids Research 2006, 34:3862-3877.
23. Kakiuchi C., Iwamoto K., Ishiwata M., Bundo M., Kasahara T., Kusumi I., et al. Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nature Genetics 2003, 35:171-175.
24. Kallunki P., Edelman G.M., Jones F.S. The neural restrictive silencer element can act as both a repressor and enhancer of L1 cell adhesion molecule gene expression during postnatal development. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:3233-3238.
25. Kallunki P., Edelman G.M., Jones F.S. Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element. The Journal of Cell Biology 1997, 138:1343-1354.
26. Knable M.B., Barci B.M., Webster M.J., Meador-Woodruff J., Torrey E.F. Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Molecular Psychiatry 2004, 9(544):609-620.
27. Kraner S.D., Chong J.A., Tsay H.J., Mandel G. Silencing the type II sodium channel gene: a model for neural-specific gene regulation. Neuron 1992, 9:37-44.
28. Kravchenco I.V., Furalev V.A. Secretion of immunoreactive corticotropin releasing factor and adrenocorticotropic hormone by T- and B-lymphocytes in response to cellular stress factors. Biochemical and Biophysical Research Communications 1994, 204:828-834.
29. Krishnan V., Graham A., Mazei-Robison M.S., Lagace D.C., Kim K.S., Birnbaum S., et al. Calcium-sensitive adenylyl cyclases in depression and anxiety: behavioral and biochemical consequences of isoform targeting. Biological Psychiatry 2008, 64:336-343.
30. Kunugi H., Urushibara T., Nanko S. Combined DEX/CRH test among Japanese patients with major depression. Journal of Psychiatric Research 2004, 38:123-128.
31. Kunugi H., Ida I., Owashi T., Kimura M., Inoue Y., Nakagawa S., et al. Assessment of the dexamethasone/CRH test as a state-dependent marker for hypothalamic-pituitary-adrenal (HPA) axis abnormalities in major depressive episode: a multicenter study. Neuropsychopharmacology 2006, 31:212-220.
32. Laifenfeld D., Karry R., Grauer E., Klein E., Ben-Shachar D. Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity. Neurobiology of Disease 2005, 20:432-441.
33. Landgraf R. Neuropeptides in anxiety and depression. Amino Acids 2006, 31:211-213.
34. Lemonde S., Rogaeva A., Albert P.R. Cell type-dependent recruitment of trichostatin A-sensitive repression of the human 5-HT1A receptor gene. Journal of Neurochemistry 2004, 88:857-868.
35. Lemonde S., Turecki G., Bakish D., Du L., Hrdina P.D., Bown C.D., et al. Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. Journal of Neuroscience 2003, 23:8788-8799.
36. Manji H.K., Bebchuk J.M., Moore G.J., Glitz D., Hasanat K.A., Chen G. Modulation of CNS signal transduction pathways and gene expression by mood-stabilizing agents: therapeutic implications. The Journal of Clinical Psychiatry 1999, 60(Suppl. 2):27-39. discussion 40-1, 113-6.
37. Matsubara T., Funato H., Kobayashi A., Nobumoto M., Watanabe Y. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biological Psychiatry 2006, 59:689-695.
38. Mikova O., Yakimova R., Bosmans E., Kenis G., Maes M. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. European Neuropsychopharmacology 2001, 11:203-208.
39. Miller C.L., Llenos I.C., Cwik M., Walkup J., Weis S. Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder. Neurochemistry International 2008, 52:1297-1303.
40. + channel genes binds a factor present in nonneuronal cells but not in neuronal cells. Neuron 1992, 9:45-54.
41. Nemeroff C.B., Widerlov E., Bissette G., Walleus H., Karlsson I., Eklund K., et al. Elevated concentrations of CSF corticotropin-releasing factor-like immunoreactivity in depressed patients. Science 1984, 226:1342-1344.
42. Nestler E.J., Barrot M., DiLeone R.J., Eisch A.J., Gold S.J., Monteggia L.M. Neurobiology of depression. Neuron 2002, 34:13-25.
43. Okazaki T., Wang H., Masliah E., Cao M., Johnson S.A., Sundsmo M., et al. SCG10, a neuron-specific growth-associated protein in Alzheimer's disease. Neurobiology of Aging 1995, 16:883-894.
44. Otsuki K., Uchida S., Watanuki T., Wakabayashi Y., Fujimoto M., Matsubara T., et al. Altered expression of neurotrophic factors in patients with major depression. Journal of Psychiatric Research 2008, 42:1145-1153.
45. Otto S.J., McCorkle S.R., Hover J., Conaco C., Han J.J., Impey S., et al. A new binding motif for the transcriptional repressor REST uncovers large gene networks devoted to neuronal functions. Journal of Neuroscience 2007, 27:6729-6739.
46. Palm K., Belluardo N., Metsis M., Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. Journal of Neuroscience 1998, 18:1280-1296.
47. Pepin M.C., Pothier F., Barden N. Impaired type II glucocorticoid-receptor function in mice bearing antisense RNA transgene. Nature 1992, 355:725-728.
48. Raadsheer F.C., Tilders F.J., Swaab D.F. Similar age related increase of vasopressin colocalization in paraventricular corticotropin-releasing hormone neurons in controls and Alzheimer patients. Journal of Neuroendocrinology 1994, 6:131-133.
49. Schoenherr C.J., Anderson D.J. Silencing is golden: negative regulation in the control of neuronal gene transcription. Current Opinion in Neurobiology 1995, 5:566-571.
50. Schoenherr C.J., Paquette A.J., Anderson D.J. Identification of potential target genes for the neuron-restrictive silencer factor. Proceedings of the National Academy of Sciences of the United States of America 1996, 93:9881-9886.
51. Schroeder F.A., Lin C.L., Crusio W.E., Akbarian S. Antidepressant-like effects of the histone deacetylase inhibitor, sodium butyrate, in the mouse. Biological Psychiatry 2007, 62:55-64.
52. Seth K.A., Majzoub J.A. Repressor element silencing transcription factor/neuron-restrictive silencing factor (REST/NRSF) can act as an enhancer as well as a repressor of corticotropin-releasing hormone gene transcription. The Journal of Biological Chemistry 2001, 276:13917-13923.
53. Singh V.K., Leu S.J. Enhancing effect of corticotropin-releasing neurohormone on the production of interleukin-1 and interleukin-2. Neuroscience Letters 1990, 120:151-154.
54. Somekawa S, Imagawa K, Naya N, Takemoto Y, Onoue K, Okayama S, et al. Regulation of aldosterone and cortisol production by the transcriptional repressor neuron restrictive silencer factor. Endocrinology, 2009. doi:10.1210/en.2008-1624.
55. Stenzel-Poore M.P., Heinrichs S.C., Rivest S., Koob G.F., Vale W.W. Overproduction of corticotropin-releasing factor in transgenic mice. A genetic model of anxiogenic behavior. Journal of Neuroscience 1994, 14:2579-2584.
56. Stewart L.Q., Roper J.A., Scott Young W., O'Carroll A.M., Lolait S.J. The role of the arginine vasopressin Avp1b receptor in the acute neuroendocrine action of antidepressants. Psychoneuroendocrinology 2008, 33:405-415.
57. Strohle A., Kellner M., Holsboer F., Wiedemann K. Atrial natriuretic hormone decreases endocrine response to a combined dexamethasone-corticotropin-releasing hormone test. Biological Psychiatry 1998, 43:371-375.
58. Su TP, Zhang L, Chung MY, Chen YS, Bi YM, Chou YH, et al. Levels of the potential biomarker p11 in peripheral blood cells distinguish patients with PTSD from those with other major psychiatric disorders. Journal of Psychiatric Research, 2009. doi:10.1016/j.jpsychires.2009.03.010.
59. Tapia-Ramirez J., Eggen B.J., Peral-Rubio M.J., Toledo-Aral J.J., Mandel G. A single zinc finger motif in the silencing factor REST represses the neural-specific type II sodium channel promoter. Proceedings of the National Academy of Sciences of the United States of America 1997, 94:1177-1182.
60. Thomas A.J., Davis S., Morris C., Jackson E., Harrison R., O'Brien J.T. Increase in interleukin-1beta in late-life depression. The American Journal of Psychiatry 2005, 162:175-177.
61. Timmusk T., Palm K., Lendahl U., Metsis M. Brain-derived neurotrophic factor expression in vivo is under the control of neuron-restrictive silencer element. The Journal of Biological Chemistry 1999, 274:1078-1084.
62. Tsankova N.M., Berton O., Renthal W., Kumar A., Neve R.L., Nestler E.J. Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action. Nature Neuroscience 2006, 9:519-525.
63. Wakabayashi Y., Uchida S., Funato H., Matsubara T., Watanuki T., Otsuki K., et al. State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders. Progress in neuro-psychopharmacology & biological psychiatry 2008, 32:1199-1205.
64. Ware C.F. The TNF superfamily. Cytokine and Growth Factor Reviews 2003, 14:181-184.
65. Webster M.J., Knable M.B., O'Grady J., Orthmann J., Weickert C.S. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Molecular Psychiatry 2002, 7(24):985-994.
66. Westbrook T.F., Hu G., Ang X.L., Mulligan P., Pavlova N.N., Liang A., et al. SCFbeta-TRCP controls oncogenic transformation and neural differentiation through REST degradation. Nature 2008, 452:370-374.
67. Yamada K., Nakamura K., Minabe Y., Iwayama-Shigeno Y., Takao H., Toyota T., et al. Association analysis of FEZ1 variants with schizophrenia in Japanese cohorts. Biological Psychiatry 2004, 56:683-690.
68. Zuccato C., Belyaev N., Conforti P., Ooi L., Tartari M., Papadimou E., et al. Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. Journal of Neuroscience 2007, 27:6972-6983.