State-dependent changes in the expression levels of NCAM-140 and L1 in the peripheral blood cells of bipolar disorders, but not in the major depressive disorders

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 32, Issue 5, 2008, Pages 1199-1205

  Wakabayashi, Yusuke ^a   Uchida, Shusaku ^a   Funato, Hiromasa ^a   Matsubara, Toshio ^a   Watanuki, Toshio ^a   Otsuki, Koji ^a   Fujimoto, Michiko ^a   Nishida, Akira ^a   Watanabe, Yoshifumi ^a  

^a YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Bipolar disorder; Cell adhesion molecule; Major depressive disorder; State marker

Indexed keywords

ANTIDEPRESSANT AGENT; CARBAMAZEPINE; CELL ADHESION MOLECULE; COMPLEMENTARY DNA; CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; HYDROCORTISONE; LITHIUM; MESSENGER RNA; MOOD STABILIZER; NERVE CELL ADHESION MOLECULE; RNA; VALPROIC ACID;

ADULT; ARTICLE; BIPOLAR DISORDER; BLOOD SAMPLING; BRAIN; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; MENTAL DISEASE; MONOTHERAPY; NERVE CELL PLASTICITY; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PERIPHERAL BLOOD MONONUCLEAR CELL; RADIOIMMUNOASSAY; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 49849104391     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2008.03.005     Document Type: Article

References (75)

1. American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 4th ed. (1994), American Psychiatric Press, Washington, DC
2. Arai M., Itokawa M., Yamada K., Toyota T., Arai M., Haga S., et al. Association of neural cell adhesion molecule 1 gene polymorphisms with bipolar affective disorder in Japanese individuals. Biol Psychiatry 55 (2004) 804-810
3. Benson D.L., Schnapp L.M., Shapiro L., and Huntley G.W. Making memories stick: cell-adhesion molecules in synaptic plasticity. Trends Cell Biol 10 (2000) 473-482
4. Beyer J.L., and Krishnan K.R. Volumetric brain imaging findings in mood disorders. Bipolar Disord 4 (2002) 89-104
5. Bukalo O., Fentrop N., Lee A.Y., Salmen B., Law J.W., Wotjak C.T., et al. Conditional ablation of the neural cell adhesion molecule reduces precision of spatial learning, long-term potentiation, and depression in the CA1 subfield of mouse hippocampus. J Neurosci 24 (2004) 1565-1577
6. Burke R.E., Antonelli M., and Sulzer D. Glial cell line-derived neurotrophic growth factor inhibits apoptotic death of postnatal substantia nigra dopamine neurons in primary culture. J Neurochem 71 (1998) 517-525
7. Castren E. Is mood chemistry?. Nat Rev Neurosci 6 (2005) 241-246
8. Cotter D., Mackay D., Landau S., Kerwin R., and Everall I. Reduced glial cell density and neuronal size in the anterior cingulate cortex in major depressive disorder. Arch Gen Psychiatry 58 (2001) 545-553
9. Cremer H., Lange R., Christoph A., Plomann M., Vopper G., Roes J., et al. Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature 367 (1994) 455-459
10. Dahme M., Bartsch U., Martini R., Anliker B., Schachner M., and Mantei N. Disruption of the mouse L1 gene leads to malformations of the nervous system. Nat Genet 17 (1997) 346-349
11. de Kloet E.R., Vreugdenhil E., Oitzl M.S., and Joels M. Brain corticosteroid receptor balance in health and disease. Endocr Rev 19 (1998) 269-301
12. Drevets W.C. Neuroimaging abnormalities in the amygdala in mood disorders. Ann NY Acad Sci 985 (2003) 420-424
13. Drevets W.C., Price J.L., Simpson Jr. J.R., Todd R.D., Reich T., Vannier M., et al. Subgenual prefrontal cortex abnormalities in mood disorders. Nature 386 (1997) 824-827
14. Feng Z., Li L., Ng P.Y., and Porter A.G. Neuronal differentiation and protection from nitric oxide-induced apoptosis require c-Jun-dependent expression of NCAM140. Mol Cell Biol 22 (2002) 5357-5366
15. Forlenza M.J., and Miller G.E. Increased serum levels of 8-hydroxy-2'-deoxyguanosine in clinical depression. Psychosom Med 68 (2006) 1-7
16. Fransen E., D'Hooge R., Van Camp G., Verhoye M., Sijbers J., Reyniers E., et al. L1 knockout mice show dilated ventricles, vermis hypoplasia and impaired exploration patterns. Hum Mol Genet 7 (1998) 999-1009
17. Gass P., Reichardt H.M., Strekalova T., Henn F., and Tronche F. Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: models for depression and anxiety?. Physiol Behav 73 (2001) 811-825
18. Gennarini G., Hirsch M.R., He H.T., Hirn M., Finne J., and Goridis C. Differential expression of mouse neural cell-adhesion molecule (N-CAM) mRNA species during brain development and in neural cell lines. J Neurosci 6 (1986) 1983-1990
19. Grant N.J., Claudepierre T., Aunis D., and Langley K. Glucocorticoids and nerve growth factor differentially modulate cell adhesion molecule L1 expression in PC12 cells. J Neurochem 66 (1996) 1400-1408
20. He H.T., Barbet J., Chaix J.C., and Goridis C. Phosphatidylinositol is involved in the membrane attachment of NCAM-120, the smallest component of the neural cell adhesion molecule. EMBO J 5 (1986) 2489-2494
21. Hemperly J.J., DeGuglielmo J.K., and Reid R.A. Characterization of cDNA clones defining variant forms of human neural cell adhesion molecule N-CAM. J Mol Neurosci 2 (1990) 71-78
22. Hemperly J.J., Edelman G.M., and Cunningham B.A. cDNA clones of the neural cell adhesion molecule (N-CAM) lacking a membrane-spanning region consistent with evidence for membrane attachment via a phosphatidylinositol intermediate. Proc Natl Acad Sci U S A 83 (1986) 9822-9826
23. Heuser I.J., Schweiger U., Gotthardt U., Schmider J., Lammers C.H., Dettling M., et al. Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and normal comparison subjects. Am J Psychiatry 153 (1996) 93-99
24. Holsboer F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23 (2000) 477-501
25. Ivanova S.A., Semke V.Y., Vetlugina T.P., Rakitina N.M., Kudyakova T.A., and Simutkin G.G. Signs of apoptosis of immunocompetent cells in patients with depression. Neurosci Behav Physiol 37 (2007) 527-530
26. Kallunki P., Edelman G.M., and Jones F.S. Tissue-specific expression of the L1 cell adhesion molecule is modulated by the neural restrictive silencer element. J Cell Biol 138 (1997) 1343-1354
27. Kiss J.Z., and Muller D. Contribution of the neural cell adhesion molecule to neuronal and synaptic plasticity. Rev Neurosci 12 (2001) 297-310
28. Knable M.B., Barci B.M., Webster M.J., Meador-Woodruff J., and Torrey E.F. Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9 544 (2004) 609-620
29. Laifenfeld D., Karry R., Grauer E., Klein E., and Ben-Shachar D. Antidepressants and prolonged stress in rats modulate CAM-L1, laminin, and pCREB, implicated in neuronal plasticity. Neurobiol Dis 20 (2005) 432-441
30. Laifenfeld D., Karry R., Klein E., and Ben-Shachar D. Alterations in cell adhesion molecule L1 and functionally related genes in major depression: a postmortem study. Biol Psychiatry 57 (2005) 716-725
31. Lampen A., Grimaldi P.A., and Nau H. Modulation of peroxisome proliferator-activated receptor delta activity affects neural cell adhesion molecule and polysialyltransferase ST8SiaIV induction by teratogenic valproic acid analogs in F9 cell differentiation. Mol Pharmacol 68 (2005) 193-203
32. Law J.W., Lee A.Y., Sun M., Nikonenko A.G., Chung S.K., Dityatev A., et al. Decreased anxiety, altered place learning, and increased CA1 basal excitatory synaptic transmission in mice with conditional ablation of the neural cell adhesion molecule L1. J Neurosci 23 (2003) 10419-10432
33. Martin K.C., and Kandel E.R. Cell adhesion molecules, CREB, and the formation of new synaptic connections. Neuron 17 (1996) 567-570
34. Matsubara T., Funato H., Kobayashi A., Nobumoto M., and Watanabe Y. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol Psychiatry 59 (2006) 689-695
35. McEwen B.S. Stress and hippocampal plasticity. Annu Rev Neurosci 22 (1999) 105-122
36. Murray B.A., Owens G.C., Prediger E.A., Crossin K.L., Cunningham B.A., and Edelman G.M. Cell surface modulation of the neural cell adhesion molecule resulting from alternative mRNA splicing in a tissue-specific developmental sequence. J Cell Biol 103 (1986) 1431-1439
37. Nelson M.D., Saykin A.J., Flashman L.A., and Riordan H.J. Hippocampal volume reduction in schizophrenia as assessed by magnetic resonance imaging: a meta-analytic study. Arch Gen Psychiatry 55 (1998) 433-440
38. Ongur D., Drevets W.C., and Price J.L. Glial reduction in the subgenual prefrontal cortex in mood disorders. Proc Natl Acad Sci U S A 95 (1998) 13290-13295
39. Paratcha G., Ledda F., and Ibanez C.F. The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands. Cell 113 (2003) 867-879
40. Pariante C.M., and Miller A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol Psychiatry 49 (2001) 391-404
41. Perlman W.R., Webster M.J., Kleinman J.E., and Weickert C.S. Reduced glucocorticoid and estrogen receptor alpha messenger ribonucleic acid levels in the amygdala of patients with major mental illness. Biol Psychiatry 56 (2004) 844-852
42. Pike J.L., and Irwin M.R. Dissociation of inflammatory markers and natural killer cell activity in major depressive disorder. Brain Behav Immun 20 (2006) 169-174
43. Plenge P., Mellerup E.T., and Jorgensen O.S. Lithium treatment regimens induce different changes in [3H]paroxetine binding protein and other rat brain proteins. Psychopharmacology (Berl) 106 (1992) 131-135
44. Poltorak M., Frye M.A., Wright R., Hemperly J.J., George M.S., Pazzaglia P.J., et al. Increased neural cell adhesion molecule in the CSF of patients with mood disorder. J Neurochem 66 (1996) 1532-1538
45. Ricard C.S., Pena J.D., and Hernandez M.R. Differential expression of neural cell adhesion molecule isoforms in normal and glaucomatous human optic nerve heads. Brain Res Mol Brain Res 74 (1999) 69-82
46. Roubin R., Deagostini-Bazin H., Hirsch M.R., and Goridis C. Modulation of NCAM expression by transforming growth factor-beta, serum, and autocrine factors. J Cell Biol 111 (1990) 673-684
47. Sadoul K., Meyer A., Low M.G., and Schachner M. Release of the 120 kDa component of the mouse neural cell adhesion molecule N-CAM from cell surfaces by phosphatidylinositol-specific phospholipase C. Neurosci Lett 72 (1986) 341-346
48. Sandi C. Stress, cognitive impairment and cell adhesion molecules. Nat Rev Neurosci 5 (2004) 917-930
49. Sandi C., Merino J.J., Cordero M.I., Touyarot K., and Venero C. Effects of chronic stress on contextual fear conditioning and the hippocampal expression of the neural cell adhesion molecule, its polysialylation, and L1. Neuroscience 102 (2001) 329-339
50. Sandi C., and Bisaz R. A model for the involvement of neural cell adhesion molecules in stress-related mood disorders. Neuroendocrinology 85 (2007) 158-176
51. Sapolsky R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry 57 (2000) 925-935
52. Schachner M. Neural recognition molecules and synaptic plasticity. Curr Opin Cell Biol 9 (1997) 627-634
53. Schoenherr C.J., and Anderson D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 267 (1995) 1360-1363
54. Schoenherr C.J., Paquette A.J., and Anderson D.J. Identification of potential target genes for the neuron-restrictive silencer factor. Proc Natl Acad Sci U S A 93 (1996) 9881-9886
55. Seidel A., Arolt V., Hunstiger M., Rink L., Behnisch A., and Kirchner H. Increased CD56+ natural killer cells and related cytokines in major depression. Clin Immunol Immunopathol 78 (1996) 83-85
56. Sheline Y.I., Sanghavi M., Mintun M.A., and Gado M.H. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 19 (1999) 5034-5043
57. Simpson C.S., and Morris B.J. Regulation of neuronal cell adhesion molecule expression by NF-kappa B. J Biol Chem 275 (2000) 16879-16884
58. Soares J.C., and Mann J.J. The anatomy of mood disorders-review of structural neuroimaging studies. Biol Psychiatry 41 (1997) 86-106
59. Stork O., Welzl H., Cremer H., and Schachner M. Increased intermale aggression and neuroendocrine response in mice deficient for the neural cell adhesion molecule (NCAM). Eur J Neurosci 9 (1997) 1117-1125
60. Stork O., Welzl H., Wotjak C.T., Hoyer D., Delling M., Cremer H., et al. Anxiety and increased 5-HT1A receptor response in NCAM null mutant mice. J Neurobiol 40 (1999) 343-355
61. Takebayashi M., Hisaoka K., Nishida A., Tsuchioka M., Miyoshi I., Kozuru T., et al. Decreased levels of whole blood glial cell line-derived neurotrophic factor (GDNF) in remitted patients with mood disorders. Int J Neuropsychopharmacol 9 (2006) 607-612
62. Thomas A.J., Davis S., Ferrier I.N., Kalaria R.N., and O'Brien J.T. Elevation of cell adhesion molecule immunoreactivity in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 55 (2004) 652-655
63. Thomas A.J., Ferrier I.N., Kalaria R.N., Davis S., and O'Brien J.T. Cell adhesion molecule expression in the dorsolateral prefrontal cortex and anterior cingulate cortex in major depression in the elderly. Br J Psychiatry 181 (2002) 129-134
64. Tomasiewicz H., Ono K., Yee D., Thompson C., Goridis C., Rutishauser U., et al. Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system. Neuron 11 (1993) 1163-1174
65. Torrey E.F., Barci B.M., Webster M.J., Bartko J.J., Meador-Woodruff J.H., and Knable M.B. Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains. Biol Psychiatry 57 (2005) 252-260
66. Touyarot K., and Sandi C. Chronic restraint stress induces an isoform-specific regulation on the neural cell adhesion molecule in the hippocampus. Neural Plast 9 (2002) 147-159
67. Vawter M.P. Dysregulation of the neural cell adhesion molecule and neuropsychiatric disorders. Eur J Pharmacol 405 (2000) 385-395
68. Vawter M.P., Freed W.J., and Kleinman J.E. Neuropathology of bipolar disorder. Biol Psychiatry 48 (2000) 486-504
69. Vawter M.P., Hemperly J.J., Hyde T.M., Bachus S.E., VanderPutten D.M., Howard A.L., et al. VASE-containing N-CAM isoforms are increased in the hippocampus in bipolar disorder but not schizophrenia. Exp Neurol 154 (1998) 1-11
70. Vawter M.P., Howard A.L., Hyde T.M., Kleinman J.E., and Freed W.J. Alterations of hippocampal secreted N-CAM in bipolar disorder and synaptophysin in schizophrenia. Mol Psychiatry 4 (1999) 467-475
71. Venero C., Tilling T., Hermans-Borgmeyer I., Schmidt R., Schachner M., and Sandi C. Chronic stress induces opposite changes in the mRNA expression of the cell adhesion molecules NCAM and L1. Neuroscience 115 (2002) 1211-1219
72. Watanabe Y., Gould E., and McEwen B.S. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 588 (1992) 341-345
73. Webster M.J., Knable M.B., O'Grady J., Orthmann J., and Weickert C.S. Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders. Mol Psychiatry 7 924 (2002) 985-994
74. Webster M.J., Vawter M.P., and Freed W.J. Immunohistochemical localization of the cell adhesion molecules Thy-1 and L1 in the human prefrontal cortex patients with schizophrenia, bipolar disorder, and depression. Mol Psychiatry 4 (1999) 46-52
75. Wright I.C., Rabe-Hesketh S., Woodruff P.W., David A.S., Murray R.M., and Bullmore E.T. Meta-analysis of regional brain volumes in schizophrenia. Am J Psychiatry 157 (2000) 16-25