Effect of bipolar disorder on lymphocyte inositol monophosphatase mRNA levels

International Journal of Neuropsychopharmacology

Volumn 2, Issue 1, 1999, Pages 25-29

  Nemanov, Lubov ^a   Ebstein, Richard P ^a   Belmaker, Robert H ^b   Osher, Yamima ^b   Agam, Galila ^b,c  

^a HERZOG HOSPITAL   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^c MINISTRY OF HEALTH   (Israel)

Author keywords

Bipolar disorder; Inositol monophosphatase; Lithium; Lymphoblastoid cells; mRNA

Indexed keywords

EID: 0001946814     PISSN: 14611457     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1461145799001315     Document Type: Article

References (16)

1. Agam G, Shimon H. (In Press). Evidence of the role of inositol in bipolar disorder and antibipolar treatment. In: Manji HK, Bowden CL, Belmaker RH (Eds.), Mechanisms of Action of Antibipolar Treatments. Washington, DC: American Psychiatric Press.
2. Banks RE, Aiton JF, Cramb G, Naylor GJ (1990). Incorporation of inositol into the phosphoinositides of lymphoblastoid cell lines established from bipolar manic-depressive patients. Journal of Affective Disorders 19, 1-8.
3. Berrettini WH, Ferraro TN, Goldin LR, et al. (1994). Chromosome 18 DNA markers and manic-depressive illness: evidence for a susceptibility gene. Proceedings of the National Academy of Sciences, USA 91, 5918-21.
4. Berridge MJ (1984). Inositol triphosphate and diacylglycerol as second messengers. Biochemistry Journal 220, 345-360.
5. Berridge MJ, Downes CP, Hanley MR (1982). Lithium amplifies agonist-dependent phosphatidylinositol responses in brain and salivary glands. Biochemistry Journal 206, 587-595.
6. Dixon JF, Hokin LE (1998). Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. Proceedings of the National Academy of Sciences, USA 95, 8363-8368.
7. Ebstein RP, Nemanov L, Lubarski G, Dano M, Trevis T, Korczyn A (1996). Changes in expression of lymphocyte amyloid precursor protein mRNA isoforms in normal aging and Alzheimer's disease. Molecular Brain Research 35, 260-268.
8. Hallcher LM, Sherman WR (1960). The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. Journal of Biological Chemistry 255, 10896-10901.
9. Honchar MP, Ackerman KE, Sherman WR (1989). Chronically administered lithium alters neither myo-inositol monophophosphatase activity nor phosphoinositide levels in rat brain. Journal of Neurochemistry 53, 590-594.
10. Horikoshi T, Danenberg KD, Stadlbauer THW, Volkenandt M, Shea LCC, Aigner K, Gustavsson B, Leichman L, Frosing R, Ray M, Gibson NW, Spears CP, Danenberg PV (1992). Quantitation of thymidylate synthetase, dihydrofolate reductase and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Research 52, 108-116.
11. Jope RS, Song L, Li PP, Young LT, Kish SJ, Pacheco MA, Warsh JJ (1996). The phosphoinositide signal transduction system is impaired in bipolar affective disorder brain. Journal of Neurochemistry 66, 2402-2409.
12. Manji HK, Potter WZ, Lenox RH (1995). Signal transduction pathways: Molecular targets for lithium's action. Archives of General Psychiatry 52, 531-543.
13. Renshaw PF, Jose NE, Leigh JS (1986). Chronic dietary lithium induces increased levels of myo-inositol-1-phosphatase activity in rat cerebral cortex homogenates. Brain Research 380, 401-404.
14. Shamir A, Ebstein RP, Nemanov L, Zohar A, Belmaker RH, Agam G. (1998). Inositol monophosphatase in immortalized lymphoblastoid cell lines indicates susceptibility to bipolar disorder and response to lithium therapy. Molecular Psychiatry 3, 481-482.
15. Sjoholt G, Molven A, Lovlie R, Wilcox A, Sikela JM, Steen VM (1997). Genomic structure and chromosomal localization of a human myo-inositol monophosphatase gene (IMPA). Genomics 45, 113-122.
16. Yoshikawa T, Turner G, Esterling LE, Sanders AR, Detera-Wadleigh SD (1997). A novel human myo-inositol monophosphatase gene, IMP.18p, maps to a susceptibility region for bipolar disorder. Molecular Psychiatry 2, 393-397.