TGF-β signaling in T cells is not essential for TH17 cell development in the mouse

Journal of Biological Regulators and Homeostatic Agents

Volumn 26, Issue 3, 2012, Pages 357-366

  Schumann, Julia ^a   Muller U ^a   Blessing, M ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Cytokines; T cell differentiation; TGF ; Th17 cells; Transgenic mouse models

Indexed keywords

LIPOPOLYSACCHARIDE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CELL STIMULATION; CONTROLLED STUDY; EX VIVO STUDY; EXPERIMENTAL MODEL; FEMALE; IN VITRO STUDY; LYMPHOCYTE COUNT; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH17 CELL; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; CELL DIFFERENTIATION; LIPOPOLYSACCHARIDES; MICE; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; TH1 CELLS; TH17 CELLS; TRANSFORMING GROWTH FACTOR BETA;

MURINAE; MUS MUSCULUS;

EID: 84868147277     PISSN: 0393974X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. Li MO, Wan YY, Sanjabi S, Robertson AK, Flavell RA. Transforming growth factor-beta regulation of immune responses. Annu Rev Immunol 2006; 24:99-146.
2. Wahl SM. TGF-βeta in the evolution and resolution of inflammatory and immune processes. Microbes Infect 1999; 1:1247-9.
3. Gorelik L, Constant S, Flavell RA. Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation. J Exp Med 2002; 195:1499-505. (Pubitemid 34602827)
4. Lin JT, Martin SL, Xia L, Gorham JD. TGF-βeta 1 uses distinct mechanisms to inhibit IFN-γamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J Immunol 2005; 174:5950-8. (Pubitemid 40663781)
5. Chen CH, Seguin-Devaux C, Burke NA, Oriss TB, Watkins SC, Clipstone N, Ray A. Transforming growth factor beta blocks Tec kinase phosphorylation, Ca2+ influx, and NFATc translocation causing inhibition of T cell differentiation. J Exp Med 2003; 197:1689-99. (Pubitemid 36745344)
6. Gorelik L, Fields PE, Flavell RA. Cutting edge: TGF-βeta inhibits Th type 2 development through inhibition of GATA-3 expression. J Immunol 2000; 165:4773-7.
7. Heath VL, Murphy EE, Crain C, Tomlinson MG, O'Garra A. TGF-βeta1 down-regulates Th2 development and results in decreased IL-4-induced STAT6 activation and GATA-3 expression. Eur J Immunol 2000; 30:2639-49.
8. Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, McGrady G, Wahl SM. Conversion of peripheral CD4+. J Exp Med 2003; 198:1875-86.
9. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 2006;24:179-89. (Pubitemid 43214587)
10. Mangan PR, Harrington LE, O'Quinn DB, et al. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature 2006; 441:231-4.
11. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, Oukka M, Weiner HL, Kuchroo VK. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006; 441:235-8.
12. Chen Z, Tato CM, Muul L, Laurence A, O'Shea JJ. Distinct regulation of interleukin-17 in human T helper lymphocytes. Arthritis Rheum 2007; 56:2936-46. (Pubitemid 47502740)
13. Wilson NJ, Boniface K, Chan JR, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat Immunol 2007; 8:950-7.
14. Acosta-Rodriguez EV, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 2007; 8:942-9. (Pubitemid 47300008)
15. Manel N, Unutmaz D, Littman DR. The differentiation of human T(H)-17 cells requires transforming growth factor-beta and induction of the nuclear receptor RORgammat. Nat Immunol 2008; 9:641-9. (Pubitemid 351714729)
16. Annunziato F, Cosmi L, Liotta F, Maggi E, Romagnani S. Human Th17 cells: Are they different from murine Th17 cells? European Journal of Immunology 2009; 39:637-40.
17. Das J, Ren G, Zhang L, et al. Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation. J Exp Med 2009; 206:2407-16.
18. Ghoreschi K, Laurence A, Yang XP, et al. Generation of pathogenic T(H)17 cells in the absence of TGF-βeta signalling. Nature 2010; 467:967-71.
19. Schramm C, Huber S, Protschka M, et al. TGFbeta regulates the CD4+CD25+ T-cell pool and the expression of Foxp3 in vivo. Int Immunol 2004; 16:1241-9. (Pubitemid 39220423)
20. Schramm C, Protschka M, Kohler HH, et al. Impairment of TGF-βeta signaling in T cells increases susceptibility to experimental autoimmune hepatitis in mice. Am J Physiol Gastrointest Liver Physiol 2003; 284:G525-G535. (Pubitemid 36227901)
21. Knauer J, Siegemund S, Muller U, Al-Robaiy S, Kastelein RA, Alber G, Straubinger RK. Borrelia burgdorferi potently activates bone marrow-derived conventional dendritic cells for production of IL-23 required for IL-17 release by T cells. FEMS Immunol Med Microbiol 2007; 49:353-63. (Pubitemid 46435013)
22. Cua DJ, Kastelein RA. TGF-βeta, a 'double agent' in the immune pathology war. Nat Immunol 2006; 7:557-9. (Pubitemid 43797335)
23. Datto MB, Frederick JP, Pan L, Borton AJ, Zhuang Y, Wang XF. Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction. Mol Cell Biol 1999; 19:2495-504. (Pubitemid 29144493)
24. Veldhoen M, Hocking RJ, Flavell RA, Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 2006; 7:1151-6. (Pubitemid 44594310)
25. Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity 2000; 12:171-81. (Pubitemid 30398631)
26. Pearce EJ, Kane CM, Sun J. Regulation of dendritic cell function by pathogen-derived molecules plays a key role in dictating the outcome of the adaptive immune response. Chem Immunol Allergy 2006; 90:82-90. (Pubitemid 43265669)
27. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, Barillot E, Soumelis V. A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 2008; 9:650-7. (Pubitemid 351712635)
28. Phillips DJ. Activins, inhibins and follistatins in the large domestic species. Domest Anim Endocrinol 2005; 28:1-16. (Pubitemid 40020313)
29. Yu EW, Dolter KE, Shao LE, Yu J. Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. Clin Exp Immunol 1998; 112:126-32. (Pubitemid 28157109)
30. Ota F, Maeshima A, Yamashita S, et al. Activin A induces cell proliferation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Rheum 2003; 48:2442-9. (Pubitemid 37129421)
31. Hubner G, Brauchle M, Gregor M, Werner S. Activin A: a novel player and inflammatory marker in inflammatory bowel disease? Lab Invest 1997; 77:311-8. (Pubitemid 27465593)
32. Smith C, Yndestad A, Halvorsen B, et al. Potential anti-inflammatory role of activin A in acute coronary syndromes. J Am Coll Cardiol 2004; 44:369-75. (Pubitemid 38950596)
33. Cho SH, Yao Z, Wang SW, Alban RF, Barbers RG, French SW, Oh CK. Regulation of activin A expression in mast cells and asthma: its effect on the proliferation of human airway smooth muscle cells. J Immunol 2003; 170:4045-52. (Pubitemid 36428166)
34. Matsuse T, Ikegami A, Ohga E, et al. Expression of immunoreactive activin A protein in remodeling lesions associated with interstitial pulmonary fibrosis. Am J Pathol 1996; 148:707-13. (Pubitemid 126660663)