Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies

Clinical and Experimental Immunology

Volumn 112, Issue 1, 1998, Pages 126-132

  Yu, E W ^a   Dolter, K E ^a   Shao, L E ^a   Yu, J ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Activin A; Anti inflammatory; Chondrocytes; IL 6; Synoviocytes

Indexed keywords

ACTIVIN A; GAMMA INTERFERON; GLUCOCORTICOID; INTERLEUKIN 1; INTERLEUKIN 6; INTERLEUKIN 8; RETINOIC ACID; TRANSFORMING GROWTH FACTOR BETA;

ARTHROPATHY; ARTICLE; CARTILAGE CELL; CELL STRAIN HEPG2; CONTROLLED STUDY; FIBRIN FORMATION; GOUT; HUMAN; HUMAN CELL; MONOCYTE; OSTEOARTHRITIS; PHAGOCYTOSIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYNOVIOCYTE;

ACTIVINS; ARTHRITIS, RHEUMATOID; CHONDROCYTES; HUMANS; INHIBINS; INTERFERON TYPE II; INTERLEUKIN-1; INTERLEUKIN-6; OSTEOARTHRITIS; SYNOVIAL FLUID; SYNOVIAL MEMBRANE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0031972131     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1998.00522.x     Document Type: Article

References (30)

1. Vale W, Hsueh A, Rivier C, Yu J. The inhibin/activin family of hormones and growth factor. Handbook Exp Pharmacol 1990; 95:211-48.
2. Ying S-Y, Zhang Z, Furst B, Batres Y, Huang G, Li G. Activins and activin receptors in cell growth. Proc Soc Exp Biol Med 1997; 214:114-22.
3. Shao LE, Frigon NL, JrSehy DW et al. Regulation of production of activin A in the human marrow stromal cells and monocytes. Exp Hematol 1992; 20:1235-42.
4. Meunier H, Rivier C, Evans RM, Vale W. Gonadal and extragonadal expression of inhibin alpha, beta A, and beta B subunits in various tissues predicts diverse functions. Proc Natl Acad Sci USA 1988; 85:247-51.
5. Mason AJ, Niall HD, Seeburg PH. Structure of two human ovarian inhibins. Biochem Biophys Res Commun 1986; 135:957-64.
6. Takahashi S, Uchimaru K, Harigaya K, Asano S, Yamashita T. Tumor necrosis factor and interleukin-1 induce activin A gene expression in a human bone marrow stromal cell line. Biochem Biophys Res Commun 1992; 188:310-7.
7. Yu J, Shao L-E, Frigon NL Jr, Lofgren J, Schwall R. Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid. Immunol 1996; 88:368-74.
8. Shao L-E, Frigon NL Jr, Yu A, Palyash J, Yu J. Contrasting effects of inflammatory cytokines and glucocorticoids on the production of activin A in human marrow stromal cells and their implications. 1997; Cytokine, in press.
9. Yu J, Dolter KE. Production of activin A and its roles in inflammation and haematopoiesis. Cytokines and Molec Therapy 1997; 3:169-77.
10. Kishimoto T. The biology of interleukin-6. Blood 1989; 74:1-10.
11. Akira S, Taga T, Kishimoto T. Interleukin-6 in biology and medicine. Adv Immunol 1993; 54:1-78.
12. Guerne P-A, Carson DA, Lotz M. IL-6 production by human articular chondrocytes: modulation of its synthesis by cytokines, growth factors, and hormones in vitro. J Immunol 1990; 144:499-505.
13. Guerne P-A, Zuraw BL, Vaughan JH, Carson DA, Lotz M. Synovium as a source of interleukin-6 in vitro: contribution to local and systemic manifestations of arthritis. J Clin Invest 1989; 83:585-92.
14. Mizel SB, Dayer JM, Krane SM, Mergenhagen SE. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte activating factor (interleukin-1). Proc Natl Acad Sci USA 1981; 78:2474-7.
15. 2 production by human synovial cells and dermal fibroblasts. J Exp Med 1985; 162:2163-8.
16. Gordon JL, Drummond AH, Galloway WA. Metalloproteinase inhibitors as therapeutics. Clin Exp Rheumatol 1993; 11:S91-S94.
17. Matrisian LM. Metalloproteinases and their inhibitors in matrix remodeling. Trends Genet 1990; 6:121-5.
18. Marquardt DW. The algorithm for least squares estimation of nonlinear parameters. J Soc Indust Appl Math 1963; 11:431-41.
19. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987; 162:156-9.
20. Carmichael J, DeGraff WG, Gasdar AF et al. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987; 47:936-42.
21. Wong WLT, Garg SJ, Woodruff T, Bald L, Fendly B, Lofgren JA. Monoclonal antibody based ELISAs for measurement of activins in biological fluids. J Immunol Methods 1993; 165:1-10.
22. Yu AW, Shao L-E, Frigon NL Jr, Yu J. Detection of functional and dimeric activin A in human marrow microenvironment: implications for the modulation of erythropoicsis. NY Acad Sci 1994; 718:285-99.
23. Revel M, Zilberstein A, Chen L et al. Biological activities of recombinant human IFN-b2/IL-6 (E. coli). In: Sehgal PB, Grieninger G, Tosato G. Regulation of the acute phase and immune responses: interleukin-6. New York: NY Acad Sci 1989:144-56.
24. Yu J, Shao L, Lemas V et al. Importance of FSH-releasing protein and inhihin in erythrodifferentiation. Nature 1987; 330:765-7.
25. Eto Y, Tsuji T, Takezawa M, Takano S, Yokogawa Y, Shibai H. Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1. Biochem Biophys Res Commun 1987; 142:1095-103.
26. Broxmeyer HE, Lu L, Cooper S, Schwall RH, Mason AJ, Nikolics K. Selective and indirect modulation of human multipotential and erythroid hematopoietic progenitor cell proliferation by recombinant human activin and inhibin. Proc Natl Acad Sci USA 1988; 85:9052-6.
27. Fong Y, Moldawer LL, Marano M et al. Endotoxemia elicits increased circulating beta 2-IFN/IL-6 in man. J Immunol 1989; 142:2321-4.
28. Brosh N, Sternberg D, Honigwachs-Sha'anani J et al. The plasmacytoma growth inhibitor restrictin-P is an antagonist of interleukin 6 and interleukin 11 - identification as a stroma-derivcd activin A. J Biol Chem 1995; 270:29594-600.
29. Nishihara T, Okahashi N, Ueda N. Activin A induces apoptotic cell death. Biochem Biophys Res Commun 1993; 197:985-91.
30. Hume M, Siljander P, Anttila H. Regulation of interleukin-1b production by glucocorticoids in human monocytes: the mechanism of action depends on the activation signal. Biochem Biophys Res Commun 1991; 180:1383-9.