IL-4 Haplotype -590T, -34T and Intron-3 VNTR R2 Is Associated with Reduced Malaria Risk among Ancestral Indian Tribal Populations

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Jha, Aditya Nath ^a   Singh, Vipin Kumar ^a   Kumari, Namrata ^a   Singh, Ashish ^a   Antony, Justin ^b   van Tong, Hoang ^b   Singh, Sakshi ^a   Pati, Sudhanshu S ^c   Patra, Pradeep K ^d   Singh, Rajender ^e   Toan, Nguyen L ^f   Song, Le H ^g   Assaf, Amal ^h   Messias Reason, Iara J T ⁱ   Velavan, Thirumalaisamy P ^b   Singh, Lalji ^a,j   Thangaraj, Kumarasamy ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ISPAT GENERAL HOSPITAL   (India)

^d Pt Jawaharlal Nehru Memorial Medical College   (India)

^e CENTRAL DRUG RESEARCH INSTITUTE   (India)

^f VIETNAM MILITARY MEDICAL UNIVERSITY   (Viet Nam)

^g Tran Hung Dao Hospital   (Viet Nam)

^h DAMASCUS UNIVERSITY   (Syrian Arab Republic)

ⁱ FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^j BANARAS HINDU UNIVERSITY   (India)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; DISEASE SEVERITY; ETHNIC DIFFERENCE; ETHNICITY; FEMALE; GENE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HAPLOTYPE; HOST SUSCEPTIBILITY; HUMAN; IL4 GENE; INDIAN; INFECTION RISK; INTRON; MAJOR CLINICAL STUDY; MALARIA; MALE; PLESIOMORPHY; POPULATION RESEARCH; RISK REDUCTION; VARIABLE NUMBER OF TANDEM REPEAT;

ADOLESCENT; ADULT; BASE SEQUENCE; BRAZIL; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INDIA; INTERLEUKIN-4; INTRONS; MALARIA, FALCIPARUM; MALE; MIDDLE AGED; MINISATELLITE REPEATS; MOLECULAR SEQUENCE DATA; RISK FACTORS; SEQUENCE HOMOLOGY, AMINO ACID; SYRIA; VIETNAM; YOUNG ADULT;

EID: 84868136462     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0048136     Document Type: Article

References (49)

1. Eid NA, Hussein AA, Elzein AM, Mohamed HS, Rockett KA, et al. (2010) Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. Malaria journal 9: 119.
2. Bairwa M, Rajput M, Khanna P, Rohilla R, Verma R, et al. (2012) Malaria vaccine: A bright prospect for elimination of malaria. Human vaccines & immunotherapeutics 8.
3. Driss A, Hibbert JM, Wilson NO, Iqbal SA, Adamkiewicz TV, et al. (2011) Genetic polymorphisms linked to susceptibility to malaria. Malaria journal 10: 271.
4. Stevenson MM, Riley EM, (2004) Innate immunity to malaria. Nature reviews Immunology 4: 169-180.
5. Hill AV, (1999) The immunogenetics of resistance to malaria. Proceedings of the Association of American Physicians 111: 272-277.
6. Fell AH, Currier J, Good MF, (1994) Inhibition of Plasmodium falciparum growth in vitro by CD4+ and CD8+ T cells from non-exposed donors. Parasite immunology 16: 579-586.
7. Gowda NM, Wu X, Gowda DC, (2012) TLR9 and MyD88 are crucial for the development of protective immunity to malaria. Journal of immunology 188: 5073-5085.
8. Gyan BA, Goka B, Cvetkovic JT, Kurtzhals JL, Adabayeri V, et al. (2004) Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children. Clinical and experimental immunology 138: 145-150.
9. Murphy KM, Reiner SL, (2002) The lineage decisions of helper T cells. Nature reviews Immunology 2: 933-944.
10. Guo L, Hu-Li J, Zhu J, Watson CJ, Difilippantonio MJ, et al. (2002) In TH2 cells the Il4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proceedings of the National Academy of Sciences of the United States of America 99: 10623-10628.
11. Banchereau J, Briere F, Galizzi JP, Miossec P, Rousset F, (1994) Human interleukin 4. Journal of lipid mediators and cell signalling 9: 43-53.
12. Cabantous S, Poudiougou B, Oumar AA, Traore A, Barry A, et al. (2009) Genetic evidence for the aggravation of Plasmodium falciparum malaria by interleukin 4. The Journal of infectious diseases 200: 1530-1539.
13. Tangteerawatana P, Pichyangkul S, Hayano M, Kalambaheti T, Looareesuwan S, et al. (2007) Relative levels of IL4 and IFN-gamma in complicated malaria: association with IL4 polymorphism and peripheral parasitemia. Acta tropica 101: 258-265.
14. Burke TF, Casolaro V, Georas SN, (2000) Characterization of P5, a novel NFAT/AP-1 site in the human IL-4 promoter. Biochemical and biophysical research communications 270: 1016-1023.
15. Rosenwasser LJ, Borish L, (1997) Genetics of atopy and asthma: the rationale behind promoter-based candidate gene studies (IL-4 and IL-10). American journal of respiratory and critical care medicine 156: S152-155.
16. Farouk SE, Dolo A, Bereczky S, Kouriba B, Maiga B, et al. (2005) Different antibody- and cytokine-mediated responses to Plasmodium falciparum parasite in two sympatric ethnic tribes living in Mali. Microbes and infection/Institut Pasteur 7: 110-117.
17. Luoni G, Verra F, Arca B, Sirima BS, Troye-Blomberg M, et al. (2001) Antimalarial antibody levels and IL4 polymorphism in the Fulani of West Africa. Genes and immunity 2: 411-414.
18. Verra F, Luoni G, Calissano C, Troye-Blomberg M, Perlmann P, et al. (2004) IL4-589C/T polymorphism and IgE levels in severe malaria. Acta tropica 90: 205-209.
19. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Friedhoff LR, et al. (1995) Total serum IgE levels and chromosome 5q. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology 25 Suppl 2: 79-83; discussion 95-76.
20. Rockman MV, Hahn MW, Soranzo N, Goldstein DB, Wray GA, (2003) Positive selection on a human-specific transcription factor binding site regulating IL4 expression. Current biology: CB 13: 2118-2123.
21. Hunt PJ, Marshall SE, Weetman AP, Bell JI, Wass JA, et al. (2000) Cytokine gene polymorphisms in autoimmune thyroid disease. The Journal of clinical endocrinology and metabolism 85: 1984-1988.
22. Nakashima H, Miyake K, Inoue Y, Shimizu S, Akahoshi M, et al. (2002) Association between IL-4 genotype and IL-4 production in the Japanese population. Genes and immunity 3: 107-109.
23. Perlmann H, Helmby H, Hagstedt M, Carlson J, Larsson PH, et al. (1994) IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria. Clinical and experimental immunology 97: 284-292.
24. Perlmann P, Perlmann H, Flyg BW, Hagstedt M, Elghazali G, et al. (1997) Immunoglobulin E, a pathogenic factor in Plasmodium falciparum malaria. Infection and immunity 65: 116-121.
25. Perlmann P, Perlmann H, Looareesuwan S, Krudsood S, Kano S, et al. (2000) Contrasting functions of IgG and IgE antimalarial antibodies in uncomplicated and severe Plasmodium falciparum malaria. The American journal of tropical medicine and hygiene 62: 373-377.
26. Kantarci OH, Schaefer-Klein JL, Hebrink DD, Achenbach SJ, Atkinson EJ, et al. (2003) A population-based study of IL4 polymorphisms in multiple sclerosis. Journal of neuroimmunology 137: 134-139.
27. Mittal RD, Manchanda PK, (2007) Association of interleukin (IL)-4 intron-3 and IL-6-174 G/C gene polymorphism with susceptibility to end-stage renal disease. Immunogenetics 59: 159-165.
28. Buchs N, Silvestri T, di Giovine FS, Chabaud M, Vannier E, et al. (2000) IL-4 VNTR gene polymorphism in chronic polyarthritis. The rare allele is associated with protection against destruction. Rheumatology 39: 1126-1131.
29. Vasudevan R, Norhasniza MN, Patimah I, (2011) Association of variable number of tandem repeats polymorphism in the IL-4 gene with end-stage renal disease in Malaysian patients. Genetics and molecular research: GMR 10: 943-947.
30. Reich D, Thangaraj K, Patterson N, Price AL, Singh L, (2009) Reconstructing Indian population history. Nature 461: 489-494.
31. Dhandapany PS, Sadayappan S, Xue Y, Powell GT, Rani DS, et al. (2009) A common MYBPC3 (cardiac myosin binding protein C) variant associated with cardiomyopathies in South Asia. Nature genetics 41: 187-191.
32. Thangaraj K, Joshi MB, Reddy AG, Gupta NJ, Chakravarty B, et al. (2002) CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations. Journal of andrology 23: 815-818.
33. Excoffier L, Laval G, Schneider S, (2005) Arlequin (version 3.0): an integrated software package for population genetics data analysis. Evolutionary bioinformatics online 1: 47-50.
34. Barrett JC, Fry B, Maller J, Daly MJ, (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: 263-265.
35. Beasley TM, Schumacker RE, (1995) Multiple Regression Approach to Analyzing Contingency Tables: Post Hoc and Planned Comparison Procedures. The Journal of Experimental Education 64: 79-93.
36. Vafa M, Maiga B, Berzins K, Hayano M, Bereczky S, et al. (2007) Associations between the IL-4-590 T allele and Plasmodium falciparum infection prevalence in asymptomatic Fulani of Mali. Microbes and infection/Institut Pasteur 9: 1043-1048.
37. Perlmann P, Perlmann H, ElGhazali G, Blomberg MT, (1999) IgE and tumor necrosis factor in malaria infection. Immunology letters 65: 29-33.
38. van der Heyde HC, Nolan J, Combes V, Gramaglia I, Grau GE, (2006) A unified hypothesis for the genesis of cerebral malaria: sequestration, inflammation and hemostasis leading to microcirculatory dysfunction. Trends in parasitology 22: 503-508.
39. Vigario AM, Belnoue E, Gruner AC, Mauduit M, Kayibanda M, et al. (2007) Recombinant human IFN-alpha inhibits cerebral malaria and reduces parasite burden in mice. Journal of immunology 178: 6416-6425.
40. Morrell CN, Srivastava K, Swaim A, Lee MT, Chen J, et al. (2011) Beta interferon suppresses the development of experimental cerebral malaria. Infection and immunity 79: 1750-1758.
41. Chang KH, Stevenson MM, (2004) Malarial anaemia: mechanisms and implications of insufficient erythropoiesis during blood-stage malaria. International journal for parasitology 34: 1501-1516.
42. McGuire W, Knight JC, Hill AV, Allsopp CE, Greenwood BM, et al. (1999) Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. The Journal of infectious diseases 179: 287-290.
43. Othoro C, Lal AA, Nahlen B, Koech D, Orago AS, et al. (1999) A low interleukin-10 tumor necrosis factor-alpha ratio is associated with malaria anemia in children residing in a holoendemic malaria region in western Kenya. The Journal of infectious diseases 179: 279-282.
44. Carvalho LH, Sano G, Hafalla JC, Morrot A, Curotto de Lafaille MA, et al. (2002) IL-4-secreting CD4+ T cells are crucial to the development of CD8+ T-cell responses against malaria liver stages. Nature medicine 8: 166-170.
45. Protzer U, Maini MK, Knolle PA, (2012) Living in the liver: hepatic infections. Nature reviews Immunology 12: 201-213.
46. Overstreet MG, Cockburn IA, Chen YC, Zavala F, (2008) Protective CD8 T cells against Plasmodium liver stages: immunobiology of an 'unnatural' immune response. Immunological reviews 225: 272-283.
47. Chakravarty S, Cockburn IA, Kuk S, Overstreet MG, Sacci JB, et al. (2007) CD8+ T lymphocytes protective against malaria liver stages are primed in skin-draining lymph nodes. Nature medicine 13: 1035-1041.
48. Schmidt NW, Podyminogin RL, Butler NS, Badovinac VP, Tucker BJ, et al. (2008) Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria. Proceedings of the National Academy of Sciences of the United States of America 105: 14017-14022.
49. Huber JP, Ramos HJ, Gill MA, Farrar JD, (2010) Cutting edge: Type I IFN reverses human Th2 commitment and stability by suppressing GATA3. Journal of immunology 185: 813-817.