CAG repeat expansion in the androgen receptor gene is not associated with male infertility in Indian populations

Journal of Andrology

Volumn 23, Issue 6, 2002, Pages 815-818

  Thangaraj, Kumarasamy ^a   Joshi, Manjunath B ^a   Reddy, Alla G ^a   Gupta, Nalini J ^b   Chakravarty, Baidyanath ^b   Singh, Lalji ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

^b Institute of Reproductive Medicine   (India)

Author keywords

Azoospermia; X chromosome

Indexed keywords

ANDROGEN RECEPTOR; CAGA PROTEIN;

ADOLESCENT; ADULT; ARTICLE; AZOOSPERMIA; CHILD; ETHNIC GROUP; GENE MAPPING; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HUMAN; INDIAN; MAJOR CLINICAL STUDY; MALE; MALE INFERTILITY; POPULATION RESEARCH; PRIORITY JOURNAL; PROTEIN MOTIF; RECEPTOR GENE; TANDEM REPEAT; TRANSACTIVATION; X CHROMOSOME;

ADENINE; CYTOSINE; GUANINE; HUMANS; INDIA; INFERTILITY, MALE; MALE; OLIGOSPERMIA; RECEPTORS, ANDROGEN; REFERENCE VALUES; TRINUCLEOTIDE REPEAT EXPANSION;

EID: 0036869078     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Adachi M, Takayanagi R, Tomura A, et al. Androgen-insensitivity syndrome as a possible coactivator disease. N Engl J Med. 2000;343:856-862.
2. Choong CS, Wilson EM. Trinucleotide repeats in the human androgen receptor: a molecular basis for disease. J Mol Endocrinol. 1998;21:235-257.
3. Cram DS, Song B, McLachlan RI, Trounson AO. CAG trinucleotide repeats in the androgen receptor gene of infertile men exhibit stable inheritance in female offspring conceived after ICSI. Mol Hum Reprod. 2000;6:861-866.
4. Dadze S, Wieland C, Jakubiczka S, Funke K, Schroder E, Royer-Pokora B, Willers R, Wieacker PF. The size of the CAG repeat in exon 1 of the androgen receptor gene show no significant relationship to impaired spermatogenesis in an infertile caucasoid sample of German origin. Mol Hum Reprod. 2000;6:207-214.
5. Dowsing AT, Yong EL, Clark M, McLachlan RI, De Krester DM, Trounson AO. Linkage between male infertility and trinucleotide repeat expansion in the androgen receptor gene. Lancet. 1999;354:640-643.
6. Fujisawa M, Shirakawa T, Kanzaki M, Okada H, Arakawa S, Kamidono S. Y-chromosome microdeletion and phenotype in cytogenetically normal men with idiopathic azoospermia. Fertil Steril. 2001;76:491- 495.
7. Giovannucci E, Stamper MJ, Kritnivas K, Brown M, Brufsky A, Talcott J, Hennekens CH, Kantoff PW. The CAG repeat within the androgen receptor gene and its relationship to prostate cancer. Proc Natl Acad Sci USA. 1997;94:3320-3323.
8. Haiman CA, Brown M, Hankinson SE, Spiegelman D, Colditz GA, Willett WC, Kantoff PW, Hunter DJ. The androgen receptor CAG repeats polymorphism and risk of breast cancer in the nurses' health study. Cancer Res. 2002;62:1045-1049.
9. La Spada AR, Wilson EM, Lubahn DB, Harding AE, Fischbeck KH. Androgen receptor gene mutation in X-linked spinal and bulbar muscular atrophy. Nature. 1991;352:77-79.
10. Lubhan DB, Joseph DR, Sullivan PM, Willard HF, Wilson EM. Cloning of the human androgen receptor complementary DNA and localization on the X chromosome. Science. 1988;240:327-330.
11. Meytes DER, Leffers H, Petersen JH, Andersen AG, Carisen E, Jorgensen N, Skakkebaek NE. CAG repeat length in androgen receptor gene and reproductive variables in fertile and infertile men. Lancet. 2002;359:44-46.
12. Mosher WD. Reproductive impairments in the United States, 1965-1982. Demography. 1985;22:415-430.
13. Patrizio P, Leonard DGB. Expansion of the CAG trinucleotide repeats in the androgen receptor gene and male infertility: a controversial association. J Androl. 2001;22:748.
14. Patrizio P, Leonard DGB, Chen K-L, Hernandez-Ayup S, Trounson AO, Larger trinucleotide repeat size in the androgen receptor gene of infertile men with extremely severe oligozoospermia. J Androl. 2001;22:444-448.
15. Sartor O, Zheng Q, Eastham JA. Androgen receptor gene CAG repeat length varies in a race specific fashion in men without prostate cancer. Urology. 1999;53:378-380.
16. Sasagawa I, Suzuki Y, Ashida J, Nakada T, Muroya K, Ogata T. CAG repeat length analysis and mutation screening of the androgen receptor gene in Japanese men with idiopathic azoospermia. J Androl. 2001;22:804-808.
17. Sasagawa I, Suzuki Y, Tateno T, Nakada T, Muroya K, Ogata T. CAG repeat length of the androgen receptor gene in Japanese males with cryptorchidism. Hum Mol Reprod. 2000;6:973-975.
18. Thangaraj K, Ramana GV, Singh L. Y-chromosome and mitochondrial DNA polymorphisms in Indian populations. Electrophoresis. 1999;20:1743-1747.
19. Tut TG, Ghadessy FJ, Trifiro MA, Pinsky L, Yong EL. Long polyglutamine tracts in the androgen receptor are associated with reduced transactivation, impaired sperm production and male infertility. J Clin Endocrinol Metab. 1997;82:3777-3782.
20. Yong EL, Ghadessy F, Wang Q, Mifsud A, Ng SC. Androgen receptor transactivation domain and control of spermatogenesis. Rev Reprod. 1998;3:141-144.
21. Yoshida KI, Yano M, Chiba K, Honda M, Kitahara S. CAG repeat length in the androgen receptor gene is enhanced in patients with idiopathic azoospermia. Urology. 1999;54:1078-1081.