Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles

Journal of Infectious Diseases

Volumn 179, Issue 1, 1999, Pages 287-290

  McGuire, William ^a   Knight, Julian C ^b   Hill, Adrian V S ^b   Allsopp, Catherine E M ^b   Greenwood, Brian M ^b   Kwiatkowski, Dominic ^b  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN; TUMOR NECROSIS FACTOR;

ANEMIA; ARTICLE; BRAIN MALARIA; CHILD; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; GAMBIA; HLA TYPING; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; PATHOGENESIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROMOTER REGION;

ALLELES; ANEMIA; BASE SEQUENCE; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DNA PRIMERS; GAMBIA; HLA ANTIGENS; HUMANS; MALARIA, CEREBRAL; MALARIA, FALCIPARUM; PROMOTER REGIONS (GENETICS); TUMOR NECROSIS FACTOR-ALPHA;

EID: 0032958707     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314533     Document Type: Article

References (15)

1. Greenwood BM, Marsh K, Snow R. Why do some African children develop severe malaria? Parasitol Today 1991;7:277-81.
2. Weatherall DJ. Haematologic manifestations of systemic diseases in children of the Third World. In: Nathan DG, Orkin SH, eds. Haematology of infancy and childhood. Philadelphia: WB Saunders, 1993:1886-904.
3. Abdalla S, Weatherall DJ, Wickramasinghe SN, Hughes M. The anaemia of P. falciparum malaria. Br J Haematol 1980;46:171-83.
4. Roodman GD, Bird A, Hutzler D, Montgomery W. Tumour necrosis factor-alpha and hematopoietic progenitors: effects of tumor necrosis factor on the growth of erythroid progenitors CFU-E and BFU-E and the hemopoietic cell lines K562, HL60, and HEL cells. Exp Haematol 1987;15:928-35.
5. Johnson RA, Waddelow TA, Caro J, Oliff A, Roodman GD. Chronic exposure to tumour necrosis factor in vivo preferentially inhibits erythropoiesis in nude mice. Blood 1989;74:130-8.
6. Clark IA, Chaudhri G. Tumour necrosis factor may contribute to the anaemia of malaria by causing dyserythropoiesis and erythrophagocytosis. Br J Haematol 1988;70:99-103.
7. Miller KL, Silverman PH, Kullgren B. Mahlmann LJ. Tumor necrosis factor-alpha and the anaemia associated with murine malaria. Infect Immun 1989;57:1542-6.
8. Taverne J, Sheikh N, de-Souza JB, Playfair JHL, Probert L, Kollias G. Anaemia and resistance to malaria in transgenic mice expressing human tumor necrosis factor. Immunology 1994;82:397-403.
9. Hill AVS. Allsopp CEM, Kwiatkowski D. et al. Common West African HLA antigens are associated with protection from severe malaria. Nature 1991;352:595-600.
10. Kwiatkowski D, Hill AVS, Sambou I, et al. TNF concentration in fatal cerebral, non-fatal cerebral, and uncomplicated Plasmodium falciparum malaria. Lancet 1990;336:1201-4.
11. McGuire W, Hill AVS, Allsopp CEM, Greenwood BM, Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature 1994;371:508-11.
12. D'Alfonso S, Richiardi PM. A polymorphic variation in a putative regulation box of the TNF-alpha promoter region. Immunogenetics 1994;39:150-4.
13. Drouet C, Shakhov AN, Jongeneel CV. Enhancers and transcription factors controlling the inducibility of human tumor necrosis factor-alpha promoter in primary macrophages. J Immunol 1991;147:1694-700.
14. Pociot F, D'Alfonso S, Compasso S, Scorza R, Richiardi PM. Functional analysis of a new polymorphism in the human TNF-alpha gene promoter. Scand J Immunol 1995;42:501-4.
15. Tsai EY, Yie J, Thanos D, Goldfeld AE. Cell-type specific regulation of the human tumor necrosis factor-alpha gene in B cells and T cells by NFATp and ATF-2/JUN. Mol Cell Biol 1996;16:5232-44.