Myeloid-Related Protein-14 Contributes to Protective Immunity in Gram-Negative Pneumonia Derived Sepsis

PLoS Pathogens

Volumn 8, Issue 10, 2012, Pages

  Achouiti, Ahmed ^a   Vogl, Thomas ^b   Urban, Constantin F ^c   Röhm, Marc ^c   Hommes, Tijmen J ^a   van Zoelen, Marieke A D ^a   Florquin, Sandrine ^a   Roth, Johannes ^b   van 't Veer, Cornelis ^a   de Vos, Alex F ^a   van der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOPLASM PROTEIN; HETERODIMER; MYELOID RELATED PROTEIN 14; MYELOID RELATED PROTEIN 8; UNCLASSIFIED DRUG; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BLOOD LEVEL; CHELATION; CONTROLLED STUDY; GRAM NEGATIVE SEPSIS; IN VITRO STUDY; INNATE IMMUNITY; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; LUNG; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; PROTEIN FUNCTION; SURVIVAL;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CALGRANULIN B; CELL LINE; HUMANS; KLEBSIELLA INFECTIONS; KLEBSIELLA PNEUMONIAE; LUNG; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUTROPHILS; PHAGOCYTOSIS; PNEUMONIA, BACTERIAL; SEPSIS;

BACTERIA (MICROORGANISMS); KLEBSIELLA; KLEBSIELLA PNEUMONIAE; MUS; NEGIBACTERIA;

EID: 84868136335     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1002987     Document Type: Article

References (57)

1. Kollef MH, Kollef KE, (2005) Antibiotic utilization and outcomes for patients with clinically suspected ventilator-associated pneumonia and negative quantitative BAL culture results. Chest 128: 2706-2713.
2. Podschun R, Ullmann U, (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11: 589-603.
3. Kang CI, Song JH, Chung DR, Peck KR, Ko KS, et al. (2011) Risk factors and pathogenic significance of severe sepsis and septic shock in 2286 patients with gram-negative bacteremia. J Infect 62: 26-33.
4. Shorr AF, Tabak YP, Killian AD, Gupta V, Liu LZ, et al. (2006) Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med 34: 2588-2595.
5. Giamarellou H, (2005) Multidrug resistance in Gram-negative bacteria that produce extended-spectrum beta-lactamases (ESBLs). Clin Microbiol Infect 11 (Suppl 4):: 1-16.
6. European Centre for Disease Prevention and Control (2011) Antimicrobial resistance surveillance in Europe 2010. Annual Report of the European Antimicrobial Resistance Surveillance Network (EARS-Net).
7. Chen GY, Nunez G, (2010) Sterile inflammation: sensing and reacting to damage. Nat Rev Immunol 10: 826-837.
8. Bianchi ME, (2007) DAMPs, PAMPs and alarmins: all we need to know about danger. J Leukoc Biol 81: 1-5.
9. Foell D, Wittkowski H, Vogl T, Roth J, (2007) S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 81: 28-37.
10. Ehrchen JM, Sunderkotter C, Foell D, Vogl T, Roth J, (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 86: 557-566.
11. Edgeworth J, Gorman M, Bennett R, Freemont P, Hogg N, (1991) Identification of p8,14 as a highly abundant heterodimeric calcium binding protein complex of myeloid cells. J Biol Chem 266: 7706-7713.
12. Leukert N, Vogl T, Strupat K, Reichelt R, Sorg C, et al. (2006) Calcium-dependent tetramer formation of S100A8 and S100A9 is essential for biological activity. J Mol Biol 359: 961-972.
13. Rammes A, Roth J, Goebeler M, Klempt M, Hartmann M, et al. (1997) Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway. J Biol Chem 272: 9496-9502.
14. Vogl T, Roth J, Sorg C, Hillenkamp F, Strupat K, (1999) Calcium-induced noncovalently linked tetramers of MRP8 and MRP14 detected by ultraviolet matrix-assisted laser desorption/ionization mass spectrometry. J Am Soc Mass Spectrom 10: 1124-1130.
15. Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, et al. (2007) Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med 13: 1042-1049.
16. van Zoelen MA, Vogl T, Foell D, Van Veen SQ, van Till JW, et al. (2009) Expression and role of myeloid-related protein-14 in clinical and experimental sepsis. Am J Respir Crit Care Med 180: 1098-1106.
17. Vandal K, Rouleau P, Boivin A, Ryckman C, Talbot M, et al. (2003) Blockade of S100A8 and S100A9 suppresses neutrophil migration in response to lipopolysaccharide. J Immunol 171: 2602-2609.
18. Ryckman C, McColl SR, Vandal K, de MR, Lussier A, et al. (2003) Role of S100A8 and S100A9 in neutrophil recruitment in response to monosodium urate monohydrate crystals in the air-pouch model of acute gouty arthritis. Arthritis Rheum 48: 2310-2320.
19. Ryckman C, Vandal K, Rouleau P, Talbot M, Tessier PA, (2003) Proinflammatory activities of S100: proteins S100A8, S100A9, and S100A8/A9 induce neutrophil chemotaxis and adhesion. J Immunol 170: 3233-3242.
20. Raquil MA, Anceriz N, Rouleau P, Tessier PA, (2008) Blockade of antimicrobial proteins S100A8 and S100A9 inhibits phagocyte migration to the alveoli in streptococcal pneumonia. J Immunol 180: 3366-3374.
21. Lusitani D, Malawista SE, Montgomery RR, (2003) Calprotectin, an abundant cytosolic protein from human polymorphonuclear leukocytes, inhibits the growth of Borrelia burgdorferi. Infect Immun 71: 4711-4716.
22. Corbin BD, Seeley EH, Raab A, Feldmann J, Miller MR, et al. (2008) Metal chelation and inhibition of bacterial growth in tissue abscesses. Science 319: 962-965.
23. Kehl-Fie TE, Chitayat S, Hood MI, Damo S, Restrepo N, et al. (2011) Nutrient metal sequestration by calprotectin inhibits bacterial superoxide defense, enhancing neutrophil killing of Staphylococcus aureus. Cell Host Microbe 10: 158-164.
24. Urban CF, Ermert D, Schmid M, Abu-Abed U, Goosmann C, et al. (2009) Neutrophil extracellular traps contain calprotectin, a cytosolic protein complex involved in host defense against Candida albicans. PLoS Pathog 5: e1000639.
25. Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, et al. (2004) Neutrophil extracellular traps kill bacteria. Science 303: 1532-1535.
26. Papayannopoulos V, Zychlinsky A, (2009) NETs: a new strategy for using old weapons. Trends Immunol 30: 513-521.
27. Bianchi M, Niemiec MJ, Siler U, Urban CF, Reichenbach J, (2011) Restoration of anti-Aspergillus defense by neutrophil extracellular traps in human chronic granulomatous disease after gene therapy is calprotectin-dependent. J Allergy Clin Immunol 127: 1243-1252.
28. Manitz MP, Horst B, Seeliger S, Strey A, Skryabin BV, et al. (2003) Loss of S100A9 (MRP14) results in reduced interleukin-8-induced CD11b surface expression, a polarized microfilament system, and diminished responsiveness to chemoattractants in vitro. Mol Cell Biol 23: 1034-1043.
29. Hobbs JA, May R, Tanousis K, McNeill E, Mathies M, et al. (2003) Myeloid cell function in MRP-14 (S100A9) null mice. Mol Cell Biol 23: 2564-2576.
30. Nacken W, Mooren FC, Manitz MP, Bode G, Sorg C, et al. (2005) S100A9 deficiency alters adenosine-5′-triphosphate induced calcium signalling but does not generally interfere with calcium and zinc homeostasis in murine neutrophils. Int J Biochem Cell Biol 37: 1241-1253.
31. Mizgerd JP, (2008) Acute lower respiratory tract infection. N Engl J Med 358: 716-727.
32. Opitz B, van L V, Eitel J, Suttorp N, (2010) Innate immune recognition in infectious and noninfectious diseases of the lung. Am J Respir Crit Care Med 181: 1294-1309.
33. Tsai WC, Strieter RM, Wilkowski JM, Bucknell KA, Burdick MD, et al. (1998) Lung-specific transgenic expression of KC enhances resistance to Klebsiella pneumoniae in mice. J Immunol 161: 2435-2440.
34. Ye P, Rodriguez FH, Kanaly S, Stocking KL, Schurr J, et al. (2001) Requirement of interleukin 17 receptor signaling for lung CXC chemokine and granulocyte colony-stimulating factor expression, neutrophil recruitment, and host defense. J Exp Med 194: 519-527.
35. Viemann D, Strey A, Janning A, Jurk K, Klimmek K, et al. (2005) Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood 105: 2955-2962.
36. Rijneveld AW, Weijer S, Florquin S, Esmon CT, Meijers JC, et al. (2004) Thrombomodulin mutant mice with a strongly reduced capacity to generate activated protein C have an unaltered pulmonary immune response to respiratory pathogens and lipopolysaccharide. Blood 103: 1702-1709.
37. Wieland CW, van Lieshout MH, Hoogendijk AJ, van der Poll T, (2011) Host defence during Klebsiella pneumonia relies on haematopoietic-expressed Toll-like receptors 4 and 2. Eur Respir J 37: 848-857.
38. Renckens R, Roelofs JJ, Bonta PI, Florquin S, de Vries CJ, et al. (2007) Plasminogen activator inhibitor type 1 is protective during severe Gram-negative pneumonia. Blood 109: 1593-1601.
39. Simard JC, Simon MM, Tessier PA, Girard D, (2011) Damage-associated molecular pattern S100A9 increases bactericidal activity of human neutrophils by enhancing phagocytosis. J Immunol 186: 3622-3631.
40. Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A, (2010) Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol 191: 677-691.
41. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, et al. (2006) Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 34: 1589-1596.
42. Mebius RE, Kraal G, (2005) Structure and function of the spleen. Nat Rev Immunol 5: 606-616.
43. BENACERRAF B, SEBESTYEN MM, SCHLOSSMAN S, (1959) A quantitative study of the kinetics of blood clearance of P32-labelled Escherichia coli and Staphylococci by the reticuloendothelial system. J Exp Med 110: 27-48.
44. Gregory SH, Wing EJ, (2002) Neutrophil-Kupffer cell interaction: a critical component of host defenses to systemic bacterial infections. J Leukoc Biol 72: 239-248.
45. Hirakata Y, Tomono K, Tateda K, Matsumoto T, Furuya N, et al. (1991) Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia. Infect Immun 59: 289-294.
46. Gregory SH, Sagnimeni AJ, Wing EJ, (1996) Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils. J Immunol 157: 2514-2520.
47. Clark SR, Ma AC, Tavener SA, McDonald B, Goodarzi Z, et al. (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13: 463-469.
48. Clohessy PA, Golden BE, (1995) Calprotectin-mediated zinc chelation as a biostatic mechanism in host defence. Scand J Immunol 42: 551-556.
49. Simard JC, Girard D, Tessier PA, (2010) Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism. J Leukoc Biol 87: 905-914.
50. Dessing MC, Butter LM, Teske GJ, Claessen N, van der Loos CM, et al. (2010) S100A8/A9 is not involved in host defense against murine urinary tract infection. PLoS One 5: e13394.
51. Knapp S, Wieland CW, van ' V, Takeuchi O, Akira S, et al. (2004) Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense. J Immunol 172: 3132-3138.
52. Lammers AJ, de Porto AP, Florquin S, de Boer OJ, Bootsma HJ, et al. (2011) Enhanced vulnerability for Streptococcus pneumoniae sepsis during asplenia is determined by the bacterial capsule. Immunobiology 216: 863-870.
53. Wiersinga WJ, Wieland CW, Roelofs JJ, van der Poll T, (2008) MyD88 dependent signaling contributes to protective host defense against Burkholderia pseudomallei. PLoS One 3: e3494.
54. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, et al. (1999) Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162: 3749-3752.
55. Wiersinga WJ, Kager LM, Hovius JW, van der Windt GJ, de Vos AF, et al. (2010) Urokinase receptor is necessary for bacterial defense against pneumonia-derived septic melioidosis by facilitating phagocytosis. J Immunol 184: 3079-3086.
56. Hunter MJ, Chazin WJ, (1998) High level expression and dimer characterization of the S100 EF-hand proteins, migration inhibitory factor-related proteins 8 and 14. J Biol Chem 273: 12427-12435.
57. Ermert D, Urban CF, Laube B, Goosmann C, Zychlinsky A, et al. (2009) Mouse neutrophil extracellular traps in microbial infections. J Innate Immun 1: 181-193.