Bacteria in the Bloodstream Are Trapped in the Liver and Killed by Immigrating Neutrophils

Journal of Immunology

Volumn 157, Issue 6, 1996, Pages 2514-2520

  Gregory, Stephen H ^a,b   Sagnimeni, Athanasia J ^a   Wing, Edward J ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ARTICLE; BACTEREMIA; BACTERIAL COUNT; C57BL MOUSE; CELL MOTION; ENTEROBACTER INFECTION; EXTRACELLULAR SPACE; FEMALE; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; LISTERIA; LISTERIOSIS; LIVER; MICROBIOLOGY; MOUSE; NEUTROPHIL; PATHOLOGY; PHAGOCYTOSIS; STAPHYLOCOCCUS INFECTION; STREPTOCOCCUS INFECTION;

ANIMALS; BACTEREMIA; CELL MOVEMENT; COLONY COUNT, MICROBIAL; ESCHERICHIA COLI INFECTIONS; EXTRACELLULAR SPACE; FEMALE; KLEBSIELLA INFECTIONS; LISTERIA; LISTERIA INFECTIONS; LIVER; MICE; MICE, INBRED C57BL; NEUTROPHILS; PHAGOCYTOSIS; PNEUMOCOCCAL INFECTIONS; STAPHYLOCOCCAL INFECTIONS;

EID: 0030587153     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. 32-labelled Escherichia coli and staphylococci by the reticuloendothelial system. J. Exp. Med. 110:27.
2. Mackaness, G. B. 1962. Cellular resistance to infection. J. Exp. Med. 116:381.
3. Mims, C. A. 1987. The Pathogenesis of Infectious Disease. Academic Press, London, p. 105.
4. Brandborg, L. L., and I. S. Goldman. 1990. Bacterial and miscellaneous infections of the liver. In Hepatology: A Textbook of Liver Disease. D. Zakim and T. D. Boyer, eds. W. B. Saunders, Philadelphia, p. 1086.
5. North, R. J. 1974. T cell dependence of macrophage activation and mobilization during infection with Mycobacterium tuberculosis. Infect. Immun. 10:66.
6. Lepay, D. A., C. F. Nathan, R. M. Steinman, H. W. Murray, and Z. A. Cohn. 1985. Murine Kupffer cells. Mononuclear phagocytes deficient in the generation of reactive oxygen intermediates. J. Exp. Med. 161:1079.
7. Conlan, W., and R. North. 1993. Neutrophil-mediated lysis of infected hepatocytes: selective lysis of permissive host cells is a strategy for controlling intracellular infection in the liver parenchyma. ASM News 59:563.
8. Klein, A., M. Zhadkewich, J. Margolick, J. Winkelstein, and G. Bulkley. 1994. Quantitative discrimination of hepatic reticuloendothelial clearance and phagocytic killing. J. Leukocyte Biol. 55:248.
9. Dramsi, S., I. Biswas, E. Maguin, L. Braun, P. Mastroeni, and P. Cossart. 1995. Entry of Listeria monocytogenes into hepatocytes requires expression of InlB, a surface protein of the internalin multigene family. Mol. Microbiol. 16:251.
10. Hirakata, Y., K. Tomono, K. Tateda, T. Matsumoto, N. Furuya, K. Shimoguchi, M. Kaku, and K. Yamaguchi. 1991. Role of bacterial association with Kupffer cells in occurrence of endogenous systemic bacteremia. Infect. Immun. 59:289.
11. Friedman, R. L., and R. J. Moon. 1980. Role of Kupffer cells, complement, and specific antibody in the bactericidal activities of perfused livers. Infect. Immun. 29:152.
12. Friedman, R. L,., and R. J. Moon. 1977. Hepatic clearance of Salmonella typhimurium in silica-treated mice. Infect. Immun. 16:1005.
13. Kongshavn, P. A. L., K. Shaw, E. Ghadirian, and O. Ulczak. 1990. Failure to demonstrate a major role for Kupffer cells and radiosensitive leukocytes in immunoglobulin-mediated elimination of Trypanosoma musculi. Infect. Immun. 58:1971.
14. Jones, D. 1990. Foodborne listeriosis. Lancet 336:1171
15. Schuchat, A., K. A. Deaver, J. D. Wenger, B. D. Plikaytis, L. Mascola, R. W. Pinner, A. L. Reingold, and C. V. Broome. 1992. Role of foods in sporadic listeriosis. I. Case-control study of dietary risk factors. JAMA 267:2041.
16. Kaufmann, S. H. E. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129.
17. Wing, E. J., A. Waheed, and R. K. Shadduck. 1984. Changes in serum colony stimulating factor (CSF) and monocytic progenitor cells during Listeria monocytogenes infection in mice. Infect. Immun. 45:180.
18. Wing, E. J. and D. Y. Kresefsky-Friedman. 1980. Decreased resistance to Listeria monocytogenes in mice injected with killed Corynebacterium parvum: association with suppression of cell-mediated immunity. J. Infect. Dis. 141:203.
19. Gregory, S. H., L. K. Barczynski, and E. J. Wing. 1992. Effector function of hepatocytes and Kupffer cells in the resolution of systemic bacterial infections. J. Leukocyte Biol. 51:421.
20. Gregory, S. H , and E. J. Wing. 1993. IFN-gamma inhibits the replication of Listeria monocytogenes in hepatocytes. J. Immunol. 151:1401.
21. Kuo, C., C. Changchien, C. Yang, J. Sheen, and Y. Liaw. 1991. Bacteremia in patients with cirrhosis of the liver. Liver 11:334.
22. Veterans Administration Systemic Sepsis Cooperative Study Group. 1987. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N. Engl. J. Med. 317:659.
23. Wisse, E., R. B. De Zanger, K. Charels, P. Van der Smissen, and R. S. McCuskey. 1985. The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse. Hepatology 5:683.
24. Ando, K., L. G. Guidotti, T. Ishikawa, and F. V. Chisari. 1994. CTL access to tissue antigen is restricted in vivo J. Immunol. 153:482.
25. Rosen, H., S. Gordon, and R. J. North. 1989. Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells: absence of monocytes at infective foci allows Listeria to multiply in nonphagocytic cells. J. Exp. Med. 170:27.
26. Conlan, J. W., and R. J. North. 1991. Neutrophil-mediated dissolution of infected host cells as a defense strategy against a facultative intracellular bacterium. J. Exp. Med. 174:741.
27. Czuprynski, C. J., J. F. Brown, R, D. Wagner, and H. Steinberg. 1994. Administration of antigranulocyte monoclonal antibody RB6-8C5 prevents expression of acquired resistance to Listeria monocytogenes infection in previously immunized mice. Infect. Immun. 62:5161.
28. Czuprynski, C. J., J. F. Brown, N. Maroushek. R. D. Wagner, and H. Steinberg. 1994. Administration of anti-granulocyte mab RB6-8C5 impairs the resistance of mice to Listeria monocytogenes infection. J. Immunol. 152:1836.
29. Rogers, H. W., and E. R. Unanue. 1993. Neutrophils are involved in acute, non-specific resistance to Listeria monocytogenes in mice. Infect. Immun. 61:5090.
30. Rakhmilevich, A. L. 1995. Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes. J. Leukocyte Biol. 57:827.
31. Appelberg, R., A. G. Castro, and M. T. Silva. 1994. Neutrophils as effector cells of T-cell-mediated, acquired immunity in murine listeriosis. Immunology 83:302.
32. Conlan, J. W., and R. J. North. 1994. Neutrophils are essential for early anti-Listeria defense in the liver, but not in the spleen or peritoneal cavity, as revealed by a granulocyte-depleting monoclonal antibody. J. Exp. Med. 179:259.
33. Conlan, J. W., and R. J. North. 1992. Early pathogenesis of infection in the liver with the facultative intracellular bacteria Listeria monocytogenes. Francisella tularensis, and Salmonella typhimurium involves lysis of infected hepatocytes by leukocytes. Infect. Immun. 60:5164.
34. Holman, J. M., and T. M. Seba. 1988. Hepatocyte injury during post-operative sepsis: activated neutrophils as potential mediators. J. Leukocyte Biol. 43:193.
35. Mavier, P., A.-M. Preaux, B. Guigui, M.-C. Lescs, E.-S. Zafrani, and D. Dhumeaux. 1988. In vitro toxicity of polymorphonuclear neutrophils to rat hepatocytes: evidence for a proteinase-mediated mechanism. Hepatology 8:254.
36. Doi, F., T. Goya, and M. Torisu. 1993. Potential role of hepatic macrophages in neutrophil-mediated liver injury in rats with sepsis. Hepatology 17:1086.
37. Farhood, A., G. M. McGuire, A. M. Manning, M. Miyasaka, C. W. Smith, and H. Jaeschke. 1995. Intercellular adhesion molecule 1 (ICAM-1) expression and its role in neutrophil-induced ischemia-reperfusion injury in rat liver. J. Leukocyte Biol. 57:368.
38. Rogers, H. W., M. P. Callery, B. Deck, and E. R. Unanue. 1996. Listeria monocytogenes induces apoptosis of infected hepatocytes. J. Immunol. 156:679.
39. Smith, J. A. 1994. Neutrophils, host defense, and inflammation: a double-edged sword. J. Leukocyte Biol. 56:672.
40. Bortolussi, R., C. M. J. E. Vandenbroucke-Grauls, B. S. van Asbeck, and J. Verhoef. 1987. Relationship of bacterial growth phase to killing of Listeria monocytogenes by oxidative agents generated by neutrophils and enzyme systems. Infect. Immun. 55:3197.
41. Czupryrski, C. J., P. A. Campbell, and P. M. Henson. 1983. Killing of Listeria monocytogenes by human neutrophils and monocytes, but not by monocyte-derived macrophages. J. Reticuloendothel. Soc. 34:29.
42. Alford, C. E., E. Amaral, and P. A. Campbell. 1990. Listericidal activity of human neutrophil cathepsin G. J. Gen. Microbiol. 136:997.
43. Lepay, D. A., R. M. Steinman, C. F. Nathan, H. W. Murray, and Z. A. Conn. 1985. Liver macrophages in murine listeriosis: cell-mediated immunity is correlated with an influx of macrophages capable of generating reactive oxygen intermediates. J. Exp. Med. 161:1503.
44. Perry, A., Y. Keisari, and I. Ofek. 1985. Liver cell and macrophage surface lectins as determinants of recognition in blood clearance and cellular attachment of bacteria. FEMS Microbiol. Lett. 27:345.
45. Perry, A., and I. Ofek. 1984. Inhibition of blood clearance and hepatic tissue binding of Escherichia coll by liver lectin-specific sugars and glycoproteins. Infect. Immun. 1984:257.
46. Ofek, I., and N. Sharon. 1988. Lectinophagocytosis: a molecular mechanism of recognition between cell surface sugars and lectins in the phagocytosis of bacteria. Infect. Immun. 56:539.
47. Leunk, R. D. F., and R. J. Moon. 1982. Association of type 1 pili with the ability of livers to clear Salmonella typhimurium. Infect. Immun. 36:1168.