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Volumn 26, Issue 10, 2012, Pages 4131-4141

Epithelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells

Author keywords

Chronic kidney disease; ERK; Tubulointerstitial fibrosis

Indexed keywords

COLLAGEN; MITOGEN ACTIVATED PROTEIN KINASE 1; NERVE CELL ADHESION MOLECULE; SMAD2 PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SNAIL1; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; VIMENTIN;

EID: 84868131612     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-207324     Document Type: Article
Times cited : (30)

References (48)
  • 2
    • 0019941790 scopus 로고
    • Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass
    • Olson, J. L., Hostetter, T. H., Rennke, H. G., Brenner, B. M., and Venkatachalam, M. A. (1982) Altered glomerular permselectivity and progressive sclerosis following extreme ablation of renal mass. Kidney Int. 22, 112-126
    • (1982) Kidney Int. , vol.22 , pp. 112-126
    • Olson, J.L.1    Hostetter, T.H.2    Rennke, H.G.3    Brenner, B.M.4    Venkatachalam, M.A.5
  • 5
    • 0026581465 scopus 로고
    • Increased glomerular filtration rate as a predictor of diabetic nephropathy-an 8-year prospective study
    • Rudberg, S., Persson, B., and Dahlquist, G. (1992) Increased glomerular filtration rate as a predictor of diabetic nephropathy-an 8-year prospective study. Kidney Int. 41, 822-828
    • (1992) Kidney Int. , vol.41 , pp. 822-828
    • Rudberg, S.1    Persson, B.2    Dahlquist, G.3
  • 6
    • 49649114844 scopus 로고    scopus 로고
    • Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes
    • Duan, Y., Gotoh, N., Yan, Q., Du, Z., Weinstein, A. M., Wang, T., and Weinbaum, S. (2008) Shear-induced reorganization of renal proximal tubule cell actin cytoskeleton and apical junctional complexes. Proc. Natl. Acad. Sci. U. S. A. 105, 11418-11423
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 11418-11423
    • Duan, Y.1    Gotoh, N.2    Yan, Q.3    Du, Z.4    Weinstein, A.M.5    Wang, T.6    Weinbaum, S.7
  • 8
    • 0034796171 scopus 로고    scopus 로고
    • Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells
    • Essig, M., Terzi, F., Burtin, M., and Friedlander, G. (2001) Mechanical strains induced by tubular flow affect the phenotype of proximal tubular cells. Am. J. Physiol. Renal Physiol. 281, F751-F762
    • (2001) Am. J. Physiol. Renal Physiol. , vol.281
    • Essig, M.1    Terzi, F.2    Burtin, M.3    Friedlander, G.4
  • 9
    • 84863049833 scopus 로고    scopus 로고
    • Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload
    • Meyer, A., Wang, W., Qu, J., Croft, L., Degen, J. L., Coller, B. S., and Ahamed, J. (2011) Platelet TGF-β1 contributions to plasma TGF-β1, cardiac fibrosis, and systolic dysfunction in a mouse model of pressure overload. Blood 119, 1064-1074
    • (2011) Blood , vol.119 , pp. 1064-1074
    • Meyer, A.1    Wang, W.2    Qu, J.3    Croft, L.4    Degen, J.L.5    Coller, B.S.6    Ahamed, J.7
  • 10
    • 84862907662 scopus 로고    scopus 로고
    • TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis
    • Lv, Z.-D., Wang, H.-B., Li, F.-N., Wu, L., Liu, C., Nie, G., Kong, B., Qu, H.-L., and Li, J.-G. (2012) TGF-β1 induces peritoneal fibrosis by activating the Smad2 pathway in mesothelial cells and promotes peritoneal carcinomatosis. Int. J. Mol. Med. 29, 373-379
    • (2012) Int. J. Mol. Med. , vol.29 , pp. 373-379
    • Lv, Z.-D.1    Wang, H.-B.2    Li, F.-N.3    Wu, L.4    Liu, C.5    Nie, G.6    Kong, B.7    Qu, H.-L.8    Li, J.-G.9
  • 11
    • 79959993387 scopus 로고    scopus 로고
    • Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis
    • Medina, C., Santos-Martinez, M. J., Santana, A., Paz-Cabrera, M. C., Johnston, M. J., Mourelle, M., Salas, A., and Guarner, F. (2011) Transforming growth factor-beta type 1 receptor (ALK5) and Smad proteins mediate TIMP-1 and collagen synthesis in experimental intestinal fibrosis. J. Pathol. 224, 461-472
    • (2011) J. Pathol. , vol.224 , pp. 461-472
    • Medina, C.1    Santos-Martinez, M.J.2    Santana, A.3    Paz-Cabrera, M.C.4    Johnston, M.J.5    Mourelle, M.6    Salas, A.7    Guarner, F.8
  • 12
    • 1642535424 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen i expression in response to transforming growth factor-β1
    • Runyan, C. E., Schnaper, H. W., and Poncelet, A.-C. (2004) The phosphatidylinositol 3-kinase/Akt pathway enhances Smad3-stimulated mesangial cell collagen I expression in response to transforming growth factor-β1. J. Biol. Chem. 279, 2632-2639
    • (2004) J. Biol. Chem. , vol.279 , pp. 2632-2639
    • Runyan, C.E.1    Schnaper, H.W.2    Poncelet, A.-C.3
  • 14
    • 79955087925 scopus 로고    scopus 로고
    • Sorafenib suppresses TGF-β1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes
    • Chen, Y.-L., Lv, J., Ye, X.-L., Sun, M.-Y., Xu, Q., Liu, C.-H., Min, L.-H., Xu, L.-M., Li, H.-P., Liu, P., and Ding, X. (2011) Sorafenib suppresses TGF-β1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology 53, 1708-1718
    • (2011) Hepatology , vol.53 , pp. 1708-1718
    • Chen, Y.-L.1    Lv, J.2    Ye, X.-L.3    Sun, M.-Y.4    Xu, Q.5    Liu, C.-H.6    Min, L.-H.7    Xu, L.-M.8    Li, H.-P.9    Liu, P.10    Ding, X.11
  • 15
    • 79956298314 scopus 로고    scopus 로고
    • Apoptotic role of TGF-β mediated by Smad4 mitochondria translocation and cytochrome c oxidase subunit II interaction
    • Pang, L., Qiu, T., Cao, X., and Wan, M. (2011) Apoptotic role of TGF-β mediated by Smad4 mitochondria translocation and cytochrome c oxidase subunit II interaction. Exp. Cell Res. 317, 1608-1620
    • (2011) Exp. Cell Res. , vol.317 , pp. 1608-1620
    • Pang, L.1    Qiu, T.2    Cao, X.3    Wan, M.4
  • 16
    • 35448997708 scopus 로고    scopus 로고
    • Transforming growth factor-β promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1
    • Ehata, S., Hanyu, A., Hayashi, M., Aburatani, H., Kato, Y., Fujime, M., Saitoh, M., Miyazawa, K., Imamura, T., and Miyazono, K. (2007) Transforming growth factor-β promotes survival of mammary carcinoma cells through induction of antiapoptotic transcription factor DEC1. Cancer Res. 67, 9694-9703
    • (2007) Cancer Res. , vol.67 , pp. 9694-9703
    • Ehata, S.1    Hanyu, A.2    Hayashi, M.3    Aburatani, H.4    Kato, Y.5    Fujime, M.6    Saitoh, M.7    Miyazawa, K.8    Imamura, T.9    Miyazono, K.10
  • 17
    • 0035196587 scopus 로고    scopus 로고
    • Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1
    • Shin, I., Bakin, A. V., Rodeck, U., Brunet, A., and Arteaga, C. L. (2001) Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol. Biol. Cell 12, 3328-3339
    • (2001) Mol. Biol. Cell , vol.12 , pp. 3328-3339
    • Shin, I.1    Bakin, A.V.2    Rodeck, U.3    Brunet, A.4    Arteaga, C.L.5
  • 19
    • 79959439429 scopus 로고    scopus 로고
    • Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: A model for diabetic podocytopathy
    • Herman-Edelstein, M., Thomas, M. C., Thallas-Bonke, V., Saleem, M., Cooper, M. E., and Kantharidis, P. (2011) Dedifferentiation of immortalized human podocytes in response to transforming growth factor-β: a model for diabetic podocytopathy. Diabetes 60, 1779-1788
    • (2011) Diabetes , vol.60 , pp. 1779-1788
    • Herman-Edelstein, M.1    Thomas, M.C.2    Thallas-Bonke, V.3    Saleem, M.4    Cooper, M.E.5    Kantharidis, P.6
  • 20
    • 34548145815 scopus 로고    scopus 로고
    • Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition
    • Zeisberg, M., Yang, C., Martino, M., Duncan, M. B., Rieder, F., Tanjore, H., and Kalluri, R. (2007) Fibroblasts derive from hepatocytes in liver fibrosis via epithelial to mesenchymal transition. J. Biol. Chem. 282, 23337-23347
    • (2007) J. Biol. Chem. , vol.282 , pp. 23337-23347
    • Zeisberg, M.1    Yang, C.2    Martino, M.3    Duncan, M.B.4    Rieder, F.5    Tanjore, H.6    Kalluri, R.7
  • 21
    • 79960243053 scopus 로고    scopus 로고
    • Characterization of fibroblasts recruited from bone marrow derived precursor in neonatal bronchopulmonary dysplasia (BPD) mice
    • Deng, C., Wang, J., Zou, Y., Zhao, Q., Feng, J., Fu, Z., and Guo, C. (2011) Characterization of fibroblasts recruited from bone marrow derived precursor in neonatal bronchopulmonary dysplasia (BPD) mice. J. Appl. Physiol. 111, 285-294
    • (2011) J. Appl. Physiol. , vol.111 , pp. 285-294
    • Deng, C.1    Wang, J.2    Zou, Y.3    Zhao, Q.4    Feng, J.5    Fu, Z.6    Guo, C.7
  • 23
    • 57149113728 scopus 로고    scopus 로고
    • Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney
    • Lin, S.-L., Kisseleva, T., Brenner, D. A., and Duffield, J. S. (2008) Pericytes and perivascular fibroblasts are the primary source of collagen-producing cells in obstructive fibrosis of the kidney. Am. J. Pathol. 173, 1617-1627
    • (2008) Am. J. Pathol. , vol.173 , pp. 1617-1627
    • Lin, S.-L.1    Kisseleva, T.2    Brenner, D.A.3    Duffield, J.S.4
  • 24
    • 24944554995 scopus 로고    scopus 로고
    • Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change
    • Kuusniemi, A.-M., Lapatto, R., Holmberg, C., Karikoski, R., Rapola, J., and Jalanko, H. (2005) Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change. Kidney Int. 68, 121-132
    • (2005) Kidney Int. , vol.68 , pp. 121-132
    • Kuusniemi, A.-M.1    Lapatto, R.2    Holmberg, C.3    Karikoski, R.4    Rapola, J.5    Jalanko, H.6
  • 26
    • 79957612245 scopus 로고    scopus 로고
    • High doses of TGF-β potently suppress type i collagen via the transcription factor CUX1
    • Fragiadaki, M., Ikeda, T., Witherden, A., Mason, R. M., Abraham, D., and Bou-Gharios, G. (2011) High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1. Mol. Biol. Cell 22, 1836-1844
    • (2011) Mol. Biol. Cell , vol.22 , pp. 1836-1844
    • Fragiadaki, M.1    Ikeda, T.2    Witherden, A.3    Mason, R.M.4    Abraham, D.5    Bou-Gharios, G.6
  • 29
    • 80053900365 scopus 로고    scopus 로고
    • Response of chondrocytes to shear stress: Antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1
    • Wang, P., Zhu, F., Tong, Z., and Konstantopoulos, K. (2011) Response of chondrocytes to shear stress: antagonistic effects of the binding partners Toll-like receptor 4 and caveolin-1. FASEB J. 25, 3401-3415
    • (2011) FASEB J. , vol.25 , pp. 3401-3415
    • Wang, P.1    Zhu, F.2    Tong, Z.3    Konstantopoulos, K.4
  • 30
    • 77955289199 scopus 로고    scopus 로고
    • Shear-induced interleukin-6 synthesis in chondrocytes: Roles of e prostanoid (EP) 2 and EP3 in cAMP/protein kinase A-and PI3-K/Akt-dependent NF-B activation
    • Wang, P., Zhu, F., Lee, N. H., and Konstantopoulos, K. (2010) Shear-induced interleukin-6 synthesis in chondrocytes: roles of E prostanoid (EP) 2 and EP3 in cAMP/protein kinase A-and PI3-K/Akt-dependent NF-B activation. J. Biol. Chem. 285, 24793-24804
    • (2010) J. Biol. Chem. , vol.285 , pp. 24793-24804
    • Wang, P.1    Zhu, F.2    Lee, N.H.3    Konstantopoulos, K.4
  • 31
    • 77954659915 scopus 로고    scopus 로고
    • Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases
    • Zhu, F., Wang, P., Kontrogianni-Konstantopoulos, A., and Konstantopoulos, K. (2010) Prostaglandin (PG)D(2) and 15-deoxy-Delta(12,14)-PGJ(2), but not PGE(2), mediate shear-induced chondrocyte apoptosis via protein kinase A-dependent regulation of polo-like kinases. Cell Death Differ. 17, 1325-1334
    • (2010) Cell Death Differ. , vol.17 , pp. 1325-1334
    • Zhu, F.1    Wang, P.2    Kontrogianni-Konstantopoulos, A.3    Konstantopoulos, K.4
  • 33
    • 0033848965 scopus 로고    scopus 로고
    • Shear stress-mediated NO production in inner medullary collecting duct cells
    • Cai, Z., Xin, J., Pollock, D. M., and Pollock, J. S. (2000) Shear stress-mediated NO production in inner medullary collecting duct cells. Am. J. Physiol. Renal Physiol. 279, F270-274
    • (2000) Am. J. Physiol. Renal Physiol. , vol.279
    • Cai, Z.1    Xin, J.2    Pollock, D.M.3    Pollock, J.S.4
  • 35
    • 79959666426 scopus 로고    scopus 로고
    • Adenovirus-mediated anti-sense ERK2 gene therapy inhibits tubular epithelial-mesenchymal transition and ameliorates renal allograft fibrosis
    • Ding, Z., Chen, Z., Chen, X., Cai, M., Guo, H., Chen, X., and Gong, N. (2011) Adenovirus-mediated anti-sense ERK2 gene therapy inhibits tubular epithelial-mesenchymal transition and ameliorates renal allograft fibrosis. Transpl. Immunol. 25, 34-41
    • (2011) Transpl. Immunol. , vol.25 , pp. 34-41
    • Ding, Z.1    Chen, Z.2    Chen, X.3    Cai, M.4    Guo, H.5    Chen, X.6    Gong, N.7
  • 37
    • 58049219746 scopus 로고    scopus 로고
    • Isolation of intrinsically active (MEKindependent) variants of the ERK family of mitogen-activated protein (MAP) kinases
    • Levin-Salomon, V., Kogan, K., Ahn, N. G., Livnah, O., and Engelberg, D. (2008) Isolation of intrinsically active (MEKindependent) variants of the ERK family of mitogen-activated protein (MAP) kinases. J. Biol. Chem. 283, 34500-34510
    • (2008) J. Biol. Chem. , vol.283 , pp. 34500-34510
    • Levin-Salomon, V.1    Kogan, K.2    Ahn, N.G.3    Livnah, O.4    Engelberg, D.5
  • 39
    • 33845981877 scopus 로고    scopus 로고
    • Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis
    • Takeji, M., Moriyama, T., Oseto, S., Kawada, N., Hori, M., Imai, E., and Miwa, T. (2006) Smooth muscle alpha-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis. J. Biol. Chem. 281, 40193-40200
    • (2006) J. Biol. Chem. , vol.281 , pp. 40193-40200
    • Takeji, M.1    Moriyama, T.2    Oseto, S.3    Kawada, N.4    Hori, M.5    Imai, E.6    Miwa, T.7
  • 40
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B. P., Deng, J., Xia, W., Xu, J., Li, Y. M., Gunduz, M., and Hung, M.-C. (2004) Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6, 931-940
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.-C.7
  • 42
    • 0034019315 scopus 로고    scopus 로고
    • Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades
    • Kholodenko, B. N. (2000) Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades. Eur. J. Biochem. 267, 1583-1588
    • (2000) Eur. J. Biochem. , vol.267 , pp. 1583-1588
    • Kholodenko, B.N.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.