High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1

Molecular Biology of the Cell

Volumn 22, Issue 11, 2011, Pages 1836-1844

  Fragiadaki, Maria ^a   Ikeda, Tetsurou ^a   Witherden, Abigail ^a   Mason, Roger M ^a   Abraham, David ^b   Bou Gharios, George ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARISTOLOCHIC ACID; COLLAGEN TYPE 1; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; SMAD2 PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR CUX1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE SILENCING; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; KIDNEY DISEASE; KIDNEY FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SKIN FIBROBLAST;

ANIMALS; ARISTOLOCHIC ACIDS; CELLS, CULTURED; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; FEEDBACK, PHYSIOLOGICAL; FIBROSIS; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; HUMANS; KIDNEY; KIDNEY DISEASES; MALE; MICE; MICE, INBRED C57BL; NUCLEAR PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROMOTER REGIONS, GENETIC; REPRESSOR PROTEINS; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION, GENETIC; TRANSFORMING GROWTH FACTOR BETA;

MURINAE;

EID: 79957612245     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-08-0669     Document Type: Article

References (39)

1. Barberis A, Superti-Furga G, Busslinger M (1987). Mutually exclusive interaction of the CCAAT-binding factor and of a displacement protein with overlapping sequences of a histone gene promoter. Cell 50, 347-359.
2. Bartram U, Speer CP (2004). The role of transforming growth factor beta in lung development and disease. Chest 125, 754-765. (Pubitemid 38223659)
3. Bou-Gharios G, Osman J, Black C, Olsen I (1994). Excess matrix accumulation in scleroderma is caused partly by differential regulation of stromelysin and TIMP-1 synthesis. Clin Chim Acta 231, 69-78. (Pubitemid 24372393)
4. Brantley JG, Sharma M, Alcalay NI, Heuvel GB (2003). Cux-1 transgenic mice develop glomerulosclerosis and interstitial fibrosis. Kidney Int 63, 1240-1248. (Pubitemid 36349989)
5. Cutroneo KR (2003). How is Type I procollagen synthesis regulated at the gene level during tissue fibrosis. J Cell Biochem 90, 1-5.
6. Czuwara-Ladykowska J, Shirasaki F, Jackers P, Watson DK, Trojanowska M (2001). Fli-1 inhibits type I collagen production in dermal fibroblasts via an Sp1-dependent pathway. J Biol Chem 276, 20839-20848.
7. Debelle FD et al. (2002). Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. J Am Soc Nephrol 13, 431-436. (Pubitemid 34106285)
8. Harada R, Berube G, Tamplin OJ, Denis-Larose C, Nepveu A (1995). DNA-binding specificity of the cut repeats from the human cut-like protein. Mol Cell Biol 15, 129-140. (Pubitemid 24379909)
9. Hasegawa T et al. (1996). Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter. Nucleic Acids Res 24, 3253-3260. (Pubitemid 26278569)
10. Hellman LM, Fried MG (2007). Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc 2, 1849-1861. (Pubitemid 47308124)
11. Higgy NA, Tarnasky HA, Valarche I, Nepveu A, Van Der Hoorn FA (1997). Cux/CDP homeodomain protein binds to an enhancer in the rat c-mos locus and represses its activity. Biochim Biophys Acta 135, 313-324. (Pubitemid 27158428)
12. Holmes A et al. (2001). CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem 276, 10594-10601. (Pubitemid 38089227)
13. Ihn H, Ihn Y, Trojanowska M (2001). Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression. J Invest Dermatol 117, 301-308. (Pubitemid 34205715)
14. Ihn H, Trojanowska M (1997). Sp3 is a transcriptional activator of the human alpha2(I) collagen gene. Nucleic Acids Res 25, 3712-3717. (Pubitemid 27390193)
15. Inagaki Y, Truter S, Ramirez F (1994). Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J Biol Chem 269, 14828-14834.
16. Jack J, Dorsett D, Delotto Y, Liu S (1991). Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer. Development 113, 735-747. (Pubitemid 21900313)
17. Kim EC, Lau JS, Rawlings S, Lee AS (1997). Positive and negative regulation of the human thymidine kinase promoter mediated by CCAAT binding transcription factors NF-Y/CBF, dbpA, and CDP/cut. Cell Growth Differ 8, 1329-1338. (Pubitemid 28008729)
18. Li J et al. (2007). Protein kinase C-mediated modulation of FIH-1 expression by the homeodomain protein CDP/Cut/Cux. Mol Cell Biol 27, 7345-7353. (Pubitemid 47549766)
19. Li J et al. (2009). TGF-beta 1/Smads signaling stimulates renal interstitial fibrosis in experimental AAN. J Recept Signal Transduct Res 29, 280-285.
20. Liu S, McLeod E, Jack J (1991). Four distinct regulatory regions of the cut locus and their effect on cell type specification in Drosophila. Genetics 127, 151-159.
21. Maity SN, Golumbek PT, Karsenty G, de Crombrugghe B (1988). Selective activation of transcription by a novel CCAAT binding factor. Science 241, 582-585.
22. Michl P et al. (2005). CUTL1 is a target of TGF(beta) signaling that enhances cancer cell motility and invasiveness. Cancer Cell 7, 521-532. (Pubitemid 40799246)
23. Nepveu A (2001). Role of the multifunctional CDP/Cut/Cux homeodomain transcription factor in regulating differentiation, cell growth and development. Gene 270, 1-15.
24. Pacheco-Sanchez M, Boutin Y, Angers P, Gosselin A, Tweddell RJ (2007). Inhibitory effect of CDP, a polysaccharide extracted from the mushroom Collybia dryophila, on nitric oxide synthase expression and nitric oxide production in macrophages. Eur J Pharmacol 555, 61-66. (Pubitemid 46019811)
25. Ponticos M, Harvey C, Ikeda T, Abraham D, Bou-Gharios G (2009). JunB mediates enhancer/promoter activity of COL1A2 following TGF-β induction. Nucleic Acids Res .
26. Postlethwaite AE, Shigemitsu H, Kanangat S (2004). Cellular origins of fibroblasts: possible implications for organ fibrosis in systemic sclerosis. Curr Opin Rheumatol 16, 733-738. (Pubitemid 39425547)
27. Sansregret L, Nepveu A (2008). The multiple roles of CUX1: insights from mouse models and cell-based assays. Gene 412, 84-94.
28. Sato N et al. (2004). Acute nephrotoxicity of aristolochic acids in mice. J Pharm Pharmacol 5, 221-229. (Pubitemid 38232752)
29. Shi-Wen X et al. (1997). Scleroderma lung fibroblasts exhibit elevated and dysregulated type I collagen biosynthesis. Arthritis Rheum 40, 1237-1244. (Pubitemid 27430134)
30. Skalnik DG, Strauss EC, Orkin SH (1991). CCAAT displacement protein as a repressor of the myelomonocytic-specific gp91-phox gene promoter. J Biol Chem 266, 16736-16744. (Pubitemid 21907861)
31. Superti-Furga G, Barberis A, Schreiber E, Busslinger M (1989). The protein CDP, but not CP1, footprints on the CCAAT region of the gamma-globin gene in unfractionated B-cell extracts. Biochim Biophys Acta 1007, 237-242. (Pubitemid 19056436)
32. Tanaka S et al. (2004). Cooperativity between far upstream enhancer and proximal promoter elements of the human α2(I) collagen (COL1A2) gene instructs tissue specificity in transgenic mice. J Biol Chem 279, 56024-56031. (Pubitemid 40066610)
33. Trojanowska M, LeRoy EC, Eckes B, Krieg T (1998). Pathogenesis of fibrosis: type 1 collagen and the skin. J Mol Med 76, 266-274. (Pubitemid 28098712)
34. van Gurp MF et al. (1999). The CCAAT displacement protein/cut homeodomain protein represses osteocalcin gene transcription and forms complexes with the retinoblastoma protein-related protein p107 and cyclin A. Cancer Res 59, 5980-5988.
35. Verrecchia F, Mauviel A (2007). Transforming growth factor-beta and fibrosis. World J Gastroenterol 13, 3056-3062.
36. Wester K et al. (2000). Paraffin section storage and immunohistochemistryEffects of time, temperature, fixation, and retrieval protocol with emphasis on p53 protein and MIB1 antigen. Appl Immunohistochem Mol Morphol 8, 61-70. (Pubitemid 30152356)
37. Wynn TA (2007). Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest 117, 524-529.
38. Wynn TA (2008). Cellular and molecular mechanisms of fibrosis. J Pathol 214, 199-210.
39. Xu Y, Wang L, Buttice G, Sengupta PK, Smith BD (2003). Interferon gamma repression of collagen (COL1A2) transcription is mediated by the RFX5 complex. J Biol Chem 278, 49134-49144.