D471G mutation in LCMV-NP affects its ability to self-associate and results in a dominant negative effect in viral RNA synthesis

Viruses

Volumn 4, Issue 10, 2012, Pages 2137-2161

  Ortiz Riaño, Emilio ^a   Cheng, Benson Y H ^a   de la Torre, Juan C ^b   Martínez Sobrido, Luis ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Dominant negative; Double stranded RNA; Lymphocytic choriomeningitis virus; Minigenome; Nucleoprotein; Self association; Type I Interferon; Viral like particles; Z matrix protein

Indexed keywords

DOUBLE STRANDED RNA; FATTY ACID BINDING PROTEIN; INTERFERON; LYMPHOCYTIC CHORIOMENINGITIS VIRUS NUCLEOPROTEIN; UNCLASSIFIED DRUG; VIRUS NUCLEOPROTEIN; VIRUS RNA;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MUTATION; NONHUMAN; OLIGOMERIZATION; PLASMID; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN INTERACTION; PROTEIN RNA BINDING; RNA SYNTHESIS; VIROGENESIS; VIRUS LIKE AGENT; WESTERN BLOTTING;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ASPARTIC ACID; BLOTTING, WESTERN; CARRIER PROTEINS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; INTERFERON TYPE I; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEOPROTEINS; PLASMIDS; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RNA REPLICASE; RNA, DOUBLE-STRANDED; RNA, VIRAL; RNA-BINDING PROTEINS; SPECIES SPECIFICITY; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRAL PROTEINS; VIRUS ASSEMBLY; VIRUS REPLICATION;

ARENAVIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS;

EID: 84868122472     PISSN: 19994915     EISSN: None     Source Type: Journal    
DOI: 10.3390/v4102137     Document Type: Article

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