MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Castilla, María Ángeles ^a,b   Díaz Martín, Juan ^a,b   Sarrió, David ^c   Romero Pérez, Laura ^a,b   López García, María Ángeles ^a,b   Vieites, Begoña ^a,b   Biscuola, Michele ^a,b   Ramiro Fuentes, Susana ^a   Isacke, Clare M ^c   Palacios, José ^a,b,d  

^a UNIVERSITY OF SEVILLE   (Spain)

^b Red Tematica de Investigacion Cooperativa en Cancer   (Spain)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; MICRORNA 200;

ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER TISSUE; DNA METHYLATION; DOWN REGULATION; EPIDERMAL GROWTH FACTOR RECEPTOR 2 POSITIVE BREAST CANCER; EPIGENETICS; EPITHELIAL MESENCHYMAL TRANSITION; ESTROGEN RECEPTOR POSITIVE BREAST CANCER; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MULTIGENE FAMILY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRIPLE NEGATIVE BREAST CANCER; UPREGULATION;

BREAST; BREAST NEOPLASMS; CELL LINE, TUMOR; DNA; DNA METHYLATION; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; PHENOTYPE; PROMOTER REGIONS, GENETIC;

EID: 84868100929     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047709     Document Type: Article

References (50)

1. Perou CM, Sorlie T, Eisen MB, van de Rijn M, Jeffrey SS, et al. (2000) Molecular portraits of human breast tumours. Nature 406: 747-752.
2. Sorlie T, Perou CM, Tibshirani R, Aas T, Geisler S, et al. (2001) Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 98: 10869-10874.
3. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, et al. (2003) Repeated observation of breast tumor subtypes in independent gene expression data sets. Proc Natl Acad Sci U S A 100: 8418-8423.
4. Toft DJ, Cryns VL, (2011) Minireview: Basal-like breast cancer: from molecular profiles to targeted therapies. Mol Endocrinol 25: 199-211.
5. Blick T, Hugo H, Widodo E, Waltham M, Pinto C, et al. (2010) Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia 15: 235-252.
6. Blick T, Widodo E, Hugo H, Waltham M, Lenburg ME, et al. (2008) Epithelial mesenchymal transition traits in human breast cancer cell lines. Clin Exp Metastasis 25: 629-642.
7. Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, et al. (2006) A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 10: 515-527.
8. Prat A, Parker JS, Karginova O, Fan C, Livasy C, et al. (2010) Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer. Breast Cancer Res 12: R68.
9. Zhang Y, Toy KA, Kleer CG, (2012) Metaplastic breast carcinomas are enriched in markers of tumor-initiating cells and epithelial to mesenchymal transition. Mod Pathol 25: 178-184.
10. Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, et al. (2010) Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A 107: 15449-15454.
11. Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, et al. (2009) Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 69: 4116-4124.
12. Kalluri R, (2009) EMT: when epithelial cells decide to become mesenchymal-like cells. J Clin Invest 119: 1417-1419.
13. Micalizzi DS, Farabaugh SM, Ford HL, (2010) Epithelial-mesenchymal transition in cancer: parallels between normal development and tumor progression. J Mammary Gland Biol Neoplasia 15: 117-134.
14. Thiery JP, Acloque H, Huang RY, Nieto MA, (2009) Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
15. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133: 704-715.
16. Klymkowsky MW, Savagner P, (2009) Epithelial-mesenchymal transition: a cancer researcher's conceptual friend and foe. Am J Pathol 174: 1588-1593.
17. Sarrio D, Rodriguez-Pinilla SM, Hardisson D, Cano A, Moreno-Bueno G, et al. (2008) Epithelial-mesenchymal transition in breast cancer relates to the basal-like phenotype. Cancer Res 68: 989-997.
18. Lien HC, Lin CW, Mao TL, Kuo SH, Hsiao CH, et al. (2004) p53 overexpression and mutation in metaplastic carcinoma of the breast: genetic evidence for a monoclonal origin of both the carcinomatous and the heterogeneous sarcomatous components. J Pathol 204: 131-139.
19. Reis-Filho JS, Milanezi F, Steele D, Savage K, Simpson PT, et al. (2006) Metaplastic breast carcinomas are basal-like tumours. Histopathology 49: 10-21.
20. Lien HC, Hsiao YH, Lin YS, Yao YT, Juan HF, et al. (2007) Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 26: 7859-7871.
21. Nieto MA, (2011) The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 27: 347-376.
22. Peinado H, Olmeda D, Cano A, (2007) Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428.
23. Cano A, Nieto MA, (2008) Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition. Trends Cell Biol 18: 357-359.
24. Brabletz S, Brabletz T, (2010) The ZEB/miR-200 feedback loop[mdash]a motor of cellular plasticity in development and cancer? EMBO Rep 11: 670-677.
25. Bracken C, Gregory P, Khew-Goodall Y, Goodall G, (2009) The role of microRNAs in metastasis and epithelial-mesenchymal transition. Cellular and Molecular Life Sciences 66: 1682-1699.
26. Bartel DP, (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
27. Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, et al. (2008) A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 68: 7846-7854.
28. Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, et al. (2008) A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 9: 582-589.
29. Sossey-Alaoui K, Bialkowska K, Plow EF, (2009) The miR200 family of microRNAs regulates WAVE3-dependent cancer cell invasion. J Biol Chem 284: 33019-33029.
30. Howe EN, Cochrane DR, Richer JK, (2011) Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res 13: R45.
31. Howe EN, Cochrane DR, Richer JK (2012) The miR-200 and miR-221/222 microRNA Families: Opposing Effects on Epithelial Identity. J Mammary Gland Biol Neoplasia.
32. Wiklund ED, Bramsen JB, Hulf T, Dyrskjot L, Ramanathan R, et al. (2011) Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer. Int J Cancer 128: 1327-1334.
33. Vrba L, Garbe JC, Stampfer MR, Futscher BW (2011) Epigenetic regulation of normal human mammary cell type-specific miRNAs. Genome Res.
34. Vrba L, Jensen TJ, Garbe JC, Heimark RL, Cress AE, et al. (2010) Role for DNA methylation in the regulation of miR-200c and miR-141 expression in normal and cancer cells. PLoS One 5: e8697.
35. Wiklund ED, Gao S, Hulf T, Sibbritt T, Nair S, et al. (2011) MicroRNA alterations and associated aberrant DNA methylation patterns across multiple sample types in oral squamous cell carcinoma. PLoS One 6: e27840.
36. Davalos V, Moutinho C, Villanueva A, Boque R, Silva P, et al. (2011) Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene.
37. Holliday DL, Brouilette KT, Markert A, Gordon LA, Jones JL, (2009) Novel multicellular organotypic models of normal and malignant breast: tools for dissecting the role of the microenvironment in breast cancer progression. Breast Cancer Res 11: R3.
38. Sarrio D, Franklin CK, Mackay A, Reis-Filho JS, Isacke CM, (2012) Epithelial and mesenchymal subpopulations within normal Basal breast cell lines exhibit distinct stem cell/progenitor properties. Stem Cells 30: 292-303.
39. Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, et al. (2008) The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 10: 593-601.
40. Herschkowitz JI, Zhao W, Zhang M, Usary J, Murrow G, et al. (2012) Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells. Proc Natl Acad Sci U S A 109: 2778-2783.
41. Bockmeyer CL, Christgen M, Muller M, Fischer S, Ahrens P, et al. (2011) MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes. Breast Cancer Res Treat 130: 735-745.
42. Neves R, Scheel C, Weinhold S, Honisch E, Iwaniuk KM, et al. (2010) Role of DNA methylation in miR-200c/141 cluster silencing in invasive breast cancer cells. BMC Res Notes 3: 219.
43. Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, et al. (2012) MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene.
44. Storci G, Sansone P, Trere D, Tavolari S, Taffurelli M, et al. (2008) The basal-like breast carcinoma phenotype is regulated by SLUG gene expression. J Pathol 214: 25-37.
45. Proia TA, Keller PJ, Gupta PB, Klebba I, Jones AD, et al. (2011) Genetic predisposition directs breast cancer phenotype by dictating progenitor cell fate. Cell Stem Cell 8: 149-163.
46. Sato F, Tsuchiya S, Meltzer SJ, Shimizu K, (2011) MicroRNAs and epigenetics. FEBS J 278: 1598-1609.
47. Wee EJ, Peters K, Nair SS, Hulf T, Stein S, et al. (2012) Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer. Oncogene.
48. Yuan JH, Yang F, Chen BF, Lu Z, Huo XS, et al. (2011) The histone deacetylase 4/SP1/microrna-200a regulatory network contributes to aberrant histone acetylation in hepatocellular carcinoma. Hepatology 54: 2025-2035.
49. Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, et al. (2000) The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2: 76-83.
50. Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, et al. (2003) The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 116: 499-511.