Mapping the regulatory sequences controlling 93 breast cancer-associated miRNA genes leads to the identification of two functional promoters of the Hsa-mir-200b cluster, methylation of which is associated with metastasis or hormone receptor status in advanced breast cancer

Oncogene

Volumn 31, Issue 38, 2012, Pages 4182-4195

  Wee, E J H ^a   Peters, K ^a   Nair, S S ^c   Hulf, T ^c   Stein, S ^b   Wagner, S ^b   Bailey, P ^a   Lee, S Y ^a   Qu, W J ^c   Brewster, B ^a   French, J D ^a   Dobrovic, A ^d   Francis, G D ^b   Clark, S J ^c   Brown, M A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b PRINCESS ALEXANDRA HOSPITAL   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

breast cancer; DNA methylation; MicroRNA; miR 200b; prognosis; promoter

Indexed keywords

ANDROGEN RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; MICRORNA; MICRORNA 200B; PROGESTERONE RECEPTOR;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BREAST CANCER; BREAST METASTASIS; CANCER CELL; CONTROLLED STUDY; DNA METHYLATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REGULATORY SEQUENCE;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMOSOME MAPPING; CPG ISLANDS; DNA METHYLATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICRORNAS; MIDDLE AGED; MULTIGENE FAMILY; NEOPLASM METASTASIS; PROMOTER REGIONS, GENETIC; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; REPRODUCIBILITY OF RESULTS; TRANSCRIPTION INITIATION SITE;

EID: 84866550833     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.584     Document Type: Article

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