Evaluation of the in vivo biodistribution of indium-111 and yttrium-88 labeled dendrimer-1B4M-DTPA and its conjugation with anti-tac monoclonal antibody

Bioconjugate Chemistry

Volumn 10, Issue 1, 1999, Pages 103-111

  Kobayashi, Hisataka ^a   Wu, Chuanchu ^a   Kim, Meyoung Kon ^a   Paik, Chang H ^a   Carrasquillo, Jorge A ^a   Brechbiel, Martin W ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DENDRIMERS; MAMMALS; MONOCLONAL ANTIBODIES; TUMORS; YTTRIUM;

BIODISTRIBUTIONS; DIETHYLENETRIAMINE PENTA-ACETIC ACIDS; IN-VITRO; IN-VIVO; POLYAMIDOAMINE DENDRIMERS; PROPERTY; SECOND GENERATION; TIME POINTS; VITRO AND IN VIVO; VIVO BIODISTRIBUTION;

INDIUM;

EID: 0032892747     PISSN: 10431802     EISSN: None     Source Type: Journal    
DOI: 10.1021/bc980091d     Document Type: Article

References (43)

1. Tomalia, D. A., Naylor, A. M., and Goddard, W. A. III (1990) Starburst dendrimers: Molecular-level control of size, shape, surface chemistry, topology, and flexibility from atoms to macroscopic matter. Angew. Chem., Int. Ed. Engl. 29, 138-175.
2. Wu, C., Brechbiel, M. W., Kozak, R. W., and Gansow, O. A. (1994) Metal-chelate-dendrimer-antibody constructs for use in radioimmunotherapy and imaging. Bioorg. Med. Chem. Lett. 4, 449-454.
3. Frechet, J. M. (1994) Functional polymers and dendrimers: reactivity, molecular architecture, and interfacial energy. Science 263, 1710-1715.
4. Earth, R. F., Adams, D. M., Soloway, A. H., Alam, F., and Darby, M. V. (1994) Boronated starburst dendrimer-monoclonal antibody immunoconjugates: evaluation as a potential delivery system for neutron capture therapy. Bioconjugate Chem. 5, 58-66.
5. Singh, P., Moll, F., III, Lin, S. H., Ferzli, C., Yu, K. S., Koski, R. K., Saul, R. G., and Cronin, P. (1994) Starburst dendrimers: enhanced performance and flexibility for immunoassays. Clin. Chem. 40, 1845-1849.
6. Wiener, E. C., Brechbiel, M. W., Brothers, H., Magin, R. L., Gansow, O. A., Tomalia, D. A., and Lauterbur, P. C. (1994) Dendrimer-based metal chelates: a new class of magnetic resonance imaging contrast agents. Magn. Reson. Med. 31, 1-8.
7. Behr, J. P. (1993) Synthetic gene-transfer vectors. Acc. Chem. Res. 26, 274-278.
8. Kukowska-Latallo, J. F., Bielinska, A. U., Johnson, J., Spindler, R., Tomalia, D. A., and Baker, J. R., Jr. (1996) Efficient transfer of genetic material into mammalian cells using Starburst polyamidoamine dendrimers. Proc. Natl. Acad. Sci. U.SA. 93, 4897-4902.
9. Larson, S. M. (1990) Clinical radioimmunodetection, 1978-1988: overview and suggestions for standardization of clinical trials. Cancer Res. 50, 892s-898s.
10. Goldenberg, D. M., and Larson, S. M. (1992) Radioimmunodetection in cancer identification. J. Nucl. Med. 33, 803-814.
11. Carrasquillo, J. A. (1996) Radioimmunotherapy of leukemia and lymphoma, In Principles of Nuclear Medicine (H. Wagner, Ed.) pp 1117-1132, W. B. Saunders and Co., Philadelphia.
12. Waldmann, T. A., White, J. D., Carrasquillo, J. A., Reynolds, J. C., Paik, C. H., Gansow, O. A., Brechbiel, M. W., Jaffe, E. S., Fleisher, T. A., Goldman, C. K., Top, L. E., Bamford, R., Zaknoen, S., Roessler, E., Kasten-Sportes, C., England, R., Litou, H., Johnson, J. A., Jackson-White, T., Manns, A., Hanchard, B., Junghans, R. P., and Nelson, D. L. (1995) Radioimmunotherapy of interleukin-2R alpha-expressing adult T-cell leukemia with yttrium-90-labeled anti-Tac. Blood 86, 4063-4075.
13. Knox, S. J., Goris, M. L., Trisler, K., Negrin, R., Davis, T., Liles, T.-M., Grillo-Lopes, A., Chinn, P., Varns, C., Ning, S.-C., Fowler, S., Deb, N., Becker, M., Marquez, C., and Levy, R. (1996) Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma. Clin. Cancer Res. 2, 457-470.
14. Denardo, S. J., Richman, C. M., Goldstein, D. S., Shen, S., Salako, Q., Kukis, D. L., Meares, C. F., Yuan, A., Welborn, J. L., and Denardo, G. L. (1997) Yttrium-90/indium-111-DOTA-peptide-chimeric L6: Pharmacokinetics, dosimetry and initial results in patients with incurable breast cancer. Anticancer Res. 17, 1735-1744.
15. Roselli, M., Schlom, J., Gansow, O. A., Raubitschek, A., Mirzadeh, S., Brechbiel, M. W., and Colcher, D. (1989) Comparative biodistributions of yttrium-and indium-labeled monoclonal antibody B72.3 in athymic mice bearing human colon carcinoma xenografts. J. Nucl. Med. 30, 672-682.
16. Camera, L., Kinuya, S., Garmestani, K., Brechbiel, M. W., Wu, C., Pai, L. H., McMurry, T. J., Gansow, O. A., Pastan, I., Paik, C. H., and Carrasquillo, J. A. (1994) Comparative biodistribution of indium-and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1, 4, 7, 10-tetraazacyclododecane tetraacetic acid (2B-DOTA). Eur. J. Nucl. Med. 21, 640-646.
17. Roselli, M., Schlom, J., Gansow, O. A., Brechbiel, M. W., Mirzadeh, S., Pippin, C. G., Milenic, D. E., and Colcher, D. (1991) Comparative biodistribution studies of DTPA-derivative bifunctional chelates for radiometal labeled monoclonal antibodies. Int. J. Rad. Appl. Instrum. B 18, 389-394.
18. Camera, L., Kinuya, S., Garmestani, K., Wu, C., Brechbiel, M. W., Pai, L. H., McMurry, T. J., Gansow, O. A., Pastan, I., Paik, C. H., and Carrasquillo, J. A. (1994) Evaluation of the serum stability and in vivo biodistribution of CHX-DTPA and other ligands for yttrium labeling of monoclonal antibodies. J. Nucl. Med. 35, 882-889.
19. 111indium-DOTA chelates: a simple and efficient method. Bioconjugate Chem. 5, 101-104.
20. Chakrabarti, M. C., Le, N., Paik, C. H., De Graff, W. G., and Carrasquillo, J. A. (1996) Prevention of radiolysis of monoclonal antibody during labeling. J. Nucl. Med. 37, 1384-1388.
21. Lewis, M. R., Raubitschek, A., and Shively, J. E. (1994) A facile, water-soluble method for modification of proteins with DOTA. Bioconjugate Chem. 5, 565-576.
22. Sakahara, H., Endo, K., Nakashima, T., Koizumi, M., Ohta, H., Torizuka, K., Furukawa, T., Ohmomo, Y., Yokoyama, A., Okada, K., Yoshida, O., and Nishi, S. (1985) Effect of DTPA conjugation on the antigen binding activity and biodistribution of monoclonal antibodies against alpha-fetoprotein. J. Nucl. Med. 26, 750-755.
23. Uchiyama, T., Nelson, D. L., Fleisher, T. A., and Waldmann, T. A. (1981) A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells, and on one of two types of helper T cells. J. Immunol. 126, 1398-1403.
24. Queen, C., Schneider, W. P., Selick, H. E., Payne, P. W., Landolfi, N. F., Duncan, J. F., Avdalovic, N. M., Levitt, M., Junghans, R. P., and Waldmann, T. A. (1989) A humanized antibody that binds to the interleukin 2 receptor. Proc. Natl. Acad. Sci. U.S.A. 86, 10029-10033.
25. Pippin, C. G., Parker, T. A., McMurry, T. J., and Brechbiel, M. W. (1992) Spectrophotometric method for the determination of a bifunctional DTPA ligand in DTPA-monoclonal antibody conjugates. Bioconjugate Chem. 3, 342-345.
26. Wu, C., Kobayashi, H., Sun, B., Yoo, T. M., Paik, C. H., Gansow, O. A., Carrasquillo, J. A., Pastan, I., and Brechbiel, M. W. (1997) Stereochemical influence on the stability of radio-metal complexes in vivo. Synthesis and evaluation of the four stereoisomers of 2-(p-nitrobenzyl)-trans-CyDTPA. Bioorg. Med. Chem. 5, 1925-1934.
27. Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., and Bunn, P. A., Jr. (1984) Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J. Immunol. Methods 72, 77-89.
28. 99mTc-labeled anti-Tac dsFv. Cancer Res. 56, 3788-3795.
29. Kreitman, R. J., and Pastan, I. (1994) Recombinant single-chain immunotoxins against T and B cell leukemias. Leuk. Lymphoma 13, 1-10.
30. Roberts, J. C., Adams, Y. E., Tomalia, D., Mercer-Smith, J. A., and Lavallee, D. K. (1990) Using starburst dendrimers as linker molecules to radiolabel antibodies. Bioconjugate Chem. 1, 305-308.
31. Roberts, J. C., Bhalgat, M. K., and Zera, R. T. (1996) Preliminary biological evaluation of polyamidoamine (PAMAM) Starburst dendrimers. J. Biomed. Mater. Res. 30, 53-65.
32. ten Kate, C. I., Fischman, A. J., Rubin, R. H., Fucello, A. J., Riexinger, D., Wilkinson, R. A., Du, L., Khaw, B. A., and Strauss, H. W. (1990) Effect of isoelectric point on biodistribution and inflammation: imaging with indium-111-labeled IgG. Eur. J. Nucl. Med. 17, 305-309.
33. Kim, I. S., Yoo, T. M., Kobayashi, H., Kim, M.-K., Le, N., Han, E. S., C., W. Q., Pastan, I., Carrasquillo, J. A., and Paik, C. H. (1997) Acylation with glycolate lowers pi of dsFv and reduces renal uptake of its Tc-99m label (abstract). J. Labeled Compd. Rad. XL, 422-424.
34. Clegg, J. A., Hudecz, F., Mezo, G., Pimm, M. V., Szekerke, M., and Baldwin, R. W. (1990) Carrier design: Biodistribution of branched polypeptides with a poly(L-lysine) backbone. Bioconjugate Chem. 1, 425-430.
35. Lescanec, R. L., and Muthukumar, M. (1990) Configurational characteristics and scaling behavior of starburst molecules-A conputational study. Macromolecules 23, 22802288.
36. Mansfield, M. L., and Klushin, L. I. (1993) Monte Carlo studies of dendrimer macromolecules. Macromolecules 26, 4262-4268.
37. Hnatowich, D. J., Virzi, F., and Doherty, P. W. (1985) DTPA-coupled antibodies labeled with yttrium-90. J. Nucl. Med. 26, 503-509.
38. Stewart, J. S., Hird, V., Snook, D., Sullivan, M., Hooker, G., Courtenay-Luck, N., Sivolapenko, G., Griffiths, M.,Myers, M. J., Lambert, H. E., Mason, W. P., Soutter, W. P., and Epenetos, A. A. (1989) Intraperitoneal radioimmunotherapy for ovarian cancer: pharmacokinetics, toxicity, and efficacy of 1-131 labeled monoclonal antibodies. Int. J. Radiat. Oncol. Biol. Phys. 16, 405-413.
39. Stewart, J. S., Hird, V., Snook, D., Dhokia, B., Sivolapenko, G., Hooker, G., Papadimitriou, J. T., Rowlinson, G., Sullivan, M., Lambert, H, E., Coulter, W. P., Mason, W. P., Soutter, W. P., and Epenetos, A. A. (1990) Intraperitoneal yttrium-90-labeled monoclonal antibody in ovarian cancer. J. Clin. Oncol. 8, 1941-1950.
40. Brechbiel, M. W., Gansow, O. A., Atcher, R. W., Schlom, J., Esteban, J., Simpson, D., and Colcher, D. (1986) Synthesis of 1-(p-isothiocyanatobenzyl) derivatives of DTPA and EDTA. Antibody labeling and tumor-imaging studies. Inorg. Chem. 25, 2772-2781.
41. Kozak, R. W., Raubitschek, A., Mirzadeh, S., Brechbiel, M. W., Junghaus, R., Gansow, O. A., and Waldmann, T. A. (1989) Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity. Cancer Res. 49, 2639-2644.
42. Sharkey, R. M., Motta-Hennessy, C., Gansow, O. A., Brechbiel, M. W., Fand, I., Griffiths, G. L., Jones, A. L., and Goldenberg, D. M. (1990) Selection of a DTPA chelate conjugate for monoclonal antibody targeting to a human colonic tumor in nude mice. Int. J. Cancer 46, 79-85.
43. 90Y-labeled monoclonal antibody CO17-1A. Int. J. Rad. Appl. Instrum. B 18, 313-321.