The galectin profile of the endothelium: Altered expression and localization in activated and tumor endothelial cells

American Journal of Pathology

Volumn 172, Issue 2, 2008, Pages 545-553

  Thijssen, Victor L ^a   Hulsmans, Sarah ^a   Griffioen, Arjan W ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ECALECTIN; GALECTIN 1; GALECTIN 3; GALECTIN 8;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TUMOR CELL; TUMOR VASCULARIZATION; WESTERN BLOTTING;

EID: 39549084700     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.2353/ajpath.2008.070938     Document Type: Article

References (34)

1. Liu FT, Rabinovich GA: Galectins as modulators of tumour progression. Nat Rev Cancer 2005, 5:29-41
2. van den Brûle F, Califice S, Castronovo V: Expression of galectins in cancer: a critical review. Glycoconj J 2004, 19:537-542
3. Huflejt ME, Leffler H: Galectin-4 in normal tissues and cancer. Glycoconj J 2004, 20:247-255
4. Bidon-Wagner N, Le Pennec JP: Human galectin-8 isoforms and cancer. Glycoconj J 2004, 19:557-563
5. Griffioen AW, Molema G: Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol Rev 2000, 52:237-268
6. Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA: Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 1994, 79:1157-1164
7. Thorpe PE, Burrows FJ: Antibody-directed targeting of the vasculature of solid tumors. Breast Cancer Res Treat 1995, 36:237-251
8. Griffioen AW, Coenen MJ, Damen CA, Hellwig SM, van Weering DH, Vooys W, Blijham GH, Groenewegen G: CD44 is involved in tumor angiogenesis: an activation antigen on human endothelial cells. Blood 1997, 90:1150-1159
9. van Beijnum JR, Dings RP, van der Linden E, Zwaans BM, Ramaekers FC, Mayo KH, Griffioen AW: Gene expression of tumor angiogenesis dissected: specific targeting of colon cancer angiogenic vasculature. Blood 2006, 108:2339-2348
10. Thijssen VL, Postel R, Brandwijk RJ, Dings RP, Nesmelova I, Satijn S, Verhofstad N, Nakabeppu Y, Baum LG, Bakkers J, Mayo KH, Poirier F, Griffioen AW: Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. Proc Natl Acad Sci USA 2006, 103:15975-15980
11. Thijssen VL, Poirier F, Baum LG, Griffioen AW: Galectins in the tumor endothelium: opportunities for combined cancer therapy. Blood 2007, 110:2819-2827
12. van Beijnum JR, van der Linden E, Griffioen AW: Angiogenic profiling and comparison of immortalized endothelial cells for functional genomics. Exp Cell Res 2008, 314:264-272
13. Thijssen VL, Brandwijk RJ, Dings RP, Griffioen AW: Angiogenesis gene expression profiling in xenograft models to study cellular interactions. Exp Cell Res 2004, 299:286-293
14. Baum LG, Seilhamer JJ, Pang M, Levine WB, Beynon D, Berliner JA: Synthesis of an endogeneous lectin, galectin-1, by human endothelial cells is up-regulated by endothelial cell activation. Glycoconj J 1995, 12:63-68
15. Rabinovich GA, Cumashi A, Bianco GA, Ciavardelli D, Iurisci I, D'Egidio M, Piccolo E, Tinari N, Nifantiev N, Iacobelli S: Synthetic lactulose amines: novel class of anticancer agents that induce tumor-cell apoptosis and inhibit galectin-mediated homotypic cell aggregation and endothelial cell morphogenesis. Glycobiology 2006, 16:210-220
16. Elola MT, Wolfenstein-Todel C, Troncoso P, Vasta GR, Rabinovich GA: Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci 2007, (in press)
17. Fukushi J, Makagiansar IT, Stallcup WB: NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell 2004, 15:3580-3590
18. Huflejt ME, Turck CW, Lindstedt R, Barondes SH, Leffler H: L-29, a soluble lactose-binding lectin, is phosphorylated on serine 6 and serine 12 in vivo and by casein kinase I. J Biol Chem 1993, 268:26712-26718
19. Cowles EA, Agrwal N, Anderson RL, Wang JL: Carbohydrate-binding protein 35: isoelectric points of the polypeptide and a phosphorylated derivative. J Biol Chem 1990, 265:17706-17712
20. Shekhar MP, Nangia-Makker P, Tait L, Miller F, Raz A: Alterations in galectin-3 expression and distribution correlate with breast cancer progression: functional analysis of galectin-3 in breast epithelial-endothelial interactions. Am J Pathol 2004, 165:1931-1941
21. Lotan R, Belloni PN, Tressler RJ, Lotan D, Xu XC, Nicolson GL: Expression of galectins on microvessel endothelial cells and their involvement in tumour cell adhesion. Glycoconj J 1994, 11:462-468
22. Glinskii OV, Turk JR, Pienta KJ, Huxley VH, Glinsky VV: Evidence of porcine and human endothelium activation by cancer-associated carbohydrates expressed on glycoproteins and tumour cells. J Physiol 2004, 554:89-99
23. Glinsky VV, Glinsky GV, Glinskii OV, Huxley VH, Turk JR, Mossine VV, Deutscher SL, Pienta KJ, Quinn TP: Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res 2003, 63:3805-3811
24. Gil CD, La M, Perretti M, Oliani SM: Interaction of human neutrophils with endothelial cells regulates the expression of endogenous proteins annexin 1, galectin-1 and galectin-3. Cell Biol Int 2006, 30:338-344
25. Spitzenberger F, Graessler J, Schroeder HE: Molecular and functional characterization of galectin 9 mRNA isoforms in porcine and human cells and tissues. Biochimie 2001, 83:851-862
26. Zick Y, Eisenstein M, Goren RA, Hadari YR, Levy Y, Ronen D: Role of galectin-8 as a modulator of cell adhesion and cell growth. Glycoconj J 2004, 19:517-526
27. Bidon N, Brichory F, Hanash S, Bourguet P, Dazord L, Le Pennec JP: Two messenger RNAs and five isoforms for Po66-CBP, a galectin-8 homolog in a human lung carcinoma cell line. Gene 2001, 274:253-262
28. Carlsson S, Oberg CT, Carlsson MC, Sundin A, Nilsson UJ, Smith D, Cummings RD, Almkvist J, Karlsson A, Leffler H: Affinity of galectin-8 and its carbohydrate recognition domains for ligands in solution and at the cell surface. Glycobiology 2007, 17:663-676
29. Levy Y, Auslender S, Eisenstein M, Vidavski RR, Ronen D, Bershadsky AD, Zick Y: It depends on the hinge: a structure-functional analysis of galectin-8, a tandem-repeat type lectin. Glycobiology 2006, 16:463-476
30. Nishi N, Itoh A, Fujiyama A, Yoshida N, Araya S, Hirashima M, Shoji H, Nakamura T: Development of highly stable galectins: truncation of the linker peptide confers protease-resistance on tandem-repeat type galectins. FEBS Lett 2005, 579:2058-2064
31. Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A: Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 2002, 94:1854-1862
32. Clausse N, van den Brule F, Waltregny D, Garnier F, Castronovo V: Galectin-1 expression in prostate tumor-associated capillary endothelial cells is increased by prostate carcinoma cells and modulates heterotypic cell-cell adhesion. Angiogenesis 1999, 3:317-325
33. Glinskii OV, Huxley VH, Glinsky GV, Pienta KJ, Raz A, Glinsky VV: Mechanical entrapment is insufficient and intercellular adhesion is essential for metastatic cell arrest in distant organs. Neoplasia 2005, 7:522-527
34. Zou J, Glinsky VV, Landon LA, Matthews L, Deutscher SL: Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion. Carcinogenesis 2005, 26:309-318