Immunoneuroendocrine alterations in patients with progressive forms of chronic Chagas disease

Journal of Neuroimmunology

Volumn 235, Issue 1-2, 2011, Pages 84-90

  Perez A R ^a   Silva Barbosa, S D ^b,c   Berbert, L R ^b   Revelli, S ^a   Beloscar, J ^c,d   Savino, W ^b   Bottasso, O ^a  

^a FACULTAD DE CIENCIAS MÉDICAS   (Argentina)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c INSTITUTO NACIONAL DE CÂNCER   (Brazil)

^d UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Cortisol; Cytokines; DHEA s; HPA axis; Human Chagas disease; Infectious diseases

Indexed keywords

HYDROCORTISONE; PRASTERONE SULFATE;

ARTICLE; CHAGAS DISEASE; CHRONIC DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE SEVERITY; FEMALE; HORMONE RESPONSE; HUMAN; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMUNE RESPONSE; IMMUNOPATHOLOGY; INFLAMMATION; MALE; MYOCARDITIS; NEUROENDOCRINE DISEASE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; SYSTEMIC DISEASE;

ADULT; CHAGAS DISEASE; CHRONIC DISEASE; DISEASE PROGRESSION; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-17; INTERLEUKIN-6; MALE; MIDDLE AGED; NEUROENDOCRINE CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958004980     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.03.010     Document Type: Article

References (52)

1. Andrade Z.A. Immunopathology of Chagas disease. Mem. Inst. Oswaldo Cruz 1999, 94:71-80.
2. Araújo-Jorge T.C., Waghabi M.C., Soeiro M.de N., Keramidas M., Bailly S., Feige J.J. Pivotal role for TGF-beta in infectious heart disease: the case of Trypanosoma cruzi infection and consequent Chagasic myocardiopathy. Cytokine Growth Factor Rev. 2008, 19:405-413.
3. Bates G.W., Egerman R.S., Umstotm E.S. Dehydroepiandrosterone attenuates study-induced declines in insulin sensitivity in postmenopausal women. Ann. N. Y. Acad. Sci. 1995, 774:291-293.
4. Besedovsky H.O., del Rey A. Immune-neuro-endocrine interactions: facts and hypotheses. Endocr. Rev. 1996, 17:64-102.
5. Bonney K.M., Engman D.M. Chagas heart disease pathogenesis: one mechanism or many?. Curr. Mol. Med. 2008, 8:510-518.
6. Bozza V.V., D'Attilio L., Mahuad C.V., Giri A.A., del Rey A., Besedovsky H., Bottasso O., Bay M.L. Altered cortisol/DHEA ratio in tuberculosis patients and its relationship with abnormalities in the mycobacterial-driven cytokine production by peripheral blood mononuclear cells. Scand. J. Immunol. 2007, 66:97-103.
7. Butcher S.K., Killampalli V., Lascelles D., Wang K., Alpar E.K., Lord J.M. Raised cortisol:DHEAS ratios in the elderly after injury: potential impact upon neutrophil function and immunity. Aging Cell 2005, 4(6):319-324.
8. Chen L., Watanabe T., Watanabe H., Sendo F. Neutrophil depletion exacerbates experimental Chagas' disease in BALB/c, but protects C57BL/6 mice through modulating the Th1/Th2 dichotomy in different directions. Eur. J. Immunol. 2001, 31:265-275.
9. Chittiprol S., Kumar A.M., Shetty K.T., Kumar H.R., Satishchandra P., Rao R.S., Ravi V., Desai A., Subbakrishna D.K., Philip M., Satish K.S., Kumar M. HIV-1 clade C infection and progressive disruption in the relationship between cortisol, DHEAS and CD4 cell numbers: a two-year follow-up study. Clin. Chim. Acta. 2009, 409:4-10.
10. Congote L.F. Monitoring insulin-like growth factors in HIV infection and AIDS. Clin. Chim. Acta. 2005, 361:30-53.
11. Corrêa-de-Santana E., Paez-Pereda M., Theodoropoulou M., Kenji Nihei O., Gruebler Y., Bozza M., Arzt E., Villa-Verde D.M., Renner U., Stalla J., Stalla G.K., Savino W. Hypothalamus-pituitary-adrenal axis during Trypanosoma cruzi acute infection in mice. J. Neuroimmunol. 2006, 173:12-22.
12. Corrêa-de-Santana E., Paez-Pereda M., Theodoropoulou M., Renner U., Stalla J., Stalla G.K., Savino W. Modulation of growth hormone and prolactin secretion in Trypanosoma cruzi-infected mammosomatotrophic cells. Neuroimmunomodulation 2009, 16:208-212.
13. Cunha-Neto E., Bilate A.M., Hyland K.V., Fonseca S.G., Kalil J., Engman D.M. Induction of cardiac autoimmunity in Chagas heart disease: a case for molecular mimicry. Autoimmunity 2006, 39:41-54.
14. Cunha-Neto E., Nogueira L.G., Teixeira P.C., Ramasawmy R., Drigo S.A., Goldberg A.C., Fonseca S.G., Bilate A.M., Kalil J. Immunological and non-immunological effects of cytokines and chemokines in the pathogenesis of chronic Chagas disease cardiomyopathy. Mem. Inst. Oswaldo Cruz 2009, 104:252-258. 1.
15. da Matta-Guedes P.M., Gutierrez F.R., Maia F.L., Milanezi C.M., Silva G.K., Pavanelli W.R., Silva J.S. IL-17 produced during Trypanosoma cruzi infection plays a central role in regulating parasite-induced myocarditis. PLoS Negl. Trop. Dis. 2010, 4(2):e604. 16.
16. del Rey A.D., Mahuad C.V., Bozza V.V., Bogue C., Farroni M.A., Bay M.L., Bottasso O.A., Besedovsky H.O. Endocrine and cytokine responses in humans with pulmonary tuberculosis. Brain Behav. Immun. 2007, 21:171-179.
17. Dluhy R.G. The growing spectrum of HIV-related endocrine abnormalities. J. Clin. Endocrinol. Metab. 1990, 70:563-565.
18. dos Santos V.M., da Cunha S.F., Teixeira V.de P., Monteiro J.P., dos Santos J.A., dos Santos T.A., dos Santos L.A., da Cunha D.F. Frequency of diabetes mellitus and hyperglycemia in chagasic and non-chagasic women. Rev. Soc. Bras. Med. Trop. 1999, 32:489-496.
19. Ernestam S., Hafström I., Werner S., Carlström K., Tengstrand B. Increased DHEAS levels in patients with rheumatoid arthritis after treatment with tumor necrosis factor antagonists: evidence for improved adrenal function. J. Rheumatol. 2007, 34:1451-1458.
20. Fernandes F., Dantas S., Ianni B.M., Ramires F.J., Buck P., Salemi V.M., Lopes H.F., Mady C. Leptin levels in different forms of Chagas' disease. Braz. J. Med. Biol. Res. 2007, 40:1631-1636.
21. Filipin M.D., Caetano L.C., Brazão V., Santello F.H., Toldo M.P., do Prado J.C. DHEA and testosterone therapies in Trypanosoma cruzi-infected rats are associated with thymic changes. Res. Vet. Sci. 2010, 89(1):98-103.
22. Frare E.O., Santello F.H., Caetano L.C., Caldeira J.C., Toldo M.P., Prado J.C. Growth hormone therapy in immune response against Trypanosoma cruzi. Res. Vet. Sci. 2010, 88:273-278.
23. Gaillard R.C., Turnill D., Sappino P., Muller A.F. Tumor necrosis factor a inhibits the hormonal response of the pituitary gland to hypothalamic releasing factors. Endocrinology 1990, 127:101-106.
24. Granado M., Priego T., Martín A.I., Vara E., López-Calderón A., Villanúa M. Anti-tumor necrosis factor agent PEG-sTNFRI improves the growth hormone/insulin-like growth factor-I system in adjuvant-induced arthritic rats. Eur. J. Pharmacol. 2006, 536:204-210.
25. Guedes P.M., Veloso V.M., Afonso L.C., Caliari M.V., Carneiro C.M., Diniz L.F., Marques-da-Silva E.A., Caldas I.S., do Valle Matta M.A., Souza S.M., Lana M., Chiari E., Galvão L.M., Bahia M.T. Development of chronic cardiomyopathy in canine Chagas disease correlates with high IFN-gamma, TNF-alpha, and low IL-10 production during the acute infection phase. Vet. Immunol. Immunopathol. 2009, 130:43-52.
26. Hazeldine J., Arlt W., Lord J.M. Dehydroepiandrosterone as a regulator of immune cell function. J. Steroid. Biochem. Mol. Biol. 2010, 120(2-3):127-136.
27. Hernández-Morante J.J., Pérez-de-Heredia F., Luján J.A., Zamora S., Garaulet M. Role of DHEA-S on body fat distribution: gender- and depot-specific stimulation of adipose tissue lipolysis. Steroids 2008, 73:209-215.
28. Jaattela M., Ilvesmäki V., Voutilainen R., Stenman U.H., Saksela E. Tumor necrosis factor as a potent inhibitor of adrenocorticotropin-induced cortisol production and steroidogenic P450 enzyme gene expression in cultured human fetal adrenal cells. Endocrinology 1991, 128:623-629.
29. Kelley K.W., Weigent D.A., Kooijman R. Protein hormones and immunity. Brain Behav. Immun. 2007, 21:384-392.
30. Knoferl M.W., Angele M.K., Catania R.A., Diodato M.D., Bland K.I., Chaudry I.H. Immunomodulatory effects of dehydroepiandrosterone in proestrus female mice after trauma-hemorrhage. J. Appl. Physiol. 2003, 95:529-535.
31. Kroboth P.D., Salek F.S., Pittenger A.L., Fabian T.J., Frye R.F. DHEA and DHEA-S: a review. J. Clin. Pharmacol. 1999, 39:327-348.
32. Lieskovska J., Guo D., Derman E. IL-6-overexpression brings about growth impairment potentially through a GH receptor defect. Growth Horm. IGF Res. 2002, 12:388-398.
33. Lula J.F., Rocha M.O., Nunes C., Ribeiro A.L., Teixeira M.M., Bahia M.T., Talvani A. Plasma concentrations of tumour necrosis factor-alpha, tumour necrosis factor-related apoptosis-inducing ligand, and FasLigand/CD95L in patients with Chagas cardiomyopathy correlate with left ventricular dysfunction. Eur. J. Heart Fail. 2009, 11:825-831.
34. Miyazaki Y., Hamano S., Wang S., Shimanoe Y., Iwakura Y., Yoshida H. IL-17 is necessary for host protection against acute-phase Trypanosoma cruzi infection. J. Immunol. 2010, 185:1150-1157.
35. Moriyama Y., Yasue H., Yoshimura M., Mizuno Y., Nishiyama K., Tsunoda R., Kawano H., Kugiyama K., Ogawa H., Saito Y., Nakao K. The plasma levels of dehydroepiandrosterone sulfate are decreased in patients with chronic heart failure in proportion to the severity. J. Clin. Endocrinol. Metab. 2000, 85:834-840.
36. Nagajyothi F., Desruisseaux M.S., Weiss L.M., Chua S., Albanese C., Machado F.S., Esper L., Lisanti M.P., Teixeira M.M., Scherer P.E., Tanowitz H.B. Chagas disease, adipose tissue and the metabolic syndrome. Mem. Inst. Oswaldo Cruz 2009, 104:219-225.
37. Onishi R.M., Gaffen S.L. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 2010, 129(3):311-321.
38. Pérez A.R., Roggero E., Nicora A., Palazzi J., Besedovsky H.O., del Rey A., Bottasso O.A. Thymus atrophy during Trypanosoma cruzi infection is caused by an immuno-endocrine imbalance. Brain Behav. Immun. 2007, 21:890-900.
39. Pérez A.R., Bottasso O., Savino W. The impact of infectious diseases upon neuroendocrine circuits. Neuroimmunomodulation 2009, 16:96-105.
40. Redelman D., Welniak L.A., Taub D., Murphy W.J. Neuroendocrine hormones such as growth hormone and prolactin are integral members of the immunological cytokine network. Cell. Immunol. 2008, 252:111-121.
41. Reincke M., Heppner C., Petzke F., Allolio B., Arlt W., Mbulamberi D., Siekmann L., Vollmer D., Winkelmann W., Chrousos G.P. Impairment of adrenocortical function with increased plasma tumor necrosis factor-alpha and interleukin-6 concentrations in African trypanosomiasis. Neuroimmunomodulation 1994, 1:14-22.
42. Roggero E., Pérez A.R., Tamae-Kakazu M., Piazzon I., Nepomnaschy I., Besedovsky H.O., Bottasso O.A., del Rey A. Endogenous glucocorticoids cause thymus atrophy but are protective during acute Trypanosoma cruzi infection. J. Endocrinol. 2006, 190:495-503.
43. Sacco M., Valenti G., Corvi Mora P., Wu F.C., Ray D.W. DHEA, a selective glucocorticoid receptor antagonist: its role in immune system regulation and metabolism. J. Endocrinol. Invest. 2002, 25:81-82.
44. Santos C.D., Toldo M.P., Santello F.H., Filipin M.del V., Brazão V., do Prado Júnior J.C. Dehydroepiandrosterone increases resistance to experimental infection by Trypanosoma cruzi. Vet. Parasitol. 2008, 153:238-243.
45. Straub R.H., Konecna L., Hrach S., Rothe G., Kreutz M., Schölmerich J., Falk W., Lang B. Serum dehydroepiandrosterone (DHEA) and DHEA sulfate are negatively correlated with serum interleukin-6 (IL-6), and DHEA inhibits IL-6 secretion from mononuclear cells in man in vitro: possible link between endocrinosenescence and immunosenescence. J. Clin. Endocrinol. Metab. 1998, 83:2012-2017.
46. Straub R.H., Lehle K., Herfarth H., Weber M., Falk W., Preuner J., Scholmerich J. Dehydroepiandrosterone in relation to other adrenal hormones during an acute inflammatory stressful disease state compared with chronic inflammatory disease: role of interleukin-6 and tumour necrosis factor. Eur. J. Endocrinol. 2002, 146:365-374.
47. Tarleton R.L. Parasite persistence in the aetiology of Chagas disease. Int. J. Parasitol. 2001, 31:550-554.
48. Tarleton R.L., Grusby M.J., Zhang L. Increased susceptibility of Stat4-deficient and enhanced resistance in Stat6-deficient mice to infection with Trypanosoma cruzi. J. Immunol. 2000, 165:520-1525.
49. Vankelecom H., Carmeliet P., Heremans H., Van Damme J., Dijkmans R., Billiau A., Denef C. Interferon-g inhibits stimulated adrenocorticotropin, prolactin, and growth hormone secretion in normal rat anterior pituitary cell cultures. Endocrinology 1990, 126:2919-2926.
50. Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. J. Clin. Invest. 2005, 115:1111-1119.
51. World Health Organization (WHO), Pan American Health Organization (PAHO) Regional Office The Burden of Neglected Diseases in Latin America and the Caribbean Compared with Some Other Communicable Diseases http://www.paho.org/English/AD/DPC/CD/psit-nd-graph.htm.
52. Yen S.S. Relationship with the severity of pulmonary involvement. Dehydroepiandrosterone sulfate and longevity: new clues for an old friend. Proc. Natl. Acad. Sci. U.S.A 2001, 98:8167-8169.