Progranulin contributes to endogenous mechanisms of pain defense after nerve injury in mice

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 4, 2012, Pages 708-721

  Lim, Hee Young ^a   Albuquerque, Boris ^a   Häussler, Annett ^a   Myrczek, Thekla ^a   Ding, Aihao ^b   Tegeder, Irmgard ^a  

^a GOETHE UNIVERSITY   (Germany)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Growth factor; Microglia; Nerve injury; Neuroinflammation; Pain dorsal root ganglia; Spinal cord

Indexed keywords

MUS;

GRN PROTEIN, MOUSE; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

ANIMAL; ARTICLE; C57BL MOUSE; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IN SITU HYBRIDIZATION; INJURY; MALE; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PAIN; PATHOPHYSIOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; SCIATIC NERVE; SPINAL GANGLION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; FLUORESCENT ANTIBODY TECHNIQUE; GANGLIA, SPINAL; IN SITU HYBRIDIZATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; PAIN; REAL-TIME POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; SCIATIC NERVE; UP-REGULATION;

EID: 84867858135     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01350.x     Document Type: Article

References (47)

1. Bateman A, Bennett HP. The granulin gene family from cancer to dementia. Bioessays. 2009; 31 1245-54.
2. Zhu J, Nathan C, Jin W, et al. Conversion of proepithelin to epithelins roles of SLPI and elastase in host defense and wound repair. Cell. 2002; 111 867-78.
3. He Z, Ong CH, Halper J, et al. Progranulin is a mediator of the wound response. Nat Med. 2003; 9 225-9.
4. Daniel R, Daniels E, He Z, et al. Progranulin (acrogranin/PC cell-derived growth factor/granulin-epithelin precursor) is expressed in the placenta, epidermis, microvasculature, and brain during murine development. Dev Dyn. 2003; 227 593-9.
5. Cruts M, Gijselinck I, van der Zee J, et al. Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. Nature. 2006; 442 920-4.
6. Baker M, Mackenzie IR, Pickering-Brown SM, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006; 442 916-9.
7. Jawaid A, Rademakers R, Kass JS, et al. Traumatic brain injury may increase the risk for frontotemporal dementia through reduced progranulin. Neurodegener Dis. 2009; 6 219-20.
8. Sleegers K, Brouwers N, Van Broeckhoven C. Role of progranulin as a biomarker for Alzheimer's disease. Biomark Med. 2010; 4 37-50.
9. Sleegers K, Brouwers N, Van Damme P, et al. Serum biomarker for progranulinassociated frontotemporal lobar degeneration. Ann Neurol. 2009; 65 603-9.
10. Philips T, De Muynck L, Thu HN, et al. Microglial upregulation of progranulin as a marker of motor neuron degeneration. J Neuropathol Exp Neurol. 2010; 69 1191-200.
11. Yin F, Dumont M, Banerjee R, et al. Behavioral deficits and progressive neuropathology in progranulin-deficient mice a mouse model of frontotemporal dementia. Faseb J. 2010; 24 4639-47.
12. Ahmed Z, Sheng H, Xu YF, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a rold for progranulin in successful aging. Am J Pathol. 2010; 177 311-24.
13. Yin F, Banerjee R, Thomas B, et al. Exaggerated inflammation, impaired host defense, and neuropathology in progranulin-deficient mice. J Exp Med. 2010; 207 117-28.
14. Scholz J, Woolf CJ. The neuropathic pain triad neurons, immune cells and glia. Nat Neurosci. 2007; 10 1361-8.
15. Coull JA, Beggs S, Boudreau D, et al. BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain. Nature. 2005; 438 1017-21.
16. Tsuda M, Shigemoto-Mogami Y, Koizumi S, et al. P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature. 2003; 424 778-83.
17. Tsuda M, Inoue K, Salter MW. Neuropathic pain and spinal microglia a big problem from molecules in small glia. Trends Neurosci. 2005; 28 101-7.
18. Milligan ED, Watkins LR. Pathological and protective roles of glia in chronic pain. Nat Rev Neurosci. 2009; 10 23-36.
19. Decosterd I, Woolf CJ. Spared nerve injury an animal model of persistent peripheral neuropathic pain. Pain. 2000; 87 149-58.
20. Bennett GJ, Chung JM, Honore M, et al. Models of neuropathic pain in the rat. Curr Protoc Neurosci. 2003; Chapter 9 Unit 9.14.
21. Tegeder I, Costigan M, Griffin RS, et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med. 2006; 12 1269-77.
22. Schnell SA, Staines WA, Wessendorf MW. Reduction of lipofuscin-like autofluorescence in fluorescently labeled tissue. J Histochem Cytochem. 1999; 47 719-30.
23. Rubinson DA, Dillon CP, Kwiatkowski AV, et al. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nat Genet. 2003; 33 401-6.
24. Goswami C, Hucho T. TRPV1 expressiondependent initiation and regulation of filopodia. J Neurochem. 2007; 103 1319-33.
25. Griffin RS, Costigan M, Brenner GJ, et al. Complement induction in spinal cord microglia results in anaphylatoxin C5amediated pain hypersensitivity. J Neurosci. 2007; 27 8699-708.
26. Jackson AL, Linsley PS. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov. 2010; 9 57-67.
27. Mannion RJ, Costigan M, Decosterd I, et al. Neurotrophins peripherally and centrally acting modulators of tactile stimulus-induced inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 1999; 96 9385-90.
28. Wilson-Gerwing TD, Dmyterko MV, Zochodne DW, et al. Neurotrophin-3 suppresses thermal hyperalgesia associated with neuropathic pain and attenuates transient receptor potential vanilloid receptor-1 expression in adult sensory neurons. J Neurosci. 2005; 25 758-67.
29. Chuang HH, Prescott ED, Kong H, et al. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature. 2001; 411 957-62.
30. Hoheisel U, Unger T, Mense S. Excitatory and modulatory effects of inflammatory cytokines and neurotrophins on mechanosensitive group IV muscle afferents in the rat. Pain. 2005; 114 168-76.
31. Scholz J, Broom DC, Youn DH, et al. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci. 2005; 25 7317-23.
32. Matzilevich DA, Rall JM, Moore AN, et al. High-density microarray analysis of hippocampal gene expression following experimental brain injury. J Neurosci Res. 2002; 67 646-63.
33. Moisse K, Volkening K, Leystra-Lantz C, et al. Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy implications for TDP-43 in the physiological response to neuronal injury. Brain Res. 2009; 1249 202-11.
34. Naphade SB, Kigerl KA, Jakeman LB, et al. Progranulin expression is upregulated after spinal contusion in mice. Acta Neuropathol. 2010; 119 123-33.
35. Hanani M. Satellite glial cells in sensory ganglia from form to function. Brain Res Brain Res Rev. 2005; 48 457-76.
36. Capuano A, De Corato A, Lisi L, et al. Proinflammatory-activated trigeminal satellite cells promote neuronal sensitization relevance for migraine pathology. Mol Pain. 2009; 5: 43. Doi: 10.1186/1744-8069-5-43.
37. Cherkas PS, Huang TY, Pannicke T, et al. The effects of axotomy on neurons and satellite glial cells in mouse trigeminal ganglion. Pain. 2004; 110 290-8.
38. van Velzen M, Laman JD, Kleinjan A, et al. Neuron-interacting satellite glial cells in human trigeminal ganglia have an APC phenotype. J Immunol. 2009; 183 2456-61.
39. Hrabal R, Chen Z, James S, et al. The hairpin stack fold, a novel protein architecture for a new family of protein growth factors. Nat Struct Biol. 1996; 3 747-52.
40. Zhou J, Gao G, Crabb JW, et al. Purification of an autocrine growth factor homologous with mouse epithelin precursor from a highly tumorigenic cell line. J Biol Chem. 1993; 268 10863-9.
41. Van Damme P, Van Hoecke A, Lambrechts D, et al. Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. J Cell Biol. 2008; 181 37-41.
42. Hu F, Padukkavidana T, Vaegter CB, et al. Sortilin-mediated endocytosis determines levels of the frontotemporal dementia protein, progranulin. Neuron. 2010; 68 654-67.
43. Zhang YJ, Xu YF, Dickey CA, et al. Progranulin mediates caspasedependent cleavage of TAR DNA binding protein-43. J Neurosci. 2007; 27 10530-4.
44. Michelucci A, Heurtaux T, Grandbarbe L, et al. Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions effects of oligomeric and fibrillar amyloid-beta. J Neuroimmunol. 2009; 210 3-12.
45. Zhang J, Shi XQ, Echeverry S, et al. Expression of CCR2 in both resident and bone marrow-derived microglia plays a critical role in neuropathic pain. J Neurosci. 2007; 27 12396-406.
46. Thacker MA, Clark AK, Bishop T, et al. CCL2 is a key mediator of microglia activation in neuropathic pain states. Eur J Pain. 2009; 13 263-72.
47. Ledeboer A, Sloane EM, Milligan ED, et al. Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation. Pain. 2005; 115 71-83.