Molecular characteristics of CTA056, a novel interleukin-2-inducible T-cell kinase inhibitor that selectively targets malignant T cells and modulates oncomirs

Molecular Pharmacology

Volumn 82, Issue 5, 2012, Pages 938-947

  Guo, Wenchang ^a   Liu, Ruiwu ^a   Ono, Yoko ^b   Ma, Ai Hong ^a   Martinez, Anthony ^a   Sanchez, Eduardo ^a   Wang, Yan ^a   Huang, Wenzhe ^a   Mazloom, Anisha ^a   Li, Jixian ^c   Ning, Jinying ^c   Maverakis, Emanual ^b   Lam, Kit S ^a   Kung, Hsing Jien ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Crown Bioscience Inc   (China)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYL 1 (3 (PIPERIDIN 1 YL)PROPYL) 2 (4 (PYRIDIN 4 YL)PHENYL) 1H IMIDAZO [4,5 G]QUINOXALIN 6 (5H)ONE; ANTINEOPLASTIC AGENT; CTA 056; GAMMA INTERFERON; INTERLEUKIN 2; MICRORNA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CELL SPECIFICITY; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; CYTOTOXICITY; ENDOTHELIUM CELL; EPITHELIUM CELL; GENE TARGETING; INCUBATION TIME; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STRUCTURE ACTIVITY RELATION; T CELL LEUKEMIA; T LYMPHOCYTE; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZIMIDAZOLES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-2; LYMPHOMA, T-CELL, CUTANEOUS; MICE; MICE, NUDE; MICRORNAS; MODELS, MOLECULAR; NEOPLASM TRANSPLANTATION; PHOSPHORYLATION; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEIN-TYROSINE KINASES; QUINAZOLINES; T-LYMPHOCYTES; TRANSPLANTATION, HETEROLOGOUS; UP-REGULATION;

EID: 84867760918     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.079889     Document Type: Article

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