The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma

Journal of Experimental Medicine

Volumn 207, Issue 5, 2010, Pages 1031-1044

  Pechloff, Konstanze ^a   Holch, Julian ^a   Ferch, Uta ^a   Schweneker, Marc ^a   Brunner, Kristina ^a   Kremer, Markus ^b   Sparwasser, Tim ^c   Quintanilla Martinez, Leticia ^d,e   Zimber Strobl, Ursula ^e   Streubel, Berthold ^f   Gewies, Andreas ^a,e   Peschel, Christian ^a   Ruland, Jürgen ^a,e  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

^f MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; HERMES ANTIGEN; HYBRID PROTEIN; INTERLEUKIN 2; ITK SYK FUSION PROTEIN; L SELECTIN; LYMPHOCYTE ANTIGEN RECEPTOR; PROTEIN TYROSINE KINASE; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER MODEL; CARCINOGENESIS; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IN VITRO STUDY; IN VIVO STUDY; LIPID RAFT; MOUSE; NONHUMAN; PERIPHERAL T CELL LYMPHOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; UPREGULATION;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; CHROMOSOMES, HUMAN, PAIR 5; CHROMOSOMES, HUMAN, PAIR 9; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERLEUKIN-2; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LECTINS, C-TYPE; LYMPHOMA, T-CELL, PERIPHERAL; LYMPHOPROLIFERATIVE DISORDERS; MICE; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SPLEEN; TRANSLOCATION, GENETIC;

EID: 77952295698     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20092042     Document Type: Article

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