SCOPUS 정보 검색 플랫폼

Volumn 20, Issue 21, 2012, Pages 6394-6402

Adamantyl carboxamides and acetamides as potent human 11β- hydroxysteroid dehydrogenase type 1 inhibitors

(7) Su, Xiangdong a Halem, Heather A b Thomas, Mark P a Moutrille, Cecile a Culler, Michael D b Vicker, Nigel a Potter, Barry V L a

a University of Bath (United Kingdom)

b Biomeasure Inc (United States)

Author keywords

11 HSD1 inhibitor; Adamantyl amide; Diabetes; Hydroxysteroid dehydrogenase; Structure activity relationship

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; 11BETA HYDROXYSTEROID DEHYDROGENASE 2; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE 1; CYTOCHROME P450; N (3 ACETAMIDOBENZYL) N METHYLADAMANTANE 1 CARBOXAMIDE; N (3 AMINOBENZYL) N METHYLADAMANTANE 1 CARBOXAMIDE; N (4 CHLOROBENZYL) N METHYLADAMANTANE 1 CARBOXAMIDE; N (FURAN 2 YLMETHYL)ADAMANTANE 1 CARBOXAMIDE; N (PYRIDIN 2 YLMETHYL)ADAMANTANE 1 CARBOXAMIDE; N (PYRIDIN 3 YLMETHYL)ADAMANTANE 1 CARBOXAMIDE; N [(1 METHYL 1H PYRROL 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N [(3 AMINOTHIOPHEN 2 YL)METHYL] N METHYLADAMANTANE 1 CARBOXAMIDE; N [(4 METHYLTHIOPHEN 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N [(5 CHLOROTHIOPHEN 2 YL)METHYL] N METHYLADAMANTANE 1 CARBOXAMIDE; N [2 (PYRIDIN 2 YL)ETHYL]ADAMANTANE 1 CARBOXAMIDE; N [2 (PYRIDIN 3 YL)ETHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N (4 METHYLBENZYL)ADAMANTANE 1 CARBOXAMIDE; N METHYL N (PYRIDIN 3 YLMETHYL)ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(1 METHYL 1H IMIDAZOL 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(1 METHYL 1H PYRAZOL 5 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(1 METHYL 1H PYRROL 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(3 METHYLTHIOPHEN 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(4 METHYLTHIAZOL 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(4 METHYLTHIOPHEN 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(5 METHYLTHIOPHEN 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [(6 METHYLPYRIDIN 2 YL)METHYL]ADAMANTANE 1 CARBOXAMIDE; N METHYL N [2 (PYRIDIN 2 YL)ETHYL]ADAMANTANE 1 CARBOXAMIDE; OXIDOREDUCTASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN HEK293; CHEMICAL MODIFICATION; CHO CELL; CONCENTRATION RESPONSE; DRUG POTENCY; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; LIVER MICROSOME; MOLECULAR DOCKING; MOLECULAR MODEL; NONHUMAN; PROCESS OPTIMIZATION; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ACETAMIDES; ADAMANTANE; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; ENZYME INHIBITORS; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867573474 PISSN: 09680896 EISSN: 14643391 Source Type: Journal
DOI: 10.1016/j.bmc.2012.08.056 Document Type: Article

Times cited : (11)

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