Adamantane sulfone and sulfonamide 11-β-HSD1 Inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 2, 2007, Pages 527-532

  Sorensen, Bryan ^a   Winn, Martin ^a   Rohde, Jeff ^a   Shuai, Qi ^a   Wang, Jiahong ^a   Fung, Steven ^a   Monzon, Katina ^a   Chiou, William ^a   Stolarik, DeAnne ^a   Imade, Hovis ^a   Pan, Liping ^a   Deng, Xiaoqing ^a   Chovan, Linda ^a   Longenecker, Kenton ^a   Judge, Russell ^a   Qin, Wenying ^a   Brune, Michael ^a   Camp, Heidi ^a   Frevert, Ernst U ^a   Jacobson, Peer ^a   Link, J T ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

11 HSD 1; 11 Hydroxysteroid dehydrogenase; Adamantane; HSD1; HSD1 inhibitor; Sulfonamide; Sulfone

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE; 2 ADAMANTANONE DERIVATIVE; ADAMANTANE DERIVATIVE; FAT; OXIDE; OXIDOREDUCTASE INHIBITOR; SULFONE DERIVATIVE;

ARTICLE; BRAIN; CONTROLLED STUDY; DRUG PENETRATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; EMBRYO; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIVER; MOUSE; NONHUMAN;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; 11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 2; ADAMANTANE; ADIPOSE TISSUE; ANIMALS; BRAIN; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INDICATORS AND REAGENTS; LIVER; MICE; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33846165085     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.10.008     Document Type: Article

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