Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6725-6729

  Tice, Colin M ^a   Zhao, Wei ^a   Krosky, Paula M ^a   Kruk, Barbara A ^a   Berbaum, Jennifer ^a   Johnson, Judith A ^a   Bukhtiyarov, Yuri ^a   Panemangalore, Reshma ^a   Scott, Boyd B ^a   Zhao, Yi ^a   Bruno, Joseph G ^a   Howard, Lamont ^a   Togias, Jennifer ^a   Ye, Yuan Jie ^a   Singh, Suresh B ^a   McKeever, Brian M ^a   Lindblom, Peter R ^a   Guo, Joan ^a   Guo, Rong ^a   Nar, Herbert ^b   Schuler Metz, Annette ^b   Gregg, Richard E ^a   Leftheris, Katerina ^a   Harrison, Richard K ^a   McGeehan, Gerard M ^a   Zhuang, Linghang ^a   Claremon, David A ^a   more..

^a Vitae Pharmaceuticals   (United States)

^b BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

11 Hydroxysteroid dehydrogenase; Diabetes

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ADAMANTANE DERIVATIVE; CARBAMIC ACID DERIVATIVE; OXIDOREDUCTASE INHIBITOR;

ADIPOCYTE; ARTICLE; DRUG BIOAVAILABILITY; DRUG SYNTHESIS; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LIPOPHILICITY; METABOLISM; REACTION OPTIMIZATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ADAMANTANE; ANIMALS; DRUG DISCOVERY; ENZYME INHIBITORS; MODELS, MOLECULAR; RATS;

RATTUS;

EID: 77958062793     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.142     Document Type: Article

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