SCOPUS 정보 검색 플랫폼

Volumn 6, Issue 8, 2011, Pages 1439-1451

Discovery of Adamantyl Heterocyclic Ketones as Potent 11β-Hydroxysteroid Dehydrogenase Type1 Inhibitors

(7) Su, Xiangdong a Vicker, Nigel a Thomas, Mark P a Pradaux Caggiano, Fabienne a Halem, Heather b Culler, Michael D b Potter, Barry V L a

a University of Bath (United Kingdom)

b Biomeasure Inc (United States)

Author keywords

11 HSD1 inhibitors; Adamantyl ethanones; Diabetes; Hydroxysteroid dehydrogenases; Metabolic syndrome

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; ADAMANTANE; ADAMANTYL ETHANONE HETEROCYCLIC DERIVATIVE; CYTOCHROME P450; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BINDING; DRUG OXIDATION; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; BINDING SITES; COMPUTER SIMULATION; CYTOCHROME P-450 ENZYME SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HETEROCYCLIC COMPOUNDS; HUMANS; KETONES; MICE; MICROSOMES, LIVER; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960688526 PISSN: 18607179 EISSN: 18607187 Source Type: Journal
DOI: 10.1002/cmdc.201100144 Document Type: Article

Times cited : (9)

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