Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 22, 2007, Pages 6250-6256

  Corbett, Jeffrey W ^a   Rauckhorst, Mark R ^a   Qian, Fang ^b   Hoffman, Robert L ^b   Knauer, Christopher S ^a   Fitzgerald, Lawrence W ^a  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Copper mediated coupling; Corticotropin releasing factor type 1 antagonist; Corticotropin releasing hormone type 1; CRF1; CRH1; Pyrazine

Indexed keywords

COPPER; CORTICOTROPIN RELEASING FACTOR ANTAGONIST; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; INDANYLPYRAZINE DERIVATIVE; PYRAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; DRUG POTENCY; DRUG STRUCTURE; HUMAN;

BINDING, COMPETITIVE; CATALYSIS; COPPER; DRUG EVALUATION, PRECLINICAL; HUMANS; INDANS; MOLECULAR STRUCTURE; PYRAZINES; PYRIDONES; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35148891651     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.008     Document Type: Article

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