Synthesis, antiproliferative activities and telomerase inhibition evaluation of novel asymmetrical 1,2-disubstituted amidoanthraquinone derivatives

European Journal of Medicinal Chemistry

Volumn 47, Issue 1, 2012, Pages 323-336

  Lee, Chia Chung ^a   Huang, Kuo Feng ^b   Lin, Pen Yuan ^c   Huang, Fong Chun ^d   Chen, Chun Liang ^a   Chen, Tsung Chih ^a   Guh, Jih Hwa ^e   Lin, Jing Jer ^d   Huang, Hsu Shan ^a  

^a NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^b CHI MEI MEDICAL CENTER   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Anthraquinone; NCI 60 cell panel assay; Sulforhodamine B (SRB) assay; Telomerase activity; TRAP assay

Indexed keywords

1 (2 CHLOROBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (2 FLUOROBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (2 METHYLBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (3 FLUOROBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (3 METHYLBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (4 CHLOROBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (4 FLUOROBENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (AMINO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 (BENZAMIDO) 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [(2 FUROYL)AMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [(2,5 DIMETHYL 3 FUROYL)AMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [(3 CHLOROPROPANYL)AMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [(4 CHLOROBUTANYL)AMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [(5 ISOXAZOLECARBONYL)AMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [2 (4 FLUOROPHENYL)ACETYLAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [2 (PHENOXY)ACETYLAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [2 (PHENYL)ACETYLAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [2 (PHENYLSULFANYL)ACETYLAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [2 (TRIFLUOROMETHYL)BENZAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [3 (TRIFLUOROMETHYL)BENZAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1 [4 (TRIFLUOROMETHYL)BENZAMIDO] 2 (CHLOROACETAMIDO) ANTHRAQUINONE; 1, 2 BIS (CHLOROACETAMIDO) ANTHRAQUINONE; 1,2 BIS (3 CHLOROPROPIONAMIDO) ANTHRAQUINONE; 1,2 BIS (4 CHLOROBUTYRAMIDO) ANTHRAQUINONE; 1,2 BIS (4 METHYLBENZAMIDO) ANTHRAQUINONE; ANTHRAQUINONE DERIVATIVE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DETERMINATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IC 50; PROSTATE CANCER;

ANTHRAQUINONES; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; TELOMERASE;

EID: 84855780132     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.10.059     Document Type: Article

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