Antrodia Cinnamomea (A. Camphorata, Neu Chang Chih): An exceptional polypore mushroom with potential antitumor and immuno-modulatory effects

Current Topics in Nutraceutical Research

Volumn 10, Issue 1, 2012, Pages 61-74

  Huang, Chia Hsin ^a,b,c   Chen, Yun Ju ^d   Lin, Chi Chen ^e,f  

^a Agricultural Research Institute   (China)

^b CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^c ASIA UNIVERSITY   (Taiwan)

^d SOUTHERN TAIWAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^e NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^f TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Antitumor; Antrodia; Camphorate; Immunomodulating; Inflammation

Indexed keywords

ANTINEOPLASTIC AGENT; ANTRODIA CINNAMOMEA EXTRACT; AROMATIC COMPOUND; BENZOQUINONE DERIVATIVE; DITERPENE; FATTY ACID; FATTY ACID ESTER; LIGNAN; MALEIC ACID; MICROBIAL PRODUCTS NOT CLASSIFIED ELSEWHERE; NUCLEIC ACID; NUCLEIC ACID BASE; NUCLEOSIDE; POLYSACCHARIDE; PROTEIN; STEROID; SUCCINIC ACID; TERPENE; TRITERPENE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTRODIA CINNAMOMEA; ARTICLE; CHEMICAL COMPOSITION; CULTURE MEDIUM; DRUG MECHANISM; HUMAN; IC 50; IMMUNOMODULATION; METASTASIS INHIBITION; NONHUMAN;

EID: 84867526025     PISSN: 15407535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (63)

1. Ao, Z.H., Xua, Z.H., Lub, Z.M., Xua, H.Y., Zhanga, X.M. and Dou, W.F. (2009). Niuchangchih (Antrodia camphorata) and its potential in treating liver diseases. Journal of Ethnopharmacology 121:194-212.
2. Chang, T.T. and Chou W.N. (1995). Antrodia cinnamomea sp. novon Cinnamomum kanehirai in Taiwan. Mycology Research 99:756-758.
3. Chang, C.Y., Huang, Z.N., Yu, H.H., Chang, L.H., Li, S.L. and Chen, Y.P. (2008) The adjuvant effects of Antrodia camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. Journal of Ethnopharmacology 118:387-395.
4. Chen, K.C., Peng, C.C., Peng, R.Y., Su, C.H., Chiang, H.S., Yan, J.H. and Hsieh-Li, H.M. (2007a) Unique Formosan Mushroom Antrodia camphorata Differentially Inhibits Androgen-Responsive LNCaP and -Independent PC-3 Prostate Cancer Cells. Nutrition and Cancer 57:111-121.
5. Chen, C.J., Krishna, R.V., Tsai, C.C., Wu, W.H. Chao, L. K., Hwang, K.H. Chien, C.M., Chang, H.Y. and Chen, S.T. (2010) Structure and functions of r-dodecalactone isolated from Antrodia camphorata for NK cell activation. Bioorganic and Medicinal Chemistry 18: 6896-6904.
6. Chen, C.C., Chyau, C.C. and Hseu, T.H. (2007a) Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata. Letters in Applied Microbiology 44: 387-392.
7. Chen, C.C. and Hseu, T.H. (2006) Functional activities and safety of Antrodia camphorata. Doctor Thesis. Department of Life Sciences, National Tsing Hua University, Taiwan
8. Chen CJ (2008) Structure and functions of y-dodecalactone isolated from Antrodia camphorata. Doctor Thesis. Institue of Biochemistry and Molecular Biology National Taiwan University, Taiwan.
9. Chen, J.J., Lin, W.J., Liao, C.H. and Shieh, P.C. (2007b) Antiinflammatory benzenoids from Antrodia camphorata. Journal of Natural Products 70:989-992.
10. Chen, T.I., Chen, C.C., Lin, T.W., Tsai, Y.T., Nam, M.K. (2011) A 90-day subchronic toxicological assessment of Antrodia cinnamomea in Sprague-Dawley rats. Food and Chemical Toxicology 49: 429-433.
11. Chen, Y.J., Chou, C.J. and Chang, T.T. (2009) Compound MMH01 possesses toxicity against human leukemia and pancreatic cancer cells. Toxicology in Vitro 23:418-424.
12. Cheng, J.J., Huang, N.K., Chang, T.T., Wang, D.L., Lu, M.K., (2005b) Study for anti-angiogenic activities of polysaccharides isolated from Antrodia cinnamomea in endothelial cells. Life Sciences 76:3029-3042.
13. Cheng, EC., Hsu, C.Y., Chen, C.C. and Lee, K.M. (2008) In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicology and Applied Pharmacology 227:291-298.
14. Chiang, P.C., Lin, S.C., Pan, S.L., Kuo, C.H., Tsai, I.L., Kuo, M.T., Wen, W.C., Chen, P. and Guh, J.H. (2010) Antroquinonol displays anticancer potential against human hepatocellular carcinoma cells: a crucial role of AMPK and mTOR pathways. Biochemical Pharmacology 79:162-171.
15. Chien, P.J., Hsieh, K.Y., Chin, K.L., Huang, W.T., Tsao CY, Chen, Y.F., Cheng, H.C. and Chang, H.H. (2009) Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antrodia camphorata (bitter mushroom) that exhibits TLR2-dependent NF-kB activation and Ml polarization within murine macrophages. Journal of Agricultural and Food Chemistry 57: 4130-4141.
16. Chien, S.C., Chen, M.L., Kuo, H.T., Tsai, Y.C., Lin, B.F. and Kuo, Y.H. (2008) Anti-inflammatory activities of new succinic and maleic derivatives from the fruiting body of Antrodia camphorata. Journal of Agricultural and Food Chemistry. 56:7017-7022.
17. Chiu, H.H. (2007) Phylogenetic analysis of Antrodia species and Antrodia camphorata inferred from internal transcribed spacer region. Antonie van Leeuwenhoek 91: 267-276.
18. Geethangili, M. and Tzeng, Y.M. (2009) Review of Pharmacological effects of Antrodia camphorata and its bioactive compounds. Evidence-based complementary and alternative medicine 2011:212641.
19. Hanahan, D. and Weinberg, R.A. (2003) The hallmarks of cancer. Cell 100:57-70.
20. Hayakawa, Y., Smyth, M.J. (2006) Innate immune recognition and suppression of tumors. Advances in Cancer Research 95:293-322.
21. Hseu, Y.C., Yang, H.L., Lai, Y.C., Lin, J.G., Chen, G.W. and Chang, Y.H. (2004) Induction of Apoptosis by Antrodia camphorata in Human Premyelocytic Leukemia HL-60 Cells. Nutrition and Cancer 48:189-197.
22. Hseu, Y.C., Chen, S.C., Chen, H.C., Liao, J.W. and Yang, H.L. (2008) Antrodia camphorata inhibits proliferation of human breast cancer cells in vitro and in vivo. Food and Chemical Toxicology 46:2680-2688.
23. Hseu, Y.C., Wu, F.Y., Wu, J.J., Chen, J.Y., Chang, W.H., Lu, F.J., Lai, Y.C. and Yang, H.L. (2005) Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. International Immunopharmacology 5:1914-1925.
24. Hsieh, Y.C., Rao, Y.K., Wu, C.C., Huang, C.Y., Geethangili, M., Hsu, S.L. and Tzeng, Y.M. (2010a) Methyl antcinate A from Antrodia camphorata induces apoptosis in human liver cancer cells through oxidant-mediated cofilin- and Bax- triggered mitochondrial pathway. Chemical Research in Toxicology 23:1256-1267.
25. Hsu, Y.L., Kuo, P.L., Cho, C.Y., Ni, W.C., Tzeng, T.F., Ng, L.T., Kuo, Y.H. and Lin, C.C. (2007) Antrodia cinnamomea fruiting bodies extract suppresses the invasive potential of human liver cancer cell line PLC/PRF/5 through inhibition of nuclear factor kB pathway. Food and Chemical Toxicology 45:1249-1257.
26. Hsu, Y.L., Kuo, Y.C., Kuo, P.L., Ng, L.T., Kuo, Y.H. and Lin, C.C. (2005) Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines. Cancer Letters 221:77-89.
27. Huang, C.H. (2010a) An investigation on the anti-tumor and hepatoprotective activities of Antrodia camphorata: anti- metastasis, synergistic anti-tumor effect with DNA vaccine, and liver damage protection against alcohol consumption. Doctor Thesis. National Cheng Kung University, Taiwan, China.
28. Huang, C.H., Chang, C.C., Lin, C.M., Wang, S.T., Wu, M.T., Li, E.I.C., Chang, H.C. and Lin, C.C. (2010b) Promoting effect of Antrodia camphorata as an immunomodulating adjuvant on the antitumor efficacy of HER-2/neu DNA vaccine. Cancer Immunology, Immunotherapy 59:1259-1272.
29. Huang, G.J., Huang, S.S., Lin, S.S., Shao, Y.Y., Chen, C.C., Hou, W.C. and Kuo, Y.H. (2010c) Analgesic effects and the mechanisms of anti-inflammation of ergostatrien- 3beta-ol from Antrodia camphorata submerged whole broth in mice. Journal of Agricultural and Food Chemistry 58:7445-7452.
30. Huang, P.C., Shao, Y.Y., Kuo, Y.H. (2007) Studies on the chemical constituents of Antrodia camphorata submerged whole broth and its essential Oil. Master Thesis, Department of Food Science, Nutrition and Nutraceutical Biotechnology Shih Chien University. Taiwan.
31. Huang, T.Z. (2008) Relationship between the volatile compounds profile and hepatoma inhibitory activity of the fermentation broth of Antrodia cinnamomea Master Thesis, Department of Food Science,National Taiwan University, Taiwan
32. Kuo, M.C., Chang, C.Y., Cheng, T.L. and Wu, M.J. (2008) Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate. Journal of Ethnopharmacology 120:196-203.
33. Kuo, P.L., Hsu, Y.L., Cho, C.Y., Ng, L.T., Kuo, Y.H. and Lin, C.C. (2006) Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food and Chemical Toxicology 44:1316-1326.
34. Li, Y.H., Chung, H.C., Liu, S.L., Chao, T.H. and Chen, J.C. (2009) A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice. International Heart Journal 50:207-20.
35. Lien, H.M., Lin, H.W., Wang, Y.J., Chen, L.C., Yang, D.Y., Lai, Y.Y. and Ho, Y.S. (2009) Inhibition of Anchorage-Independent Proliferation and G0/G1 Cell-Cycle Regulation in Human Colorectal Carcinoma Cells by 4,7-Dimethoxy-5- methyl-l,3-benzodioxole Isolated from the Fruiting Body of Antrodia camphorate. Evidence-based Complementary and Alternative Medicine 17: doi: 10.1093/ecam/nep020
36. Lin, Y.W., Pan, J.H., Liu, R.H., Kuo, Y.H., Sheen, L.Y. and Chiang, B.H. (2010a) The 4-acetylantroquinonol B isolated from mycelium of Antrodia cinnamomea inhibits proliferation of hepatoma cells. Journal ofthe Science of Food and Agriculture 90:1739-1744.
37. Lin, S.Y., Sheen, L.Y., Chiang, B.H., Yang, J.S., Pan, J.H., Chang, Y.H. Hsu, Y.M. Chiang, J.H. Lu, C.C. Wu, C.L. and Chung, J.G. (2010b) Dietary Effect of Antrodia Camphorata Extracts on Immune Responses in WEHI-3 Leukemia BALBI c Mice. Nutrition and Cancer 62:593- 600.
38. Liu, D.Z., Liang, H.J., Chen, C.H., Su, C.H., Lee, T.H., Huang, C.T., Hou, W.C., Lin, S.Y., Zhong, W.B., Lin, P.J., Hung, L.F. and Liang, Y.C. (2007) Comparative antiinflammatory characterization of wild fruiting body, liquid- state fermentation, and solid-state culture of Taiwanofungus camphoratus in microglia and the mechanism of its action. Journal of Ethnopharmacology 113:45-53.
39. Liu, H., Jia, W., Zhang, J. S. and Pan, Y. J. (2008) GC-MS and GC-olfactometry analysis of aroma compounds extracted from culture fluids of Antrodia camphorata. World Journal of Microbiology and Biotechnology 24:1599-1602.
40. Liu, K.J., Leu, S.J., Su, C.H., Chiang, B.L., Chen, Y.L. and Lee, Y.L. (2010) Administration of polysaccharides from Antrodia camphorata modulates dendritic cell function and alleviates allergen-induced T helper type 2 responses in a mouse model of asthma. Immunology 129:351-62.
41. Liu, J.J., Huang, T.S., Hsu, M.L., Chen, C.C., Lin, W.S., Lu, F.J. and Chang, W.H. (2004) Antitumor effects of the partially purified polysaccharides from Antrodia cinnamomea and the mechanism of its action. Toxicology and Applied Pharmacology 201:186-193.
42. Lu, M.C., Du, Y.C., Chuu, J.J., Hwang, S.L., Hsieh, P.C., Hung, C.S., Chang, F.R. and Wu, Y.C. (2009) Active extracts of wild fruiting bodies of Antrodia camphorata (EEAC) induce leukemia HL 60 cells apoptosis partially through histone hypoacetylation and synergistically promote anticancer effect of trichostatin A. Archives of Toxicology 83:121-129.
43. Lu, Z.M., Tao, W.Y., Xu, H.Y., Lim, J., Zhang, X.M., Wang, L.P., Chen, J.H. and Xu, Z.H. (2011) Analysis of volatile compounds of Antrodia camphorata in submerged culture using headspace solid-phase microextraction. Food Chemistry 127:662-668.
44. Mukai, M. Hayakawa, K. Okamura, M. Tagawa, Y. Nakajima, S. Saito, Y. Takahashi, S. Yao, J. Nishimura, D. Sugi, M. Matsunaga, M. and Kitamura, M. (2009) Preferential Blockade of Dioxin-Induced Activation of the Aryl Hydrocarbon Receptor by Antrodia camphorata. Biological and Pharmaceutical Bulletin 32:1510-1515.
45. Oh, G.S., Lee, M.S., Pae, H.O., Kwon, J., Lee, S.S., Jeong, J.G., Shin, M.K., Kwon.T.O. and Chung, H.T. (2006) Effects of oral administration of Phellinus linteus on the production of Thl-and Th2-type cytokines in mice. Immunopharmacology and Immunotoxicology 28:281-293.
46. Peng, C.C., Chen, K.C., Peng, R.Y., Chyau, C.C., Su, C.H. and Hsieh-Li, H.M. (2007) Antrodia camphorata extract induces replicate senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. Journal of Ethnopharmacology 109: 93-103.
47. Rao, Y.K., Wu, A.T., Geethangili, M., Huang, M.T., Chao, W.J., Wu, C.H., Deng, W.P., Yeh, C.T. and Tzeng, Y.M. (2011) Identification of antrocin from Antrodia camphorata as a selective and novel class of small molecule inhibitor of Akt/mTOR signaling in metastatic breast cancer MDA-MB- 231 cells. Chemical Research in Toxicology 24:238-245.
48. Seliger, B., Ritz, U. and Ferrone, S. (2006) Molecular mechanisms of HLA class I antigen abnormalities following viral infection and transformation. International Journal of Cancer 118:129-138.
49. Shen, Y.C., Chou, C.J., Wang, Y.H., Chen, C.F., Chou, Y.C. and Lu, M.K. (2004a) Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiology Letters 231:137-143.
50. Shen, Y.C., Wang, Y.H., Chou, Y.C., Chen, C.F., Lin, L.C., Chang, T.T., Tien, J.H. and Chou, C.J. (2004b) Evaluation of the anti-inflammatory activity of zhankuic acids isolated from the fruiting bodies of Antrodia camphorata. Pianta medica. 70: 310-314
51. Sheu, F., Chien, P.J., Hsieh, K.Y., Chin, K.L., Huang, W.T., Tsao, C.Y., Chen, Y.F., Cheng, H.C. and Chang, H.H. (2009) Purification, cloning, and functional characterization of a novel immunomodulatory protein from Antrodia camphorata (bitter mushroom) that exhibits TLR2-dependent NF-kB activation and Ml polarization within murine macrophages. Journal of Agricultural and Food Chemistry 57:4130-4141.
52. Shao, Y.Y., Chen, C.C., Wang, H.Y., Chiu., H.L., Hseu, T.H. and Kuo, Y.H. (2008) Chemical constituents of Antrodia camphorata submerged whole broth. Natural Product Research 22:1151-1157.
53. Shi, L.S., Chao, C.H., Shen, D.Y., Chan, H.H., Chen, C.H., Liao, Y.R., Wu, S.J., Leu, Y.L., Shen, Y.C., Kuo, Y.H., Lee, E.J., Qian, K., Wu, T.S. and Lee KH. (2011) Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Bioorganic and Medicinal Chemistry 19:677-683.
54. Song, T.Y., Hsu, S.L. and Yen, G.C. (2005a) Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture. Journal of Ethnopharmacology 100:158-167.
55. Song, T.Y., Hsu, S.L., Yeh, C.T and Yen, G.C. (2005b) Mycelia from Antrodia camphorata in submerged culture induced apoptosis of human heptoma Hep G2 cells possibility through regulation of Fas pathway. Journal of Agricultural and Food Chemistry 53: 5559-5564.
56. Tsai, W.C., Rao, Y.K., Lin, S.S., Chou, M.Y., Shen, Y.T., Wu, C.H., Geethangili, M., Yang, C.C. and Tzeng, Y.M. (2010) Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway. Bioorganic and Medicinal Chemistry Letters 20: 6145-6148
57. Wang, S.Y., Hsu, M.L., Hsu, H.C., Tzeng, C.H., Lee, S.S., Shiao, M.S., Ho, C.K. (1997) The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. International Journal of Cancer 70: 699-705.
58. Wang, W.M., Wu, R.Y, and Ko, W.H. (2005) Variation and segregation following nuclear transplantation in Antrodia cinnamomea. Botanical Bulletin of Academia Sinica 46: 217-222.
59. Wu, S.H., Yu, Z.H., Dai, Y.C., Chen, C.T., Su, C.H., Chen, L.C., Hsu, W.C. and Hwang, G.Y. (2004) Taiwanofungus, a polypore new genus. Fungal Sciences 19: 109-116.
60. Yang, H.L., Kuo, Y.H., Tsai, C.T., Huang, Y.T., Chen, S.C., Chang, H.W., Lin, E., Lin, W.H. and Hseu, Y.C. (2011) Anti- metastatic activities of Antrodia camphorata against human breast cancer cells mediated through suppression of the MAPK signaling pathway. Food and Chemical Toxicology 49:290-298.
61. Yeh, C.T., Rao, Y.K., Yao, C.J., Yeh, C.F., Li, C.H., Chuang, S.E., Luong, J.H.T., Lai, G.M. and Tzeng, Y.M. (2009) Cytotoxic triterpenes from Antrodia camphorata and their mode of actionin HT-29 human colon cancer cells. Cancer Letters 285:73-79.
62. Yu, Y.L., Chen, I.H., Shen, K.Y., Huang, RY., Wang, W.R., Chou, C.J., Chang, T.T. and Chu, C.L. (2009) A triterpenoid methyl antcinate K isolated from Antrodia cinnamomea promotes dendritic cell activation and Th2 differentiation. European Journal of Immunology 39:2482-2491.
63. Zhao, S.S., and Leung, K.S.Y. (2010). Quality evaluation of mycelial Antrodia camphorata using high-performance liquid chromatography (HPLC) coupled with diode array detector and mass spectrometry (DAD-MS) Chinese Medicine 5:2-6.