Immunomodulatory effect of Antrodia camphorata mycelia and culture filtrate

Journal of Ethnopharmacology

Volumn 120, Issue 2, 2008, Pages 196-203

  Kuo, Mei Chun ^a   Chang, Chien Yu ^b   Cheng, Tso Lin ^b   Wu, Ming Jiuan ^a  

^a CHIA NAN UNIVERSITY OF PHARMACY AND SCIENCE   (Taiwan)

^b Taiwan Sugar Research Institute   (Taiwan)

Author keywords

Adenosine; Antrodia camphorata; CD11b; IL 6; Phagocytosis; TNF

Indexed keywords

ADENOSINE DERIVATIVE; ANTRODIA CAMPHORATA EXTRACT; CD11B ANTIGEN; INTERLEUKIN 6; MONOCLONAL ANTIBODY; NATURAL PRODUCT; POLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANTRODIA CAMPHORATA; ARTICLE; BLOOD CULTURE; CONCENTRATION RESPONSE; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FUNGUS CULTURE; GEL PERMEATION CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IMMUNOMODULATION; MOLECULAR WEIGHT; MONOCYTE; MUSHROOM; MYCELIUM; NEUTROPHIL; NORMAL HUMAN; PHAGOCYTOSIS; PROTEIN EXPRESSION;

ADENOSINE; ADULT; ANTIGENS, CD11B; ANTRODIA; CHROMATOGRAPHY, GEL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HOT TEMPERATURE; HUMANS; IMMUNOLOGIC FACTORS; INTERLEUKIN-6; MEDICINE, CHINESE TRADITIONAL; MYCELIUM; NEUTROPHILS; PHAGOCYTOSIS; POLYSACCHARIDES; TAIWAN; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

BASIDIOMYCOTA; ESCHERICHIA COLI; TAIWANOFUNGUS CAMPHORATUS;

EID: 55149095382     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2008.08.011     Document Type: Article

References (52)

1. Adachi Y., Okazaki M., Ohno N., and Yadomae T. Enhancement of cytokine production by macrophages stimulated with (1→3)-beta-d-glucan, Grifolan (GRN), isolated from Grifola frondosa. Biological & Pharmaceutical Bulletin 17 (1994) 1554-1560
2. Cavanagh S.P., Gough M.J., and Homer-Vanniasinkam S. The role of the neutrophil in ischaemia-reperfusion injury: potential therapeutic interventions. Cardiovascular Surgery 6 (1998) 112-118
3. Chan W.K., Law H.K., Lin Z.B., Lau Y.L., and Chan G.C. Response of human dendritic cells to different immunomodulatory polysaccharides derived from mushroom and barley. International Immunology 19 (2007) 891-899
4. Chang C.Y., Huang Z.N., Yu H.H., Chang L.H., Li S.L., Chen Y.P., Lee K.Y., and Chuu J.J. The adjuvant effects of Antrodia camphorata extracts combined with anti-tumor agents on multidrug resistant human hepatoma cells. Journal of Ethnopharmacology 118 (2008) 387-395
5. Chang C.Y., Lee C.L., and Pan T.M. Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures. Applied Microbiology and Biotechnology 72 (2006) 654-661
6. Chang T.T., and Chou W.N. Antrodia cinnamomea sp. nov. on Cinnamomum kanehirai in Taiwan. Mycological Research 99 (1995) 756-758
7. Chaplin M.F. Monosaccharides. In: Chaplin M.F., and Kennedy J.F. (Eds). Carbohydrate Analysis: A Practical Approach (1986), IRL, Washington, DC 1-36
8. Chen C.C., Chyau C.C., and Hseu T.H. Production of a COX-2 inhibitor, 2,4,5-trimethoxybenzaldehyde, with submerged cultured Antrodia camphorata. Letters in Applied Microbiology 44 (2007) 387-392
9. Chen C.C., Liu Y.W., Ker Y.B., Wu Y.Y., Lai E.Y., Chyau C.C., Hseu T.H., and Peng R.Y. Chemical characterization and anti-inflammatory effect of polysaccharides fractionated from submerge-cultured Antrodia camphorata mycelia. Journal of Agricultural and Food Chemistry 55 (2007) 5007-5012
10. Chen J.J., Lin W.J., Liao C.H., and Shieh P.C. Anti-inflammatory benzenoids from Antrodia camphorata. Journal of Natural Products 70 (2007) 989-992
11. Chen Y.J., Cheng P.C., Lin C.N., Liao H.F., Chen Y.Y., Chen C.C., and Lee K.M. Polysaccharides from Antrodia camphorata mycelia extracts possess immunomodulatory activity and inhibits infection of Schistosoma mansoni. International Immunopharmacology 8 (2008) 458-467
12. Cheng P.C., Hsu C.Y., Chen C.C., and Lee K.M. In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni. Toxicology and Applied Pharmacology 227 (2008) 291-298
13. Cinco M., Vecile E., Murgia R., Dobrina P., and Dobrina A. Leptospira interrogans and Leptospira peptidoglycans induce the release of tumor necrosis factor alpha from human monocytes. FEMS Microbiology Letters 138 (1996) 211-214
14. Cronstein B.N. Adenosine, an endogenous anti-inflammatory agent. Journal of Applied Physiology 76 (1994) 5-13
15. Ehlers M.R. CR3: a general purpose adhesion-recognition receptor essential for innate immunity. Microbes and Infection 2 (2000) 289-294
16. Hasko G., and Cronstein B.N. Adenosine: an endogenous regulator of innate immunity. Trends in Immunology 25 (2004) 33-39
17. Hasko G., Sitkovsky M.V., and Szabo C. Immunomodulatory and neuroprotective effects of inosine. Trends in Pharmacological Sciences 25 (2004) 152-157
18. Heptinstall S., May J., Fox S., Kwik-Uribe C., and Zhao L. Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults. Journal of Cardiovascular Pharmacology 47 (2006) S197-205
19. Hickstein D.D., Back A.L., and Collins S.J. Regulation of expression of the CD11b and CD18 subunits of the neutrophil adherence receptor during human myeloid differentiation. Journal of Biological Chemistry 264 (1989) 21812-21817
20. Hseu Y.C., Chen S.C., Yech Y.J., Wang L., and Yang H.L. Antioxidant activity of Antrodia camphorata on free radical-induced endothelial cell damage. Journal of Ethnopharmacology 118 (2008) 237-245
21. Hseu Y.C., Wu F.Y., Wu J.J., Chen J.Y., Chang W.H., Lu F.J., Lai Y.C., and Yang H.L. Anti-inflammatory potential of Antrodia camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. International Immunopharmacology 5 (2005) 1914-1925
22. Hseu Y.C., Yang H.L., Lai Y.C., Lin J.G., Chen G.W., and Chang Y.H. Induction of apoptosis by Antrodia camphorata in human premyelocytic leukemia HL-60 cells. Nutrition and Cancer 48 (2004) 189-197
23. Hsiao G., Shen M.Y., Lin K.H., Lan M.H., Wu L.Y., Chou D.S., Lin C.H., Su C.H., and Sheu J.R. Antioxidative and hepatoprotective effects of Antrodia camphorata extract. Journal of Agricultural and Food Chemistry 51 (2003) 3302-3308
24. Kuo M.C., Weng C.Y., Ha C.L., and Wu M.J. Ganoderma lucidum mycelia enhance innate immunity by activating NF-kappaB. Journal of Ethnopharmacology 103 (2006) 217-222
25. Kuo P.L., Hsu Y.L., Cho C.Y., Ng L.T., Kuo Y.H., and Lin C.C. Apoptotic effects of Antrodia cinnamomea fruiting bodies extract are mediated through calcium and calpain-dependent pathways in Hep 3B cells. Food and Chemical Toxicology 44 (2006) 1316-1326
26. Lee T.H., Lee C.K., Tsou W.L., Liu S.Y., Kuo M.T., and Wen W.C. A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata. Planta Medica 73 (2007) 1412-1415
27. Lehmann A.K., Sornes S., and Halstensen A. Phagocytosis: measurement by flow cytometry. Journal of Immunological Methods 243 (2000) 229-242
28. Lin Z.B., and Zhang H.N. Anti-tumor and immunoregulatory activities of Ganoderma lucidum and its possible mechanisms. Acta Pharmacologica Sinica 25 (2004) 1387-1395
29. Liu J.J., Huang T.S., Hsu M.L., Chen C.C., Lin W.S., Lu F.J., and Chang W.H. Antitumor effects of the partially purified polysaccharides from Antrodia camphorata and the mechanism of its action. Toxicology and Applied Pharmacology 201 (2004) 186-193
30. Lu M.K., Cheng J.J., Lai W.L., Lin Y.J., and Huang N.K. Fermented Antrodia cinnamomea extract protects rat PC12 cells from serum deprivation-induced apoptosis: the role of the MAPK family. Journal of Agricultural and Food Chemistry 56 (2008) 865-874
31. Lu M.K., Cheng J.J., Lai W.L., Lin Y.R., and Huang N.K. Adenosine as an active component of Antrodia cinnamomea that prevents rat PC12 cells from serum deprivation-induced apoptosis through the activation of adenosine A(2A) receptors. Life Sciences 79 (2006) 252-258
32. Lu Z.M., Tao W.Y., Zou X.L., Fu H.Z., and Ao Z.H. Protective effects of mycelia of Antrodia camphorata and Armillariella tabescens in submerged culture against ethanol-induced hepatic toxicity in rats. Journal of Ethnopharmacology 110 (2007) 160-164
33. McCallion K., Harkin D.W., and Gardiner K.R. Role of adenosine in immunomodulation: review of the literature. Critical Care Medicine 32 (2004) 273-277
34. Moradali M.F., Mostafavi H., Ghods S., and Hedjaroude G.A. Immunomodulating and anticancer agents in the realm of macromycetes fungi (macrofungi). International Immunopharmacology 7 (2007) 701-724
35. Peng C.C., Chen K.C., Peng R.Y., Chyau C.C., Su C.H., and Hsieh-Li H.M. Antrodia camphorata extract induces replicative senescence in superficial TCC, and inhibits the absolute migration capability in invasive bladder carcinoma cells. Journal of Ethnopharmacology 109 (2007) 93-103
36. Rao Y.K., Fang S.H., and Tzeng Y.M. Evaluation of the anti-inflammatory and anti-proliferation tumoral cells activities of Antrodia camphorata, Cordyceps sinensis, and Cinnamomum osmophloeum bark extracts. Journal of Ethnopharmacology 114 (2007) 78-85
37. Rice P.J., Lockhart B.E., Barker L.A., Adams E.L., Ensley H.E., and Williams D.L. Pharmacokinetics of fungal (1-3)-beta-d-glucans following intravenous administration in rats. International Immunopharmacology 4 (2004) 1209-1215
38. Shen C.C., Wang Y.H., Chang T.T., Lin L.C., Don M.J., Hou Y.C., Liou K.T., Chang S., Wang W.Y., Ko H.C., and Shen Y.C. Anti-inflammatory ergostanes from the basidiomata of Antrodia salmonea. Planta Medica 73 (2007) 1208-1213
39. Shen Y.C., Chou C.J., Wang Y.H., Chen C.F., Chou Y.C., and Lu M.K. Anti-inflammatory activity of the extracts from mycelia of Antrodia camphorata cultured with water-soluble fractions from five different Cinnamomum species. FEMS Microbiology Letters 231 (2004) 137-143
40. Su C.H. Health Guardian Angel: Antrodia camphorata (2002), EKS Book Publishing Co., Taipei
41. Tsai M.-C., Song T.-Y., Shih P.-H., and Yen G.-C. Antioxidant properties of water-soluble polysaccharides from Antrodia cinnamomea in submerged culture. Food Chemistry 104 (2007) 1115-1122
42. Vetvicka V., Thornton B.P., Wieman T.J., and Ross G.D. Targeting of natural killer cells to mammary carcinoma via naturally occurring tumor cell-bound iC3b and beta-glucan-primed CR3(CD11b/CD18). Journal of Immunology 159 (1997) 599-605
43. 2+-NO-cGMP pathway. Life Sciences 73 (2003) 2769-2783
44. Wang S.Y., Hsu M.L., Hsu H.C., Tzeng C.H., Lee S.S., Shiao M.S., and Ho C.K. The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes. International Journal of Cancer 70 (1997) 699-705
45. Wasser S.P. Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides. Applied Microbiology and Biotechnology 60 (2002) 258-274
46. Wu M.J., Cheng T.L., Cheng S.Y., Lian T.W., Wang L., and Chiou S.Y. Immunomodulatory properties of Grifola frondosa in submerged culture. Journal of Agricultural and Food Chemistry 54 (2006) 2906-2914
47. Wu S.H., Ryvarden L., and Chang T.T. Antrodia camphorata ("niu-chang-chih"), new combination of a medicinal fungus in Taiwan. Botanical Bulletin of Academia Sinica (Taipei) 38 (1997) 273-275
48. Wu S.H., Yu S.H., Dai Y.H., Chen C.T., Su C.H., Chen L.C., Hsu W.C., and Hwang Y.H. Taiwanofungus, a polypore new genus. Fungal Science 19 (2004) 109-116
49. Xia Y., Vetvicka V., Yan J., Hanikyrova M., Mayadas T., and Ross G.D. The beta-glucan-binding lectin site of mouse CR3(CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells. Journal of Immunology 162 (1999) 2281-2290
50. Yang H.L., Chen C.S., Chang W.H., Lu F.J., Lai Y.C., Chen C.C., Hseu T.H., Kuo C.T., and Hseu Y.C. Growth inhibition and induction of apoptosis in MCF-7 breast cancer cells by Antrodia camphorata. Cancer Letters 231 (2006) 215-227
51. Zang M., and Su C.H. Ganoderma comphoratum, a new taxon in genus Ganoderma from Taiwan, China. Acta Botanica Yunnanica 12 (1990) 395-396
52. Zarkesh-Esfahani H., Pockley A.G., Wu Z., Hellewell P.G., Weetman A.P., and Ross R.J. Leptin indirectly activates human neutrophils via induction of TNF-alpha. Journal of Immunology 172 (2004) 1809-1814